Journal
REGENERATIVE MEDICINE
Volume 13, Issue 5, Pages 611-626Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2018-0003
Keywords
adhesive; annulus fibrosus; biomaterial; herniation; intervertebral disc; polyurethane; scaffold; sealant; tissue engineering
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Funding
- Brazilian Agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- CNPq - National Counsel of Technological and Scientific Development, Brazil [308241/2015-0]
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Aim: Disc herniation is a spine disease that leads to suffering and disability. Discectomy is a Janus-faced approach that relieves pain symptoms but leave the intervertebral discs predisposed to herniation. This systematic review discussed the mechanical and biological requirements for a polyurethane-based biomaterial to be used in annular repair. Methods: Search strategy was performed in PubMed, Web of Science and Scopus databases to define the main mechanical properties, biological findings and follow-up aspects of these biomaterials. The range was limited to articles published from January 2000 to December 2017 in English language. Results: The search identified 82 articles. From these, a total of 18 articles underwent a full-text analysis, and 16 studies were included in the review. Conclusion: The polyurethane presents suitable properties to be used as an engineered solution to re-establish the microenvironment and biomechanical features of the intervertebral disc.
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