Article
Medicine, Research & Experimental
Sofiana Mootassim-Billah, Gwen Van Nuffelen, Jean Schoentgen, Marc De Bodt, Dirk Van Gestel
Summary: This study aims to develop an acoustic cough analysis method to enhance the assessment of radiation-associated dysphagia in head and neck cancer patients following (chemo)radiation.
Article
Medicine, Research & Experimental
Maria Giulia Cristofaro, Ida Barca, Francesco Ferragina, Daniela Novembre, Yvelise Ferro, Roberta Pujia, Tiziana Montalcini
Summary: The study found that malnutrition is common in cancer patients, especially in those with head and neck neoplasms, due to dysphagia symptoms and adverse effects of chemotherapy/radiotherapy. Patients with dysphagia were more likely to experience involuntary weight loss and severe malnutrition compared to non-dysphagia patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Sarah Weppler, Harvey Quon, Colleen Schinkel, Adam Yarschenko, Lisa Barbera, Nabhya Harjai, Wendy Smith
Summary: The study aimed to reduce toxicity incidence among head and neck cancer patients through adaptive radiation therapy (ART). Results showed a strong association between patient-reported dysphagia symptoms and the delivered dose to the pharyngeal constrictor.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Agata Gawryszuk, Hendrik P. Bijl, Arjen van der Schaaf, Nathalie Perdok, Jan Wedman, Irma M. Verdonck-de Leeuw, Rico N. Rinkel, Roel J. H. M. Steenbakkers, Johanna G. M. van den Hoek, Hans Paul van der Laan, Johannes A. Langendijk
Summary: This study evaluated swallowing disorders in HNC patients undergoing radiation therapy and found an increased risk of aspiration, with prediction models to aid in patient selection for baseline and follow-up VF examinations.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Physiology
Amy Fullerton, Yuhan Mou, Natalie Silver, Neil N. Chheda, Kathryn Hitchcock, Karen Hegland
Summary: The study found reduced airflow during reflexive cough in advanced stage head and neck cancer survivors, with even lower airflow in aspirators. Surprisingly, patients recently post-treatment showed worse cough airflow compared to those further post-treatment.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Oncology
L. Belgioia, C. Becherini, A. Bacigalupo, P. Bonomo
Summary: Immunotherapy plays a significant role in the treatment of head and neck squamous cell carcinoma, but its role in upfront management of locally advanced disease and its integration with standard of care remains unclear.
Article
Dentistry, Oral Surgery & Medicine
Yoshiaki Ihara, Hirotaka Kato, Yuichi Tashimo, Yoshiki Iizumi, Yuma Fukunishi, Hitoshi Sato, Toshikazu Shimane, Koji Takahashi
Summary: This study aimed to evaluate the changes in quality of life (QOL) among patients with early-stage head and neck cancer (HNC) and identify factors affecting their QOL. The results showed that restoration of oral function alone is insufficient in improving QOL, and treatment should consider multiple factors.
Article
Otorhinolaryngology
Elissa Greco, Jolie Ringash, George Tomlinson, Shao Hui Huang, Brian O'Sullivan, John Waldron, Rosemary Martino
Summary: In patients with advanced head and neck cancer receiving intensity-modulated radiation therapy, there were no differences in prophylactic G-tube use during the first 5 years post-IMRT. Overall, the median number of days with a G-tube post-IMRT was 63 days, with patients with hypopharyngeal tumors requiring the longest duration.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Linda Sharp, Laura-Jayne Watson, Liya Lu, Sam Harding, Katrina Hurley, Steve J. Thomas, Joanne M. Patterson
Summary: This study investigated cancer-related fatigue (CRF) in head and neck cancer patients using data from the Head and Neck 5000 prospective clinical cohort. The findings revealed a high prevalence of CRF, indicating the need for additional interventions and supports for affected patients.
Review
Oncology
Gabriela Barbieri Ortigara, Laura Izabel Lampert Bonzanini, Rieli Elis Schulz, Kivia Linhares Ferrazzo
Summary: Radiotherapy is essential in managing head and neck cancer, but can lead to significant late complications. These effects impact the ability of patients to speak, eat, and their overall quality of life.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Alexander J. Nicol, Jerry C. F. Ching, Victor C. W. Tam, Kelvin C. K. Liu, Vincent W. S. Leung, Jing Cai, Shara W. Y. Lee
Summary: Head and neck cancer patients often experience chemoradiation-induced toxicities, such as oral mucositis and dysphagia, which can greatly impact treatment outcomes and quality of life. This scoping review evaluates the reported predictors and performance of predictive models for these conditions, and provides recommendations for improvement. The review highlights the importance of accurate prediction for severe cases and suggests areas for improvement, such as external validation, standardization of predictor and outcome definitions, and more comprehensive reporting.
Article
Multidisciplinary Sciences
Mariana Inri de Carvalho, Marina Gatti, Renata Ligia Vieira Guedes, Renata Camilla Favarin Froes, Danila Rodrigues Costa, Jhonatan da Silva Vitor, Paulo Sergio da Silva Santos, Giedre Berretin-Felix
Summary: This study investigated the relationship between swallowing function, nutritional status, and salivary flow in patients after head and neck cancer treatment. Results showed that appropriate protein intake influences muscle activity during swallowing in head and neck cancer survivors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Christopher Nutting, Laura Finneran, Justin Roe, Mark A. Sydenham, Matthew Beasley, Shree Bhide, Cheng Boon, Audrey Cook, Emma De Winton, Marie Emson, Bernadette Foran, Robert Frogley, Imran Petkar, Laura Pettit, Keith Rooney, Tom Roques, Devraj Srinivasan, Justine Tyler, DARS Trialist Grp
Summary: The study found that dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) improved swallowing function and reduced radiation dose-related damage in patients with oropharyngeal and hypopharyngeal cancers. Therefore, DO-IMRT should be considered as a new standard treatment for patients receiving radiotherapy for pharyngeal cancers.
Article
Medicine, Research & Experimental
Xenia Ray, Whitney Sumner, Leisa Sutton, Parag Sanghvi, Ida Deichaite, Vitali Moiseenko
Summary: This study evaluated if HPV status serves as an independent predictor of dysphagia outcomes for head and neck cancer patients undergoing radiotherapy. The results indicated that cancer type, smoking history, and mean dose were consistently selected as covariates for predicting early dysphagia outcomes. HPV status was seldom selected and oropharyngeal cancer patients were found to have an increased risk of high-grade dysphagia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zahra Dorna Mojdami, Abdelahhad Barbour, Morvarid Oveisi, Chunxiang Sun, Noah Fine, Sourav Saha, Cara Marks, Omnia Elebyary, Erin Watson, Howard Tenenbaum, Amir Azarpazhooh, Michael Glogauer
Summary: This study aimed to investigate the effects of radiation therapy (RT) on oral neutrophils (oPMNs) and the oral microbiome in patients undergoing head and neck tumor (HNT) treatment. The results showed that RT caused a significant decrease in oPMN counts and suppressed their activation state, while also altering the composition of the oral microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Otorhinolaryngology
Martine F. van der Kamp, Friso O. W. Muntinghe, Rene S. Iepsma, Boudewijn E. C. Plaat, Bernard F. A. M. van der Laan, Ayat Algassab, Roel J. H. M. Steenbakkers, Max J. H. Witjes, Boukje A. C. van Dijk, Geertruida H. de Bock, Gyorgy B. Halmos
Summary: This study found that male gender, hypopharyngeal tumors, advanced T-stage, histopathological poor differentiation grade, regional lymph node metastasis, and extranodal extension are independent prognostic factors for the presence or development of distant metastasis in HNSCC patients, while age does not play a significant role.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, Research & Experimental
Manon A. Zwakenberg, Gyorgy B. Halmos, Jan Wedman, Bernard F. A. M. van Der Laan, Boudewijn E. C. Plaat
Summary: The study showed that the sensitivity of NBI during flexible endoscopy was comparable to WLI during rigid endoscopy, with higher tumor extension observed using NBI. NBI during flexible laryngoscopy led to upstaging and downstaging of T classification, improving visualization of tumor extension and accuracy of staging.
Article
Otorhinolaryngology
Constanze Scholman, Jeroen M. Westra, Manon A. Zwakenberg, Frederik G. Dikkers, Gyorgy B. Halmos, Jan Wedman, Jan E. Wachters, Bernard F. A. M. van der Laan, Boudewijn E. C. Plaat
Summary: In a large population of observers with different levels of clinical expertise, high definition laryngoscopy (HDL) is superior to fiberoptic laryngoscopy (FOL) in identifying laryngeal lesions.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
N. C. Kuipers, B. J. de Kleijn, J. Wedman, B. F. A. M. van der Laan, B. E. C. Plaat, G. B. Halmos
Summary: The new energy-based sutureless vessel ligation device Thunderbeat can reduce blood loss and operative time in neck dissection surgery, without increasing complications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Koos Boeve, Mirjam F. Mastik, Lorian Slagter-Menkema, Boukje A. C. van Dijk, Jan L. N. Roodenburg, Bernard F. A. M. van der Laan, Max J. H. Witjes, Bert van der Vegt, Ed Schuuring
Summary: This feasibility study evaluated the value of molecular tumor biomarkers associated with lymph node metastasis in OSCC. Tumor infiltration depth and pattern of invasion were independent prognostic markers for sentinel lymph node status. Cortactin expression showed promise as a marker to identify low-risk patients who may not benefit from SLNB or END.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Medicine, Research & Experimental
Leonie Bruine de Bruin, Martijn J. A. M. Clausen, Lorian Slagter-Menkema, Gertruida H. de Bock, Johannes A. Langendijk, Bert van der Vegt, Bernard F. A. M. van der Laan, Ed Schuuring
Summary: This study investigated the association between DNA methyltransferase 1 (DNMT1) expression and local control in early-stage laryngeal squamous cell carcinoma (LSCC) patients treated with radiotherapy. The results showed that high expression of DNMT1 was associated with worse local control. Patients with higher T-stage and positive N-status also had worse local control.
Review
Oncology
Martine Froukje van der Kamp, Gyorgy Bela Halmos, Victor Guryev, Peter Laszlo Horvatovich, Ed Schuuring, Bernardus Franciscus Augustinus Maria van der Laan, Bert van der Vegt, Boudewijn Evert Christiaan Plaat, Cornelia Johanna Verhoeven
Summary: In recent clinical practice, an increasing number of elderly patients with head and neck squamous cell carcinoma (HNSCC) of unknown pathophysiology is observed. HNSCC patients can be divided into three subcategories: young patients with genomic aberrations and inheritable diseases, HPV-related HNSCCs with a more favorable prognosis, and HPV-negative tumors involving lifestyle factors. The proposed fourth subcategory is elderly (HPV-negative) HNSCC patients without a history of tobacco and alcohol consumption, which may have different pathophysiological mechanisms. Future research is needed to fill the knowledge gap.
Article
Oncology
Rosanne C. Schoonbeek, Julius de Vries, Linda Bras, Grigory Sidorenkov, Boudewijn E. C. Plaat, Max J. H. Witjes, Bernard F. A. M. van der Laan, Johanna G. M. van den Hoek, Boukje A. C. van Dijk, Johannes A. Langendijk, Gyorgy B. Halmos
Summary: This study aimed to assess the impact of treatment delay on quality of life (QOL) and overall survival in patients with head and neck squamous cell carcinomas (HNSCC). The results showed that delay in treatment initiation did not significantly affect overall survival and had only a slight positive impact on QOL scores.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Otorhinolaryngology
Cindy H. Nabuurs, Wietske Kievit, C. Rene Leemans, Conrad F. G. M. Smit, Michiel W. M. van den Brekel, Robert J. Pauw, Bernard F. A. M. van der Laan, Jeroen C. Jansen, Martin Lacko, Weibel W. Braunius, Chunfu Dai, Xunbei Shi, Giovanni Danesi, Jan Boucek, Robert P. Takes, Henricus P. M. Kunst
Summary: The study evaluated the impact of different subclasses of T4-classified squamous cell carcinoma of the external auditory canal on treatment strategies and survival outcomes. The results suggest that using different treatment strategies based on different subclasses may affect disease-free survival rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Jeroen E. van Schaik, Anna C. Muller Kobold, Bernard F. A. M. van der Laan, Bert van der Vegt, Bettien M. van Hemel, Boudewijn E. C. Plaat
Summary: The diagnostic value of measuring SCC-Ag and CA15-3 concentrations in FNA samples for the detection of SCC metastases in cervical lymph nodes was evaluated. SCC-Ag measurement showed comparable sensitivity to FNAC and could be used as a cost-effective screening tool in samples with nondiagnostic or indeterminate FNAC results or when multiple lymph nodes are sampled. However, SCC-Ag in FNA samples had lower specificity compared to FNAC assessed by experienced pathologists in head and neck oncology. The addition of CA15-3 measurement did not enhance accuracy.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Julius de Vries, Anouk Poelman, Grigory Sidorenkov, Suzanne Festen, Geertruida H. de Bock, Johannes A. Langendijk, Bernard F. A. M. van der Laan, Roel J. H. M. Steenbakkers, Gyorgy B. Halmos
Summary: This study investigated the association of frailty and geriatric assessment (GA) with radiation-induced toxicity (RIT) in patients with head and neck cancer. The results showed that age, regional radiotherapy, and concurrent chemotherapy were independent factors associated with increasing toxicity during the treatment period. However, none of the individual items of GA and the frailty screening instruments were associated with increasing RIT.
Article
Oncology
Rosanne C. Schoonbeek, Suzanne Festen, Bernard F. A. M. van der Laan, Boudewijn E. C. Plaat, Johannes A. Langendijk, Boukje A. C. van Dijk
Summary: This study aimed to assess the impact of delayed treatment initiation on adverse events and recurrence in older HNSCC patients. The results showed that delayed treatment initiation was independently associated with increased recurrence risk in patients treated with initial surgery, but not associated with postoperative complications or acute radiation-induced toxicity.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Jaron G. de Wit, Jeroen E. van Schaik, Floris J. Voskuil, Jasper Vonk, Sebastiaan A. H. J. de Visscher, Kees-Pieter Schepman, Bernard F. A. M. van der Laan, Jan J. Doff, Bert van der Vegt, Boudewijn E. C. Plaat, Max J. H. Witjes
Summary: This study compared narrow band imaging (NBI) with fluorescence molecular imaging (FMI) in assessing the mucosal tumor margins in oral squamous cell carcinoma (OSCC) surgery. The results showed that FMI performed more accurately than NBI in evaluating the mucosal margin, especially in early-stage and not previously irradiated tumors.
Article
Otorhinolaryngology
Karlijn van den Bovenkamp, Bert van der Vegt, Gyorgy B. Halmos, Lorian Slagter-Menkema, Johannes A. Langendijk, Boukje A. C. van Dijk, Ed Schuuring, Bernard F. A. M. van der Laan
Summary: This study examined the predictive value of various tumor markers in patients with advanced-stage laryngeal squamous cell carcinoma, and found that overexpression of HIF-1α was associated with locoregional recurrence.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Manon A. Zwakenberg, Jeroen M. Westra, Gyorgy B. Halmos, Jan Wedman, Bernard F. A. M. van Der Laan, Boudewijn E. C. Plaat
Summary: This study aimed to assess whether the additional use of narrow-band imaging (NBI) in transoral laser surgery (TOLS) for early laryngeal cancer improves clinical outcomes. The results showed that the use of NBI significantly reduced the number of positive resection margins and potentially decreased the recurrence rate and improved recurrence-free survival in patients treated with NBI-supported TOLS. Further studies with larger patient groups are needed to confirm these findings.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)