Article
Oncology
J. F. Huisman, I. J. H. Schoenaker, R. M. Brohet, O. Reerink, H. van der Sluis, F. C. P. Moll, E. de Boer, J. C. de Graaf, W. H. de Vos tot Nederveen Cappel, G. L. Beets, H. L. van Westreenen
Summary: The study demonstrates that the introduction of structured multidisciplinary response evaluation leads to a significant decrease in patients with locally advanced rectal cancer achieving complete response after nCRT, reducing the need for surgery and improving stoma-free survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Fuqiang Wang, Boon Fei Tan, Sharon Shuxian Poh, Tian Rui Siow, Faye Lynette Wei Tching Lim, Connie Siew Poh Yip, Michael Lian Chek Wang, Wenlong Nei, Hong Qi Tan
Summary: A feasibility study investigated the role of CT-based radiomics in predicting treatment response and survival rates in rectal cancer patients. By constructing NAR and survival models, radiomics features were found to be more accurate in predicting outcomes. CTV radiomics features were especially important in NAR prediction.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Yixiao Lin, Sitai Kou, Haolin Nie, Hongbo Luo, Ahmed Eltahir, Will Chapman Jr, Steven Hunt, Mathew Mutch, Quing Zhu
Summary: A deep learning model combining ultrasound and photoacoustic imaging has been developed to accurately identify complete responders after rectal cancer preoperative treatment, improving clinical care for patients.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Surgery
H. E. Haak, G. L. Beets, K. Peeters, P. J. Nelemans, V. Valentini, C. Rodel, L. Kuo, F. A. Calvo, J. Garcia-Aguilar, R. Glynne-Jones, S. Pucciarelli, J. Suarez, G. Theodoropoulos, S. Biondo, D. M. J. Lambregts, R. G. H. Beets-Tan, M. Maas
Summary: This study found that the risk of nodal metastases (ypN+) after chemoradiotherapy increases with advancing ypT category in locally advanced rectal cancer patients. Patients with ypN+ disease had lower 5-year disease-free survival and overall survival rates than patients with ypN0 tumors, with ypN+ status being an independent predictor of recurrence and death. Therefore, the presence of residual cancer cells in lymph nodes following (chemo)radiotherapy should be considered in treatment decision-making, especially when contemplating organ-preserving strategies.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Seung Yeun Chung, Hirotoshi Takiyama, Jae Hyun Kang, Jee Suk Chang, Byung Soh Min, Hiroshi Tsuji, Shigeru Yamada, Woong Sub Koom
Summary: This study compared the effectiveness of carbon ion radiotherapy (CIRT) and X-ray radiotherapy (XRT) for the treatment of locoregional rectal cancer recurrence. The results showed that CIRT had better outcomes in terms of local control, overall survival, and late toxicity rate compared to XRT.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Ning Li, Yuan Zhu, Lu-Ying Liu, Yan-Ru Feng, Wen-Ling Wang, Jun Wang, Hao Wang, Gao-Feng Li, Yuan Tang, Chen Hu, Wen-Yang Liu, Hua Ren, Shu-Lian Wang, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Yu Tang, Ning-Ning Lu, Bo Chen, Shu-Nan Qi, Xin-Fan Liu, Ye-Xiong Li, Jing Jin
Summary: The addition of oxaliplatin to postoperative capecitabine-based chemoradiotherapy did not improve treatment efficacy but increased the risk of severe acute toxic effects. Postoperative capecitabine with radiotherapy plays a fundamental role in the treatment of locally advanced rectal cancer.
Article
Medicine, General & Internal
Weerapat Suwanthanma, Saowanee Kitudomrat, Chakrapan Euanorasetr
Summary: The study investigated the clinical and pathological outcomes of locally advanced rectal cancer patients treated with neoadjuvant chemoradiation followed by curative surgery, identifying tumor length and lymph node involvement as potential predictive factors for pathological complete response. Patients achieving pCR showed higher 5-year disease-free and overall survival rates compared to non-pCR patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Toru Tochigi, Sophia C. Kamran, Anushri Parakh, Yoshifumi Noda, Balaji Ganeshan, Lawrence S. Blaszkowsky, David P. Ryan, Jill N. Allen, David L. Berger, Jennifer Y. Wo, Theodore S. Hong, Avinash Kambadakone
Summary: This study assessed the use of CT-based fractal dimension and texture analysis in predicting the therapeutic response to nCRT in patients with locally advanced rectal cancer. The research found that fractal dimension was a significant parameter for predicting the efficacy of nCRT.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiandong Leng, K. M. Shihab Uddin, William Chapman, Hongbo Luo, Sitai Kou, Eghbal Amidi, Guang Yang, Deyali Chatterjee, Anup Shetty, Steve Hunt, Matthew Mutch, Quing Zhu
Summary: The study reported the development of an imaging system comprising an endorectal coregistered photoacoustic/US system and convolutional neural network for assessing rectal cancer treatment response. The PAM CNN model showed unique imaging markers in differentiating changes in tumor treatment response and demonstrated high diagnostic performance.
Article
Multidisciplinary Sciences
Reem Mislati, Taylor P. Uccello, Zixi Lin, Katia T. Iliza, Kimani C. Toussaint, Scott A. Gerber, Marvin M. Doyley
Summary: This study found that shear wave elastography can provide valuable insights into tumor response to radiation therapy, helping distinguish radiation-responsive from radiation-non-responsive tumors and shedding light on changes in the tumor microenvironment that may affect radiation response.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Jessica M. Keilson, Adriana C. Gamboa, Michael K. Turgeon, Lillias Maguire, Katherine Hrebinko, Jennifer Holder-Murray, Jason T. Wiseman, Aslam Ejaz, Alexander T. Hawkins, Ebunoluwa Otegbeye, Matthew Silviera, Shishir K. Maithel, Glen C. Balch
Summary: This study evaluates the need for adjuvant chemotherapy in patients with rectal adenocarcinoma who have pathologic lymph node (pLN)-negative disease after receiving neoadjuvant chemoradiation therapy. The results show that adjuvant chemotherapy does not appear to improve survival in patients with pLN-negative disease, while it is associated with improved survival in patients with pLN-positive disease.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jaeseung Shin, Nieun Seo, Song-Ee Baek, Nak-Hoon Son, Joon Seok Lim, Nam Kyu Kim, Woong Sub Koom, Sungwon Kim
Summary: This study evaluated radiomics models based on T2-weighted imaging and diffusion-weighted MRI for predicting pCR after nCRT in LARC and compared their performance with visual assessment by radiologists. The results showed that the MRI-based radiomics model had better classification performance than experienced radiologists for diagnosing pathologic complete response in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy.
Article
Oncology
Maxiaowei Song, Shuai Li, Hongzhi Wang, Ke Hu, Fengwei Wang, Huajing Teng, Zhi Wang, Jin Liu, Angela Y. Jia, Yong Cai, Yongheng Li, Xianggao Zhu, Jianhao Geng, Yangzi Zhang, XiangBo Wan, Weihu Wang
Summary: This study aimed to analyze the performance of multicentre pre-treatment MRI-based radiomics (MBR) signatures combined with clinical baseline characteristics and neoadjuvant treatment modalities in predicting complete response to neoadjuvant (chemo)radiotherapy in locally advanced rectal cancer (LARC). The results showed that the radiomics-based models outperformed the non-imaging models, accurately reflecting the true nature of LARC and helping to identify patients who can undergo organ preservation strategies.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
C. S. Wong, W. Chu, S. Ashamalla, D. Fenech, S. Berry, A. Kiss, M. Koritzinsky
Summary: The study aimed to investigate whether adding metformin to neoadjuvant chemoradiation therapy for rectal cancer could improve pathologic complete response rates in non-diabetic patients. Results revealed that the addition of metformin did not increase toxicities. Future research will refine the design and implementation of a phase 2 trial to assess whether metformin enhances pCR/cCR rates.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Pritam Tayshetye, Andrew J. Friday, Ashten N. Omstead, Tanvi Verma, Stacey Miller, Ping Zheng, Prashant Jani, Ali Zaidi, Gene Finley
Summary: Localized rectal cancer is currently managed with neoadjuvant therapy before surgery, and immunotherapy has entered the treatment paradigm for advanced rectal cancer. Clinical trials incorporating immunotherapy in the neoadjuvant settings are underway, and better understanding of the tumor microenvironment and specific biomarkers is needed. This study analyzes changes in the tumor microenvironment following neoadjuvant chemoradiation and suggests that upregulated biomarkers could be used for clinical trials and targeted drug development.
Article
Oncology
Merel A. Spiekerman van Weezelenburg, Loeki Aldenhoven, Sander M. J. van Kuijk, Geerard L. Beets, James van Bastelaar
Summary: The study found that using a minimum of 15 sutures spaced approximately 3.7 cm apart during mastectomy can significantly reduce the incidence of seroma formation. Surgical technique and flap fixation both play a crucial role in preventing seromas after mastectomy.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laura M. Fernandez, Guilherme P. Sao Julio, Andrew G. Renehan, Geerard L. Beets, Ana L. Papoila, Bruna B. Vailati, Renu R. Bahadoer, Elma Meershoek-Klein Kranenbarg, Annet G. H. Roodvoets, Nuno L. Figueiredo, Cornelis J. H. Van de Velde, Angelita Habr-Gama, Rodrigo O. Perez
Summary: This study retrospectively reviewed data from an international watch and wait database and found that local regrowth is a risk factor for distant metastases in patients with rectal cancer. Patients remain at higher risk for distant metastases for 5 years after the development of local regrowth.
DISEASES OF THE COLON & RECTUM
(2023)
Review
Oncology
Erich P. Huang, James P. B. O'Connor, Lisa M. McShane, Maryellen L. Giger, Philippe Lambin, Paul E. Kinahan, Eliot L. Siegel, Lalitha K. Shankar
Summary: Integration of computer-extracted tumour characteristics into medical imaging computer-aided diagnosis (CAD) algorithms has been a long-standing practice. However, the translation of radiomics, an extension of CAD involving quantitative characterization of healthy or pathological structures and processes captured by medical imaging, into clinically useful tools has been limited. This may be due to factors such as varying imaging and radiomic feature extraction protocols, potential pitfalls in radiomic data analysis, and a lack of evidence demonstrating the clinical benefit of radiomic-based tools. The authors provide 16 criteria to guide the clinical translation of radiomics, with the aim of accelerating the use of this technology to improve patient outcomes.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Oncology
Abdalla Ibrahim, Akshayaa Vaidyanathan, Sergey Primakov, Flore Belmans, Fabio Bottari, Turkey Refaee, Pierre Lovinfosse, Alexandre Jadoul, Celine Derwael, Fabian Hertel, Henry C. C. Woodruff, Helle D. D. Zacho, Sean Walsh, Wim Vos, Mariaelena Occhipinti, Francois-Xavier Hanin, Philippe Lambin, Felix M. M. Mottaghy, Roland Hustinx
Summary: The study aims to develop a deep learning (DL) algorithm for classifying areas of increased uptake on bone scintigraphy scans. The algorithm was trained and validated on a dataset of 2365 scans, and its performance was evaluated on an external testing set of 998 scans. The results showed that the DL algorithm achieved higher specificity and sensitivity compared to nuclear medicine physicians, and it can detect metastatic bone disease (MBD) in a shorter time.
Review
Biochemistry & Molecular Biology
Annemarie J. F. Westheim, Lara M. Stoffels, Ludwig J. Dubois, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Ramon C. J. Langen, Ronit Shiri-Sverdlov, Jan Theys
Summary: Cancer burden is increasing rapidly globally, with lifestyle factors such as unhealthy diet being major contributors. The specific fatty acids that contribute to a healthy and balanced diet in terms of cancer risk and prognosis are still unclear. This review explores the associations between intake of different fatty acids and cancer risk, as well as the effects of specific fatty acids on tumor cells and inflammation-induced cancer progression, highlighting challenges and opportunities for fatty acid tailored nutritional interventions.
Editorial Material
Microbiology
Aleksandra M. Kubiak, Jella van de Laak, Yanchao Zhang, Tom S. Bailey, Luuk Claessen, Philip Hittmeyer, Carlijn Vlaswinkel, Alexsandra Mowday, Ludwig J. Dubois, Jan Theys
FUTURE MICROBIOLOGY
(2023)
Article
Geriatrics & Gerontology
Wouter R. P. H. van de Worp, Jan Theys, Alba Sanz Gonzalez, Brent van der Heyden, Frank Verhaegen, Duncan Hauser, Florian Caiment, Hubertus J. M. Smeets, Annemie M. W. J. Schols, Ardy van Helvoort, Ramon C. J. Langen
Summary: A syngeneic, orthotopic lung cancer mouse model was evaluated to see if it replicates the systemic and muscle-specific alterations associated with human lung cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Oncology
Zohaib Salahuddin, Yi Chen, Xian Zhong, Henry C. Woodruff, Nastaran Mohammadian Rad, Shruti Atul Mali, Philippe Lambin
Summary: Automatic delineation and detection of primary tumour (GTVp) and lymph nodes (GTVn) in head and neck cancer using PET and CT can help diagnose and stratify patient risk. This study utilized data from nine centres and developed a segmentation model that estimated uncertainty for false positive reduction. Radiomics features extracted from GTVp and GTVn in PET and CT were found to be prognostic for recurrence-free survival prediction. The framework incorporated uncertainty estimation, fairness, and explainability.
Article
Gastroenterology & Hepatology
Najim El Khababi, Regina G. H. Beets-Tan, Renaud J. Tissier, Max Lahaye, Monique Maas, Luis Curvo-Semedo, Raphaela C. Dresen, Stephanie L. Nougaret, Geerard Beets, Doenja M. J. Lambregts, Rectal MRI Study Grp
Summary: The study aimed to investigate the value of rectal cancer T-staging on MRI in relation to fibrotic transformation of the tumour bed. The results showed that ymrT-staging has moderate accuracy, with higher accuracy in patients with predominant fibrosis. Therefore, radiologists should focus on detecting residual disease and identifying potential candidates for organ preservation.
COLORECTAL DISEASE
(2023)
Article
Oncology
Xian Zhong, Zohaib Salahuddin, Yi Chen, Henry C. Woodruff, Haiyi Long, Jianyun Peng, Xiaoyan Xie, Manxia Lin, Philippe Lambin
Summary: This study developed and validated an interpretable radiomics model based on two-dimensional shear wave elastography (2D-SWE) for predicting symptomatic post-hepatectomy liver failure in patients with hepatocellular carcinoma. The clinical-radiomics model outperformed the clinical model and radiomics model, and the first-order radiomics features were identified as the most important for PHLF prediction.
Article
Medicine, General & Internal
Tania C. Sluckin, Marije Hekhuis, Sabrine Q. Kol, Joost Nederend, Karin Horsthuis, Regina G. H. Beets-Tan, Geerard L. Beets, Jacobus W. A. Burger, Jurriaan B. Tuynman, Harm J. T. Rutten, Miranda Kusters, Sean Benson
Summary: This study developed an artificial intelligence model to predict the risk of (L)LR in rectal cancer patients by combining imaging and clinical features, providing a basis for identifying high-risk patients and developing risk stratification models.
Article
Microbiology
Yanchao Zhang, Aleksandra M. Kubiak, Tom S. Bailey, Luuk Claessen, Philip Hittmeyer, Ludwig Dubois, Jan Theys, Philippe Lambin
Summary: Clostridium species have gained attention in industrial and medical applications, with the development of genetic tools enabling the advancement of the CRISPR-Cas systems. This study demonstrated the establishment of a CRISPR-Cas12a system in clostridia with two different cas12a genes, allowing for efficient and rapid genome modification. The results showed that the CRISPR-FnCas12a system offers flexible target selection in clostridia, with a specific folding pattern of the precursor crRNA being important for high mutation generation efficiency.
MICROBIOLOGY SPECTRUM
(2023)
Meeting Abstract
Oncology
Yara L. Verschoor, Doenja M. J. Lambregts, Jose van den Berg, Brechtje A. Grotenhuis, Arend Aalbers, Baukelien Van Triest, Regina G. H. Beets-Tan, Marieke van de Belt, Simone Dokter, Sara Balduzzi, Emile E. Voest, John B. A. G. Haanen, Monique E. van Leerdam, Geerard Beets, Myriam Chalabi
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Laura M. Fernandez, Guilherme P. Sao Juliao, Andrew G. Renehan, Geerard L. Beets, Ana L. Papoila, Bruna B. Vailati, Elma Meershoek-Klein Kranenbarg, Annet G. H. Roodvoets, Nuno L. Figueiredo, Cornelis J. H. van de Velde, Angelita Habr-Gama, Rodrigo O. Perez
DISEASES OF THE COLON & RECTUM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Najim El Khababi, Regina G. H. Beets-Tan, Renaud Tissier, Max J. Lahaye, Monique Maas, Luis Curvo-Semedo, Raphaela C. Dresen, Joost J. M. van Griethuysen, Stephanie Nougaret, Geerard L. Beets, Baukelien van Triest, Stuart A. Taylor, Doenja M. J. Lambregts
Summary: This study aims to explore the potential impact of a dedicated virtual training course on MRI staging confidence and performance in rectal cancer. The results show that although most of the findings are not statistically significant, there is a mild increase in diagnostic accuracy for most staging variables after completing the course, ranging from +2% to +17%. There is also an improvement in interobserver agreement for almost all variables when comparing the pre- and post-course. The perceived difficulty level decreases significantly after completion of the course, indicating an improved diagnostic confidence.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)