Article
Clinical Neurology
Zeinab Sinaeifar, Mahsa Mayeli, Mahdieh Shafie, Atefe Pooyan, Giulia Cattarinussi, Mohammad Hadi Aarabi, Fabio Sambataro
Summary: This is a study that used DMRI connectometry approach to investigate white matter tracts associated with anger, while exploring potential sex differences. The results showed that the pathways associated with the limbic system and movement-related regions were involved in anger in men, while no brain pathways showed a significant relationship with anger in women.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Wasim Khan, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann
Summary: Advanced diffusion MRI was used to assess microstructural properties of normal-appearing white matter (NAWM) before it converted to white matter hyperintensities (WMHs) in ischemic stroke. The study found that NAWM converting to WMHs already exhibited changes in tissue compositions, with lower white matter-like and increased fluid-like and gray matter-like properties compared to persistent NAWM. Furthermore, the microstructural compositions were related to overall WMH burden, indicating greater fluid-like properties in NAWM vulnerable to WMH development.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hediye Pinar Gunbey, Arzu Ceylan Has, Kerim Aslan, Dilek Saglam, Ugur Avci, Asli Tanrivermis Sayit, Lutfi Incesu
Summary: This study investigated the effects of hypothyroidism on white matter integrity using TBSS, finding significant reductions in FA and AD, and an increase in RD in several WM tracts. The results suggest a demyelination process underlying the clinical aspects of hypothyroidism.
Article
Radiology, Nuclear Medicine & Medical Imaging
June van Aalst, Martijn Devrome, Donatienne Van Weehaeghe, Ahmadreza Rezaei, Ahmed Radwan, Georg Schramm, Jenny Ceccarini, Stefan Sunaert, Michel Koole, Koen Van Laere
Summary: The study found that as individuals age, there is a reduction in gray matter density, decrease in glucose metabolism, and weakening of white matter integrity in the brain. White matter tracts connecting regions with declining glucose metabolism were identified, showing correlations with changes in fractional anisotropy and mean diffusivity. Further research is needed to explore the temporal course and potential causality between ageing effects on glucose metabolism and white matter integrity.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Donovan J. Roediger, Claire Griffin, Frances Marin, Hannah Verdoorn, Mark Fiecas, Bryon A. Mueller, Kelvin O. Lim, Jazmin Camchong
Summary: This study examined whether microstructural measures in white matter pathways associated with relapse in alcohol use disorder (AUD). The findings showed that anisotropy measures in these pathways were generally lower in those who relapsed during the follow-up period and positively associated with the duration of sustained abstinence. However, only the right fornix showed significant results in this sample. This highlights the potential utility of the three-factor model of addiction and the role of white matter alterations in AUD treatment outcomes.
Article
Clinical Neurology
Malte Klingenberg, Didem Stark, Fabian Eitel, Celine Budding, Mohamad Habes, Kerstin Ritter, Alzheimers Dis Neuroimaging Initiat
Summary: This study trained a convolutional neural network using a balanced dataset to detect Alzheimer's disease. The results showed that the machine learning classifier had different performance for men and women, indicating the presence of sex bias. The findings emphasize the importance of examining and reporting classifier performance across population subgroups to ensure algorithmic fairness.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Alena Stasenko, Erik Kaestner, Anny Reyes, Sanam J. Lalani, Brianna Paul, Manu Hegde, Jonathan L. Helm, Sharona Ben-Haim, Carrie R. McDonald
Summary: This study highlights that preoperative asymmetry of deep and superficial white matter structures within the temporal lobe can predict postoperative memory decline in patients with temporal lobe epilepsy. Furthermore, asymmetry of the superficial white matter is shown to be the strongest predictor in predicting and classifying memory outcomes.
Article
Neurosciences
Anthony Gagnon, Gabrielle Grenier, Christian Bocti, Virginie Gillet, Andrea A. Baccarelli, Jonathan Posner, Maxime Descoteaux, Larissa Takser
Summary: Structural and functional MRI studies have explored the neuroanatomical basis of ADHD, but the anatomical ground truth remains unknown. This study used a state-of-the-art connectivity pipeline to analyze white matter connections and found that children with lower microstructural complexity and axonal density showed higher impulsive behavior. Subsection analysis revealed localized white matter alterations along each connection.
Article
Multidisciplinary Sciences
Amandine Crombe, Renaud Nicolas, Nathalie Richard, Thomas Tourdias, Bassem Hiba
Summary: This study investigated the effects of different b-values and numbers of diffusion-encoding directions (NDIRs) on DTI metrics in capturing early alterations in the microstructure of the hippocampus. The results emphasized the importance of high b-values and sufficient NDIR in achieving GM DTI with more biologically meaningful correlations, although caution should be exercised when interpreting DTI metrics in these settings.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Chun-Hung Yeh, Rung-Yu Tseng, Hsing-Chang Ni, Luca Cocchi, Jung-Chi Chang, Mei-Yun Hsu, En-Nien Tu, Yu-Yu Wu, Tai-Li Chou, Susan Shur-Fen Gau, Hsiang-Yuan Lin
Summary: This study aims to provide a comprehensive understanding of white matter alterations in individuals with autism spectrum disorder (ASD), particularly those with intellectual impairment (II) and/or minimally verbal (MV) status. The results suggest that ASD patients show specific white matter changes that are associated with symptoms and cognitive abilities.
Article
Neurosciences
Ruike Chen, Cong Sun, Tingting Liu, Yuhao Liao, Junyan Wang, Yi Sun, Yi Zhang, Guangbin Wang, Dan Wu
Summary: This study used fetal brain dMRI atlas to investigate the spatiotemporal pattern of white matter development, and found complex non-monotonic trends in microstructural parameters of eight white matter tracts, providing reference for diagnosing abnormal fetal white matter development.
Article
Clinical Neurology
Raffaello Bonacchi, Alessandro Meani, Elisabetta Pagani, Olga Marchesi, Andrea Falini, Massimo Filippi, Maria A. Rocca
Summary: In patients with multiple sclerosis, younger individuals are initially more resilient to brain damage, but compensatory mechanisms eventually fail, leading to loss of white matter integrity, followed by gray matter atrophy and ultimately disability.
Article
Clinical Neurology
Paolo Preziosa, Elisabetta Pagani, Alessandro Meani, Olga Marchesi, Lorenzo Conti, Andrea Falini, Maria A. Rocca, Massimo Filippi
Summary: Using diffusion tensor and neurite orientation dispersion and density imaging (NODDI), this study found that neuro-axonal damage and loss of microarchitecture integrity in focal WM lesions, NAWM, and GM contribute to cognitive impairment in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Jun-Yeop Kim, Jae-Hyuk Shim, Hyeon-Man Baek
Summary: Parkinson's disease (PD) is characterized by motor and non-motor symptoms, with white matter alterations in various brain areas detected using diffusion magnetic resonance imaging. This study compared quantitative anisotropy in PD patients and healthy controls, finding significant differences in subcortical and cortical structures. Subcortical structures correlated with motor dysfunction, while cortical structures showed links to olfactory dysfunction in PD, suggesting potential neural compensation in early-stage PD.
Article
Neurosciences
Dae Lim Koo, Ryan P. Cabeen, Soon Hyun Yook, Steven Yong Cen, Eun Yeon Joo, Hosung Kim
Summary: Obstructive sleep apnea (OSA) can cause disruptions in white matter (WM) and cognitive deficits. This study used diffusion tensor imaging (DTI) to analyze the extent of WM abnormalities and their connection to cognitive deficits in untreated OSA patients. The results showed lower fractional anisotropy (FA) values in various WM fibers and a correlation between lower FA values in the rostrum of the corpus callosum and impaired visual memory in OSA patients. The study revealed the negative impact of untreated OSA on WM integrity and identified specific fiber tract abnormalities associated with cognitive deficits.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Eva Catenaccio, Becky J. Riggs, Lisa R. Sun, Victor C. Urrutia, Brenda Johnson, Adriana Gonzalez Torriente, Ryan J. Felling
JOURNAL OF CHILD NEUROLOGY
(2020)
Editorial Material
Clinical Neurology
Eva Catenaccio, Ann M. Bergin, Anna L. R. Pinto, Katherine Nickels, Eric H. Kossoff
PEDIATRIC NEUROLOGY
(2021)
Article
Pediatrics
Eva Catenaccio, Jonathan M. Rochlin, Harold K. Simon
Summary: The financial impact of pursuing fellowship training in pediatric subspecialties compared to practicing as a general pediatrician varied widely, with the differences becoming more pronounced over time. Shortening the length of training or implementing specialty-specific loan repayment programs could help mitigate the negative financial impact.
Article
Pediatrics
Eva Catenaccio, Jonathan M. Rochlin, Harold K. Simon
Summary: The study found that adult physicians generally have higher lifetime earning potential than pediatric physicians, primarily due to differences in compensation. In both academic pediatric and adult medicine, inpatient-based, procedure-oriented subspecialties had higher lifetime earning potential than outpatient, less procedure-oriented subspecialties.
Article
Pediatrics
Eva Catenaccio, Jonathan M. Rochlin, Harold K. Simon
Summary: Differences in lifetime earning potential between pediatric subspecialties may impact workforce distribution, and the implementation of a pediatric subspecialist-specific loan repayment program could help address workforce shortages in the field.
Article
Medicine, General & Internal
Eva Catenaccio, Jonathan M. Rochlin, Harold K. Simon
Summary: This study reveals the gender-based disparities in starting salary and early career earning potential in academic medicine in the US. Equalizing starting salaries could address the majority of the differences in earning potential.
Article
Neurosciences
Kengo Onda, Eva Catenaccio, Jill Chotiyanonta, Raul Chavez-Valdez, Avner Meoded, Bruno P. Soares, Aylin Tekes, Harisa Spahic, Sarah C. Miller, Sarah-Jane Parker, Charlamaine Parkinson, Dhananjay M. Vaidya, Ernest M. Graham, Carl E. Stafstrom, Allen D. Everett, Frances J. Northington, Kenichi Oishi
Summary: By using diffusion tensor imaging (DTI) score, the study aimed to predict the short-term neurological function of neonates with hypoxic-ischemic encephalopathy (HIE). The cDTI score was strongly correlated with the short-term oral feeding (STO) score, indicating its potential prognostic value.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Eva Catenaccio, Mariko L. Bennett, Shavonne L. Massey, Nicholas S. Abend, Christina Bergqvist
Summary: Quantitative analysis of continuous electroencephalography (QEEG) is increasingly used to enhance seizure detection, recognizing different seizure patterns on QEEG is crucial for its widespread use in both adult and pediatric populations. In this case report, we present a 16-year-old patient with Lennox-Gastaut syndrome who had unique QEEG patterns termed icicles, characterized by abrupt decreases in power during tonic seizures.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Developmental Biology
Eva Catenaccio, Rachel J. J. Smith, Raul Chavez-Valdez, Vera J. J. Burton, Ernest Graham, Charlamaine Parkinson, Dhananjay Vaidya, Aylin Tekes, Frances J. J. Northington, Allen D. D. Everett, Carl E. E. Stafstrom, Eva K. K. Ritzl
Summary: Quantitative analysis of electroencephalography (qEEG) is a potential source of biomarkers for neonatal encephalopathy (NE). We piloted a fully automated method to calculate qEEG features using commercially available software. We found that qEEG features were associated with the degree of encephalopathy, severity of neuroimaging abnormalities, and brain maturity in neonates undergoing therapeutic hypothermia.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Meeting Abstract
Behavioral Sciences
Eva Catenaccio, Jonathan Rochlin, Marilyn Augustyn, Carol Weitzman, Harold Simon
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2023)
Article
Pediatrics
Eva Catenaccio, Jonathan M. Rochlin, Carol Weitzman, Marilyn Augustyn, Harold K. Simon
Summary: This study compares the lifetime earning potential (LEP) for developmental and behavioral pediatrics (DBP) to general pediatrics and other pediatric subspecialties. The study finds that DBP has the lowest LEP among all pediatric fields, and this is associated with workforce shortages.
ACADEMIC PEDIATRICS
(2023)
Article
Pediatrics
Eva Catenaccio, Jonathan M. Rochlin, Harold K. Simon
Summary: This study examines the relationship between the gender distribution of the pediatric subspecialty workforce and their lifetime earning potential. The results show that subspecialties with a higher proportion of women have lower lifetime earning potential. Similarly, a higher proportion of female first-year fellows is associated with lower lifetime earning potential. This trend may worsen over time as the number of women in pediatrics and individual subspecialties increases.
ACADEMIC PEDIATRICS
(2022)
Meeting Abstract
Pediatrics
Eva Catenaccio, Jonathan Rochlin, Harold Simon
Meeting Abstract
Clinical Neurology
Rebecca Riggs, Lisa R. Sun, Eva Catenaccio, Gonzalez Adriana Torriente, Ryan J. Felling
Article
Neurosciences
Wouter S. Hoogenboom, Todd G. Rubin, Kenny Ye, Min-Hui Cui, Kelsey C. Branch, Jinyuan Liu, Craig A. Branch, Michael L. Lipton
JOURNAL OF EXPERIMENTAL NEUROSCIENCE
(2019)