Article
Cardiac & Cardiovascular Systems
You-Jung Choi, Jun-Bean Park, Chan Soon Park, Inchang Hwang, Yeonyee E. Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Goo-Yeong Cho, Dae-Won Sohn
Summary: Abnormal LV geometry is associated with a worse prognosis in individuals with no or nonobstructive CAD, suggesting that LV geometry assessment can improve risk stratification in these patients.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Tijn P. J. Jansen, Suzette E. Elias-Smale, Stijn van den Oord, Helmut Gehlmann, Aukelien Dimitiriu-Leen, Angela H. E. M. Maas, Regina E. Konst, Niels van Royen, Peter Damman
Summary: In the invasive coronary function testing for patients with angina and no obstructive coronary artery disease, men and women show a comparable prevalence of coronary vasomotor dysfunction. However, men have a higher rate of epicardial spasm, while women are more likely to have microvascular spasm and impaired CFR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Side Gao, Sizhuang Huang, Xuze Lin, Li Xu, Mengyue Yu
Summary: The stress hyperglycemia ratio (SHR) is independently associated with the prognosis of patients with myocardial infarction with nonobstructive coronary arteries (MINOCA). SHR is a better predictor of prognosis than admission glycemia alone, especially in diabetic patients with MINOCA. SHR may serve as a prognostic marker for risk stratification as well as a potential target for tailored glucose-lowering treatment in MINOCA.
ANNALS OF MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Gu, Bin Lu, Yang Gao, Zhihui Hou, Shifeng Yang, Xianshun Yuan, Shuo Zhao, Ximing Wang
Summary: The study aimed to investigate the relationship between coronary atherosclerosis progression and cardiovascular events in patients with nonobstructive coronary artery disease. The results showed that the progression of coronary atherosclerosis was significantly associated with MACE, with patients with diabetes, dyslipidemia, and family history of CAD being at higher risk.
ACADEMIC RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yipu Ding, Zinuan Liu, Guanhua Dou, Xia Yang, Xi Wang, Dongkai Shan, Bai He, Jing Jing, Yundai Chen, Junjie Yang
Summary: The study investigated the prognostic value of atherosclerotic extent shown by CCTA in diabetic patients with nonobstructive CAD, revealing an association between atherosclerotic extent and adverse cardiac events. This highlights the importance of better risk stratification and management in these patients.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Peripheral Vascular Disease
Daniel Kosuta, Borut Jug, Zlatko Fras
Summary: The presence of nonobstructive and obstructive CAD on CCTA is associated with an increased risk of coronary events, with patients having nonobstructive CAD showing a 2-fold increase in risk compared to those with no CAD.
Article
Cardiac & Cardiovascular Systems
Juhwan Lee, Kashif Shaikh, Rine Nakanishi, Heidi Gransar, Stephan Achenbach, Mouaz H. Al-Mallah, Daniele Andreini, Jeroen J. Bax, Daniel S. Berman, Filippo Cademartiri, Tracy Q. Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Ronen Rubinshtein, Todd C. Villines, Yao Lu, Jessica M. Pena, Fay Y. Lin, James K. Min, Leslee J. Shaw, Matthew J. Budoff
Summary: This study investigated the relationship between non-obstructive left main (LM) disease, diabetes mellitus (DM), and all-cause mortality (ACM). The results showed that while DM was associated with increased ACM, the presence of non-obstructive LM disease was not an independent risk factor for ACM.
HEART LUNG AND CIRCULATION
(2023)
Article
Cardiac & Cardiovascular Systems
Rahul Chaudhary, Michael Bashline, Enrico M. Novelli, Kevin P. Bliden, Udaya S. Tantry, Oladipupo Olafiranye, Aref Rahman, Paul A. Gurbel, John J. Pacella
Summary: Women with MINOCA may have higher rates of adverse events, particularly a higher incidence of stroke compared to men.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Donghee Han, Billy Chen, Heidi Gransar, Stephan Achenbach, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Erica Maffei, Tracy Q. Callister, Kavitha Chinnaiyan, Benjamin J. W. Chow, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Todd C. Villines, Yong-Jin Kim, Jonathon Leipsic, Gudrun Feuchtner, Ricardo C. Cury, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Hyuk-Jae Chang, Fay Y. Lin, Leslee J. Shaw, James K. Min, Daniel S. Berman
Summary: This study found that proximal coronary involvement is associated with increased risk of major adverse cardiovascular events in patients with non-obstructive coronary artery disease, independent of plaque extent.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Masahiko Noguchi, Fotios Gkargkoulas, Mitsuaki Matsumura, Lak N. Kotinkaduwa, Xun Hu, Eisuke Usui, Tatsuhiro Fujimura, Fumiyasu Seike, Hanan Salem, Ge Jin, Chenguang Li, Kei Yamamoto, Takao Sato, Bjorn Redfors, Khady N. Fall, Tamim M. Nazif, Ziad A. Ali, Dimitri Karmpaliotis, Sahil A. Parikh, Giora Weisz, Michael B. Collins, Lauren T. Privitera, LeRoy E. Rabbani, Martin B. Leon, Jeffery W. Moses, Gregg W. Stone, Ajay J. Kirtane, Gary S. Mintz, Akiko Maehara
Summary: This large-scale study found that increasing plaque burden in the left main coronary artery (LMCA) was associated with long-term all-cause and cardiac mortality in patients not undergoing LMCA revascularization, even when the lumen area was preserved.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Kai M. Eggers, Tomasz Baron, Marcus Hjort, Anna M. Nordenskjold, Per Tornvall, Bertil Lindahl
Summary: The study found no specific inflammatory pattern in acute MINOCA compared to MI-CAD, but CRP levels were independently and moderately associated with adverse outcomes.
CLINICAL CARDIOLOGY
(2021)
Article
Hematology
Nadia Akhiyat, Terra Lasho, Morsaleh Ganji, Takumi Toya, Chang-Xin Shi, Xianfeng Chen, Esteban Braggio, Ali Ahmad, Michel T. Corban, Keith Stewart, Jenna Fernandez, Zhuoer Xie, Christy Finke, Lilach O. Lerman, Mrinal M. Patnaik, Amir Lerman
Summary: This study aims to investigate the relationship between clonal hematopoiesis (CH) and coronary microvascular dysfunction (CMD), as well as the risk for adverse cardiovascular outcomes. The study found that patients with CMD are more likely to have CH, and nearly one-third of major adverse cardiovascular events in CMD are mediated by CH.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Filippo Luca Gurgoglione, Davide Rizzello, Rossella Giacalone, Marco Ferretti, Antonella Vezzani, Bettina Pfleiderer, Giovanna Pela, Chiara De Panfilis, Maria Alberta Cattabiani, Giorgio Benatti, Iacopo Tadonio, Francesca Grassi, Giulia Magnani, Manjola Noni, Martina Cancellara, Francesco Nicolini, Diego Ardissino, Luigi Vignali, Giampaolo Niccoli, Emilia Solinas
Summary: Our study compares clinical, angiographic, and prognostic features in patients with spontaneous coronary artery dissection (SCAD) according to the type of precipitating stressors. The results show that emotional stressors leading to SCAD may identify a SCAD subtype with specific features and a worse clinical outcome trend.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi Yue Zu, Peng Peng Xu, Qian Chen, Yan Chun Chen, Jian Chen Qi, Chun Xiang Tang, Chang Sheng Zhou, Cheng Xu, Xin Jie Sun, Meng Jie Lu, Guang Ming Lu, Yi Ning Wang, Yi Xu, Long Jiang Zhang
Summary: This study investigated the predictive value of CT-derived fractional flow reserve (FFRCT) in predicting anastomosis occlusion after coronary artery bypass graft (CABG) surgery. The results showed that FFRCT≤0.80 was associated with a significant risk reduction of anastomosis occlusion after CABG. Preoperative assessment of hemodynamic significance may improve the CABG surgery strategy and reduce graft failure.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mehmet Eyuboglu, Canan Eyuboglu
Summary: Coronary artery ectasia (CAE) may be considered as a risk factor for myocardial infarction with nonobstructive coronary arteries (MINOCA) and may have a role in its pathogenesis.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ahmed Ibrahim Ahmed, Mahmoud Al Rifai, Fares Alahdab, Jean Michel Saad, Yushui Han, Moath Said Alfawara, Faisal Nabi, John J. Mahmarian, Mouaz H. Al-Mallah
Summary: This study aimed to assess the prognostic value of myocardial flow reserve (MFR) using the latest generation of digital PET scanners in patients with suspected or known CAD. The results showed that impaired MFR was significantly associated with adverse events, and it significantly improved the predictive ability over traditional risk factors.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeff Moore, Suvasini Lakshmanan, Venkat Sanjay Manubolu, April Kinninger, George Stojan, Daniel W. Goldman, Michelle Petri, Matthew Budoff, George A. Karpouzas
Summary: This study compared the baseline and progression of coronary plaques in patients with SLE and RA. The results showed that SLE patients had a greater increase in plaque volume, which may explain their higher cardiovascular risk.
CORONARY ARTERY DISEASE
(2023)
Review
Peripheral Vascular Disease
Samuel C. R. Sherratt, Peter Libby, Matthew J. Budoff, Deepak L. Bhatt, R. Preston Mason
Summary: This review examines the effects of omega-3 fatty acids (n3-FAs) on cardiovascular risk reduction. It has been found that high-purity EPA ethyl ester has significant benefits in reducing cardiovascular events and atherosclerosis progression compared to mixed EPA/DHA treatments. Mechanistic differences between n3-FAs, including membrane interactions, metabolic products, cholesterol efflux, antioxidant properties, and tissue distribution, have been explored.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Juhwan Lee, Kashif Shaikh, Rine Nakanishi, Heidi Gransar, Stephan Achenbach, Mouaz H. Al-Mallah, Daniele Andreini, Jeroen J. Bax, Daniel S. Berman, Filippo Cademartiri, Tracy Q. Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Ronen Rubinshtein, Todd C. Villines, Yao Lu, Jessica M. Pena, Fay Y. Lin, James K. Min, Leslee J. Shaw, Matthew J. Budoff
Summary: This study investigated the relationship between non-obstructive left main (LM) disease, diabetes mellitus (DM), and all-cause mortality (ACM). The results showed that while DM was associated with increased ACM, the presence of non-obstructive LM disease was not an independent risk factor for ACM.
HEART LUNG AND CIRCULATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, Inge J. van den Hoogen, Fay Y. Lin, Daniele Andreini, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araujo Goncalves, Ilan Gottlieb, Martin Hadamitzky, Jonathon A. Leipsic, Erica Maffei, Gianluca Pontone, Gilbert L. Raff, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang-Eun Lee, Renu Virmani, Habib Samady, Peter H. Stone, James K. Min, Jagat Narula, Leslee J. Shaw, Hyuk-Jae Chang, Alexander R. van Rosendael, Jeroen J. Bax
Summary: This study aimed to investigate factors associated with statin nonresponse-defined atherosclerosis progression in patients treated with statins. The results showed that age, diabetes, hypertension, and baseline plaque characteristics were significantly different between patients with and without statin nonresponse. Diabetes, number of high-risk plaque features, and plaque volume were independently associated with statin nonresponse.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Lohendran Baskaran, Jing Kai Lee, Michelle Shi Min Ko, Subhi J. Al'Aref, Yu Pei Neo, Jien Sze Ho, Weiting Huang, Yeonyee Elizabeth Yoon, Donghee Han, Rine Nakanishi, Swee Yaw Tan, Mouaz Al-Mallah, Matthew J. Budoff, Leslee J. Shaw
Summary: This study compared the abilities of pooled cohort equations (PCE) and coronary artery calcium (CAC) assessment in predicting major adverse cardiovascular events (MACE) in an Asian population. Age, presence of CAC, and ln(Volume) were significantly associated with MACE in the overall subgroup, while age and PCE score were significantly associated with MACE in the CAC = 0 subgroup. No risk factors were associated with MACE in the CAC > 0 subgroup. The performance of PCE deteriorated in statin versus non-statin users, while the Agatston score performed consistently in both groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Clinical Neurology
Meiyuzhen Qi, Imke Janssen, Emma Barinas-Mitchell, Matthew Budoff, Maria M. Brooks, Arun S. Karlamangla, Carol A. Derby, Chung-Chou H. Chang, Kelly J. Shields, Samar R. El Khoudary
Summary: This study found that the quantity and quality of thoracic perivascular adipose tissue (PVAT) in middle age are related to cognitive performance in later years. Higher thoracic PVAT volume is associated with better future episodic memory, while higher thoracic PVAT radiodensity is related to poorer future working and episodic memories, particularly at higher thoracic PVAT volume.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Ramzi Dudum, Zeina A. Dardari, David I. Feldman, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee Shaw, Omar Dzaye, Miguel Cainzos-Achirica, Jaideep Patel, Michael J. Blaha
Summary: Coronary artery calcium is useful for assessing subclinical atherosclerosis and improving risk stratification. The dispersion of calcified vessels and CAC phenotype have different impacts on cause-specific mortality. This study demonstrated that increasing calcium dispersion, characterized by multiple vessel involvement and less dense calcification, is associated with higher all-cause mortality and cardiovascular disease-specific mortality.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Chemistry, Analytical
Lisa Anita De Santi, Antonella Meloni, Maria Filomena Santarelli, Laura Pistoia, Anna Spasiano, Tommaso Casini, Maria Caterina Putti, Liana Cuccia, Filippo Cademartiri, Vincenzo Positano
Summary: This paper focuses on using the Visual Transformer (ViT) neural network architecture to automatically detect the left ventricle (LV) from cardiac magnetic resonance (CMR) relaxometry sequences. Performance evaluation showed variations in performance based on slice location, but overall performance was comparable to other state-of-the-art methods. The study confirms the feasibility of using ViT architectures for LV detection and establishes a benchmark for relaxometry imaging.
Review
Medicine, General & Internal
Antonella Meloni, Francesca Frijia, Daniele Panetta, Giulia Degiorgi, Carmelo De Gori, Erica Maffei, Alberto Clemente, Vincenzo Positano, Filippo Cademartiri
Summary: Photon-counting computed tomography (PCCT) is a new advanced imaging technique that offers improved spatial and contrast resolution, reduced image noise and artifacts, reduced radiation exposure, and multi-energy/multi-parametric imaging based on tissue properties. It has the potential to transform the standard clinical use of computed tomography (CT) imaging.
Article
Medicine, General & Internal
Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Paolo Ricchi, Calogera Gerardi, Gennaro Restaino, Riccardo Righi, Vincenzo Positano, Filippo Cademartiri
Summary: We evaluated the prognostic value of multiparametric cardiovascular magnetic resonance (CMR) in predicting death from heart failure in patients with thalassemia major (TM). Iron overload, ventricular dysfunction, ventricular dilation, and replacement myocardial fibrosis were identified as significant predictors of heart failure death. Patients with all four markers had a significantly higher risk of dying from heart failure compared to patients without markers or with one to three markers.
Editorial Material
Cardiac & Cardiovascular Systems
Jairo Aldana-Bitar, Ronald P. Karlsberg, Matthew J. Budoff
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Article
Computer Science, Interdisciplinary Applications
Simone Garzia, Martino Andrea Scarpolini, Marilena Mazzoli, Katia Capellini, Angelo Monteleone, Filippo Cademartiri, Vincenzo Positano, Simona Celi
Summary: This study proposes a pipeline for generating synthetic thoracic aorta phase contrast magnetic resonance angiography (PCMRA) to expand the limited dataset of patient-specific PCMRA MRA images, ultimately improving the accuracy of neural network segmentation. The results demonstrate that incorporating synthetic data into the training set significantly improves the segmentation performance compared to using only real data.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Alessandro Galgani, Giovanni Palermo, Francesco Lombardo, Nicola Martini, Luca Bastiani, Andrea Vergallo, Luca Tommasini, Gabriele Bellini, Filippo Baldacci, Daniela Frosini, Gloria Tognoni, Marco Gesi, Filippo Cademartiri, Francesco Fornai, Nicola Pavese, Roberto Ceravolo, Filippo Sean Giorgi
Summary: Magnetic Resonance Imaging successfully detects widespread Locus Coeruleus degeneration in patients suffering from Dementia with Lewy Bodies. Patients with Dementia with Lewy Bodies show global and bilateral involvement of the Locus Coeruleus, whereas alterations in Alzheimer's Dementia patients are more likely to be localized in the rostral part of the left nucleus.
CURRENT ALZHEIMER RESEARCH
(2023)