Article
Biochemistry & Molecular Biology
Hashim B. Ali, Aleksei L. Lulla, Alex Nicholson, Jack C. Hankinson, Elizabeth E. Wignall-Fleming, Rhian O'Connor, Diem-Lan Vu, Stephen Graham, Janet Deane, Susana Guix, Valeria Lulla
Summary: During the last decade, there has been a significant increase in the detection of neurotropic astroviruses. These astroviruses, known as the MLB genogroup, are genetically distinct from other zoonotic astroviruses and are associated with gastroenteritis and severe neurological complications. Researchers have identified regions in the capsid-coding region of MLB astroviruses responsible for attenuation and have developed methods to create recombinant viruses with these deletions. This approach could be used to develop vaccines using attenuated astroviruses that infect humans, livestock animals, and poultry.
Review
Biochemistry & Molecular Biology
Abdallah Mohammad Ibrahim, Lalita Chauhan, Aditi Bhardwaj, Anjali Sharma, Faizana Fayaz, Bhumika Kumar, Mohamed Alhashmi, Noora AlHajri, Md Sabir Alam, Faheem Hyder Pottoo
Summary: Globally, neurodegenerative diseases lead to significant disability and distress. Brain-derived neurotrophic factor (BDNF) plays a crucial role in the development and maintenance of various nerve functions and is associated with the family of neurotrophins. Decreased levels of BDNF have been shown to disrupt neuronal functioning and survival. Additionally, BDNF is involved in synaptic plasticity and long-term memory formation. Studies have linked BDNF to the pathology of common neurodegenerative disorders like Alzheimer's and Parkinson's disease, with higher levels of BDNF associated with lower risk.
Review
Cell Biology
Wen-Rong Zhan, Jing Huang, Peng-Ming Zeng, Wei-Ya Tian, Zhen-Ge Luo
Summary: COVID-19 caused by SARS-CoV-2 has presented various neurological manifestations, but it is still unclear whether these symptoms are due to virus invasion into the brain or comorbidities caused by systemic dysregulation. Researchers are discussing the potential neurotropism of SARS-CoV-2 and the potential mechanisms of COVID-19-associated neurological diseases.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Wenbin Wang, Yajie Zhang, Sa Xiao, Xuelan Liu, Peipei Yan, Chunyan Fu, Zengqi Yang
Summary: Avian neurotropic viruses cause severe central nervous system damage in poultry industry. The biomarker for neurotropic viral intracranial invasion in avian neurotropic viruses is still unclear. CARD11 was found to be upregulated in virulent Newcastle disease virus-infected chickens and chicken primary neuronal cells. The relative mRNA and protein expression of CARD11 were upregulated in avian brain-neurotropic viruses (AEV and PPMV-1) infected animals, suggesting that CARD11 could be a potential brain biomarker for avian brain-neurotropic virus invasion.
Review
Virology
Nicole Wildi, Torsten Seuberlich
Summary: Astrovirus infections are a major cause of diarrhea in children, but their significance for animal health has been underestimated. Recently identified neurotropic astroviruses have been found in cases of encephalitis and neurological disease in humans, pigs, ruminant species and minks, leading to neurological symptoms in affected animals.
Article
Medicine, Research & Experimental
Ha-Na Lee, Mohanraj Manangeeswaran, Aaron P. Lewkowicz, Kaliroi Engel, Monica Chowdhury, Mamatha Garige, Michael A. Eckhaus, Carole Sourbier, Derek D. C. Ireland, Daniela Verthelyi
Summary: LILRB4/gp49B is an important inhibitory checkpoint receptor that regulates NK cell function during viral infections, particularly in neonatal mice with ZIKV-associated meningoencephalitis.
Article
Immunology
Florian Bakoa, Christophe Prehaud, Guillaume Beauclair, Maxime Chazal, Nathalie Mantel, Monique Lafon, Nolwenn Jouvenet
Summary: The live attenuated vaccine YF-17D is commonly used for yellow fever virus (YFV) prevention but can lead to post-vaccination neurological syndrome in a small percentage of patients. Understanding the neuroinvasion of the vaccine strain YF-FNV can help improve its biosafety. Research has shown that YF-FNV's neuroinvasiveness occurs through both infection and passage through human brain endothelial cells. Additionally, studying viral population diversity is crucial for understanding YFV vaccine neuroinvasiveness.
Review
Neurosciences
Petra Tavcar, Maja Potokar, Marko Kolenc, Misa Korva, Tatjana Avsic-Zupanc, Robert Zorec, Jernej Jorgacevski
Summary: The article discusses the neurological manifestations of COVID-19 and its relationship with astrocytes, emphasizing the impact of neurotropic mechanisms on the CNS. This provides key information for understanding the pathophysiology of COVID-19 and developing new strategies to mitigate its neurotropic manifestations.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Environmental Sciences
Hassan Karimi-Maleh, Alireza Khataee, Fatemeh Karimi, Mehdi Baghayeri, Li Fu, Jalal Rouhi, Ceren Karaman, Onur Karaman, Rabah Boukherroub
Summary: Pt- and Pd-incorporated ZnO nanoparticles-decorated single-wall carbon nanotubes (Pt-Pd-ZnO/SWCNTs) nanocomposites were used to modify a glassy carbon electrode (GCE) for the detection of idarubicin. The morphology and structure of the nanocomposite were characterized using transmission electron microscopy (TEM) and field-emission scanning electron microscopy (FE-SEM) with energy-dispersive X-ray spectroscopy (EDS). The modified electrode, ds-DNA/Pt-Pd-ZnO/SWCNTs/GCE, was fabricated using a layer-by-layer modification technique and used as a voltammetric sensor for sensitive monitoring of idarubicin. The biosensor showed good performance in detecting idarubicin with a detection limit of 0.8 nM.
Article
Multidisciplinary Sciences
Krisztina Mekli, Artitaya Lophatananon, Rachel Cant, Alistair Burns, Curtis B. Dobson, Ruth F. Itzhaki, Kenneth R. Muir
Summary: The causes of dementia are still unknown, but recent studies suggest that neurotropic viruses, especially HSV1, may play a role in the development of this condition. In this study, researchers found a statistically significant association between HSV1 seropositivity and dementia risk, and combining the data also showed an increased risk with seropositivity for HSV1, HHV6, HHV7, and VZV. These neurotropic viruses may contribute to the pathology of dementia.
Article
Behavioral Sciences
Hasan Bozkurt, Seref Simsek, Serkan Sahin
Summary: Multiple studies have shown that levels of cortisol, BDNF, and tPA are significantly higher in male children with ASD compared to healthy peers, suggesting a potential role of these neurotrophic factors in the pathogenesis of ASD. Further research is needed to understand the exact mechanisms and implications of these findings.
Article
Pharmacology & Pharmacy
Zhuo-Hao Liu, Yin-Cheng Huang, Chang-Yi Kuo, Chi-Cheng Chuang, Ching-Chang Chen, Nan-Yu Chen, Ping K. Yip, Jyh-Ping Chen
Summary: In the process of repairing spinal cord injury, electrospun membranes containing DHA and BDNF can be used to achieve neurogenesis and guide neurite extension through the controlled release of these two pro-regenerative agents and the topography of aligned fibers. In the rat experiment, it was also demonstrated that drug-loaded fibrous membranes are important for improving neurological function recovery and promoting neuroprotection and neuroplasticity changes.
Review
Chemistry, Medicinal
Juliana Helena Castro e Silva, Jessica Teles Souza, Clarissa Schitine, Anibal de Freitas Santos Junior, Eduardo Muniz Santana Bastos, Silvia Lima Costa
Summary: This study investigates the pharmacological potential of flavonoids against neurotropic viruses. The analysis of 205 articles shows that flavonoids have a wide range of antiviral activities against viruses affecting the CNS, including influenza, hepatitis C, coronavirus, enterovirus, and arbovirus. The use of flavonoids with both neuroprotective and antiviral effects could be an alternative therapy for CNS infections.
Article
Developmental Biology
Ana Monserrat Vela-Alcantara, Ariadna Rios-Ramirez, Juan Santiago-Garcia, Juan Carlos Rodriguez-Alba, Elisa Tamariz Dominguez
Summary: The present study evaluated the impact of substrate stiffness on the response of DRG neurons to Sema3a, showing that stiffness can regulate cell morphology, Sema3a receptor expression, and cytoskeleton distribution, affecting the collapse response of growth cones.
CELLS & DEVELOPMENT
(2022)
Article
Cell & Tissue Engineering
So Yoon Ahn, Dong Kyung Sung, Young Eun Kim, Sein Sung, Yun Sil Chang, Won Soon Park
Summary: This study confirmed the efficacy of MSC-derived EVs in attenuating severe IVH-induced brain injuries, showing that the neuroprotection is primarily achieved through BDNF transfer via EVs, which is as effective as parental MSCs.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Cell & Tissue Engineering
Citlalli Regalado-Santiago, Enrique Juarez-Aguilar, Juan David Olivares-Hernandez, Elisa Tamariz
STEM CELLS INTERNATIONAL
(2016)
Article
Biochemistry & Molecular Biology
Luz M. Lopez-Marin, Elisa Tamariz, Laura S. Acosta-Torres, Victor M. Castano
CURRENT DRUG METABOLISM
(2013)
Article
Agriculture, Dairy & Animal Science
D. Montoya-Flores, O. Mora, E. Tamariz, L. Gonzalez-Davalos, A. Gonzalez-Gallardo, A. Antaramian, A. Shimada, A. Varela-Echavarria, J. L. Romano-Munoz
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2012)
Article
Engineering, Biomedical
Elisa Tamariz, Andrew C. A. Wan, Y. Shona Pek, Magda Giordano, Genoveva Hernandez-Padron, Alfredo Varela-Echavarria, Ivan Velasco, Victor M. Castano
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2011)
Article
Neurosciences
Amaya Miquelajauregui, Alfredo Varela-Echavarria, M. Laura Ceci, Fernando Garcia-Moreno, Itzel Ricano, Kimmi Hoang, Daniela Frade-Perez, Carlos Portera-Cailliau, Elisa Tamariz, Juan A. De Carlos, Heiner Westphal, Yangu Zhao
JOURNAL OF NEUROSCIENCE
(2010)
Article
Biotechnology & Applied Microbiology
N. Emmanuel Diaz-Martinez, Elisa Tamariz, N. Fabian Diaz, Claudia M. Garcia-Pena, Alfredo Varela-Echavarria, Ivan Velasco
Article
Acoustics
Blanca Millan-Chiu, Giselle Camacho, Alfredo Varela-Echavarria, Elisa Tamariz, Francisco Fernandez, Luz M. Lopez-Marin, Achim M. Loske
ULTRASOUND IN MEDICINE AND BIOLOGY
(2014)
Article
Anatomy & Morphology
Claudia M. Garcia-Pena, Minkyung Kim, Daniela Frade-Perez, Daniela Avila-Gonzalez, Elisa Tellez, Grant S. Mastick, Elisa Tamariz, Alfredo Varela-Echavarria
FRONTIERS IN NEUROANATOMY
(2014)
Article
Anatomy & Morphology
Claudia M. Garcia-Pena, Daniela Avila-Gonzalez, Amaya Miquelajauregui, Carlos Lozano-Flores, Grant S. Mastick, Elisa Tamariz, Alfredo Varela-Echavarria
FRONTIERS IN NEUROANATOMY
(2018)
Article
Anatomy & Morphology
Melissa Matrecitos-Avila, Remy Avila, Reinher Pimentel-Dominguez, Salvador Cuevas, Elisa Tamariz, Pablo Loza-Alvarez
Summary: Precise and stable focus is crucial in confocal microscopy to ensure image sharpness and prevent misinterpretation of radiometric fluctuations as variations in fluorescence intensity. This study reports a focus drift caused by a continuous wave laser of 810-nm wavelength introduced along the optical path of an inverted confocal microscope. The drift is observed when the laser is turned on or off, with the focus position shifting towards lower or higher values of the vertical coordinate z, respectively. Analysis suggests that the focus drift is due to heating of the immersion oil.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Cell Biology
E. M. Olascoaga-Caso, E. Tamariz-Dominguez, J. C. Rodriguez-Alba, E. Juarez-Aguilar
Summary: In cancer, GH regulates EMT to promote metastasis, while in non-cancer cells, it does not affect EMT. GH might participate in cervical cancer progression by favoring a hybrid EMT phenotype.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Developmental Biology
Ana Monserrat Vela-Alcantara, Ariadna Rios-Ramirez, Juan Santiago-Garcia, Juan Carlos Rodriguez-Alba, Elisa Tamariz Dominguez
Summary: The present study evaluated the impact of substrate stiffness on the response of DRG neurons to Sema3a, showing that stiffness can regulate cell morphology, Sema3a receptor expression, and cytoskeleton distribution, affecting the collapse response of growth cones.
CELLS & DEVELOPMENT
(2022)
Article
Virology
Nancy Martinez-Martinez, Silvia Ivonne Mora-Herrera, Elisa Tamariz, Vicenta Trujillo-Alonso, Clara Luz Sampieri, Monica Flores-Munoz, Rocio Coutino-Rodriguez, Juan Carlos Rodriguez-Alba, Hilda Montero
Summary: Respiratory syncytial virus (RSV) is a major causative agent in acute respiratory infections. The role of helicase eIF4AI, a key protein involved in the translation process, in the replicative cycle of RSV is still under intense research. Knockdown of eIF4AI has been shown to decrease positive-strand viral RNA and viral progeny, indicating its potential involvement in the replicative cycle of RSV.
Article
Neurosciences
Hebert L. Hernandez-Montiel, Elisa Tamariz, M. Teresa Sandoval-Minero, Alfredo Varela-Echavarria
JOURNAL OF COMPARATIVE NEUROLOGY
(2008)