Article
Medicine, Research & Experimental
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Roberta Modica, Daniela Laudisio, Sara Aprano, Antongiulio Faggiano, Annamaria Colao, Silvia Savastano
Summary: Patients with GEP-NET tend to have lower chronotype scores and more commonly display evening chronotypes compared to healthy subjects. Morning chronotype patients show better anthropometric measurements and MetS percentages. Patients with metastasis, G2 grading, and progressive disease tend to have lower chronotype scores.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Marco De Martino, Simona Pellecchia, Francesco Esposito, Nadia Tosti, Cristina Quintavalle, Serenella Eppenberger-Castori, Vincenza Carafa, Alberto Righi, Paolo Chieffi, Alfredo Fusco, Luigi Maria Terracciano, Pierlorenzo Pallante
Summary: This study evaluated the expression of HMGA1 in neuroendocrine tumors and its role in tumor development. The results showed that HMGA1 is overexpressed in tumor samples and that its silencing interferes with the proliferation and migration abilities of tumor cells.
Review
Medicine, General & Internal
Daniel Vogele, Stefan A. Schmidt, Daniel Gnutzmann, Wolfgang M. Thaiss, Thomas J. Ettrich, Marko Kornmann, Meinrad Beer, Markus S. Juchems
Summary: Gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) is a heterogeneous and complex group of tumors that are often difficult to classify due to their heterogeneity and varying locations. Standard radiological methods, including ultrasound, CT, MRI, and PET/CT, are available for localization and staging of NEN. Nuclear medical imaging methods with somatostatin analogs are superior in detection, especially in gastrointestinal NEN, while CT and MRI have high detection rates and have been further improved by developments such as diffusion-weighted imaging. PET/CT with somatostatin analogs should be used as the subsequent method.
Review
Oncology
Kristen McClellan, Emerson Y. Chen, Adel Kardosh, Charles D. Lopez, Jaydira Del Rivero, Nadine Mallak, Flavio G. Rocha, Yilun Koethe, Rodney Pommier, Erik Mittra, Guillaume J. Pegna
Summary: This review summarizes the current treatments for neuroendocrine tumors and explores the cellular changes involved in treatment resistance. It provides an up-to-date summary of clinical findings regarding therapy-resistant neuroendocrine tumors and discusses potential strategies to overcome resistance.
Review
Oncology
Eduardo de Souza M. Fernandes, Camila V. Garcia Kyt, Felipe Pedreira Tavares de Mello, Leandro Savattone Pimentel, Ronaldo de Oliveira Andrade, Camila Girao, Camilla Cesar, Munique Siqueira, Maria Eduarda Monachesi, Anderson Brito, Claudia Cristina Tavares de Sousa, Wellington Andraus, Orlando Jorge M. Torres
Summary: Neuroendocrine tumors are a diverse group of tumors found in various organs such as the gastrointestinal tract, lungs, thymus, thyroid, and adrenal glands. These tumors, particularly in the small intestine, appendix, and pancreas, often have metastases upon diagnosis. Classification of neuroendocrine tumors is based on cell differentiation and proliferation index. Treatment options for metastatic neuroendocrine tumors include surgery, peptide receptor radionuclide therapy, percutaneous therapy, chemotherapy, and radiotherapy. Liver surgery, specifically orthotopic liver transplantation, has shown promising results in selected cases. The aim of this study is to review the literature on orthotopic liver transplantation as a curative treatment for gastroenteropancreatic neuroendocrine tumors with liver metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Judy S. Crabtree
Summary: Gastroenteropancreatic neuroendocrine neoplasms are rare and diverse tumors associated with genetic disorders and epigenetic regulation. Epigenetic signatures can be used as biomarkers for diagnosis and as targets for the development of new treatment approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Chanjuan Shi, Michael A. Morse
Summary: This article summarizes the treatment methods for advanced neuroendocrine tumors in the intestinal tract and pancreas, as well as the limitations in therapeutic resistance. Although the mechanisms of resistance are poorly understood, early studies suggest that combination therapy or the use of novel targeted drugs may be promising.
Article
Oncology
Jaydira Del Rivero, Kimberly Perez, Erin B. Kennedy, Erik S. Mittra, Namrata Vijayvergia, Junaid Arshad, Sandip Basu, Aman Chauhan, Arvind N. Dasari, Andrew M. Bellizzi, Alexandra Gangi, Erin Grady, James R. Howe, Jana Ivanidze, Mark Lewis, Josh Mailman, Nitya Raj, Heloisa P. Soares, Michael C. Soulen, Sarah B. White, Jennifer A. Chan, Pamela L. Kunz, Simron Singh, Thorvardur R. Halfdanarson, Jonathan R. Strosberg, Emily K. Bergsland
Summary: This article aims to provide systemic therapy recommendations for patients with well-differentiated grade 1 to grade 3 metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Through a systematic review and analysis of relevant studies, the recommendations for first-line and second-line therapies for different stages and types of GEP-NETs are provided, along with qualifying statements for treatment choice. The importance of multidisciplinary team management and shared decision-making with patients is emphasized.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Valentina Andreasi, Stefano Partelli, Francesca Muffatti, Marco F. Manzoni, Gabriele Capurso, Massimo Falconi
Summary: The incidence of GEP-NENs has increased over the past three decades, leading to a variety of treatment options including conservative management, surgical resection, and medical therapies based on disease characteristics.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Medicine, Research & Experimental
Federica Campolo, Franz Sesti, Tiziana Feola, Giulia Puliani, Antongiulio Faggiano, Maria Grazia Tarsitano, Marta Tenuta, Valeria Hasenmajer, Elisabetta Ferretti, Monica Verrico, Daniele Gianfrilli, Mary Anna Venneri, Andrea M. M. Isidori, Elisa Giannetta
Summary: This proof-of-concept study demonstrates that circRNA signatures from tumor-educated platelets may serve as liquid biopsy biomarkers for the detection of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and the prediction of early treatment response.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Hui-Jen Tsai, Chin-Fu Hsiao, Jeffrey S. Chang, Li-Tzong Chen, Ying-Jui Chao, Chia-Ju Yen, Yan-Shen Shan
Summary: The study revealed an association between CgA levels and tumor burden, overall survival, and tumor progression in GEP-NET patients. Higher baseline CgA levels were linked to worse overall survival, and the rate of change in CgA levels could predict tumor progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Samantha E. Hoffman, Todd W. Dowrey, Carlos Villacorta Martin, Kevin Bi, Breanna Titchen, Shreya Johri, Laura Dellostritto, Miraj Patel, Colin Mackichan, Stephanie Inga, Judy Chen, Grace Grimaldi, Sara Napolitano, Isaac Wakiro, Jingyi Wu, Jason Yeung, Asaf Rotem, Ewa Sicinska, Erin Shannon, Thomas Clancy, Jiping Wang, Sarah Denning, Lauren Brais, Naomi R. Besson, Kathleen L. Pfaff, Ying Huang, Katrina Z. Kao, Scott Rodig, Jason L. Hornick, Sebastien Vigneau, Jihye Park, Matthew H. Kulke, Jennifer Chan, Eliezer M. Van Allen, George J. Murphy
Summary: This study investigated the single-cell transcriptomes of patients with gastroenteropancreatic NETs and found the transcriptomic heterogeneity of neuroendocrine tumor cells and the influence of tumor microenvironment on tumor pathophysiology, revealing potential avenues for future precision medicine therapeutics.
Article
Endocrinology & Metabolism
Chiara Liverani, Chiara Spadazzi, Toni Ibrahim, Federica Pieri, Flavia Foca, Chiara Calabrese, Alessandro De Vita, Giacomo Miserocchi, Claudia Cocchi, Silvia Vanni, Giorgio Ercolani, Davide Cavaliere, Nicoletta Ranallo, Elisa Chiadini, Giovanna Prisinzano, Stefano Severi, Maddalena Sansovini, Giovanni Martinelli, Alberto Bongiovanni, Laura Mercatali
Summary: Neuroendocrine neoplasms (NENs) are a rare group of tumors with a wide range of clinical presentations. Lenvatinib, a multi-tyrosine kinase inhibitor, has been shown to be effective in treating gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The overexpression of HRAS in tumor tissue may be a potential biomarker for lenvatinib response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Gastroenterology & Hepatology
Anupama Ramachandran, Kumble Seetharama Madhusudhan
Summary: This article reviews the various imaging modalities used in the evaluation of neuroendocrine neoplasms, discusses the role of advanced imaging techniques, and provides a glimpse into the newer imaging horizons, primarily in the research stage.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Daisuke Takayanagi, Hourin Cho, Erika Machida, Atsushi Kawamura, Atsuo Takashima, Satoshi Wada, Takuya Tsunoda, Takashi Kohno, Kouya Shiraishi
Summary: This review provides updates on the epidemiology, diagnosis, and management of gastroenteropancreatic neuroendocrine neoplasms. The incidence of these malignancies originating from the pancreatic and gastrointestinal neuroendocrine cell system has been increasing. Advances in molecular diagnosis, treatment strategies, and liquid biopsy have contributed to personalized management for patients.
Article
Pediatrics
Ludovico Dulcetta, Paolo Marra, Francesco Saverio Carbone, Pietro Andrea Bonaffini, Claudio Sallemi, Naire Sansotta, Michele Colledan, Lorenzo D'Antiga, Sandro Sironi
Summary: This study retrospectively analyzed the prevalence of biliary complications after pediatric liver transplantation and the efficacy of percutaneous transhepatic cholangiography in their management. The results showed a high incidence of biliary complications, and percutaneous transhepatic cholangiography played an important role in diagnosis and treatment.
PEDIATRIC RADIOLOGY
(2022)
Article
Medicine, General & Internal
Roberto Simonini, Pietro Andrea Bonaffini, Marco Porta, Cesare Maino, Francesco Saverio Carbone, Ludovico Dulcetta, Paolo Brambilla, Paolo Marra, Sandro Sironi
Summary: IFIR-MRA demonstrated higher image quality compared to standard MRA in the assessment of upper abdominal arteries, particularly for visualizing LHA and RHA branches.
Article
Medicine, General & Internal
Elona Collaku, Roberto Simonini, Maurizio Balbi, Pietro Andrea Bonaffini, Clarissa Valle, Cesare Morzenti, Romina Fatima Faseli, Alberto Ferrari, Davide Ippolito, Paolo Marra, Tiziano Barbui, Sandro Sironi
Summary: This study compares the efficacy of superb microvascular imaging (SMI) and conventional Doppler imaging (CDI) in evaluating hepatic artery (HA) in pediatric liver transplant recipients. The results showed that SMI had higher overall scores compared to CDI, suggesting that SMI could serve as a non-invasive complementary tool to CDI.
Article
Medicine, General & Internal
Paolo Niccolo Franco, Simona Annibali, Sara Vigano, Caterina Cazzella, Chiara Marra, Antonella Smedile, Pietro Andrea Bonaffini, Paolo Marra, Maria Milagros Otero Garcia, Caroline Reinhold, Sandro Sironi
Summary: Magnetic resonance imaging (MRI) is effective for diagnosing and staging deep infiltrative endometriosis (DIE). The diagnostic performance of MRI sequences susceptible to chronic blood degradation products, such as T2*-weighted imaging, is still uncertain. This study evaluated the usefulness of these sequences in addition to the conventional protocol for DIE assessment. The results showed that T2*-weighted sequences do not provide significant added value in the evaluation of DIE, especially for less experienced readers. Additionally, artifacts caused by undesirable sources of magnetic inhomogeneity may lead to overdiagnosis.
Article
Medicine, General & Internal
Federico Raimondi, Sara Cazzaniga, Simona Annibali, Luca Novelli, Matteo Brivio, Simone Pappacena, Luca Malandrino, Pietro Andrea Bonaffini, Ilaria Bianco, Noemi Liggeri, Paolo Gritti, Ferdinando Luca Lorini, Sandro Sironi, Fabiano Di Marco
Summary: This study investigated whether baseline CT scans could predict oxygenation improvement during prone positioning in COVID-19 related ARDS patients. The results showed that baseline CT scans could not predict the gas-exchange response in awake prone-positioned patients. Physicians should not solely rely on imaging at presentation when evaluating whether to pronate patients.
Article
Medicine, General & Internal
Alberto Stefano Tagliafico, Clarissa Valle, Pietro Andrea Bonaffini, Ali Attieh, Matteo Bauckneht, Liliana Belgioia, Bianca Bignotti, Nicole Brunetti, Alessandro Bonsignore, Enrico Capaccio, Sara De Giorgis, Alessandro Garlaschi, Silvia Morbelli, Federica Rossi, Lorenzo Torri, Simone Caprioli, Simona Tosto, Michele Cea, Alida Dominietto
Summary: This study assessed the reliability of the myeloma spine and bone damage score (MSBDS) among readers with different levels of expertise and from different institutions. The results showed substantial agreement among the readers, confirming the potential of MSBDS for large-scale applications.
Article
Medicine, General & Internal
Andrea Corsi, Elisabetta De Bernardi, Pietro Andrea Bonaffini, Paolo Niccolo Franco, Dario Nicoletta, Roberto Simonini, Davide Ippolito, Giovanna Perugini, Mariaelena Occhipinti, Luigi Filippo Da Pozzo, Marco Roscigno, Sandro Sironi
Summary: The clinical management of PI-RADS 3 prostate lesions is still debated, and the application of radiomics to multiparametric MR shows promise. External validation is needed to assess reproducibility. This study proposes a new model combining PSA density and radiomic features from routinely performed sequences to differentiate clinically significant cancers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Pooya Torkian, Javid Azadbakht, Pietro Andrea Bonaffini, Behrang Amini, Majid Chalian
Summary: This paper explores the benefits and challenges of novel and more functional imaging techniques used for the management of patients with plasma cell dyscrasias, particularly multiple myeloma (MM).
Review
Gastroenterology & Hepatology
Davide Ippolito, Cesare Maino, Federica Vernuccio, Roberto Cannella, Riccardo Inchingolo, Michele Dezio, Riccardo Faletti, Pietro Andrea Bonaffini, Marco Gatti, Sandro Sironi
Summary: During the COVID-19 pandemic, it was initially believed to primarily affect the lungs. However, it has been observed that the virus can also cause liver damage. This damage can be a result of direct viral damage, thrombosis, or drug-induced injury. Ultrasonography is commonly used for evaluating liver involvement, but CT and MRI offer higher sensitivity and specificity for assessing both the liver tissue and blood vessels. This review aims to discuss the spectrum of liver involvement in COVID-19 and the typical imaging features of liver damage.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Medicine, General & Internal
Paolo Marra, Barbaro Di Fazio, Ludovico Dulcetta, Francesco Saverio Carbone, Riccardo Muglia, Pietro Andrea Bonaffini, Clarissa Valle, Fabio Corvino, Francesco Giurazza, Giuseppe Muscogiuri, Massimo Venturini, Sandro Sironi
Summary: Embolization in pediatric patients covers a wide range of indications, from congenital diseases to acute hemorrhagic conditions. The endovascular treatment of vascular malformations and tumors has become more popular than surgery, thanks to new devices and materials. This review will discuss main embolization procedures, clinical indications, and the latest minimally invasive techniques.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Pietro Andrea Bonaffini, Elisabetta De Bernardi, Andrea Corsi, Paolo Niccolo Franco, Dario Nicoletta, Riccardo Muglia, Giovanna Perugini, Marco Roscigno, Mariaelena Occhipinti, Luigi Filippo Da Pozzo, Sandro Sironi
Summary: Radiomic MRI feature analysis has the potential to improve the accuracy of mpMRI in discriminating between clinically significant cancers in PI-RADS 4 and 5 lesions.
Review
Medicine, General & Internal
Ehsan Alipour, Atefe Pooyan, Firoozeh Shomal Zadeh, Azad Duke Darbandi, Pietro Andrea Bonaffini, Majid Chalian
Summary: This study reviews current research on the use of artificial intelligence (AI) in multiple myeloma (MM) imaging. The most popular studies focused on radiomics analysis and segmentation tasks, with goals including differentiating MM bone lesions from other lesions and predicting relapse.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Corsi, Anna Caroli, Pietro Andrea Bonaffini, Caterina Conti, Alberto Arrigoni, Elisa Mercanzin, Gianluca Imeri, Marisa Anelli, Maurizio Balbi, Marina Pace, Adriana Zanoletti, Milena Capelli, Fabiano Di Marco, Sandro Sironi
Summary: PFT is normal in most COVID-19 survivors 12 months post-discharge, but CT structural abnormalities persist (although sensibly improved over time) and are associated with higher D-dimer values.
Article
Cardiac & Cardiovascular Systems
Paolo Marra, Francesco Saverio Carbone, Luigi Augello, Ludovico Dulcetta, Riccardo Muglia, Pietro Andrea Bonaffini, Angelo Della Corte, Stephanie Steidler, Simone Gusmini, Giorgia Guazzarotti, Diego Palumbo, Massimo Venturini, Francesco De Cobelli, Sandro Sironi
Summary: This study compares the safety and efficacy of different techniques of hemostasis of the parenchymal tract. The results show that embolisation of the parenchymal tract after percutaneous portal vein catheterization is technically safe and effective, with no significant differences in effectiveness and complications rate between coils, glue, and gelfoam.
Article
Medicine, Research & Experimental
Pietro Andrea Bonaffini, Paolo Niccolo Franco, Alice Bonanomi, Cinzia Giaccherini, Clarissa Valle, Paolo Marra, Lorenzo Norsa, Marina Marchetti, Anna Falanga, Sandro Sironi
Summary: The study retrospectively analyzed the abdominal CT results of 30 COVID-19 patients and found that some patients developed ischemic and hemorrhagic abdominal complications. These complications are related to lung involvement, laboratory tests, comorbidities, and anticoagulant treatment, suggesting a correlation between the severity of lung disease and abdominal complications.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)