Article
Oncology
Jiuhui Xu, Chenglong Chen, Kunkun Sun, Qianyu Shi, Boyang Wang, Yi Huang, Tingting Ren, Xiaodong Tang
Summary: This study found that interleukin-6 (IL-6) and its downstream pathway STAT3 were activated in anlotinib-resistant osteosarcoma. Tocilizumab, an anti-IL-6 receptor drug, can block tumor progression in anlotinib-resistant OS cells by inhibiting STAT3 expression. Combination treatment with anlotinib enhances these effects. IL-6 is highly expressed in osteosarcoma patients and is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Anibal Mendez-Clemente, Alejandro Bravo-Cuellar, Salvador Gonzalez-Ochoa, Maria Santiago-Mercado, Luis Palafox-Mariscal, Luis Jave-Suarez, Fabiola Solorzano-Ibarra, Maria Villasenor-Garcia, Pablo Ortiz-Lazareno, Georgina Hernandez-Flores
Summary: This study investigated the effect of inhibiting the STAT-3 pathway on metastatic prostate cancer cells and found that the combination of Stattic and Tocilizumab can reduce the invasive and migratory abilities of the cells. Additionally, the study found that IL-6 plays an important role in regulating the metastasis process of prostate cancer.
Article
Medicine, General & Internal
Maximilian Lennartz, Dennis Atug, Sebastian Dwertmann Rico, Viktor Reiswich, Florian Viehweger, Franziska Buescheck, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Christian Bernreuther, Guido Sauter, Eike Burandt, Andreas H. Marx, Till Krech, Ronald Simon, Sarah Minner, Till S. Clauditz, Frank Jacobsen, Patrick Lebok, Natalia Gorbokon, Katharina Moeller, Stefan Steurer, Christoph Fraune
Summary: Uroplakin 3B (Upk3b) plays a role in maintaining the integrity of the bladder's urothelial cell layer. Its expression is limited in both normal and tumor tissues, and it can be used as a diagnostic marker for mesotheliomas and urothelial tumors.
Article
Oncology
Soeren Weidemann, Jan Lukas Boehle, Hendrina Contreras, Andreas M. Luebke, Martina Kluth, Franziska Buescheck, Claudia Hube-Magg, Doris Hoeflmayer, Katharina Moeller, Christoph Fraune, Christian Bernreuther, Michael Rink, Ronald Simon, Anne Menz, Andrea Hinsch, Patrick Lebok, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Rainer Krech, David Dum, Till Krech, Andreas Marx, Sarah Minner
Summary: Napsin A is a functional aspartic protease involved in protein maturation and lysosomal protein catabolism. It is highly expressed in adenocarcinomas of the lung but can also be found in other tumors. A systematic approach identified a ranking order of tumors based on their Napsin A expression, with loss of Napsin A linked to tumor dedifferentiation in renal cell carcinomas.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anna-Sophia Lieselott Beyer, Daniel Kaemmerer, Joerg Saenger, Katja Evert, Amelie Lupp
Summary: FAM159B, an adaptor protein, plays crucial roles in various cell signalling pathways. Experimental validation showed its expression in neuronal and neuroendocrine tissues and high expression levels in different types of tumors, making the antibody HPA011778 a useful tool for researching and detecting FAM159B expression in tissue samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Cosima Volkel, Noemi De Wispelaere, Soren Weidemann, Natalia Gorbokon, Maximilian Lennartz, Andreas M. Luebke, Claudia Hube-Magg, Martina Kluth, Christoph Fraune, Katharina Moeller, Christian Bernreuther, Patrick Lebok, Till S. Clauditz, Frank Jacobsen, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Sarah Minner, Rainer H. Krech, David Dum, Till Krech, Andreas H. Marx, Ronald Simon, Eike Burandt, Anne Menz
Summary: 】CK5 and CK6 have different expression patterns in tumors, with CK5 predominantly present in basal layers and CK6 in suprabasal layers. In certain tumor types, the expression of both CKs varies, and careful consideration is needed in distinguishing them during analysis.
Article
Chemistry, Medicinal
Kevin J. H. Allen, Ohyun Kwon, Matthew R. Hutcheson, Joseph J. Grudzinski, Stuart M. Cain, Frederic A. Cruz, Remitha M. Vinayakamoorthy, Ying S. Sun, Lindsay Fairley, Chandra B. Prabaharan, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Bryan P. Bednarz, Ekaterina Dadachova
Summary: This study examines the pharmacokinetics of a novel human antibody, IF3, targeting insulin growth factor receptor type 2 (IGF2R) in Beagle dogs and assesses its cross-reactivity with human tissues. The results demonstrate that the antibody accumulates in bone marrow and adrenal glands in dogs, but does not affect the expression of healthy human cells, suggesting its potential as a candidate for radioimmunotherapy of osteosarcoma.
Article
Immunology
Mohammad Abul Kashem, Lin Li, Xin-Yong Yuan, Francis A. Plummer, Ma Luo
Summary: This study demonstrated for the first time that TILRR protein is expressed in healthy adult human and monkey tissues and PBMCs, suggesting its potential role in the inflammatory response to infectious pathogens in these tissues and cells.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, General & Internal
Laura Sophie Tribian, Maximilian Lennartz, Doris Hoeflmayer, Noemi de Wispelaere, Sebastian Dwertmann Rico, Clara von Bargen, Simon Kind, Viktor Reiswich, Florian Viehweger, Florian Lutz, Veit Bertram, Christoph Fraune, Natalia Gorbokon, Soeren Weidemann, Claudia Hube-Magg, Anne Menz, Ria Uhlig, Till Krech, Andrea Hinsch, Eike Burandt, Guido Sauter, Ronald Simon, Martina Kluth, Stefan Steurer, Andreas H. Marx, Patrick Lebok, David Dum, Sarah Minner, Frank Jacobsen, Till S. Clauditz, Christian Bernreuther
Summary: Prostate-specific acid phosphatase (PSAP) is a marker for prostate cancer and its expression is limited in normal tissues but higher in prostate cancers. The expression level of PSAP is associated with clinical characteristics and prognosis of prostate cancer, making it a potential marker for prognostic evaluation.
Editorial Material
Medicine, Research & Experimental
Dinah V. Parums
Summary: Tocilizumab, a humanized monoclonal antibody targeting IL-6 receptor, has been approved for the treatment of various diseases and is now also used for hospitalized patients with severe COVID-19. Future clinical trials will continue to assess the therapeutic effects of targeting IL-6 and IL-6R, providing rationales for more personalized combination treatments to control the systemic effects of SARS-CoV-2 infection in hospitalized patients with moderate and severe COVID-19.
MEDICAL SCIENCE MONITOR
(2021)
Article
Veterinary Sciences
Dohee Lee, Sanggu Kim, Yoonhoi Koo, Yeon Chae, Juwon Wang, Soochong Kim, Taesik Yun, Mhan-Pyo Yang, Byeong-Teck Kang, Hakhyun Kim
Summary: This study evaluated the expression of vitamin D receptor and two enzymes involved in vitamin D metabolism in the canine pancreas. The results showed a decrease in vitamin D receptor expression in inflamed pancreases, indicating a potential role of the pancreas in regulating vitamin D metabolism and suggesting its involvement in the pathophysiology of pancreatitis.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Engineering, Biomedical
Georgios Lappas, Cecile J. A. Wolfs, Nick Staut, Natasja G. Lieuwes, Rianne Biemans, Stefan J. van Hoof, Ludwig J. Dubois, Frank Verhaegen
Summary: A deep learning model with standardized 3D micro cone-beam CT volumes as input was proposed for automatic contouring of normal tissues in small animals. The model provided high quality contours with sub-millimeter performance, as demonstrated through quantitative and qualitative evaluations. In addition, uncertainty analysis showed low inherent model variability.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Chi Zhang, Xiaofan Yang, Tao Jiang, Chengqi Yan, Xiang Xu, Zhenbing Chen
Summary: Extracellular vesicles (EVs) released from cells have intercellular or inter-tissue communication abilities due to the bioactive molecules enclosed in their lipid bilayer membrane. Tissue-derived extracellular vesicles (Ti-EVs) directly isolated from the interstitial space of tissue can better reflect the physiological or pathological state of the tissue microenvironment. This review summarizes the isolation procedures of Ti-EVs and discusses their potential roles in understanding pathogenesis, guiding disease diagnosis and therapy, and exploring cell-free treatments.
Article
Health Care Sciences & Services
Mukta Sharma, Ming-Jer Jeng, Chi-Kuang Young, Shiang-Fu Huang, Liann-Be Chang
Summary: This study demonstrated the clinical potential of Raman spectroscopy in detecting oral squamous cell carcinoma in surgical resection specimens. By analyzing the Raman spectra, higher levels of nucleic acid, protein, and amino acids were found in OSCC tissues compared to healthy tissues, suggesting the possibility of developing an in vivo Raman spectroscopic method for tumor-free resection during surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Veterinary Sciences
Namiko Ikeda, Daiki Kato, Masaya Tsuboi, Ryohei Yoshitake, Shotaro Eto, Sho Yoshimoto, Masahiro Shinada, Satoshi Kamoto, Yuko Hashimoto, Yousuke Takahashi, James Chambers, Kazuyuki Uchida, Ryohei Nishimura, Takayuki Nakagawa
Summary: Cancer immunotherapy targeting IDO1 shows potential for treating canine tumors, as IDO1 was found to be expressed in tumor tissues but limited in normal tissues. This study sheds light on the promising use of IDO1 as a novel target for cancer treatment in dogs.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Cell Biology
Masaki Yamazaki, Atsuhiko Kato, Yoko Zaitsu, Takeshi Watanabe, Makoto Iimori, Shinichi Funahashi, Hiroyuki Kitao, Hiroshi Saeki, Eiji Oki, Masami Suzuki
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2015)
Article
Pathology
Masaki Yamazaki, Nami Yabuki, Yasunori Suzuki, Mayumi Ito, Asuka Ikeda, Osamu Natori, Masami Suzuki, Atsuhiko Kato
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2018)
Article
Pathology
Etsuko Fujii, Masaki Yamazaki, Shigeto Kawai, Yoshimi Ohtani, Takeshi Watanabe, Atsuhiko Kato, Masami Suzuki
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2018)
Article
Biochemistry & Molecular Biology
K. Taniguchi, K. Katagiri, H. Kashiwagi, S. Harada, Y. Sugimoto, Y. Shimizu, H. Arakawa, T. Ito, M. Yamazaki, T. Watanabe, A. Kato, E. Hoshino, T. Takahashi, T. Esaki, M. Suzuki, S. Takeda, F. Ichikawa, A. Harada, N. Sekiguchi, M. Ishigai, H. Kawata, T. Yoneya, E. Onuma, M. Sudoh, Y. Aoki
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2010)
Letter
Toxicology
Masami Suzuki, Etsuko Fujii, Chie Kato, Masaki Yamazaki, Kenji Adachi, Tetsuro Sugimoto, Kunio Doi
JOURNAL OF TOXICOLOGICAL SCIENCES
(2008)
Article
Toxicology
Masami Suzuki, Kaori Isobe, Etsuko Fujii, Masaki Yamazaki, Yayoi Takai, Tomomi Soshin, Sho Akai, Takeshi Watanabe, Atsuhiko Kato
JOURNAL OF TOXICOLOGICAL SCIENCES
(2010)
Article
Cell & Tissue Engineering
Shinta Kobayashi, Hisafumi Yamada-Okabe, Masami Suzuki, Osamu Natori, Atsuhiko Kato, Koichi Matsubara, Yu Jau Chen, Masaki Yamazaki, Shinichi Funahashi, Kenji Yoshida, Eri Hashimoto, Yoshinori Watanabe, Hironori Mutoh, Motooki Ashihara, Chie Kato, Takeshi Watanabe, Takashi Yoshikubo, Norikazu Tamaoki, Takahiro Ochiya, Masahiko Kuroda, Arnold J. Levine, Tatsumi Yamazaki
Article
Pathology
Masaki Yamazaki, Atsuhiko Kato, Chie Kato, Etsuko Fujii, Kenji Adachi, Akio Miyoshi, Masami Suzuki
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2009)
Article
Multidisciplinary Sciences
Shigeto Kawai, Masaki Yamazaki, Keita Shibuya, Masaya Yamazaki, Etsuko Fujii, Kiyotaka Nakano, Masami Suzuki
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Masaki Yamazaki, Atsuhiko Kato, Eiji Oki, Yoko Zaitsu, Chie Kato, Kiyotaka Nakano, Miho Nakamura, Takuya Sakomura, Shigeto Kawai, Etsuko Fujii, Noriaki Sawada, Takeshi Watanabe, Hiroshi Saeki, Masami Suzuki
Summary: This study reveals that small clusters of tumor cells with high expression of LGR5 continuously form in the invasive front in a colorectal cancer xenograft model. These clusters are characterized by stress response and partial/hybrid epithelial-mesenchymal transition. They are important contributors to tumor growth and the expansion of cancer stem cells.
LABORATORY INVESTIGATION
(2021)
Article
Pathology
Minto Nakagawa, Shuji Hayashi, Saori Matsuo, Masaki Yamazaki, Atsuhiko Kato
Summary: This report describes the first case of lymph node lipomatosis in a young adult cynomolgus monkey with bilateral axillary lymph nodes. Macroscopic and histopathological examination revealed the replacement of lymphatic parenchyma by adipose tissue without any malignant findings.
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2022)
Article
Cell Biology
Atsuko Murai, Masaki Yamazaki, Kaori Nishihara, Aki Kito, Sohei Oyama, Naoshi Horiba, Atsuhiko Kato
Summary: The article examined the pathological features of kidneys in a mouse model of SLE induced by a toll-like receptor 7 agonist, imiquimod (IMQ). The results showed that the mice exhibited pathological characteristics corresponding to class II lupus nephritis and podocyte injury.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Cell Biology
Masaki Yamazaki, Atsuhiko Kato, Noriaki Sawada, Takeshi Watanabe, Masami Suzuki
Summary: Recurrence after chemotherapy is a major obstacle in cancer therapy; more detailed histopathological analyses are needed to understand tumor growth process; this study found that protruding structures on flattened ducts are a crucial first step in tumor regrowth.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Pathology
Masaki Yamazaki, Etsuko Fujii, Takeshi Watanabe, Atsuhiko Kato, Masami Suzuki
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2020)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)