Review
Food Science & Technology
Wang Liao, Jianping Wu
Summary: Food protein-derived bioactive peptides, especially antihypertensive peptides, play an important role in regulating blood pressure through the ACE2/Ang (1-7)/MasR axis, demonstrating a new mechanism for reducing hypertension.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Taylor Morganstein, Zahraa Haidar, Joshua Trivlidis, Ilan Azuelos, Megan Jiaxin Huang, David H. Eidelman, Carolyn J. Baglole
Summary: Pulmonary fibrosis is a chronic lung disease affecting 3 million people worldwide, with a potential association with the ACE2/Ang-(1-7)/MasR axis due to its anti-fibrotic action. COVID-19 can lead to pulmonary fibrosis and is linked to smoking. Cannabis, similar to smoking, contains cannabinoids that may reduce inflammation and ACE2 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Hang Pan, Wenhan Huang, Zhongjie Wang, Feifeng Ren, Lei Luo, Jun Zhou, Mengxue Tian, Lin Tang
Summary: The study showed that Ang-(1-7) inhibited pro-inflammatory cytokines while promoting anti-inflammatory cytokines, modulated macrophage polarization through the ACE2-Ang-(1-7)-MAS axis, and regulated TLR4 expression and NF-kappa B and MAPK pathways for anti-inflammatory effects. Additionally, splenomegaly and macrophage infiltration were observed in CLP-induced mouse models, with Ang-(1-7) effectively inhibiting M1 macrophage polarization.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Medicine, Research & Experimental
Jithin Kuriakose, Augusto C. Montezano, Rhian M. Touyz
Summary: ACE2 is a crucial protein in the renin-angiotensin system, responsible for regulating vascular tone and serving as the receptor for SARS-CoV and SARS-CoV-2. It plays a significant role in cardiovascular health and disease, potentially acting as a key mediator of vascular injury in COVID-19.
Article
Agriculture, Multidisciplinary
Hongbing Fan, Wang Liao, Sandra T. Davidge, Jianping Wu
Summary: This study found that chicken muscle-derived peptide V-F can alleviate Ang II-induced inflammation in vascular smooth muscle cells through the ACE2/Ang (1-7)/MasR pathway, supporting its application in the prevention and treatment of hypertension and cardiovascular diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Shiyuan Zhao, Wenxue Sun, Pei Jiang
Summary: The renin-angiotensin system (RAS) consists of two axes: the classic ACE/Ang II/AT1 axis, which regulates blood pressure, vascular oxidative stress, coagulation, and cellular proliferation, and the ACE2/Ang-(1-7)/Mas axis, which inhibits the former and improves fat metabolism, reduces inflammation and oxidative stress, enhances glucose tolerance and insulin sensitivity.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Virendra Tiwari, Jitendra Singh, Priya Tiwari, Swati Chaturvedi, Shivangi Gupta, Akanksha Mishra, Sonu Singh, Muhammad Wahajuddin, Kashif Hanif, Shubha Shukla
Summary: In this study, the role of the ACE2/Ang-(1-7)/Mas receptor axis in Alzheimer's disease (AD) was investigated using various methods. The results showed that activation of this axis could improve cognitive impairment and amyloid deposition in an AD-like rat model. These findings suggest the potential involvement of the ACE2/Ang-(1-7)/Mas axis in the pathophysiology of AD by regulating inflammation and cognitive functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Maha M. Abdel-Fattah, Abdel Nasser A. M. Elgendy, Wafaa R. Mohamed
Summary: The study evaluated the protective effects of the ACE2 activator xanthenone against gentamicin-induced nephrotoxicity, revealing significant antioxidant and anti-inflammatory effects of xanthenone in alleviating kidney damage.
Article
Immunology
Zhongjie Wang, Wenhan Huang, Feifeng Ren, Lei Luo, Jun Zhou, Dongmei Huang, Mei Jiang, Huaan Du, Jinqi Fan, Lin Tang
Summary: The study demonstrated that Ang-(1-7) and AVE0991 can reduce inflammatory cytokine levels, inhibit joint inflammation and bone destruction, as well as alleviate myocardial interstitial fibrosis. Ang-(1-7) may mediate these effects through the Mas receptor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaohui Liu, Yating Sun, Qilu Wei, Wuqiang Jiang, Ming Jiao, Junteng Yan, Run Tian, Pei Yang, Kunzheng Wang, Chunsheng Wang
Summary: This study investigated the therapeutic effects and potential mechanisms of the angiotensin-converting enzyme inhibitor (ACEI) captopril (CAP) in a rat model of glucocorticoid-induced femoral head necrosis (GIONFH). The results showed that CAP promoted cell proliferation, reduced apoptosis and reactive oxygen species accumulation, and promoted osteogenesis. In vivo experiments showed that CAP prevented osteonecrosis, attenuated inflammation levels, and corrected bone metabolism and bone loss. The findings suggest that CAP exerts anti-inflammatory, antioxidant, anti-apoptotic, and osteoprotective effects against GIONFH by activating the ACE2/Ang-(1-7)/Mas receptor signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Samuel N. Heyman, Thomas Walther, Zaid Abassi
Summary: Membrane-bound angiotensin converting enzyme (ACE) 2 acts as a receptor for the Sars-CoV-2 spike protein, allowing viral attachment to host cells. COVID-19 has shed light on the importance of ACE2 and Ang-(1-7), which may offer renoprotective effects in acute kidney injury (AKI) but could also have detrimental effects in certain conditions. Activation of the ACE2/Ang-(1-7)/MasR axis may provide renal protection in AKI patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Guangjin Gu, Bin Zhu, Jie Ren, Xiaomeng Song, Baoyou Fan, Han Ding, Jun Shang, Heng Wu, Junjin Li, Hongda Wang, Jinze Li, Zhijian Wei, Shiqing Feng
Summary: This study aimed to investigate whether activating the Ang-(1-7)/MasR axis can regulate local neuroinflammation to achieve functional recovery after SCI. The results showed that activating the Ang-(1-7)/MasR axis can effectively improve the inflammatory microenvironment after spinal cord injury, promote the polarization of microglia/macrophages towards the M2 phenotype, and support the recovery of motor function. Therefore, using Ang-(1-7) as a treatment strategy for spinal cord injury is suggested to minimize the negative consequences of the inflammatory microenvironment.
CELL AND BIOSCIENCE
(2023)
Article
Food Science & Technology
Rui Ge, Yuanhui Mao, Yuxin Zhao, Yanna Fan, Yannan Zhang, Xiujuan Tao, Jianjun Yang
Summary: In this study, it was found that ACEIP derived from Lycium barbarum L. could improve cardiac hypertrophy and diastolic dysfunction in a HFpEF mouse model. These effects were mediated through the activation of the ACE2/Ang (1-7)/MasR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Che Mohd Nasril Che Mohd Nassir, Mohd K. Zolkefley, Muhammad Danial Ramli, Haziq Hazman Norman, Hafizah Abdul Hamid, Muzaimi Mustapha
Summary: Cerebrovascular events, especially acute ischemic strokes, can occur in patients with COVID-19 infection. The exact cause is still unclear, but it is believed to be multifactorial and related to viral invasion and prothrombotic state. COVID-19 patients are more at risk of long-term neurological problems. Targeting the molecular mechanisms of ACE2/Ang-(1-7)/MasR axis and NLRP3 inflammasome may improve brain repair and secondary prevention in AIS rehabilitation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Changsheng Cong, Shiying Niu, Yifan Jiang, Xinhui Zhang, Wang Jing, Yawen Zheng, Xiaoyue Zhang, Guohai Su, Yueying Zhang, Meili Sun
Summary: Radiation pneumonitis (RP) is a complication of lung cancer radiation therapy, and effective drugs for RP are currently lacking. This study investigated the effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on RP and ACE2/angiotensin-(1-7)/Mas receptor pathway activation. The findings suggest that ACE2 plays a critical role in RP and renin-angiotensin system inhibitors (RASis) may be potential therapeutic drugs for RP.
SCIENTIFIC REPORTS
(2023)
