Article
Pediatrics
Ermelinda Santos Silva, Susana Rocha, Rita Candeias Ramos, Helena Coutinho, Cristina Catarino, Fernanda Teixeira, Graca Henriques, Ana Isabel Lopes, Alice Santos-Silva, Dora Brites
Summary: This study found a potential association between bile acids profile and redox status in healthy infants, with the type of diet potentially influencing this relationship.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Natalia Kurhaluk, Halyna Tkachenko, Vladimir Tomin
Summary: Low-intensity infrared laser irradiation and red LED radiation were used to irradiate plasma and erythrocyte samples from healthy individuals and diabetes mellitus patients in vitro. The results showed that both low-intensity infrared laser irradiation and red LED radiation can decrease lipid peroxidation levels in the erythrocytes of both healthy individuals and DM patients. The irradiation also led to a decrease in the percent of hemolyzed erythrocytes.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Environmental Sciences
Fatima El Zahra M. Fathi, Kadry M. Sadek, Asmaa F. Khafaga, Abdel Wahab Al Senosy, Hanan A. Ghoniem, Sahar Fayez, Mohamed F. Zeweil
Summary: This study demonstrates that vitamin D can improve the harmful effects of type 2 diabetes by increasing insulin secretion and sensitivity, improving beta-cell function, reducing cortisol levels, and exerting anti-inflammatory and antioxidant effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Yaxian Tian, Yuxuan Li, Sujing Sun, Yanrong Dong, Zhaoju Tian, Linsheng Zhan, Xiaohui Wang
Summary: With the acceleration of industrialisation and urbanisation, air pollution has become a serious global concern, particularly in terms of urban particulate matter (UPM) and its impact on human health. This study investigated the effects of UPM on erythrocyte quality, showing that UPM can have haemolytic properties and influence the oxygen-carrying function and metabolism of erythrocytes. UPM can also adhere to or be internalised by erythrocytes, altering their morphology and leading to increased phosphatidylserine exposure and subsequent clearance in vivo.
Article
Environmental Sciences
Heidi Samantha Moraes Utsunomiya, Joao Victor Cassiel Ferraz, Gabriel Hiroshi Fujiwara, Davi Marques Gutierres, Isabela Ferreira Fernandes, Bruno Serra de Lacerda Valverde, Classius de Oliveira, Lilian Franco-Belussi, Marisa Narciso Fernandes, Cleoni dos Santos Carvalho
Summary: This study evaluated the effects of exposure to water from different sites of the Sorocaba River on genetic damage, oxidative stress, neurotoxicity, and energy metabolism in bullfrog tadpoles. The results indicated that exposure to water from different sites caused changes in various indicators, which may have effects on the development of tadpoles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Physiology
Toru Maruyama, Michinari Hieda, Shiro Mawatari, Takehiko Fujino
Summary: Erythrocytes are vulnerable to oxidative injury, leading to impaired filterability and systemic microcirculation. This is particularly evident in diseases such as diabetes, hypertension, and sickle cell disease. Oxidative inflammation and excessive reactive oxygen species are the main causes of these pathophysiological conditions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jinsong Shao, Lingzi Feng, Qingyu Zhao, Chao Chen, Jia Li, Qian Ma, Xiaohan Jiang, Ying Sun, Yanguang Yang, Haiying Gu, Yong Hu, Donglin Xia
Summary: The study team developed a laser-regulated insulin release system that can release insulin subcutaneously through laser control without frequent injections, effectively controlling diabetes.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Environmental Sciences
Mohamed R. Metawea, Heba M. A. Abdelrazek, Heba Nageh Gad El-Hak, Mona M. Moghazee, Ohoud M. Marie
Summary: This study assessed the histological, immunohistochemical, morphometric, and biochemical changes in pancreatic beta cells in streptozocin-induced diabetes rats treated with curcumin (CU) or nano-curcumin (nCU). The results showed that CU and nCU significantly reduced blood glucose levels, increased the number of immunoreactive beta cells and insulin expression, and reduced the immunoreactive beta cells against caspase-3 expression. The study suggests that CU and nCUR may have a therapeutic role in the biochemical and microscopic changes in pancreatic beta cells in diabetes-induced rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amin Arif, Ruhul Quds, Samreen Salam, Riaz Mahmood
Summary: In this study, we found that dietary antioxidant esculin can protect human erythrocytes from oxidative damage caused by the insecticide bioallethrin. Bioallethrin induced oxidative stress, resulting in increased oxidative proteins and lipids, decreased amino groups and reduced to oxidized glutathione ratio in erythrocytes. It also increased the generation of reactive oxygen and nitrogen species, altered plasma membrane integrity, oxidized hemoglobin, and affected antioxidant enzyme activities and redox system. However, pretreatment with esculin significantly restored these parameters in a concentration-dependent manner. Therefore, esculin can be an effective chemoprotectant against xenobiotic-induced toxicity in human erythrocytes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samreen Salam, Amin Arif, Monika Sharma, Riaz Mahmood
Summary: The fungicide Thiram can cause oxidative damage in human erythrocytes, but the flavonoid glycoside Rutin has a protective effect against Thiram-induced damage, reducing oxidative stress and improving erythrocyte function.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Victor Toro-Roman, Maria C. Robles-Gil, Ignacio Bartolome, Francisco J. Grijota, Diego Munoz, Marcos Maynar-Marino
Summary: Iron metabolism and concentrations change during a sports season, potentially leading to iron deficiency in women athletes. This study analyzed hematological parameters and iron concentrations in different biological matrices of female soccer players during a sports season. The results showed no differences in iron intake, but increased hemoglobin and mean corpuscular hemoglobin concentrations at the end of the season. Extracellular iron concentrations did not significantly change, but erythrocyte iron concentrations decreased. These findings highlight the importance of monitoring and addressing iron status in women soccer players throughout the sports season.
Review
Cell Biology
Alessia Remigante, Rossana Morabito, Angela Marino
Summary: Band 3 protein (B3p) is an anion transporter that plays a crucial role in erythrocyte homeostasis and cell shape, particularly under oxidative stress conditions. Investigating the functions and anion exchange capability of B3p is significant for understanding related diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rashmi S. Tupe, Nilima Bangar, Akib Nisar, Amruta Kulkarni, Neena Sankhe, Rohan Chauhan, Nidhi Mistry, Shamim Shaikh
Summary: Piperine demonstrates preventive, protective, and therapeutic effects on albumin glycation, while also safeguarding red blood cells from oxidative damage induced by glycated albumin.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ruhul Quds, Zarmin Iqbal, Amin Arif, Riaz Mahmood
Summary: Mancozeb induces oxidative stress and impairs the antioxidant defense system in human erythrocytes, resulting in damage to cellular components and adverse effects on erythrocyte structure and function.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jakub Lipski, Anna Duda-Sobczak, Marta Napierala, Ewa Florek, Dorota Zozulinska-Ziolkiewicz, Marzena Wyganowska-Swiatkowska
Summary: The study found that using toothpaste containing chlorhexidine digluconate and cetylpyridine chloride can significantly improve periodontal status and reduce inflammation, with changes in oxidative stress markers in saliva.
Meeting Abstract
Clinical Neurology
L. Stroica, L. E. Gaman, E. Tarta-Arsene, T. Marinescu, B. Cristea, C. Paparau, M. Petran, V. Atanasiu, C. Muscurel, I. Stoian, M. Gilca, C. A. Petran, D. Dragos
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Meeting Abstract
Clinical Neurology
E. M. Petran, L. E. Gaman, B. Ciocea, M. Gilca, D. Dragos, C. A. Petran, C. Muscurel, V. Atanasiu, I. Stoian, L. Stroica, E. Tarta-Arsene, B. Cristea
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Review
Nutrition & Dietetics
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Article
Pharmacology & Pharmacy
Liviu Iosif, Daniela Lixandru, Laura Gaman, Mihaela Ilie, Bogdan Smeu, Diana Simona Stefan, Laura Petcu, Ariana Picu, Alina Constantin, Constantin Ionescu-Tirgoviste, Cristian Guja, Catalin Copaescu, Irina Stoian
Article
Environmental Sciences
Laura Gaman, Corina Elena Delia, Octavio P. Luzardo, Manuel Zumbado, Mihaela Badea, Irina Stoian, Marilena Gilca, Luis D. Boada, Luis Alberto Henriquez-Hernandez
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2020)
Article
Environmental Sciences
Laura Gaman, Mugurel Petrinel Radoi, Corina Elena Delia, Octavio P. Luzardo, Manuel Zumbado, Angel Rodriguez-Hernandez, Irina Stoian, Marilena Gilca, Luis D. Boada, Luis Alberto Henriquez-Hernandez
Summary: The study found that the blood levels of cadmium, lead, and nickel were higher in brain tumor patients compared to healthy subjects, while gadolinium and tantalum showed higher concentrations in brain tumor tissue. The presence of inorganic elements in brain tumor tissue differed significantly from non-tumor brain tissue and brain metastasis tissue.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ariana Picu, Laura Petcu, Diana Simona Stefan, Gratiela Gradisteanu Pircalabioru, Manuela Mitu, Daiana Bajko, Daniela Lixandru, Cristian Guja, Octavian Savu, Anca Pantea Stoian, Alina Constantin, Bogdan Smeu, Catalin Copaescu, Mariana Carmen Chifiriuc, Elena Ionica, Constantin Ionescu-Tirgoviste
Review
Biochemistry & Molecular Biology
Gratiela Gradisteanu Pircalabioru, Nicolae Corcionivoschi, Ozan Gundogdu, Mariana-Carmen Chifiriuc, Luminita Gabriela Marutescu, Bogdan Ispas, Octavian Savu
Summary: The global incidence of T1DM is increasing and research suggests that the gut microbiota may play a role in its pathogenesis. Interventions such as probiotics may help prevent and treat T1DM, emphasizing the importance of further clinical trials to confirm their efficacy and safety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gratiela Gradisteanu Pircalabioru, Mariana-Carmen Chifiriuc, Ariana Picu, Laura Madalina Petcu, Maria Trandafir, Octavian Savu
Summary: The gut microbiota patterns in patients with type 2 diabetes mellitus (T2D) were analyzed in this study. It was found that the levels of beneficial butyrate-producing bacteria were reduced, while potentially pathogenic microorganisms such as Enterobacteriaceae and Fusobacterium were enriched in T2D patients. The genera Bacteroides, Alistipes, Dialister, Bilophila, and Sutterella were identified as potential detrimental factors in T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gratiela Gradisteanu Pircalabioru, Georgiana Alexandra Grigore, Ilda Czobor Barbu, Mariana-Carmen Chifiriuc, Octavian Savu
Summary: SARS-CoV-2 infection disrupts intestinal microbiota, particularly in patients with type 2 diabetes, leading to more severe disease outcomes. The infection results in changes in the gut microbiome, with an increase in pathogenic bacteria and a decrease in beneficial bacteria. Additionally, certain members of the microbiota are associated with the severity of the disease and inflammatory markers.
Review
Biochemistry & Molecular Biology
Carmen Beatrice Dogaru, Carmen Duta, Corina Muscurel, Irina Stoian
Summary: Selenoproteins, a group of proteins containing selenium, play diverse roles in the body and cell processes, functioning as antioxidants, immune modulators, and detoxification agents. Deficiency in selenium or polymorphisms in selenoprotein genes and synthesis are implicated in various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
A. E. Rosca, L. Iosif, I. C. Tivig, R. Mirica, C. Caruntu, C. M. Timaru, S. E. Voiculesu, L. Zagrean, I Stoian
Summary: Chronic exposure to nandrolone decanoate results in a modified redox status favoring oxidants. In Wistar rats, this leads to decreased total antioxidant activity and increased paraoxonase activity, while myeloperoxidase activity remains unaffected.
ROMANIAN BIOTECHNOLOGICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Liviu Iosif, Laura Gaman, Marilena Gilca, Mugurel Radoi, Eugenia Kovacs, Irina Stoian, Dorin Dragos
Proceedings Paper
Gastroenterology & Hepatology
Andra Consuela Ionescu, Laura Gaman, Alina Vasilescu, Valeriu Atanasiu, Irina Stoian, Lucian Ionescu, Mircea Diculescu
NEUROGASTRO 2017 - MEETING OF THE ROMANIAN SOCIETY OF NEUROGASTROENTEROLOGY WITH ROME IV REGIONAL CENTRAL EAST EUROPEAN MEETING
(2017)
Article
Chemistry, Multidisciplinary
Doriana Lupescu, Maria Greabu, Alexandra Totan, Mihail Nagea, Gheorghe Ion Popescu, Olivera Lupescu, Alexandru Lisias Dimitriu, Irina Stoian, Ioana Marina Grintescu, Dan Corneci