Article
Oncology
Roni Hytonen, Reynald Vanderstraeten, Max Dahele, Wilko F. A. R. Verbakel
Summary: The study found that deviations in beam angle and number had minimal effects on plan quality, indicating the robustness of the KBP model to different beam arrangements. Knowledge-based planning solutions have significantly improved treatment planning.
Article
Oncology
Yong Gan, Johannes A. Langendijk, Arjen van der Schaaf, Lisa van den Bosch, Edwin Oldehinkel, Zhixiong Lin, Stefan Both, Charlotte L. Brouwer
Summary: This study aimed to develop an efficient strategy to select candidates for adaptive radiotherapy (ART) in the first two weeks of head and neck cancer (HNC) radiotherapy. By retrospectively analyzing data from 110 HNC patients, it was found that using the difference between planning and actual dose and clinical relevance as cut-off points could identify potential candidates for ART. The proposed strategy showed improved sensitivity, specificity, and predictive values.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Jin-Jie Yan, Shan-Shan Guo, Da-Feng Lin, Li-Ting Liu, Sai-Lan Liu, Bei-Bei Xiao, Jin-Hao Yang, Dong-Xiang Wen, Zhen-Chong Yang, Yu-Jing Liang, Qing-Nan Tang, Chao Lin, Xiao-Yun Li, Xue-Song Sun, Ji-Bin Li, Lin-Quan Tang, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study successfully established and validated an NTCP model and nomogram for predicting acquired nasal cavity stenosis and atresia in nasopharyngeal carcinoma patients after radiotherapy, providing a valuable tool for risk assessment and management of this complication.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Athanasios Tzikas, Eleftherios Lavdas, Dimitrios Kehagias, Robert Amdur, William Mendenhall, Nathan Sheets, Rebecca Green, Bhishamjit Chera, Panayiotis Mavroidis
Summary: This study aimed to determine the parameter values of three normal tissue complication probability (NTCP) models for contralateral parotid gland, contralateral submandibular gland (SMG), and contralateral salivary glands in relation to xerostomia 6-24 months after radiotherapy for oropharynx cancer. The results showed that a mean dose <22 Gy and V50 <10% for contralateral salivary glands, and a mean dose <18 Gy and V45 <10% for contralateral parotid significantly reduce the risk for radiation-induced xerostomia observed 6-24 months post-radiotherapy.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Oncology
Dan-Wan Wen, Li Lin, Yan-Ping Mao, Chun-Yan Chen, Fo-Ping Chen, Chen-Fei Wu, Xiao-Dan Huang, Zhi-Xuan Li, Si-Si Xu, Jia Kou, Xing-Li Yang, Jun Ma, Ying Sun, Guan-Qun Zhou
Summary: The study aimed to develop predictive models using dosimetric and clinical variables for temporal lobe injury in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy. Results showed that D-0.5cc was the most predictive dosimetric factor and the nomogram accurately predicted temporal lobe injury, guiding personalized follow-up management.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Vitali Moiseenko, Lawrence B. Marks, Jimm Grimm, Andrew Jackson, Michael T. Milano, Jona A. Hattangadi-Gluth, Minh-Phuong Huynh-Le, Niclas Pettersson, Ellen Yorke, Issam El Naqa
Summary: This article presents an overview of common approaches used to assess the dose response for radiation therapy-associated endpoints, using lung toxicity data sets as an example. Established methods such as data-driven analysis, dose-response analysis, and calculating uncertainties on model prediction are addressed in detail. The use of maximum likelihood method, profile-likelihood, likelihood ratio, and bootstrap method are discussed for calculating parameter values, confidence intervals, and model predictions. The correlated behavior of model parameters and implications for interpreting dose response are also explored.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Ameneh Haghbin, Ahmad Mostaar, Reza Paydar, Mohsen Bakhshandeh, Alireza Nikoofar, Mohammad Houshyari, Susan Cheraghi
Summary: This study aims to predict chronic kidney disease (CKD) in patients with abdominal cancers undergoing radiotherapy by evaluating clinical and functional assays. The researchers found that the mean dose model predicts radiation-induced CKD more accurately than other models. This finding is important for the treatment of abdominal cancers.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Mostafa Alizade-Harakiyan, Amir Ghasemi Jangjoo, Tohid Jafari-Koshki, Ali Fatemi, Asghar Mesbahi
Summary: This study evaluated the performance of various radiobiological models in predicting acute esophagitis during radiation therapy. The results showed that the behavior of dose-response curves differed between the treatment groups, and different models had different predictive accuracy. New parameter estimates could be used for predicting the probability of acute esophagitis.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Anastassia Loeser, Kerstin Ramke, Maximilian Grohmann, Linda Krause, Pia Roser, Franziska Greinert, Anna Finger, Margaret Sommer, Eva Culmann, Tessa Lorenz, Saskia Becker, Marvin Henze, Daniel Schodrok, Julia von Grundherr, Silke Tribius, Andreas Kruell, Cordula Petersen
Summary: Nutritional counseling has an impact on the development of hypothyroidism in head and neck cancer patients undergoing (chemo)radiotherapy, with baseline TSH and ferritin acting as independent predictors. The newly developed NTCP model showed good performance, based on baseline TSH and ferritin levels.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Anne G. H. Niezink, Arjen van der Schaaf, Robin Wijsman, Olga Chouvalova, Anthonie J. van der Wekken, Steven R. Rutgers, Remge M. Pieterman, John W. G. van Putten, Sander M. de Hosson, Annija H. D. van der Leest, Jan F. Ubbels, Marleen Woltman-van Iersel, Joachim Widder, Johannes A. Langendijk, Christina Muijs
Summary: This study aimed to externally validate the QUANTEC and APPELT models for radiation pneumonitis (RP) prediction in a large cohort of lung cancer patients treated with IMRT or VMAT. These models were revised and updated, with the APPELT model showing better discrimination than the recalibrated QUANTEC model.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Stefano Ursino, Alessia Giuliano, Fabio Di Martino, Paola Cocuzza, Alessandro Molinari, Antonio Stefanelli, Patrizia Giusti, Giacomo Aringhieri, Riccardo Morganti, Emanuele Neri, Claudio Traino, Fabiola Paiar
Summary: A predictive model for radiation-induced dysphagia (RID) was developed by incorporating DVH parameters of swallowing organs at risk (SWOARs) in machine learning analysis using videofluoroscopy. The relevance of SWOARs DVH features emerged at both 6 and 12 months after treatment, indicating high discriminative ability of the model. Additional training datasets are expected to further improve the predictive power of the model.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Oncology
Pratik Samant, Dirk de Ruysscher, Frank Hoebers, Richard Canters, Emma Hall, Chris Nutting, Tim Maughan, Frank Van den Heuvel
Summary: This study compares the performance of the LKB model and machine learning models in predicting radiotherapy toxicity. The results show that machine learning models outperform the LKB model in terms of accuracy and predictive power, and they are more stable with optimization algorithms.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Hanbo Chen, Famke L. Schneiders, Anna M. E. Bruynzeel, Frank J. Lagerwaard, John R. van Sornsen de Koste, Paul Cobussen, Omar Bohoudi, Berend J. Slotman, Alexander Louie, Suresh Senan
Summary: This study shows that MR-guided daily-adaptive SABR can reduce gastric toxicity in patients with left adrenal tumors, while dose escalation may be considered for patients with right-sided lesions due to low predicted NTCP. Adaptation benefits were significantly associated with lesion laterality, with left-sided lesions benefiting more than right-sided lesions.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Oncology
Gabriela Barbieri Ortigara, Laura Izabel Lampert Bonzanini, Rieli Elis Schulz, Kivia Linhares Ferrazzo
Summary: Radiotherapy is essential in managing head and neck cancer, but can lead to significant late complications. These effects impact the ability of patients to speak, eat, and their overall quality of life.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariana Inri de Carvalho, Marina Gatti, Renata Ligia Vieira Guedes, Renata Camilla Favarin Froes, Danila Rodrigues Costa, Jhonatan da Silva Vitor, Paulo Sergio da Silva Santos, Giedre Berretin-Felix
Summary: This study investigated the relationship between swallowing function, nutritional status, and salivary flow in patients after head and neck cancer treatment. Results showed that appropriate protein intake influences muscle activity during swallowing in head and neck cancer survivors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jing de Haan-Du, Klaas H. Groenier, Brendy Wauben-Spaetgens, Mathilde Jalving, Nanne Kleefstra, Gijs W. D. Landman, Geertruida H. de Bock
Summary: This study investigated the association between pre-diagnosis glycemic control and all-cause mortality in patients with type 2 diabetes (T2DM) who develop cancer. The results showed that among T2DM patients in the Netherlands, poor glycemic control before diagnosis with breast and colorectal cancer can increase mortality compared with good control.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Fithria Dyah Ayu Suryanegara, M. Rifqi Rokhman, Ericko Ekaputra, Lisa Aniek de Jong, Didik Setiawan, Geertruida H. de Bock, Maarten Jacobus Postma
Summary: This study aimed to explore problems in radiotherapy for breast cancer patients in Yogyakarta, Indonesia, focusing on overall treatment time (OTT) and completion rate. The study found that there are issues with prolonged OTT and low completion rate in radiotherapy among breast cancer patients, but there were no significant differences between different insurance schemes.
Article
Oncology
M. Y. Errahmani, M. Locquet, D. Broggio, D. Spoor, G. Jimenez, J. Camilleri, J. A. Langendijk, A. P. G. Crijns, M. O. Bernier, J. Ferrieres, J. Thariat, S. Boveda, Y. Kirova, P. Loap, V Monceau, S. Jacob
Summary: This study assessed the doses of sinoatrial node (SAN) and atrioventricular node (AVN) in breast cancer patients treated with 3D-CRT and evaluated the relevance of large cardiac structures as surrogates. The results showed that right-sided breast cancer patients may have higher AVN doses exceeding 1 Gy, while left-sided breast cancer patients had lower SAN and AVN doses. Among the large cardiac structures, the right atrium may be a meaningful surrogate, especially for left-sided breast cancer patients with inclusion of IMN.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marc Andrea Walser, Nicolas Bachmann, Jonas Kluckert, A. Kothe, Carson Tully, Dominic Leiser, Antony John Lomax, Nicola Bizzocchi, Johannes Albertus Langendijk, Damien C. Weber
Summary: The objective of this study is to report the outcomes, toxicities, and NTCP calculation for PBSPT in SGT patients. The study reviewed 26 SGT patients treated with PBSPT and estimated overall survival, local control, locoregional control, and distant control. The results showed good oncological outcomes and low toxicity rates, and NTCP calculation indicated reduced risk for certain complications.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Iris A. S. Stroot, Jan Brouwer, Joost Bart, Harry J. Hollema, Denise M. Stommel-Jenner, Marise C. Wagner, Helena A. van Doorn, Joanne N. de Hullu, Katja Gaarenstroom, Marc Beurden, Luc R. C. W. van Lonkhuijzen, Brigitte F. M. P. Slangen, Ronald B. Zweemer, Encarna B. Gomez Garcia, Margreet G. E. M. A. Ausems, Ingrid Boere, Klaartje J. van Engelen, Christi K. van Asperen, Marjanka R. Schmidt, Marijke H. Wevers, Geertruida de Bock, Marian J. E. Mourits, HEBON Investigators
Summary: This study aimed to investigate the prevalence of and clinical factors associated with high-grade serous carcinoma (HGSC) at risk-reducing salpingo-oophorectomy (RRSO) in asymptomatic BRCA1/2-pathogenic variant (PV) carriers. The study found a prevalence of 1.5% (BRCA1-PV) and 0.6% (BRCA2-PV) of HGSC in RRSO specimens, with long-term oral contraceptive use being protective against cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Manon A. Zwakenberg, Jeroen M. Westra, Gyorgy B. Halmos, Jan Wedman, Bernard F. A. M. van Der Laan, Boudewijn E. C. Plaat
Summary: This study aimed to assess whether the additional use of narrow-band imaging (NBI) in transoral laser surgery (TOLS) for early laryngeal cancer improves clinical outcomes. The results showed that the use of NBI significantly reduced the number of positive resection margins and potentially decreased the recurrence rate and improved recurrence-free survival in patients treated with NBI-supported TOLS. Further studies with larger patient groups are needed to confirm these findings.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Annechien Stuursma, Bert van der Vegt, Liesbeth Jansen, Lieke P. V. Berger, Marian J. E. Mourits, Geertruida H. de Bock
Summary: This study investigated the effect of RRSO on breast cancer incidence and histopathological features in female BRCA1/2 GPV carriers. The results showed that RRSO did not decrease the risk of breast cancer in BRCA1 and BRCA2 GPV carriers, but the breast cancer cases diagnosed after RRSO tended to be smaller.
Article
Oncology
C. J. H. Kramer, L. Lanjouw, D. Ruano, A. ter Elst, G. Santandrea, N. Solleveld-Westerink, N. Werner, A. H. van Der Hout, C. D. de Kroon, T. van Wezel, L. P. Berger, M. Jalving, J. Wesseling, V. T. H. B. M. Smit, G. H. de Bock, C. J. van Asperen, M. J. E. Mourits, M. P. G. Vreeswijk, J. Bart, T. Bosse
Summary: This study analyzed the causal BRCA1/2 gene variants in different types of ovarian cancer tissues. The results showed that except for high-grade serous ovarian carcinoma, there were minimal BRCA1/2 PVs in other types of ovarian cancer. The study also identified some potentially misdiagnosed cases and conducted in-depth analysis of the pathogenic mechanism of BRCA1/2 variants. These findings suggest that histotype-directed sequencing may be more informative than universal sequencing.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Anneke de Haan, Johanna G. H. van Nes, M. Willemijn Kolff, Peter-Paul van der Toorn, A. Helen Westenberg, Annelies E. van der Vegt, Henk Groen, Jelle Overbosch, Hans Paul van der Laan, Paul M. N. Werker, Johannes A. Langendijk, Roel J. H. M. Steenbakkers
Summary: The LedRad-study is a randomized controlled trial examining the efficacy of radiotherapy in treating Ledderhose disease. The study found that patients in the radiotherapy group had significantly lower pain scores at 12 and 18 months after treatment compared to the sham-radiotherapy group. Radiotherapy also improved quality of life scores and bare feet walking abilities.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Kelvin Ng Wei Siang, Stefan Both, Edwin Oldehinkel, Johannes A. Langendijk, Dirk Wagenaar
Summary: The study assesses the impact of residual geometrical errors on clinical target volumes dose coverage in head and neck cancer proton therapy. The results indicate that the difference in residual geometrical errors between propagated CTV and physician corrected CTV is minor, but variations in different regions are significant.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yihui Du, Marcel J. W. Greuter, Mathias W. Prokop, Geertruida H. de Bock
Summary: This study aimed to determine appropriate pricing for DL-CAD to be cost-saving and to identify the potentially most cost-effective reading mode for lung cancer screening. The results showed that DL-CAD as a pre-screening reader had the largest potential for cost savings.
INSIGHTS INTO IMAGING
(2023)
Article
Oncology
Mieke C. Zwager, Iris Holt-Kedde, Hetty Timmer-Bosscha, Geertruida H. de Bock, Paul M. N. Werker, Carolien P. Schroeder, Bert van der Vegt, Marlous Arjaans
Summary: CLS were more frequently present in breast adipose tissue of breast cancer patients compared to BRCA1/2 gene mutation carriers and healthy controls. The presence of CLS was associated with obesity. However, there was no correlation between CLS and breast cancer subtypes, BRCA mutation status, or age. In triple-negative breast cancer, CLS were related to lymphovascular invasion. Further evaluation is needed to determine the prognostic significance and impact on clinical outcome of CLS numbers.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Medicine, General & Internal
Joost F. Hop, Anna N. H. Walstra, Gert-Jan Pelgrim, Xueqian Xie, Noor A. Panneman, Niels W. Schurink, Sebastian Faby, Marcel van Straten, Geertruida H. de Bock, Rozemarijn Vliegenthart, Marcel J. W. Greuter, Chiara Martini, Paolo Perini
Summary: This study assessed the detectability and volumetric accuracy of pulmonary nodules using photon-counting detector CT (PCD-CT) and conventional energy-integrating detector CT (EID-CT) at different low-dose levels. The results showed that low-dose PCD-CT has the potential to reduce radiation dose while still detecting and evaluating the volume of pulmonary nodules.
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)