Article
Medicine, General & Internal
Alexander Martin Keppler, Moritz Kraus, Matthias Blaschke, Nicole Thomasser, Christian Kammerlander, Wolfgang Boecker, Carl Neuerburg, Ulla Cordula Stumpf
Summary: The study found that overall willingness of osteoporosis patients to undergo further diagnosis was low, with patients with distal radius fractures showing significantly lower awareness compared to proximal femur fracture patients. Younger patients tended to underestimate the risks of osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
S. Haleem, S. Yousaf, T. Hamid, S. Nagappa, M. J. Parker
Summary: This study reveals that lower limb amputees are at increased risk of developing fragility fractures of the neck of femur, with particular characteristics and outcomes yet to be studied in detail. By comparing them with standard hip fracture patients, it was found that preoperative optimisation, planning and postoperative rehabilitation can lead to comparable results in terms of mobility and residence. Amputees exhibit reduced bone density, increasing the risk for osteoporosis and fragility fractures in the hip.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Geriatrics & Gerontology
Annabel Fenwick, Michael Pfann, Jakob Mayr, Iana Antonovska, Franziska von der Helm, Stefan Nuber, Stefan Foerch, Edgar Mayr
Summary: This study investigated the impact of concomitant fractures on patients with a proximal femur fracture treated operatively. The results showed that concomitant fractures significantly increased the length of hospital stay, but did not increase the complication rate or in-house mortality.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Phillip W. Lam, David Putnam, Marissa M. Song Mayeda, Kenneth R. Gundle
Summary: This study aimed to investigate mortality rates and hospital stay duration in patients with pathologic proximal femur fractures treated with either intramedullary nailing or arthroplasty within the Veterans Health Administration system. Hospital stays were similar for both groups, and mortality was associated with increased age and comorbidity scores. Arthroplasty showed a survival benefit even when accounting for age and comorbidities in treating metastatic disease of the proximal femur.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Orthopedics
Jan Bartonicek, Stefan Rammelt, Ondrej Nanka
Summary: German-speaking surgeons have made significant contributions to the development of the treatment of proximal femur fractures. However, their historical contribution has been undervalued in English publications.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Endocrinology & Metabolism
Frida Igland Nissen, Camilla Andreasen, Tove Tveitan Borgen, Ashild Bjornerem, Ann Kristin Hansen
Summary: This study suggests that cortical bone measurements using clinical CT do not provide substantial added value in fracture risk assessment compared to FN aBMD and FRAX.
Article
Orthopedics
Yanhua Wang, Wei Chen, Lijia Zhang, Chen Xiong, Xiaomeng Zhang, Kai Yu, Jiabao Ju, Xiaofeng Chen, Dianying Zhang, Yingze Zhang
Summary: The study compared the biomechanical properties of PFBN, PFNA, and InterTan in the treatment of elderly intertrochanteric fractures. The results showed that PFBN had better mechanical properties compared to PFNA and InterTan.
ORTHOPAEDIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Aleksandar Cirovic, Ana Cirovic, Danica Djukic, Danijela Djonic, Vladimir Zivkovic, Slobodan Nikolic, Marija Djuric, Petar Milovanovic
Summary: In this study, inter-individual and intra-individual differences in femoral neck cortical microstructure were analyzed. High porosity and/or low thickness were found in specific subregions and segments of the femoral neck. These findings provide anatomical evidence for explaining fracture initiation at various sites of the superolateral neck.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Bjorn Hernefalk, Anders Bruggemann, Jabbar Mohammed, Sebastian Mukka, Olof Wolf
Summary: The study examined mortality rates in older patients with distal femoral fractures, finding a 90-day mortality rate of 11% and a 1-year mortality rate of 21%. Periprosthetic fractures were associated with lower mortality rates.
Article
Orthopedics
David A. Patch, Eli B. Levitt, Nicholas A. Andrews, Alex R. Heatherly, Henry Bonner, Jared R. Halstrom, Jared B. Watson, Clay A. Spitler
Summary: Ballistic femoral shaft fractures have higher complication rates, increased risk of thigh compartment syndrome, and require more soft tissue reconstruction compared to blunt closed fractures. Overall rates of nonunion and infection were similar between all groups, but the all-cause complication rate was significantly higher in the ballistic group compared with the blunt closed group.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Orthopedics
Marilena Giannoudi, Peter Giannoudis
Summary: With the increasing incidence of hip fractures in an ageing population, there is a clinical dilemma on how to manage patients taking blood-thinning agents. This article provides up-to-date evidence and recommendations based on existing literature.
EFORT OPEN REVIEWS
(2022)
Article
Orthopedics
Daniel A. Portney, Manoj Reddy, Hayden P. Baker, Daryl B. Dillman, Douglas R. Dirschl, Jason A. Strelzow
Summary: The rate of intra-articular extension is higher in blunt distal femur fractures compared to ballistic fractures. Preoperative radiographs are slightly less sensitive in detecting intra-articular extension in blunt fractures than in ballistic fractures. Additionally, CT imaging led to changes in operative plans for some blunt fractures but not for ballistic fractures.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Medicine, General & Internal
Johannes Gleich, Carl Neuerburg, Christoph Linhart, Alexander Martin Keppler, Daniel Pfeufer, Christian Kammerlander, Wolfgang Boecker, Christian Ehrnthaller
Summary: The study found that outcomes for patients with unstable trochanteric fractures were significantly worse compared to those with stable fractures, likely due to increased surgical trauma and the mechanical impact of the lesser trochanter.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Omer Nasim, Suraj Kohli, Boulos Eskander, Sameh Girgis, Michael Kent
Summary: This retrospective study aimed to evaluate the peri-prosthetic fracture rate and failure rates in elderly patients with neck of femur fractures treated with either a short or long proximal femoral nail (PFN). The study found that in a predominantly female and over 75-year-old patient population, the risk of peri-prosthetic fracture and failure rate was similar regardless of the use of a short or long PFN for intertrochanteric fractures.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Omer Marom, Inbar Paz, David Segal, Guy Topaz, Nitzan Abelson, Alex Tavdi, Refael Behrbalk, Ezequiel Palmanovich, Nissim Ohana, Eyal Yaacobi
Summary: This study investigated the use of neutrophil-to-lymphocyte ratio (NLR) as a predictor of postoperative mortality in elderly patients with proximal femur fractures (PFF). The results showed that higher NLR0 levels were associated with higher all-cause mortality rates in patients who underwent surgical treatment for PFF. Therefore, NLR0 might be a valuable, inexpensive, and reliable prognostic biomarker for risk stratification in elderly patients undergoing PFF surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, William H. Moore, Thomas O'Donnell, Mylene T. Truong, James Babb, Bowen Niu, Andreas Wimmer, Saman Kiumehr, Jane P. Ko
Summary: This study evaluated the inter-observer consistency of radiomic features for subsolid pulmonary nodules. The results showed that some features had high consistency among observers, and nodule morphology influenced both feature consistency and segmentation accuracy.
ACADEMIC RADIOLOGY
(2022)
Article
Engineering, Biomedical
Priya Katyal, Aubryanna Hettinghouse, Michael Meleties, Sadaf Hasan, Changhong Chen, Min Cui, Guodong Sun, Rajiv Menon, Bonnie Lin, Ravinder Regatte, Jin Kim Montclare, Chuan-Ju Liu
Summary: Protein-based biomaterials, such as the E5C gel developed in this study, offer advantages in terms of stimuliresponsive properties, biocompatibility, and modularity. By combining E5C with Atsttrin, the gel can protect against the onset and progression of post-traumatic osteoarthritis. The study provides evidence of the potential therapeutic application of the E5C gel.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcelo V. W. Zibetti, Azadeh Sharafi, Ravinder R. Regatte
Summary: By comparing optimization criteria, it was found that the modified CRLB and MSF based on MNAE are robust optimization approaches for choosing TSLs in T-1 rho mapping, performing well in different test cases.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Biophysics
Azadeh Sharafi, Marcelo V. W. Zibetti, Gregory Chang, Martijn A. Cloos, Ravinder R. Regatte
Summary: This prospective study demonstrated the feasibility of magnetic resonance fingerprinting for bilateral simultaneous T-1, T-2, and T-1 rho mapping of the hip joint. The results showed differences in relaxation times between different subregions in the left and right hip, with excellent repeatability in the experiments.
NMR IN BIOMEDICINE
(2022)
Article
Biophysics
Azadeh Sharafi, Marcelo V. W. Zibetti, Gregory Chang, Martijn Cloos, Ravinder R. Regatte
Summary: This article introduces a fast, reproducible, and robust three-dimensional magnetic resonance fingerprinting technique that can simultaneously measure parameters such as T-1, T-2, and T-1 rho in knee articular cartilage. It is highly valuable for detecting early biochemical changes in cartilage.
NMR IN BIOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Richard Kijowski, Azadeh Sharafi, Marcelo V. W. Zibetti, Gregory Chang, Martijn A. Cloos, Ravinder R. Regatte
Summary: This study investigated age-dependent changes in knee cartilage among healthy volunteers using a 3D-MRF sequence. The results showed that there were increased T-1, T-2, and T-1ρ relaxation times in both global and regional cartilage with higher age groups, primarily within the medial compartment.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rajiv G. Menon, Marcelo V. W. Zibetti, Ravinder R. Regatte
Summary: The purpose of this study was to apply a fast data-driven optimization algorithm for MR brain T-1 rho mapping to generate optimized sampling patterns for compressed sensing reconstruction. The study compared different sampling patterns and found that the use of optimized sampling patterns and suitable compressed sensing techniques can potentially accelerate 3D T-1 rho mapping for brain imaging applications.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Orthopedics
J. Hirvasniemi, J. Runhaar, R. A. van der Heijden, M. Zokaeinikoo, M. Yang, X. Li, J. Tan, H. R. Rajamohan, Y. Zhou, C. M. Deniz, F. Caliva, C. Iriondo, J. J. Lee, F. Liu, A. M. Martinez, N. Namiri, V Pedoia, E. Panfilov, N. Bayramoglu, H. H. Nguyen, M. T. Nieminen, S. Saarakkala, A. Tiulpin, E. Lin, A. Li, V Li, E. B. Dam, A. S. Chaudhari, R. Kijowski, S. Bierma-Zeinstra, E. H. G. Oei, S. Klein
Summary: The KNOAP2020 challenge aimed to compare methods for predicting incident symptomatic radiographic knee osteoarthritis. Participants were allowed to use any available data sources to train their models. The results showed that the model using deep learning to extract X-ray image information and clinical variables performed the best.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Multidisciplinary Sciences
Hector L. de Moura, Rajiv G. Menon, Marcelo V. W. Zibetti, Ravinder R. Regatte
Summary: This study compares two optimization criteria based on Cramer-Rao Bounds and non-optimized schedules for T-1 rho mapping. The optimized spin-lock time (TSL) schedules provided improved results and reduced acquisition times in synthetic data, model phantoms, and in-vivo knee cartilage.
SCIENTIFIC REPORTS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Marcelo V. W. Zibetti, Rajiv G. G. Menon, Hector L. L. de Moura, Xiaoxia Zhang, Richard Kijowski, Ravinder R. R. Regatte
Summary: Osteoarthritis (OA) is a degenerative joint disease that causes significant burdens to society. Compositional MRI is a quantitative imaging technique that can provide valuable information about cartilage changes in early OA, serving as early imaging biomarkers for objective evaluation. This review summarizes current and emerging techniques for cartilage compositional MRI, including MR fingerprinting, compressed sensing, multiexponential relaxometry, improved pulse sequences, and deep learning-based methods.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biotechnology & Applied Microbiology
Aniket A. Tolpadi, Upasana Bharadwaj, Kenneth T. Gao, Rupsa Bhattacharjee, Felix G. Gassert, Johanna Luitjens, Paula Giesler, Jan Nikolas Morshuis, Paul Fischer, Matthias Hein, Christian F. Baumgartner, Artem Razumov, Dmitry Dylov, Quintin van Lohuizen, Stefan J. Fransen, Xiaoxia Zhang, Radhika Tibrewala, Hector Lise de Moura, Kangning Liu, Marcelo V. W. Zibetti, Ravinder Regatte, Sharmila Majumdar, Valentina Pedoia
Summary: Magnetic Resonance Imaging (MRI) faces challenges such as long acquisition times and manual annotation. To address these challenges, the K2S challenge was organized to explore the potential of end-to-end approaches. The challenge involved segmenting knee bones and cartilage from undersampled k-space, and showcased strong submissions with high similarity coefficients and preserved features for downstream biomarker analysis.
BIOENGINEERING-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Dilbag Singh, Anmol Monga, Hector L. de Moura, Xiaoxia Zhang, Marcelo V. W. Zibetti, Ravinder R. Regatte
Summary: Magnetic Resonance Imaging (MRI) is an essential medical imaging modality that can provide detailed information on the human body. By integrating deep learning models with undersampled MRI acquisition methods, the speed and quality of MRI reconstruction can be significantly improved. This systematic literature review comprehensively analyzes and discusses the development and application of deep MRI reconstruction models, providing valuable insights for future research and development.
BIOENGINEERING-BASEL
(2023)
Article
Engineering, Electrical & Electronic
Marcelo Victor Wust Zibetti, Florian Knoll, Ravinder R. Regatte
Summary: This study proposes an alternating learning approach to learn the sampling pattern (SP) and the parameters of variational networks (VN) in accelerated parallel magnetic resonance imaging (MRI). The results show that this approach improves the imaging quality by improving the SP and the parameters of the VN, achieving better performance compared to other methods.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2022)
Meeting Abstract
Orthopedics
E. B. Dam, A. Desai, C. Deniz, H. Rajamohan, R. Regatte, C. Iriondo, V. Pedoia, S. Majumdar, M. Perslev, C. Igel, A. Pai, S. Gaj, M. Yang, K. Nakamura, X. Li, H. Maqbool, I. Irmakci, S-E. Song, U. Bagci, B. Hargreaves, G. Gold, A. Chaudhari
OSTEOARTHRITIS AND CARTILAGE
(2022)
Meeting Abstract
Orthopedics
C. Deniz, N. Segal, V. Sodha, J. Lynch, M. Nevitt, D. Felson, R. Kijowski
OSTEOARTHRITIS AND CARTILAGE
(2022)