Article
Neurosciences
Nikolaos Kladisios, Kathrin D. Wicke, Christina Paetz-Warncke, Felix Felmy
Summary: Comparative analysis reveals that MNTB neurons in bats and gerbils show similar membrane properties but differ in dendrotoxin-sensitive potassium currents and synaptic properties. The spike generator in bats is able to sustain higher frequency input-output functions and maintain temporal precision compared to gerbils.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Physiology
Jessica C. Pressey, Miranda de Saint-Rome, Vineeth A. Raveendran, Melanie A. Woodin
Summary: Synaptic inhibition plays a crucial role in regulating neuronal excitability, which depends on the neurotransmitters GABA and glycine and their effects on the Cl- gradient. CCCs, specifically NKCC1 and KCC2, regulate the Cl- gradient in neurons and play a critical role in healthy brain function. Understanding the mechanisms of CCC regulation and their impact on inhibitory synaptic plasticity can provide insights into neurological disorders. Techniques for estimating and recording intracellular Cl- can be useful for researchers interested in studying CCCs and neuronal excitability. Additionally, nonneuronal cells regulate neuronal excitability by modulating Cl- levels, and CCC-mediated alterations in neuronal excitability are implicated in neurological disorders.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jung-Soo Kim, Jongwoon Kim, Jinchul Ahn, Seok Chung, Chang-Soo Han
Summary: The cell-inspired ionic power device successfully utilizes the Donnan effect to generate high ionic currents and reduce the osmotic imbalance of the membrane. By implementing a mechanical switching system similar to mechanosensitive ion channels, it presents artificial neuronal signaling. Compared to reverse electrodialysis, this device achieves ten times the current and 8.5 times the power density, demonstrating the potential of an ion-based artificial nervous system.
Article
Neurosciences
Nicolas I. C. Muller, Isabelle Paulussen, Lina N. Hofmann, Jonas O. Fisch, Abhyudai Singh, Eckhard Friauf
Summary: Sound localization involves information analysis in the lateral superior olive (LSO), a conspicuous nucleus in the mammalian auditory brainstem. This study shows that acoustic experience plays a significant role in the development of reliable neurotransmission in the LSO, which is essential for effective interaural level difference (ILD) detection.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Limin Ma, Qingyuan Wu, Jinxian Yuan, You Wang, Peng Zhang, Qiankun Liu, Dandan Tan, Minxue Liang, Yangmei Chen
Summary: This study reveals a crucial role of ANXA2 in epilepsy. It regulates excitatory synaptic activity mediated by AMPAR subunit GluA1 to improve seizure activity, which provides novel insights for the treatment and prevention of epilepsy.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Tsang-Shan Chen, Ming-Chi Lai, Huai-Ying Ingrid Huang, Sheng-Nan Wu, Chin-Wei Huang
Summary: Epilepsy is a common chronic neurological disorder in modern society. The immunological factors and the interaction between ion channels and the immune system play important roles in the development and progression of epilepsy. Recognizing immune-mediated epilepsy and understanding the pathophysiology are crucial for early intervention and effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W. B. Goetz, Susanne Ditlevsen, Alexander M. Walter
Summary: Synaptic transmission relies on the release of neurotransmitter from synaptic vesicles and its detection by postsynaptic receptors. There are two principal modes of transmission: action-potential evoked and spontaneous transmission. This study investigates the functional interdependence of these modes at individual synaptic contacts in Drosophila larval neuromuscular junctions. The results show that spontaneous activity can predict the responsiveness of synapses to action-potential stimulation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Andres Hernandez-Clavijo, Nicole Sarno, Kevin Y. Gonzalez-Velandia, Rudolf Degen, David Fleck, Jason R. Rock, Marc Spehr, Anna Menini, Simone Pifferi
Summary: The mouse vomeronasal system controls several social behaviors by detecting pheromones and social cues. TMEM16A and TMEM16B chloride channels in vomeronasal neurons play a role in modulating firing patterns in response to mouse pheromones, with TMEM16A being active under basal conditions and both channels influencing activity upon exposure to pheromones.
Article
Biochemistry & Molecular Biology
Asfree Gwanyanya, Inga Andriule, Bogdan M. Istrate, Farjana Easmin, Kanigula Mubagwa, Regina Macianskiene
Summary: TRPM6 and TRPM7 proteins in the heart may be the molecular candidates for native cardiac Mg2+-sensitive channels, potentially influencing the duration of action potentials and having implications in arrhythmogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Cuiping Wu, Yuefan Jin, Yaqi Cui, Yidan Zhu, Shankai Yin, Chunyan Li
Summary: In the past several decades, bilirubin has been found to be toxic to the central nervous system (CNS), particularly in cases with severely elevated bilirubin levels. The CNS relies on the integrity of neural circuits, which develop and mature during the neonatal period and are affected by physiological or pathological jaundice. This review aims to comprehensively discuss the effects of bilirubin on neural circuit development and electrical activity, providing insights into the mechanisms of bilirubin-induced acute neurotoxicity and chronic neurodevelopmental disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Wenjun Guo, Qinglin Tang, Miao Wei, Yunlu Kang, Jing-Xiang Wu, Lei Chen
Summary: In this study, the cryo-EM structures of TRPC3 and TRPC6 channels were determined, revealing the calcium-dependent regulation and the pathogenic mechanism of GOF mutations associated with diseases like FSGS. These findings provide important insights for further research and structure-based drug design.
Editorial Material
Biochemistry & Molecular Biology
Colin Brownlee
Summary: A new study has identified the major components that enable the Venus flytrap to fire action potentials, revealing the recruitment of different ion channels and transporters that give rise to this unique plant behavioral response.
Article
Chemistry, Multidisciplinary
Yu Wang, Xiao-yun Qiu, Jia-ying Liu, Bei Tan, Fei Wang, Min-juan Sun, Xu-hong Jiang, Xu-ming Ji, Ceng-lin Xu, Yi Wang, Zhong Chen
Summary: In this study, the therapeutic potential of borneol, a plant-derived compound, in the treatment of epilepsy was investigated. Borneol showed anti-seizure effects in acute and chronic epilepsy models and also regulated neurotransmission. The findings suggest that borneol could be a promising candidate for anti-seizure pharmacotherapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Eric R. Wengert, Raquel M. Miralles, Kyle C. A. Wedgwood, Pravin K. Wagley, Samantha M. Strohm, Payal S. Panchal, Abrar Majidi Idrissi, Ian C. Wenker, Jeremy A. Thompson, Ronald P. Gaykema, Manoj K. Patel
Summary: SCN8A epileptic encephalopathy is a devastating epilepsy syndrome caused by mutant SCN8A gene encoding NaV1.6 channel, with inhibitory interneurons playing a critical role in seizure generation through hyperexcitability and sensitivity to action potential failure. Aberrantly large persistent sodium currents directly contribute to abnormal physiology in SST interneurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Hans Holthausen, Roland Coras, Yingying Tang, Lily Bai, Irene Wang, Tom Pieper, Manfred Kudernatsch, Till Hartlieb, Martin Staudt, Peter Winkler, Wiebke Hofer, Samir Jabari, Katja Kobow, Ingmar Blumcke
Summary: This study described the clinical phenotype of 19 children with FCD1A, including drug-resistant epilepsy, cognitive impairment, and abnormal EEG findings. Individualized multilobar resections were performed with 47% achieving seizure freedom.DNA methylation analysis distinguished FCD1A samples from all other epilepsy specimens and controls.
