Journal
REDOX REPORT
Volume 17, Issue 2, Pages 90-94Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/1351000212Y.0000000007
Keywords
Carbonylation; Cell signaling; Reactive oxygen species; Redox signaling
Categories
Funding
- National Institutes of Health [R01HL72844, R01HL97514]
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Reactive oxygen species (ROS) mediate various cell signaling processes, but the mechanism for how ROS promote cell signaling is poorly understood. Protein carbonylation occurs because of the direct metal-catalyzed oxidation of amino acid side chains (primary protein carbonylation) or the addition of reactive aldehydes to amino acid side chains (secondary protein carbonylation). We hypothesize that primary protein carbonylation plays a role in the mechanism of ROS signaling. Specifically, we propose that (i) primary protein carbonylation mediates cell signaling and (ii) primary protein carbonylation is reversible.
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