Article
Biochemistry & Molecular Biology
Prasanta Dey, Amit Kundu, Ha Eun Lee, Babli Kar, Vineet Vishal, Suvakanta Dash, In Su Kim, Tejendra Bhakta, Hyung Sik Kim
Summary: The extract of Molineria recurvata exhibits protective effects on nephropathy in diabetic rats by suppressing inflammation and oxidative stress.
Article
Food Science & Technology
Bo-sai He, Xiao Wang, Ying Zhang, Cheng Gao, Cheng-kai Wu, Si-rui Guo, Yan-ting Gu, Qing Li, Jia-hong Wang
Summary: The seeds of Moringa oleifera Lam have renal protective effects in diabetic nephropathy by modulating multiple signaling pathways, exerting anti-inflammatory, anti-fibrosis, and anti-oxidative effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Jesus Roman Martinez Alvarez, Ana Belen Lopez Jaen, Monica Cavia-Saiz, Pilar Muniz, Victoria Valls-Belles
Summary: The study aimed to determine the effects of olive oil enriched with lycopene on oxidative stress biomarkers in hypercholesterolemic subjects. The results showed that consumption of oil enriched with lycopene led to an increase in plasma antioxidant capacity and a decrease in biomarkers of oxidative stress and inflammatory markers related to atherosclerosis risk.
Article
Medicine, Research & Experimental
Tarfa Albrahim, Mona A. Alonazi
Summary: The study found that LYC effectively reversed the changes induced by HFD through its antioxidant, anti-inflammatory, and anti-fibrotic properties, showing therapeutic potential in managing obesity and its associated pathologies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Nada H. Eisa, Ahmed E. Khodir, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Eman Said
Summary: PEITC showed renal protective effects against DN in rats induced by STZ, improving kidney and liver functions, histopathological features, tissue fibrosis, macrophage infiltration, and blood glucose levels. The mechanisms involved modulation of glycation, oxidative stress, and inflammatory response, including activation of GLO1 and Nrf2 pathways and suppression of NLRP3 inflammasome activation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Amit Kundu, Sreevarsha Gali, Swati Sharma, Jae Hyeon Park, So Young Kyung, Sam Kacew, In Su Kim, Kwang Youl Lee, Hyung Sik Kim
Summary: The study demonstrates that Tenovin-1 has a protective effect against renal fibrosis in HFD-induced ZDF rats, reducing inflammation, oxidative stress, apoptosis, and levels of urinary protein. Additionally, Tenovin-1 restores the abnormal architecture of the kidney and pancreas and decreases ECM protein levels.
Article
Biochemistry & Molecular Biology
Maryam Nasri, Glavizh Adibhesami, Sina Mahdavifard, Esmaeel Babaeenezhad, Hassan Ahmadvand
Summary: Gln alleviates diabetic nephropathy and other complications in type 2 diabetes mellitus in rats through its antioxidant and anti-inflammatory activities.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Caina Li, Quan Liu, Wenming Ji, Yaxin Fu, Hui Cao, Yi Huan, Lei Lei, Xuefeng Gao, Leilei Chen, Cunyu Feng, Lin Zhang, Pingping Li, Yuling Liu, Shuainan Liu, Zhufang Shen
Summary: This study evaluated the effects of Morus alba L. (Sangzhi) alkaloid (SZ-A) on diabetic nephropathy (DN) in Zucker diabetic fatty (ZDF) rats and explored the underlying mechanisms. The results showed that SZ-A significantly improved DN by regulating nitrosative stress, inflammation, and fibrosis. This provides evidence for the additional application of SZ-A in clinical use for the treatment of DN.
FRONTIERS IN MEDICINE
(2023)
Article
Food Science & Technology
Shan Shan Qi, Meng Li Shao, Ze Sun, Si Min Chen, Ying Jun Hu, Hong Tao Wang, Tian Kuo Wei, Xing Sheng Li, Hong Xing Zheng
Summary: The study demonstrates that lycopene can ameliorate diabetic-induced bone loss by reducing blood sugar, improving symptoms, increasing bone density, enhancing antioxidant response, and regulating bone turnover markers and cytokine levels in diabetic rats.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Jungang Kang, Yang Li, Zhanfei Ma, Yabo Wang, Weifeng Zhu, Guojun Jiang
Summary: This study found that lycopene can protect the uterus from damage caused by zearalenone and improve pregnancy outcomes. Lycopene reduces oxidative stress and inflammation by its antioxidant and anti-inflammatory effects, as well as improves uterine cell proliferation and apoptosis. These findings suggest that lycopene could be a potential new drug for the prevention or treatment of zearalenone-induced reproductive toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eva Tvrda, Jan Kovac, Kristina Ferenczyova, Barbora Kalocayova, Michal Duracka, Filip Benko, Viera Almasiova, Monika Bartekova
Summary: The aim of this study is to investigate the effects of quercetin on testicular architecture and markers of oxidative, inflammatory, and apoptotic profile in Zucker diabetic fatty rats with Type 2 diabetes mellitus. The results showed that quercetin improved testicular appearance, stabilized antioxidant capacity, decreased lipid peroxidation, and reduced inflammation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: Geniposide has been shown to have protective effects in a mouse model of diabetic nephropathy, improving renal function and reducing pathological changes through modulation of AMPK and AKT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Mohamed Aboubakr, Said M. Elshafae, Ehab Y. Abdelhiee, Sabreen E. Fadl, Ahmed Soliman, Afaf Abdelkader, Mohamed M. Abdel-Daim, Khaled A. Bayoumi, Roua S. Baty, Enas Elgendy, Amira Elalfy, Bodour Baioumy, Samah F. Ibrahim, Ahmed Abdeen
Summary: The study demonstrated that thymoquinone and/or lycopene showed significant protective effects against chlorpyrifos-induced neurotoxicity, likely through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Article
Food Science & Technology
Tong Jin, Cheng Chen
Summary: The findings suggest that umbelliferone has a protective effect on diabetic nephropathy by activating the Nrf2/HO-1 pathway and attenuating high glucose-induced ferroptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Melike Karayakali, Eyup Altinoz, Hulya Elbe, Oguzhan Koca, Melike Ozgul Onal, Yasemin Bicer, Mehmet Demir
Summary: Diabetes mellitus is a chronic metabolic disorder that is becoming more prevalent globally, leading to significant health issues. This study investigates the protective effects of crocin, a compound with antioxidant, anti-diabetic, and anti-inflammatory properties, against liver damage in diabetic rats. The results demonstrate that crocin reduces markers of liver damage and increases antioxidant enzyme levels and total antioxidant status of the tissue. Histological findings also indicate a protective effect of crocin against liver injury caused by streptozotocin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.