Article
Radiology, Nuclear Medicine & Medical Imaging
Oscar Casares-Magaz, Loredana G. Marcu, Yolanda Prezado, Efi Koutsouveli, Marco Brambilla
Summary: The study found that approximately half of the European countries require dosimetry audits in radiotherapy departments, but there is still a lack of transposition and implementation of the Council Directive, leading to heterogeneities in national policies regarding dosimetry audits.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Engineering, Biomedical
Sebastian Hoefel, Michael Stehle, Felix Zwicker, Michael K. Fix, Malte Drescher
Summary: In EPR dosimetry, uncertainty analysis was conducted for doses ranging from 1 to 70 Gy using AL and LFM pellets. LFM pellets demonstrated lower dose uncertainties compared to AL pellets, making them more suitable for applications in radiotherapy.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. De Saint -Hubert, C. De Angelis, Z. Knezevic, B. Michalec, B. Reniers, E. Pyszka, L. Stolarczyk, J. Swakon, G. Foltynska, A. Wochnik, A. Parisi, M. Majer, R. M. Harrison, R. Kopec, F. Vanhavere, P. Olko
Summary: The lack of mailed dosimetry audits of proton therapy centres in Europe has led researchers to compare existing passive detector systems in therapeutic pencil beam scanning. The study found that alanine detectors have the lowest energy dependence for different parameters of therapeutic pencil beam scanning and are suitable for mail auditing in proton therapy. The luminescence detector systems show promise, but more careful calibration and corrections are needed for implementation as part of a mailed dosimetry audit system.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Computer Science, Interdisciplinary Applications
Tomppa Pakarinen, Jarkko Ojala
Summary: Profeel is an open-source dosimetry data visualization and analysis software based on Matlab, designed to support quality assurance, dosimetry, and research in radiotherapy. The software offers processing and analysis tools such as gamma analysis, data normalizations, and data filtering, and automatically performs one-dimensional profile and depth dose analysis according to international standards.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Chemistry, Physical
Jakob G. Hjorringgaard, Arne Miller, Claus E. Andersen, Dominique Cloetta, Willi Wandfluh, Alan Tallentire
Summary: In this study, the radiation response of Bacillus pumilus spores exposed to different radiation qualities was investigated, and it was found that the radiation resistance of the spores is independent of beam quality.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Chemistry, Physical
L. F. Souza, A. Nolasco, G. R. Barrera, W. R. C. Campos, D. N. Souza, M. S. Nogueira
Summary: The study investigated the potential use of two new borate matrices in radiotherapy quality assurance tests, with 80-20MBO showing significantly higher OSL sensitivity compared to MBO. Additionally, 80-20MBO exhibited a supralinear dose response and significant fading after irradiation.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David A. Roberts, Carlos Sandin, Panu T. Vesanen, Hannah Lee, Ian M. Hanson, Simeon Nill, Thijs Perik, Seng Boh Lim, Sastry Vedam, Jinzhong Yang, Simon W. Woodings, Jochem W. H. Wolthaus, Brian Keller, Geoff Budgell, Xinfeng Chen, X. Allen Li
Summary: Magnetic resonance image-guided radiotherapy systems have introduced new challenges to quality assurance due to the unique characteristics of the systems. There is currently no consensus guidance on QA equipment and test requirements, necessitating the development of an overview and recommendations for different aspects of QA for such systems. This consensus work aims to provide a foundation for future research and development in QA protocols and measurement methods.
Article
Engineering, Multidisciplinary
Marek Kozicki, Piotr Maras
Summary: This work reviews the issue of determining the radiation isocenter for quality assurance tests of medical accelerators. It presents a protocol using high resolution 3D polymer gel dosimetry and discusses potential problems in determining the radiation isocenter.
Article
Biology
Seung-Hyeop Baek, Sang-Hyoun Choi, Moo-Jae Han, Gyu-Seok Cho, Wonil Jang, Jin-Sung Kim, Kum-Bae Kim
Summary: Pre-treatment patient-specific quality assurance is crucial in preventing radiation accidents. The electronic portal imaging device (EPID) is a dose measurement tool with high resolution and minimal volume-averaging effect. This study evaluated the effectiveness of EPID-based patient-specific QA tool (EPIbeam) compared to the previously used PTW729 detector. The results showed that EPIbeam had higher gamma passing rates and can be an effective QA tool for patient-specific treatment verification.
Article
Oncology
Joerg Lehmann, Mohammad Hussein, Miriam A. Barry, Shankar Siva, Alisha Moore, Michael Chu, Patricia Diez, David J. Eaton, Jeffrey Harwood, Peta Lonski, Elizabeth Claridge Mackonis, Carole Meehan, Rushil Patel, Xenia Ray, Maddison Shaw, Justin Shepherd, Gregory Smyth, Therese S. Standen, Brindha Subramanian, Peter B. Greer, Catharine H. Clark
Summary: This study aims to improve the quality of radiation therapy and patient outcomes by assessing institutions' ability to detect errors through routine Patient Specific Quality Assurance (PSQA). A new audit concept is needed as existing dosimetry audits may not catch all errors. The study evaluates institutions' ability to detect errors by embedding deliberately introduced edits into radiation treatment plans.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jun Zhang, Ziting Fan, Xile Zhang, Ruijie Yang, Junhai Wen
Summary: This study proposed a simple yet effective method with correction matrices to rectify backscatter and off-axis effects for EPID images, converting pixel values into absolute dose values. The experimental results showed accurate correction of EPID images and high efficiency in using EPID as a dosimetry tool for radiotherapy.
Article
Engineering, Biomedical
Anastasios Episkopakis, Vasiliki Margaroni, Stamatiki Kanellopoulou, Nikolas Marinos, Efi Koutsouveli, Pantelis Karaiskos, Eleftherios P. Pappas
Summary: This study focuses on the dose-response characterization of optically stimulated luminescence dosimetry (OSLD), with emphasis on 1.5T MR-Linacs. The results show that the dose-response supralinearity in an MR-Linac setting agrees with that in a conventional linac. The signal fading rate of OSLD does not depend on irradiation conditions. The angular dependence of OSLD is more pronounced under the presence of a magnetic field. OSLDs irradiated with and without real-time MR imaging yield the same response. Correction factors for different detector orientations were determined.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
J. Taprogge, J. Wadsley, E. Miles, G. D. Flux
Summary: Multicentre clinical trials with dosimetry components are increasingly important in molecular radiotherapy. Standardization of methodologies is crucial to ensure comparable results across centres. Quality assurance programs should be implemented to support meaningful results.
Article
Environmental Sciences
Barbara Michalec, Cinzia De Angelis, Gabriela Foltynska, Tomasz Horwacik, Brigitte Reniers, Agnieszka Wochnik, Renata Kopec, Jan Swakon
Summary: Quality control of therapeutic photon beams is widely used in photon radiotherapy, while there is no standardized dosimetry audit program for proton centers in Europe. This study evaluated the applicability of alanine/EPR dosimetry systems developed at different institutions for routine mailed dose audits of passively scattered therapeutic proton beams. The evaluation demonstrated good agreement between the measured dose by three laboratories and the delivered dose determined with an ionization chamber. The properties of alanine, such as non-destructive readout, tissue equivalence, weak energy dependence, dose rate independence, and insignificant fading, make it a suitable candidate for dosimetry in postal auditing in proton ocular radiotherapy.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Oncology
Sebastian Hoefel, Matteo Gandalini, Michael K. Fix, Malte Drescher, Felix Zwicker
Summary: The study examined the clinical feasibility of superficial electron paramagnetic resonance (EPR) in-vivo dosimetry (IVD) for breast cancer patients undergoing helical intensity-modulated radiotherapy. Results showed that EPR IVD is suitable as an additional safeguard for dose delivery, with observed dose deviations at the ipsilateral breast being small compared to national reporting thresholds. This method may help detect critical dose errors during whole breast irradiations.
RADIATION ONCOLOGY
(2021)
Article
Construction & Building Technology
Katrijn Gijbels, Yiannis Pontikes, Pieter Samyn, Sonja Schreurs, Wouter Schroeyers
CEMENT AND CONCRETE RESEARCH
(2020)
Article
Materials Science, Multidisciplinary
Bram Mast, Andrea Cambriani, Alexios P. Douvalis, Yiannis Pontikes, Wouter Schroeyers, Bram Vandoren, Sonja Schreurs
JOURNAL OF NUCLEAR MATERIALS
(2020)
Article
Engineering, Environmental
Tom Haeldermans, P. Samyn, R. Cardinaels, D. Vandamme, K. Vanreppelen, A. Cuypers, S. Schreurs
Summary: Biochar is a less-utilized candidate for serving as an alternative filler in PHB-based composites. Adding biochar to the composites can enhance morphology and crystallization kinetics up to a certain percentage, but higher percentages of filler may have an opposite effect. Additionally, the study reveals that TPS can work as an excellent intermediary between biochar and PHB, maintaining limited degradation and reduction in molecular weight compared to the PHB/char samples. Like biochar, TPS also acts as a nucleation agent and removes the influence of biochar on the thermal stability of the composites.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Engineering, Electrical & Electronic
Luana de F. Nascimento, Jo Goossens, Paul Leblans, Paul Sterckx, Filip Vanhavere, Lara Struelens, Mark Akselrod, Dirk Verellen
Summary: The article investigates the response of Al2O3:C and Al2O3:C,Mg radioluminescence films for medical dosimetry, finding that Al2O3:C,Mg films have advantages over Al2O3:C films, with better performance, suitable for small field beam dosimetry, and capable of real-time measurement of two-dimensional dose-rate distributions, making it an effective dosimetry system.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Construction & Building Technology
Bram Mast, Sylke Fransis, Bram Vandoren, Andrea Cambriani, Wouter Schroeyers, Yiannis Pontikes, Pieter Samyn, Sonja Schreurs
Summary: The properties of plasma slag based IPs can be affected by changing the precursor fineness and molar ratios of SiO2/Na2O and H2O/Na2O in the activating solution. Decreasing SiO2/Na2O ratio increases strength while decreasing H2O/Na2O ratio increases elastic modulus. The effect of elastic modulus of the binder phase on strain softening was found to be negligible.
CEMENT & CONCRETE COMPOSITES
(2021)
Article
Chemistry, Inorganic & Nuclear
Lowie Brabants, Guilaume Lutter, Jan Paepen, Bram Vandoren, Brigitte Reniers, Wouter Schroeyers
Summary: The efficiency of a coaxial p-type HPGe detector from Canberra was modeled using TOPAS MC software and validated by comparing experimental efficiencies with those calculated by simulations. Three different radionuclide source geometries were used to validate the model, meeting a 5% relative difference criteria for various radionuclides and gamma-ray energies. Consequently, the detector model created with TOPAS MC was considered validated.
APPLIED RADIATION AND ISOTOPES
(2021)
Article
Engineering, Environmental
Christophe Gueibe, Jos Rutten, Johan Camps, Dominique Moyaux, Wouter Schroeyers, Matthias Auer, Sonja Schreurs
Summary: Atmospheric radioxenon releases from fission-based medical isotope production facilities are the main contributors to the observed radioxenon background in the International Monitoring System. To reduce these emissions, optimizing filtration processes and researching more efficient Xe adsorption materials are crucial.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Medicine, General & Internal
Maria Ghita, Charlotte Billiet, Dana Copot, Dirk Verellen, Clara Mihaela Ionescu
Summary: The study utilized a PKPD model to accurately predict lung growth curves in non-small cell lung cancer patients, demonstrating the potential value of mathematical modeling in anticancer research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Construction & Building Technology
Michiel Giels, Tobias Hertel, Katrijn Gijbels, Wouter Schroeyers, Yiannis Pontikes
Summary: This study investigates the transformation of bauxite residue into a reactive precursor after heat treatment and the synthesis of high performance inorganic polymer mortars. Calcium addition plays a key role in increasing the compressive strength and reducing shrinkage and permeability. The results suggest that bauxite residue can be an ideal raw material for producing high-performance binders.
CEMENT AND CONCRETE RESEARCH
(2022)
Article
Oncology
Yawo A. C. Fiagan, Evy Bossuyt, Daan Nevens, Melanie Machiels, Ibrahim Chiairi, Ines Joye, Paul Meijnders, Thierry Gevaert, Dirk Verellen
Summary: This study investigated the sensitivity of an electronic portal imaging device (EPID)-based in-vivo dosimetry (EIVD) system in detecting the need for adaptive radiotherapy (ART) in head and neck cancer (HNC) patients, and identified its limitations. The results showed that EIVD combined with 3D imaging techniques can be synergistic in detecting anatomical changes in HNC patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Engineering, Chemical
Christophe Gueibe, Jos Rutten, Johan Camps, Dominique Moyaux, Wouter Schroeyers, Romano Plenteda, Nikolaus Hermanspahn, Daria Minta, Sonja Schreurs
Summary: This study compared the potential of two AgZs, two MOFs and one AC in collecting and separating Xe from air. It was found that both AgZs exhibited high selectivity and adsorption capacity for Xe at room temperature, and were able to efficiently separate Xe from other gases. However, a limitation of these AgZs was the strong co-adsorption of moisture, which significantly reduced Xe collection.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Oncology
Geert De Kerf, Michael Claessens, Fadoua Raouassi, Carole Mercier, Daan Stas, Piet Ost, Piet Dirix, Dirk Verellen
Summary: This study investigates the use of combined geometrical and dose-volume metrics as performance monitoring tools in clinical artificial intelligence (AI) implementations. The results show that the combination of dose-volume and geometrical metrics can effectively detect clinically relevant changes, and the Local Surface Dice is more sensitive to local changes compared to the Standard Surface Dice.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Polymer Science
T. Haeldermans, P. Samyn, R. Cardinaels, D. Vandamme, K. Vanreppelen, A. Cuypers, S. Schreurs
Summary: Biochar is commonly used as a filler material in biodegradable composites for its favorable thermal and mechanical properties. The study shows that as the biochar content increases in PLA/biochar composites, the thermal degradation temperature decreases, while in PLA/TPS/biochar composites, the impact of biochar is shielded by TPS. This work highlights the shielding effect TPS has on biochar and its potential for optimizing the production and biodegradability of these composites.
EXPRESS POLYMER LETTERS
(2021)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
