Journal
REGENERATIVE MEDICINE
Volume 9, Issue 6, Pages 733-741Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/RME.14.61
Keywords
abdominal aortic aneurysm; adipose-derived stem cells; elastin; regeneration
Categories
Funding
- National Institutes of Health [T32 HL076124, T32 EB000392, HL086418, AG037120]
- Peripheral Vascular Surgical Society
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development
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Aim: Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). Materials & methods: AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a delivery device consisting of a subcutaneous port, tubing and porous scaffold was implanted. Five days after elastase perfusion, 100,000 ADMSCs were delivered through the port to the aorta. After sacrifice at day 14, analyzed metrics included aortic diameter and structure of aortic elastin. Results: ADMSC treated aneurysms had a smaller diameter and less fragmented elastin versus saline controls. Conclusion: Periadventitial stem cell delivery prevented the expansion of an established aneurysm between days 5 and 14 after elastase perfusion.
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