Journal
RADIOLOGY
Volume 267, Issue 2, Pages 328-338Publisher
RADIOLOGICAL SOC NORTH AMERICA
DOI: 10.1148/radiol.12120725
Keywords
-
Funding
- Ministry of Health and Welfare, Republic of Korea
- GE Healthcare Medical Diagnostics
- National Research Foundation of Korea
- Ministry of Health and Welfare
- Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea [A102065]
Ask authors/readers for more resources
Demonstrating similarity between compared groups-that is, equivalence or noninferiority of the outcome of one group to the outcome of another group-requires a different analytic approach than determining the difference between groups-that is, superiority of one group over another. Neither a statistically significant difference between groups (P < .05) nor a lack of significant difference (P >= .05) from conventional statistical tests provides answers about equivalence/noninferiority. Statistical testing of equivalence/noninferiority generally uses a confidence interval, where equivalence/noninferiority is claimed when the confidence interval of the difference in outcome between compared groups is within a predetermined equivalence/noninferiority margin that represents a clinically or scientifically acceptable range of differences and is typically described by Delta. The equivalence/noninferiority margin should be justified both clinically and statistically, considering the loss in the main outcome and the compensatory gain, and be chosen conservatively to avoid making a false claim of equivalence/noninferiority for an inferior outcome. Sample size estimation needs to be specified for equivalence/noninferiority design, considering Delta in addition to other general factors. The need for equivalence/ noninferiority research studies is expected to increase in radiology, and a good understanding of the fundamental principles of the methodology will be helpful for conducting as well as for interpreting such studies. (C) RSNA, 2013
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available