Article
Gastroenterology & Hepatology
Taru M. Lehtonen, Laura E. Koskenvuo, Toni T. Seppala, Anna H. Lepisto
Summary: This study found that extramural venous invasion observed in preoperative MRI is a significant prognostic factor for poorer survival and recurrences in rectal cancer patients. A circumferential margin <= 1 mm is associated with local recurrence, but this risk can be controlled with chemoradiotherapy and extended surgery.
COLORECTAL DISEASE
(2022)
Review
Surgery
Francois Rouleau Fournier, Mohammad Ali K. Motamedi, Carl J. Brown, Terry Phang, Manoj J. Raval, Cameron J. Hague, Ahmer A. Karimuddin
Summary: This review aimed to demonstrate the significance of pre- and post-treatment MRI-detected EMVI as independent prognostic factors in patients undergoing neoadjuvant therapy followed by total mesorectal excision.
Review
Radiology, Nuclear Medicine & Medical Imaging
Akitoshi Inoue, Shannon P. Sheedy, Jay P. Heiken, Payam Mohammadinejad, Rondell P. Graham, Hee Eun Lee, Scott R. Kelley, Stephanie L. Hansel, David H. Bruining, Jeff L. Fidler, Joel G. Fletcher
Summary: MRI is commonly used for staging rectal cancer and detecting EMVI, a predictor for worse prognosis. T2-weighted and diffusion-weighted images can help identify EMVI, while contrast enhanced T1-weighted images show tumor signal intensity.
INSIGHTS INTO IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weiqun Ao, Xian Zhang, Xiuzhen Yao, Xiandi Zhu, Shuitang Deng, Jianju Feng
Summary: This study explored the value of quantitative dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging parameters in assessing extramural venous invasion in rectal cancer. The results showed that Ktrans and Kep values were associated with mrEMVI positivity, while ADC values were associated with mrEMVI negativity. The combined model based on quantitative DCE parameters and ADC values had good prediction efficiency for pathologic EMVI in rectal cancer.
BMC MEDICAL IMAGING
(2022)
Article
Oncology
Siye Liu, Xiaoping Yu, Songhua Yang, Pingsheng Hu, Yingbin Hu, Xiaoyan Chen, Yilin Li, Zhe Zhang, Cheng Li, Qiang Lu
Summary: A radiomics nomogram based on primary tumor features was established and validated to predict preoperative pathological extramural venous invasion (EMVI) in rectal cancer using machine learning. The nomogram showed high efficiency in predicting EMVI, helping patients choose optimal treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Jessica Juliana Tan, Rachel V. Carten, Amna Babiker, Muti Abulafi, Amy C. Lord, Gina Brown
Summary: mrEMVI is significantly associated with worsened survival outcomes in rectal cancer, both at baseline and after neoadjuvant treatment. Regression of mrEMVI after neoadjuvant treatment is associated with improved survival outcomes. Accurate and consistent reporting of mrEMVI status is essential.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Mo Chen, Yan Ma, Yi-wen Song, Jinhua Huang, Yuan-hong Gao, Jian Zheng, Fang He
Summary: In this retrospective study, we found that most LARC patients with mrEMVI converted to EMVI-negative after neoadjuvant treatment, resulting in improved overall survival and disease-free survival. Patients receiving neoadjuvant chemoradiotherapy had better survival outcomes compared to those receiving neoadjuvant chemotherapy alone, suggesting the importance of including radiotherapy in the treatment. Patients receiving neoadjuvant chemotherapy in addition to chemoradiotherapy had higher rates of pathological complete response and downstaging, but their survival rates were not improved.
Article
Surgery
Osman Serhat Guner, Latif Volkan Tumay
Summary: In rectal cancer patients, persistent EMVI positivity after neoadjuvant therapy may serve as an independent predictor of poor overall survival and disease-free survival, along with mesorectal fascia involvement and poor differentiation as significant independent predictors of worse disease-free survival.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenyu Shu, Dewang Mao, Qiaowei Song, Yuyun Xu, Peipei Pang, Yang Zhang
Summary: In patients with rectal cancer, a radiomics signature based on the Bayes algorithm performed well in both the training and test sets, while the joint model showed the best performance in predicting EMVI, serving as a key tool for clinical individualized EMVI prediction.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung Yoon Yang, Heejin Bae, Nieun Seo, Kyunghwa Han, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Nam Kyu Kim, Kang Young Lee, Joon Seok Lim
Summary: This study evaluated the role of pretreatment MRI-detected extramural venous invasion (pmrEMVI) as a predictor of survival in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy. The results showed that pmrEMVI was associated with worse disease-free survival and systemic recurrence, but not local recurrence. In patients with pmrEMVI, neoadjuvant chemoradiotherapy had no benefit for oncological outcomes and pmrEMVI(+) was the only factor associated with early recurrence.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Shunsuke Kubota, Takuya Miura, Taiichi Wakiya, Tadashi Yoshizawa, Shintaro Goto, Hajime Morohashi, Yoshiyuki Sakamoto, Yota Tatara, Hiroshi Kijima, Kenichi Hakamada
Summary: This study found that extramural vascular invasion (EMVI) and tumor deposits (TD) are poor prognostic factors in rectal cancer (RC), especially when resistant to neoadjuvant chemotherapy (NAC). The differential expression of SELENBP1 may contribute to NAC resistance and poor prognosis in RC.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Hannah M. M. Thompson, David D. B. Bates, Jennifer Golia Pernicka, Sun Jin Park, Mahra Nourbakhsh, James L. L. Fuqua, Megan Fiasconaro, Jessica A. A. Lavery, Iris H. H. Wei, Emmanouil P. P. Pappou, J. Joshua Smith, Garrett M. M. Nash, Martin R. R. Weiser, Philip B. B. Paty, Julio Garcia-Aguilar, Maria Widmar
Summary: This study investigated the association of persistent extramural venous invasion (EMVI) after total neoadjuvant therapy (TNT) with survival in patients with locally advanced rectal cancer. The results showed that EMVI regression on surgical pathology was associated with improved disease-free survival and overall survival. However, the impact of persistent EMVI on post-TNT MRI on decision-making and prognosis remains unclear.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhen Guan, Xiao-Yan Zhang, Xiao-Ting Li, Rui-Jia Sun, Qiao-Yuan Lu, Ai-Wen Wu, Ying-Shi Sun
Summary: This study investigates the association between CT-detected extramural vascular invasion (ctEMVI) and lymph-vascular invasion (LVI) in colon cancer, as well as the prognostic value of ctEMVI in different LVI conditions. The results show that ctEMVI is an independent prognostic risk factor and has different prognostic value in different LVI states.
ABDOMINAL RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ke-xin Wang, Jing Yu, Qing Xu
Summary: Histogram analysis of DCE-MRI K-trans maps can be used for the identification of extramural venous invasion (EMVI) in rectal cancer patients. The mean values of K-trans and V-e were significantly higher in the EMVI-positive group compared to the EMVI-negative group. Parameters such as kurtosis and entropy of K-trans were identified as independent predictors for EMVI.
BMC MEDICAL IMAGING
(2023)
Article
Oncology
Lianfen Tian, Ningqin Li, Dong Xie, Qiang Li, Chuanji Zhou, Shilai Zhang, Lijuan Liu, Caiyun Huang, Lu Liu, Shaolu Lai, Zheng Wang
Summary: This study verified the value of MRI to construct a nomogram for preoperatively predicting EMVI in rectal cancer. The nomogram including MRI characteristics showed good predictive ability for EMVI in both the internal training and external validation groups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gabriel F. Hess, Philipp Sedlaczek, Fabian Haak, Sebastian M. Staubli, Simone Muenst, Martin Bolli, Christoph J. Zech, Martin H. Hoffmann, Robert Mechera, Otto Kollmar, Savas D. Soysal
Summary: The outcome of patients after percutaneous cholecystostomy (PC) was retrospectively analysed. It was found that performing upfront cholecystectomy (CCY) after PC was associated with a lower mortality rate compared to PC alone. PC should not be considered as a definitive treatment for acute cholecystitis and should be used as a short-term solution.
