Journal
RADIOTHERAPY AND ONCOLOGY
Volume 96, Issue 1, Pages 123-130Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2010.05.006
Keywords
MR; TCD(50); Re-oxygenation; Perfusion; Lactate; Histology; Correlation
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Purpose: To correlate non-invasively acquired radiobiologically relevant magnetic resonance (MR) parameters with functional histology and tumor control doses (TCD(50)). Materials and methods: The MR parameters relative perfusion, re-oxygenation and lactate (Lac) concentration from eight human xenograft squamous tumor lines were compared with the histologically acquired pimonidazole hypoxic fraction, the perfused vessel area and TCD(50). Results: Good spatial correlation in the parameter maps could be observed between the pimonidazole staining and tumor regions, which can be reoxygenated when breathing carbogen. A strong positive correlation (R = 0.74) was found between whole tumor pimonidazole hypoxic fraction and re-oxygenation, as one would expect. A good correlation was also observed between Lac concentration and re-oxygenation (R = 0.71) and between TCD(50) and re-oxygenation (R = 0.64), whereas Lac and TCD(50) showed a moderate relation (R = 0.44). The in vivo measurement of relative perfusion could be validated to reflect the perfused vessel area (R = 0.63). No correlation was detected between perfusion and re-oxygenation or TCD(50). Conclusions: Lac and re-oxygenation were shown to be pretreatment predictive markers independent from the pathophysiological changes induced during a fractionated course of radiotherapy. These parameters hold promise to be acquired non-invasively with results just a few minutes after measurement and to tailor radiotherapy to individual patterns of a tumor microenvironment. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 96 (2010) 123-130
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