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Agricultural Engineering
Yuanyue Wang, Yanjiao Luo, Yixin Zhang, Chaoqun Xu, Yu Yao, Jiajun Gu, Yude Peng, Yongzhen Pang, Gang Ding, Fengmei Suo, Guoan Shen, Shangang Jia, Baolin Guo
Summary: In this study, researchers identified PcPT11 as a prenyltransferase in Psoralea corylifolia capable of utilizing 23 substrates for the biosynthesis of prenylated polyphenols. PcPT11 exhibited highly regio-specific prenyltransferase activity at the C-6 position of flavonoids, leading to the production of compounds with important pharmacological effects. The study also demonstrated the strong expression of PcPT11 in fruits and leaves, as well as its localization in chloroplasts when expressed in Nicotiana benthamiana.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Qing-Xia Xu, Zhao-Jing Wang, Zi-Chao He, Jing Xu, Wei Xu, Xiu-Wei Yang
Summary: Nine new flavonoid dimers, named psocorylins R-Z (1-9), were isolated from the fruits of Psoralea corylifolia L. These compounds exhibited diverse structures, including rare cyclobutane-containing chalcone dimers and flavonoid monomer-linked dimers. Cytotoxicity assays showed that some of the compounds demonstrated cytotoxic activities against MCF-7 cells, and further experiments revealed their potential mechanism of action involving the Bcl-2/Bax/Cleaved caspase-3 pathway.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Jingwen Liu, Wen Zhang, Yahui Li, Xiaoye Li, Yiming Li, Fujiang Guo
Summary: Flavonoid extract from the seeds of Psoralea corylifolia L. can alleviate atherosclerosis through multiple mechanisms, including preventing endothelium injury, attenuating vascular inflammation, and alleviating the formation of foam cells.
Article
Multidisciplinary Sciences
Sylvia Kalli, Carla Araya-Cloutier, Jos Hageman, Jean-Paul Vincken
Summary: High resistance to traditional antibiotics has led to the development of new natural therapeutics against MRSA. Prenylated (iso)flavonoids in Fabaceae plants have shown promise as anti-MRSA compounds, with di-prenylated flavonoids and mono-prenylated isoflavones being the most active. A QSAR model with good predictive power was developed to predict activity against MRSA and other Gram-positive bacteria, highlighting the importance of formal charge in the activity of prenylated (iso)flavonoids.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Liqiong Sun, Zhijuan Tang, Minxin Wang, Jun Shi, Yajuan Lin, Tiefeng Sun, Zhilu Zou, Zebin Weng
Summary: This study developed a fast and reliable method to screen antimicrobial compounds targeting MRSA membrane from Psoralea corylifolia Linn. seed. The research identified prenylated flavonoids in Psoralea corylifolia Linn. seed and showed that these compounds have a unique destructive effect on MRSA cell membranes without leading to drug resistance.
Article
Biochemistry & Molecular Biology
Sarah van Dinteren, Jocelijn Meijerink, Renger Witkamp, Bo van Ieperen, Jean-Paul Vincken, Carla Araya-Cloutier
Summary: This study analyzed the composition, antimicrobial activity, and cytotoxicity of prenylated phenolic extracts from different species of liquorice. The results showed that the extracts contained potent antimicrobial compounds that could inhibit the growth of various bacteria.
Article
Chemistry, Analytical
Jishuang Yang, Xia Zhou, Xiuqin Li, Xiaomin Li, Yan Gao, Qinghe Zhang
Summary: This study developed a fast and high throughput method based on the QuEChERS technique combined with GC-QTOF/MS for the simultaneous determination of 21 OPFRs in rice samples. The factors affecting sample pretreatment and GC-QTOF/MS were optimized, and IDMS was used for accurate quantification. The method showed good recoveries and low LOQs, and successfully detected 14 OPFRs in real rice samples within a wide concentration range.
Article
Chemistry, Analytical
Liguo Song, Gabrielle Valenzuela, Shelby Carlson, Zachary Dodson, Mojisola Adisa
Summary: The growing demand for accurate cannabinoid quantification has led to the development of a liquid chromatography diode array detector (LC-DAD) method, which significantly improved existing methods by targeting 20 cannabinoids and quantifying 18 of them.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Mohammad Bagher Majnooni, Seid-Shahram Miraghaee, Samira Keshavarzi, Bahareh Mohammadi, Soraya Sajadimajd, Razieh Hatami, Gholamreza Bahrami
Summary: This study aimed to develop a rapid, simple, and accurate method for simultaneous determination of SOF and LED in human plasma for bioavailability and pharmacokinetic studies. The method showed good precision, reproducibility, and was successfully applied to healthy volunteers with a short total analysis time.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Hao Liu, Siyuan Guo, Shuyi Xi
Summary: This study investigated the in vitro metabolism of graveoline using rat or human liver microsomes and hepatocytes. Multiple metabolic pathways were identified, resulting in the formation of 12 metabolites. The most abundant metabolite was produced by opening the ring of the methylenedioxyphenyl moiety.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Han Yeol Bang, Yong-Kyoung Kim, Hyoyoung Kim, Eun Joo Baek, Taewoong Na, Kyu Sang Sim, Ho Jin Kim
Summary: In this study, a simultaneous multicomponent analysis method based on UHPLC-QTOF-MS pretreated by the QuEChERS method was developed to control the maximum residual levels in sweet peppers. The method was validated and found to meet international standards, providing a possibility for effective pesticide residue management in other agricultural products.
Article
Chemistry, Applied
Juan Yang, Xin Dong, Xiao-Ting Zhen, Yan Chen, Hui Zheng, Li-Hong Ye, Fang-Ming Liu, Jun Cao
Summary: In this study, an electrochemical microreactor (EM) technique was developed for analyzing natural flavonoids and organic acids in fruits. The combination of EM and MS proved to be an effective method for simulating the oxidative metabolism of active compounds in food.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Chemistry, Medicinal
Taghreed A. Ibrahim, Mostafa M. Hegazy, Galal T. Maatooq, Atef A. El-Hela
Summary: The metabolic profiling and biological activity assessment of Stellaria pallida revealed that it contains abundant active compounds and has high medicinal value. The methanol extract showed significant scavenging activity against free radicals and chelating capacity towards iron ions. It also exhibited selective cytotoxicity against various cancer cells and broad-spectrum antiviral activity.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Applied
Hui Zheng, Xiao-Ting Zhen, Yan Chen, Si-Chen Zhu, Li-Hong Ye, Si-Wei Yang, Qiu-Yan Wang, Jun Cao
Summary: A simple and sensitive in situ antioxidation process combined with matrix solid-phase dispersion method was established for extracting chiral flavonoids in citrus fruit. The method showed satisfactory limits of detection and good recoveries for the four target compounds. The IC50 values of DPPH radical-scavenging activities were obtained to evaluate the antioxidant capacity of the samples.
Article
Chemistry, Applied
Xiao-Ting Zhen, Si-Chen Zhu, Min-Zhen Shi, Ya-Ling Yu, Tian-Ci Yan, Zi-Xuan Yue, Yu-Xin Gu, Hui Zheng, Jun Cao
Summary: A rapid, efficient and simple method using CE-ESI-Q-TOF-MS was developed for the determination of eight flavonoids in citrus samples. The method showed good linearity and repeatability, and the citrus samples were classified into different clusters based on the peak areas of the target components.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Analytical
Guoliang Dai, Shitang Ma, Bingting Sun, Tao Gong, Shijia Liu, Changyin Li, Wenzheng Ju
ANALYTICAL METHODS
(2015)
Article
Biochemical Research Methods
Chang-Yin Li, Ji-Hong Chu, Jun Zhang, Bing-Ting Sun, Guo-Liang Dai, Shi-Jia Liu, Wen-Zheng Ju
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2015)
Article
Chemistry, Analytical
Guoliang Dai, Zhitao Jiang, Lijing Zhu, Qian Zhang, Yang Zong, Shijia Liu, Changyin Li, Wenzheng Ju
JOURNAL OF SEPARATION SCIENCE
(2016)
Article
Chemistry, Analytical
Chang-Yin Li, Hui-Ting Song, Shi-Jia Liu, Qiong Wang, Guo-Liang Dai, Xuan-Sheng Ding, Wen-Zheng Ju
JOURNAL OF SEPARATION SCIENCE
(2016)
Article
Integrative & Complementary Medicine
Jihong Chu, Chong Zou, Changyin Li, Jun Zhang, Yang Zhao, Meijuan Xu, Ting Wu, Wenzheng Ju
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2016)
Article
Biochemical Research Methods
Shijia Liu, Peidong Chen, Nongshan Zhang, Luning Sun, Guoliang Dai, Lei Zhu, Changyin Li, Yang Zha, Li Zhang, Haiyan Fu, Wenzheng Ju
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2017)
Article
Multidisciplinary Sciences
Chang-Yin Li, Hui-Ting Song, Xiao-Xiao Wang, Yao-Yao Wan, Xuan-Sheng Ding, Shi-Jia Liu, Guo-Liang Dai, Yue-Heng Liu, Wen-Zheng Ju
SCIENTIFIC REPORTS
(2017)
Article
Plant Sciences
Jian Wu, Xing-Xing Zhang, Xi Zou, Min Wang, Hong-xing Wang, Yao-hui Wang, Chang-yin Li, Lin-gang Zhao, Min Chen, Li-xia Pei, Shen-Lin Liu, Qing-Min Sun
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Ruihan Xu, Jian Wu, Xingxing Zhang, Xi Zou, Changyin Li, Hongxing Wang, Mengyun Yuan, Min Chen, Qingmin Sun, Shenlin Liu
PHARMACOLOGICAL RESEARCH
(2020)
Article
Medicine, General & Internal
Wei-long Xu, Su Liu, Nan Li, Li-fang Ye, Min Zha, Chang-yin Li, Yue Zhao, Qiang Pu, Jin-jing Bao, Xing-jie Chen, Jiang-yi Yu, Ying-hao Pei
Summary: The study demonstrates that quercetin can mitigate glucose fluctuation-induced renal injury by suppressing aerobic glycolysis via the HIE-1 alpha/miR-210/ISCU/FeS pathway in a cell model. This protective effect is dose-dependent and provides new insights into the mechanism of glucose fluctuation-induced renal injury and the potential therapeutic effects of quercetin.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemical Research Methods
Jihong Chu, Ming Liu, Guoliang Dai, Changyin Li, Ting Wu, Jiandong Zou, Wenzheng Ju, Meijuan Xu
Summary: A rapid and sensitive LC-MS/MS method was developed and validated for the simultaneous determination of nicotinamide and its metabolite N-1-methylnicotinamide in human serum. The method demonstrated high sensitivity, accuracy, and stability.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Integrative & Complementary Medicine
Xingxing Wu, Kexin Liu, Qi Wu, Mao Wang, Xuelian Chen, Yuge Li, Lin Qian, Changyin Li, Guoliang Dai, Qide Zhang, Genglin Mu, Jing Wu, Zhaowei Shan
Summary: This study aimed to explore the potential biomarkers of inflammatory bowel disease (IBD) and IBD with damp-heat syndrome (IBD-DH) through metabolomics. Plasma and urine samples were collected from healthy controls and IBD patients, and differential metabolites were identified. A number of metabolites were found to be potential biomarkers for distinguishing IBD from healthy controls, and glycerophospholipids metabolites could be used to differentiate IBD-DH from IBD-SD.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Oncology
Rui Zhao, Shuai Ren, Changyin Li, Kai Guo, Zipeng Lu, Lei Tian, Jian He, Kai Zhang, Yingying Cao, Shijia Liu, Donghui Li, Zhongqiu Wang
Summary: This study identified metabolic features of pancreatic ductal adenocarcinoma (PDAC) and discovered potential early detection biomarkers for PDAC through tissue and serum metabolomics analysis. The identified biomarker panel showed promising performance in distinguishing PDAC from benign pancreatic neoplasms and healthy controls, especially when combined with carbohydrate antigen 19-9 (CA19-9).
Article
Chemistry, Analytical
Xin Gao, Yao-Yao Wan, Chang-Yin Li, Xu-Bin Duan, Xuan-Sheng Ding, Wen-Zheng Ju
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Song Hui-Ting, Li Chang-Yin, Wan Yao-Yao, Ding Xuan-Sheng, Dai Guo-Liang, Liu Shi-Jia, Ju Wen-Zheng
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2017)