Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 22, Issue 16, Pages 2515-2520Publisher
WILEY
DOI: 10.1002/rcm.3639
Keywords
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Funding
- Chinese Academy of Sciences [YZ200764]
- Natural Science Foundation of China [10705026, 10675112]
- Ministry of Science and Technology of China [2007CB815204]
- China Postdoctoral Science Foundation [20070410793]
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Some selected drugs including captopril, fudosteine and racecadotril have been analyzed by infrared (IR) laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (PIMS). The molecular ions of captopril and racecadotril are exclusively observed without any fragments at near threshold single-photon ionization (SPI). However, fudosteine easily forms fragments even at a photon energy near the ionization threshold, indicating the instability of its molecular ion. For these drugs, a number of fragments are yielded with the increase of photon energy. The structures of such fragments proposed by IR LD/VUV PIMS are supported by electron ionization time-of-flight mass spectrometry (EI-TOFMS) results. Fragmentation pathways are discussed in detail. Copyright (C) 2008 John Wiley & Sons, Ltd.
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