Article
Biochemistry & Molecular Biology
Seiji Tanabe, Jieming Fu, Jianhua Cang
Summary: The study found differences in the responses of V1 neurons in tree shrews and mice to different disparities, but similar tuning to interocular phase differences. The stimulus-dependent dissociation of disparity tuning was explained by a network model combining feedforward and recurrent connections, supported by specific cortical organizations in each species.
Article
Neurosciences
Lucija Rapan, Sean Froudist-Walsh, Meiqi Niu, Ting Xu, Thomas Funck, Karl Zilles, Nicola Palomero-Gallagher
Summary: In this study, the parcellation scheme of the macaque frontal agranular cortex was reevaluated using quantitative cytoarchitectonic and multireceptor analyses, identifying 16 distinct areas. Multivariate analysis of receptor fingerprints revealed three clusters, while functional connectivity analysis showed different connectivity patterns between various premotor and motor areas with other brain regions. This 3D atlas provides valuable insights into the microstructure and encoding strategies underlying brain functions evolution.
Article
Neurosciences
Harvey Huang, Nicholas M. Gregg, Gabriela Ojeda Valencia, Benjamin H. Brinkmann, Brian N. Lundstrom, Gregory A. Worrell, Kai J. Miller, Dora Hermes
Summary: This study used electrical brain stimulation to investigate the electrophysiological responses in the human ventral temporal cortex (VTC) to different inputs from multiple brain regions. Four distinct response shapes were identified, which were primarily elicited by stimulation of the hippocampus, amygdala, lateral cortical sites, and multiple distributed sites. This research provides a novel description of connectivity to the VTC and reveals significant differences in input from cortical and limbic structures.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Daniel A. N. Barbosa, Fiene Marie Kuijper, Jeffrey Duda, Allan R. Wang, Samuel C. D. Cartmell, Sabir Saluja, Tricia Cunningham, Rajat S. Shivacharan, Mahendra T. Bhati, Debra L. Safer, James D. Lock, Robert C. Malenka, Ricardo De Oliveira-Souza, Nolan R. Williams, Murray Grossman, James C. Gee, Jennifer A. McNab, Cara Bohon, Casey H. Halpern
Summary: This study revealed aberrations in the vmPFC-NAc shell circuit in obesity and explored the potential of modulating this circuit to restore control over eating behavior in obese individuals.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Yanshuai Tu, Duyan Ta, Zhong-Lin Lu, Yalin Wang
Summary: This study aims to address the issue of non-topological retinotopic maps caused by low signal-to-noise ratio and spatial resolution of fMRI, proposing a method that directly models the topological condition and generates topology-preserving and smooth retinotopic maps. Experimental results demonstrate that the proposed method can generate topological and smooth retinotopic maps in V1, V2, and V3 simultaneously.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biology
Gregory G. Grecco, Briana E. Mork, Jui-Yen Huang, Corinne E. Metzger, David L. Haggerty, Kaitlin C. Reeves, Yong Gao, Hunter Hoffman, Simon N. Katner, Andrea R. Masters, Cameron W. Morris, Erin A. Newell, Eric A. Engleman, Anthony J. Baucum, Jiuen Kim, Bryan K. Yamamoto, Matthew R. Allen, Yu-Chien Wu, Hui-Chen Lu, Patrick L. Sheets, Brady K. Atwood
Summary: The study found that prenatal methadone exposure can lead to impaired physical and neurobehavioral development in offspring after birth, including physical growth, motor activity, and sensorimotor development; these effects are associated with methadone accumulation in the placenta and fetal brain, as well as reduced neuronal density in the motor cortex and disruption in motor neuron intrinsic properties and local circuitry connectivity.
Article
Neurosciences
Jianxun Ren, Catherine S. Hubbard, Jyrki Ahveninen, Weigang Cui, Meiling Li, Xiaolong Peng, Guoming Luan, Ying Han, Yang Li, Ann K. Shinn, Danhong Wang, Luming Li, Hesheng Liu
Summary: This study identified multiple auditory cortico-cerebellar pathways, revealing different levels of functional connectivity between auditory subareas and cerebellar regions. It also showed divergent connectivity patterns between auditory and sensorimotor areas, as well as the potential for functional segmentation of the AC based on different connectivity methods.
Article
Neurosciences
Marta Czime Litwi Czuk, Nils Muhlert, Lauren Cloutman, Nelson Trujillo-Barreto, Anna Woollams
Summary: This study investigated whether a combination of structural and functional connectivity can improve the fit of regression models of cognitive performance. The results showed that structural connectivity, functional connectivity, and combined structural-functional connectivity all produced generalizable models of language performance. The best explanatory models varied for different cognitive domains, and the structural connectivity models performed the best at predicting language performance in unseen samples.
Article
Biochemistry & Molecular Biology
Seonhye Cheon, Allison M. Culver, Anna M. Bagnell, Foster D. Ritchie, Janay M. Vacharasin, Mikayla M. McCord, Carin M. Papendorp, Evelyn Chukwurah, Austin J. Smith, Mara H. Cowen, Trevor A. Moreland, Pankaj S. Ghate, Shannon W. Davis, Judy S. Liu, Sofia B. Lizarraga
Summary: ASH1L plays a role in regulating neuronal morphogenesis by counteracting the catalytic activity of PRC2. Depletion of ASH1L leads to decreased neurite outgrowth and decreased expression of the gene TrkB, which is linked to neuronal morphogenesis. The neuronal morphogenesis defect can be overcome by inhibiting PRC2 activity.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Anna-Lisa Schuler, Diandra Brkic, Giulio Ferrazzi, Giorgio Arcara, Daniele Marinazzo, Giovanni Pellegrino
Summary: Cortical excitability, commonly measured by magnetic stimulation and behavioral response, can be limited in spatial range and fail to account for intrinsic fluctuations. This study introduces a measure for intrinsic excitability based on phase synchronization and applies it to magnetoencephalography (MEG) recordings during exposure to auditory white noise. Results show a specific pattern of decreased frontal lobe excitability and increased temporal lobe excitability during white noise exposure, providing insight into the effects of specific environmental stimuli on cortical excitability.
Article
Multidisciplinary Sciences
Nafiseh Atapour, Katrina H. Worthy, Marcello G. P. Rosa
Summary: The study reports a previously unknown form of thalamocortical plasticity observed in marmoset monkeys following lesions of the primary visual area (V1). The specificity of LGN projections to the cortex is disrupted after long-term V1 lesions, leading to neurochemical and structural remodeling of the circuit. This has potential implications for understanding residual visual abilities after V1 lesions and could inform rehabilitation strategies for cortical blindness.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Dian Lyu, Shruti Naik, David K. Menon, Emmanuel A. Stamatakis
Summary: This study reveals that intrinsic EEG oscillations in the default mode network can predict upcoming involuntary perceptual transitions, suggesting the importance of the brain's endogenous dynamics in consciousness.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Lucija Rapan, Sean Froudist-Walsh, Meiqi Niu, Ting Xu, Ling Zhao, Thomas Funck, Xiao-Jing Wang, Katrin Amunts, Nicola Palomero-Gallagher
Summary: Based on quantitative analyses, this study identified 35 prefrontal areas and revealed regional differences in receptor densities. Additionally, functional connectivity analyses showed distinct patterns in frontal lobe areas. The study provides comprehensive insights into the molecular structure underlying the organization of the cortex and reconciles discrepancies between structural and functional organization.
Article
Clinical Neurology
Cristina Filipescu, Elisabeth Landre, Baris Turak, Bertrand Devaux, Francine Chassoux
Summary: This study describes pure insular ictal semiology and patterns of extra-insular spread using SEEG based on the classification of insular cytoarchitecture. The findings suggest that the classification and corresponding ictal features can help in grading insular seizures and optimizing SEEG planning for presumed insular epilepsy.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Biology
Mehrshad Golesorkhi, Javier Gomez-Pilar, Federico Zilio, Nareg Berberian, Annemarie Wolff, Mustapha C. E. Yagoub, Georg Northoff
Summary: The study discusses the role of intrinsic neural timescales in input processing, emphasizing the importance of sharing across different species, exploring the influence of different temporal mechanisms on input processing, as well as the importance of this research in understanding mental features and psychiatric disorders.
COMMUNICATIONS BIOLOGY
(2021)
Article
Anatomy & Morphology
Alexandros Goulas, Harry B. M. Uylings, Claus C. Hilgetag
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Monica N. Toba, Melissa Zavaglia, Federica Rastelli, Romain Valabregue, Pascale Pradat-Diehl, Antoni Valero-Cabre, Claus C. Hilgetag
HUMAN BRAIN MAPPING
(2017)
Article
Multidisciplinary Sciences
Klaus H. Maier-Hein, Peter F. Neher, Jean-Christophe Houde, Marc-Alexandre Cote, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying-Chia Lin, Qing Ji, Wilburn E. Reddick, John O. Glass, David Qixiang Chen, Yuanjing Feng, Chengfeng Gao, Ye Wu, Jieyan Ma, H. Renjie, Qiang Li, Carl-Fredrik Westin, Samuel Deslauriers-Gauthier, J. Omar Ocegueda Gonzalez, Michael Paquette, Samuel St-Jean, Gabriel Girard, Francois Rheault, Jasmeen Sidhu, Chantal M. W. Tax, Fenghua Guo, Hamed Y. Mesri, Szabolcs David, Martijn Froeling, Anneriet M. Heemskerk, Alexander Leemans, Arnaud Bore, Basile Pinsard, Christophe Bedetti, Matthieu Desrosiers, Simona Brambati, Julien Doyon, Alessia Sarica, Roberta Vasta, Antonio Cerasa, Aldo Quattrone, Jason Yeatman, Ali R. Khan, Wes Hodges, Simon Alexander, David Romascano, Muhamed Barakovic, Anna Auria, Oscar Esteban, Alia Lemkaddem, Jean-Philippe Thiran, H. Ertan Cetingul, Benjamin L. Odry, Boris Mailhe, Mariappan S. Nadar, Fabrizio Pizzagalli, Gautam Prasad, Julio E. Villalon-Reina, Justin Galvis, Paul M. Thompson, Francisco De Santiago Requejo, Pedro Luque Laguna, Luis Miguel Lacerda, Rachel Barrett, Flavio Dell'Acqua, Marco Catani, Laurent Petit, Emmanuel Caruyer, Alessandro Daducci, Tim B. Dyrby, Tim Holland-Letz, Claus C. Hilgetag, Bram Stieltjes, Maxime Descoteaux
NATURE COMMUNICATIONS
(2017)
Article
Neurosciences
Felix Fischer, Florian Pieper, Edgar Galindo-Leon, Gerhard Engler, Claus C. Hilgetag, Andreas K. Engel
Article
Behavioral Sciences
C. Malherbe, R. M. Umarova, M. Zavaglia, C. P. Kaller, L. Beume, G. Thomalla, C. Weiner, C. C. Hilgetag
Review
Neurosciences
Alexandros Goulas, Karl Zilles, Claus C. Hilgetag
TRENDS IN NEUROSCIENCES
(2018)
Article
Biochemical Research Methods
Arnaud Messe, Marc-Thorsten Huett, Claus C. Hilgetag
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Christoph Fretter, Annick Lesne, Claus C. Hilgetag, Marc-Thorsten Huett
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Claus C. Hilgetag, Alexandros Goulas, Jean-Pierre Changeux
Summary: This study proposes a set of fundamental principles underlying the connectivity features of the human brain, including increased sparsification, hierarchical modularization, and increased depth and cytoarchitectonic differentiation of brain networks. Additionally, the characteristic organization of the human brain aligns evolutionary, developmental, cytoarchitectonic, functional, and plasticity features along a natural axis from sensory to association areas. These features have important implications for explaining human cognitive abilities.
NETWORK NEUROSCIENCE
(2022)
Article
Neurosciences
Astrid Rollenhagen, Ora Ohana, Kurt Saetzler, Claus C. Hilgetag, Dietmar Kuhl, Joachim H. R. Luebke
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2018)
Article
Clinical Neurology
Jan-Patrick Stellmann, Sibylle Hodecker, Bastian Cheng, Nadine Wanke, Kim Lea Young, Claus Hilgetag, Christian Gerloff, Christoph Heesen, Gotz Thomalla, Susanne Siemonsen
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2017)
Meeting Abstract
Clinical Neurology
B. Cheng, E. Schlemm, F. Fischer, C. Gerloff, G. Thomalla
EUROPEAN JOURNAL OF NEUROLOGY
(2017)
Article
Psychology, Multidisciplinary
Farid I. Kandil, Bettina Olk, Claus C. Hilgetag
FRONTIERS IN PSYCHOLOGY
(2017)
Article
Mathematics, Applied
Fabrizio Damicelli, Claus C. Hilgetag, Marc-Thorsten Huett, Arnaud Messe
Article
Anatomy & Morphology
Maximilian Schmidt, Rembrandt Bakker, Claus C. Hilgetag, Markus Diesmann, Sacha J. van Albada
BRAIN STRUCTURE & FUNCTION
(2018)