Journal
REGENERATIVE MEDICINE
Volume 13, Issue 6, Pages 729-739Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2018-0028
Keywords
fibroblast; hedgehog signal pathway; IL-6; STAT3 signaling pathway; stem cell; Wnt; -catenin pathway; wound-induced hair follicle neogenesis
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Funding
- National Natural Science Funding of China [81602740]
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Wound-induced hair follicle neogenesis (WIHN) is a regenerative phenomenon that occurs widely in the skin of adult mammalians. A fully functional follicle can regenerate in the center of a full-thickness wound with a large enough size. The cellular origin of this process is similar to embryonic process. Many growth and development-related pathways are involved in WIHN. Studying WIHN can deeply explore the mechanism of biological growth, development and regeneration, and can identify new treatments for hair-related disorders. Our review aims to enlighten future study by summarizing the clinical manifestation of WIHN, as well as the cellular and molecular mechanism of WIHN in recent studies.
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