Article
Chemistry, Analytical
G. Asher Newsome, Kathleen M. Martin
Summary: This study examines selected Native American woven woodsplint basketry created between 1870 and 1983 to recover traditional knowledge on their manufacture by identifying dyes or colorants. An ambient mass spectrometry system is used to non-invasively sample from intact objects, with no cutting or exposure to liquid. The analysis process involves thermal desorption, gas phase analysis, and photoionization for real-time identification of dye molecules.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Fangfang Lu, Yajun Zheng, Yuan Zhang, Qiang Ma, Zhiping Zhang
Summary: Portable sampling of target analytes in complex biofluid samples using paper-in-tip spray ionization enables efficient and high sensitivity mass spectrometric analysis of therapeutic drugs and proteins. This technique allows for a long and stable spray duration with minimal spray solvent, enabling quick analysis of complex samples with high quantitation precision at picogram-per-milliliter levels.
ANALYTICAL METHODS
(2022)
Article
Biochemical Research Methods
Dilip Kumar Singh, Siddheshwar Kisan Chauthe, Prakash Anjanappa, Sumit Kumar, Ruba A. Arulraj, Raju Gajjela, Noor Mohammed, Venkatesh T. Kanthappa, Ananta Karmakar, Arun Kumar Gupta, Lakshmikant Bajpai, Muralidhararao Bagadi, Arvind Mathur
Summary: The study successfully differentiated pairs of N,N'-substituted urea positional isomers using electrospray ionization tandem mass spectrometry, demonstrating the method's potential for characterizing a series of derivatives.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Article
Chemistry, Analytical
Weiwei Chen, Zhan Gao, Fengjian Chu, Quan He, Yuanji Gao, Yaqin Liu, Hongru Feng, Yuanjiang Pan
Summary: A novel heat-assisted dual neutral spray ionization (HADSI) method was developed for online desalting and high ionization, allowing analysis of salty samples. The method exhibited good sensitivity and linearity, as well as good repeatability and stability. Additionally, it showed promising performance in tolerating long-time analysis of high-salt LC eluates.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Margaux Fresnais, Siwen Liang, Deniz Seven, Nevena Prodanovic, Julia Sundheimer, Walter E. Haefeli, Juergen Burhenne, Remi Longuespee
Summary: The development and validation of desorption/ionization mass spectrometric assays for drug quantification in tissue sections is crucial for their widespread application in (clinical) pharmacology. Advances in desorption electrospray ionization have demonstrated its usefulness for developing targeted quantification methods that meet validation requirements. Factors such as desorption spot morphology, analytical time, and sample surface need to be considered for successful method development. This study highlights the importance of considering desorption kinetics during DESI analyses, which can help reduce analytical time, verify solvent-based drug extraction methods, and predict feasibility of imaging assays. These findings provide valuable guidance for future development of validated DESI-profiling and imaging methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Dale A. Cooper-Shepherd, Hernando J. Olivos, Zhaoxiang Wu, Martin E. Palmer
Summary: The characterization of enantiomers is a significant challenge in chemical and life sciences. Evaluating the purity of chiral molecules is especially crucial in the pharmaceutical industry. This study utilizes the formation of dimers as diastereomeric pairs of enantiomers to separate them using high resolution cyclic ion mobility-mass spectrometry.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Theoneste Muyizere, Janvier Mukiza
Summary: This review summarizes the application of metal ion-assisted ionization sources in the mass spectrometric analysis of polymers and discusses different ionization systems. It also provides an outlook on the future research trends and challenges in this field.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Meng Chen, Yuhan Shang, Hua Bai, Qiang Ma
Summary: A green analytical protocol has been developed for the analysis of anionic compounds. By optimizing operational parameters and using specific ionization and mass spectrometry analysis strategies, the signal intensity was significantly enhanced, and the accuracy and sensitivity of the method were validated. The high greenness score indicates a wide range of potential applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Meng Chen, Yuhan Shang, Hua Bai, Qiang Ma
Summary: Green analytical chemistry aims to develop analytical methods that minimize the use and generation of hazardous substances to protect human health and the environment. In this study, a green analytical protocol was developed for the analysis of anionic compounds using ionization spraying and a miniature mass spectrometer. The method achieved efficient analysis of haloacetic acids through optimization of operational parameters and the use of dual-channel ionization and mass spectrometry. The method demonstrated high recoveries, low detection and quantification limits, and displayed a high degree of greenness.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Daiya Nagai, Akimasa Fujihara
Summary: Chemical properties of gas-phase hydrogen-bonded clusters were studied as a model for interstellar molecular clouds. Cold gas-phase hydrogen-bonded clusters of tryptophan enantiomers and disaccharide isomers were generated and analyzed using tandem mass spectrometry. The photoreactivity and quantification methods of the clusters were investigated, providing important insights into their composition and behavior.
CARBOHYDRATE RESEARCH
(2023)
Article
Biochemical Research Methods
Mark A. Strege, Trent J. Oman, Donald S. Risley, Laura K. Muehlbauer, Ankur Jalan, Zhirui Jerry Lian
Summary: This article describes a chiral high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method for the rapid and accurate determination of amino acid chiral purity in peptides. The method involves hydrolysis of the peptide in deuterated acid, separation of the amino acids by chiral chromatography interfaced with ESI-MS/MS, and direct analysis of the samples using high-low chromatography and extraction of selected ion response. The method was validated for all nineteen chiral proteogenic amino acids and shown to be comparable to traditional testing methods through the analysis of four model peptides.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Chemistry, Analytical
Monica Lin, Molly S. Blevins, Marta Sans, Jennifer S. Brodbelt, Livia S. Eberlin
Summary: In this study, solvent-based ambient ionization mass spectrometry techniques were used to investigate the extraction processes of lipids in biological tissues. The results suggest that the physicochemical properties of the solvent systems and the extraction time significantly influence the molecular extraction and detection of lipids.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Erlu Feng, Xin Ma, Hilkka Kenttamaa
Summary: Substituted ureas are a class of organic compounds commonly used in agriculture and chemical fields, and distinguishing them from other compounds with similar structures can be challenging. A four-stage tandem mass spectrometry method (MS4) was introduced in this study to differentiate between different ureas and similar compounds. The method utilizes gas-phase ion-molecule reactions followed by collision-activated dissociation (CAD) steps to generate diagnostic fragment ions that can effectively distinguish ureas, amides, and carbamates.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ana F. F. Lucena, Leonor Maria, John K. K. Gibson, Joaquim Marcalo
Summary: Gas-phase experiments were conducted to study the basic interactions between the uranyl(VI) ion and selected amino acids using electrospray ionization quadrupole ion trap mass spectrometry. The results revealed that the binding strength of neutral amino acids to uranyl decreased in the order His > Asp > Cys > Gly, similar to their proton affinities. In negative ion mode, the dissociation tendency of the amino acids was found to be Gly >> His ≈ Cys > Asp, indicating enhanced binding to uranyl of the doubly deprotonated amino acids formed in CID.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Analytical
Carmina Vejar-Vivar, Jaime Millan-Santiago, Claudia Mardones, Rafael Lucena, Soledad Cardenas
Summary: This study evaluates polydopamine inner wall-coated hypodermic needles as microextraction devices and electrospray ionization emitters for determining illicit drugs in oral fluid samples.
Article
Toxicology
Jeremy Gingrich, Yong Pu, Jennifer Roberts, Rajendiran Karthikraj, Kurunthachalam Kannan, Richard Ehrhardt, Almudena Veiga-Lopez
ARCHIVES OF TOXICOLOGY
(2018)
Article
Environmental Sciences
Rajendiran Karthikraj, Rasya Bollapragada, Kurunthachalam Kannan
ENVIRONMENTAL POLLUTION
(2018)
Article
Environmental Sciences
Germaine M. Buck Louis, Melissa M. Smarr, Liping Sun, Zhen Chen, Masato Honda, Wei Wang, Rajendiran Karthikraj, Jennifer Weck, Kurunthachalam Kannan
ENVIRONMENTAL RESEARCH
(2018)
Article
Environmental Sciences
Melissa M. Smarr, Kurunthachalam Kannan, Liping Sun, Masato Honda, Wei Wang, Rajendiran Karthikraj, Zhen Chen, Jennifer Weck, Germaine M. Buck Louis
ENVIRONMENTAL RESEARCH
(2018)
Article
Engineering, Environmental
Rajendiran Karthikraj, Sonali Borkar, Sunmi Lee, Kurunthachalam Kannan
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Multidisciplinary Sciences
N. M. Grindler, L. Vanderlinden, R. Karthikraj, K. Kannan, S. Teal, A. J. Polotsky, T. L. Powell, I. V. Yang, T. Jansson
SCIENTIFIC REPORTS
(2018)
Article
Environmental Sciences
Patricia A. Fair, Beth Wolf, Natasha D. White, Stephen A. Arnott, Kurunthachalam Kannan, Rajendiran Karthikraj, John E. Vena
ENVIRONMENTAL RESEARCH
(2019)
Article
Genetics & Heredity
Nara Shin, Luciann Cuenca, Rajendiran Karthikraj, Kurunthachalam Kannan, Monica P. Colaiacovo
Article
Environmental Sciences
Jeremy Gingrich, Yong Pu, Richard Ehrhardt, Rajendiran Karthikraj, Kurunthachalam Kannan, Almudena Veiga-Lopez
Article
Environmental Sciences
Sheela Sathyanarayana, Joseph T. Flynn, Mary Jo Messito, Rachel Gross, Kathryn B. Whitlock, Kurunthachalam Kannan, Rajendiran Karthikraj, Debra Morrison, Maryann Huie, Dimitri Christakis, Leonardo Trasande
ENVIRONMENTAL RESEARCH
(2019)
Article
Environmental Sciences
Rajendiran Karthikraj, Kurunthachalam Kannan
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Environmental Sciences
Rajendiran Karthikraj, Sunmi Lee, Kurunthachalam Kannan
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Editorial Material
Environmental Sciences
Jeremy Gingrich, Yong Pu, Richard Ehrhardt, Rajendiran Karthikraj, Kurunthachalam Kannan, Almudena Veiga-Lopez
Article
Environmental Sciences
Leonardo Trasande, Sandra India Aldana, Howard Trachtman, Kurunthachalam Kannan, Deborah Morrison, Dimitri A. Christakis, Kathryn Whitlock, Mary Jo Messito, Rachel S. Gross, Rajendiran Karthikraj, Sheela Sathyanarayana
ENVIRONMENTAL POLLUTION
(2020)
Article
Environmental Sciences
Rajendiran Karthikraj, Sunmi Lee, Kurunthachalam Kannan
ENVIRONMENTAL RESEARCH
(2020)