Article
Multidisciplinary Sciences
Ping Li, Lin Jin, Lan Feng, Yingchun Wang, Rong Yang
Summary: The study demonstrated that ICAM-1-targeted nano ultrasonic contrast could be used to assess the degree of inflammatory injury at different stages of the abdominal aorta in rabbits with atherosclerosis. This novel imaging method shows potential for clinical applications.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Cayla A. Wood, Sangheon Han, Chang Soo Kim, Yunfei Wen, Diego R. T. Sampaio, Justin T. Harris, Kimberly A. Homan, Jody L. Swain, Stanislav Y. Emelianov, Anil K. Sood, Jason R. Cook, Konstantin Sokolov, Richard R. Bouchard
Summary: Photoacoustic imaging is enhanced by the development of a contrast agent based on targeted liposomes loaded with J-aggregated indocyanine green dye, which provides improved contrast-agent quantification/sensitivity and SO2 estimation accuracy compared to monomeric ICG, making it a promising agent for future clinical molecular PA imaging.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Zaizhu Zhang, Nina Zhou, Xiaoyi Guo, Nan Li, Hua Zhu, Zhi Yang
Summary: This study found that whole-body FDG PET/CT plus delayed abdomen PET/MR imaging showed similar diagnostic performance to contrast-enhanced CT/MR imaging in assessing the resectability and staging of pancreatic cancer, and it provided additional value in terms of metastatic information.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Aino Rajamaki, Hanne Kuitunen, Marc Sorigue, Salla-Maarit Kokkonen, Outi Kuittinen, Kaisa Sunela
Summary: The clinical impact of FDG-PET/CT followed by a new biopsy based on maximum standardized uptake value was evaluated for detecting clinically unsuspected HT of FL. The study results suggest that rebiopsy based on high SUVmax is valuable in detecting clinically unsuspected FL HT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yaping Luo, Qingqing Pan, Huaxia Yang, Linyi Peng, Wen Zhang, Fang Li
Summary: Ga-68-FAPI shows promising potential as an imaging agent for assessing IgG4-RD, with higher detection rates in involved organs compared to F-18-FDG PET/CT, especially in the pancreas, bile duct/liver, and lacrimal gland. This suggests its potential utility in improving the evaluation of IgG4-related disease.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Julie E. Walcutt, Craig M. Johnson, Quan P. Ly, Ryan T. Downey
Summary: This case report describes an 89-year-old male patient with a history of malignant giant cell tumor of soft parts, who had recurrent/metastatic tumors in the right pelvis and pulmonary nodules suggestive of metastatic disease. Unexpectedly, a PET/CT scan revealed a right lower quadrant intussusception with a hypermetabolic mass as the lead point. Pathology of the resected mass confirmed it to be a metastasis from the patient's malignant giant cell tumor of soft parts.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sameer Taywade, Tanisha Gupta, Rajesh Kumar, Rahul Choudhary, Deepak Kumar
Summary: Nuclear imaging plays a crucial role in evaluating cardiac diseases of infective, inflammatory, innervation, and infiltrative origins. We report a case of persistent pyrexia after percutaneous transluminal coronary angioplasty in a patient with a history of inferior wall myocardial infarction. Molecular imaging techniques, such as F-18-FDG PET/CT and Tc-99m-MIBI myocardial perfusion study, helped in narrowing the differentials and eventually diagnosing the patient with Dressler syndrome.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qingqing Pan, Xinxin Cao, Yaping Luo, Jian Li, Fang Li
Summary: Ga-68-pentixafor PET/CT outperforms F-18-FDG PET/CT in response assessment of WM/LPL, showing different tumor responses and detecting disease progression more effectively.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Fei Wang, Rui Guo, Yan Zhang, Boqi Yu, Xiangxi Meng, Hanjing Kong, Yang Yang, Zhi Yang, Nan Li
Summary: This study investigated the value of F-18-FDG PET/MRI in the preoperative assessment of ESCC and compared it with other imaging methods. The results showed that F-18-FDG PET/MRI had higher accuracy and area under the curve in diagnosing primary tumors and regional lymph node metastases. Therefore, F-18-FDG PET/MRI may be a potential supplement or alternative imaging method for preoperative staging of ESCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Fanglan Li, Liu Xiao, Huawei Cai, Lin Li
Summary: In this report, we present the FDG PET/CT findings of a colonic Castleman disease in a 72-year-old man. The imaging showed a colonic soft tissue mass with intense FDG uptake. The final pathology confirmed the diagnosis of Castleman disease, plasma cell variant. This case highlights the importance of considering Castleman disease as a differential diagnosis for hypermetabolic colon masses on PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Esra Arslan, Aytul Hande Yardimci, Enver Yarikkaya, Goksel Alcin, Tevfik Fikret Cermik
Summary: Hyalinizing cholecystitis is a rare subtype of chronic cholecystitis characterized by moderate inflammatory cell infiltration in the gallbladder wall. When observing gallbladder wall thickening with intense F-18-FDG uptake, hyalinizing cholecystitis should be considered in the differential diagnosis.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sherif Elsobky, Vruti Dattani, Thomas Wagner, Sri Mandumula, Aniket Tavare
Summary: A 68-year-old woman presented with abdominal pain and elevated C-reactive protein underwent CT, which revealed a neoplastic soft tissue mass anterior to the aorta. Subsequent F-18-FDG PET/CT showed hypermetabolic activity in the mass and other areas, leading to the diagnosis of IgG4-related disease after a CT-guided biopsy of the sacroiliac joint.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Nuh Filizoglu, Kevser Oksuzoglu, Salih Ozguven, Tunc Ones, Tanju Yusuf Erdil
Summary: Schwannomas are benign tumors that arise from Schwann cells of neural sheath and can occur in any part of the body, with the most common locations being the head, neck, spinal cord, and extremities. However, Schwannoma in the porta hepatis is extremely rare. This case describes a 36-year-old woman presenting with abdominal pain due to porta hepatic schwannoma.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yong Liu, Guansheng Tong, Zhe Wen
Summary: Xanthogranulomatous pyelonephritis is a rare disease that can be misdiagnosed as malignancy, and FDG PET/CT imaging is helpful for diagnosis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Mathematical & Computational Biology
Shengchun Kong, Dominik Heinzmann, Sabine Lauer, Lu Tian
Summary: This research introduces a novel weighted principal stratum approach called weighted imputation regression (WRI) to address missing status information in the experimental treatment arm. The method is theoretically justified for different types of outcomes and demonstrated to yield valid inference in simulations and a clinical study.
STATISTICS IN BIOPHARMACEUTICAL RESEARCH
(2023)
Article
Biology
Xuan Wang, Layla Parast, Larry Han, Lu Tian, Tianxi Cai
Summary: Identifying effective surrogate markers is crucial for improving clinical trial efficiency. Replacing long-term outcomes with shorter-term and/or cheaper surrogate markers can shorten study duration and reduce costs. However, methods for combining multiple markers to construct a composite marker with improved surrogacy are limited.
Article
Surgery
Madeline D. Cetlin, Tamar Polonsky, Karen Ho, Dongxue Zhang, Lu Tian, Lihui Zhao, Philip Greenland, Diane Treat-Jacobson, Melina R. Kibbe, Michael H. Criqui, Jack M. Guralnik, Mary M. McDermott
Summary: This study identified barriers to participation in supervised exercise therapy covered by CMS for lower extremity PAD. The majority of participants had never been prescribed or recommended supervised exercise therapy by their physicians, and most were unwilling or unable to pay the required copay for CMS-covered sessions. Many individuals also cited travel to medical centers as a significant obstacle to participation. These findings highlight the significant barriers faced by PAD patients in accessing and participating in supervised exercise therapy.
JOURNAL OF VASCULAR SURGERY
(2023)
Letter
Peripheral Vascular Disease
Pooja Nayak, Tamar Polonsky, Lu Tian, Philip Greenland, Shujun Xu, Dongxue Zhang, Lihui Zhao, Michael H. Criqui, Melina R. Kibbe, Barbara Gladders, Philip Goodney, Karen Ho, Jack M. Guralnik, Mary M. McDermott
Article
Peripheral Vascular Disease
Michelle Guo, Mary M. McDermott, Sudarshan Dayanidhi, Christiaan Leeuwenburgh, Stephanie Wohlgemuth, Luigi Ferrucci, Charlotte A. Peterson, Kate Kosmac, Lu Tian, Lihui Zhao, Robert Sufit, Karen Ho, Michael Criqui, Shujun Xu, Dongxue Zhang, Philip Greenland
Summary: This study evaluated the association of smoking with mitochondrial function in gastrocnemius muscle of people with peripheral artery disease (PAD). Among people with PAD, cigarette smoking may stimulate mitochondrial biogenesis to compensate for reduced oxidative capacity per unit of mitochondrial membrane, resulting in no difference in overall mitochondrial oxidative capacity according to current smoking status. However, these results were cross-sectional and a longitudinal study is needed.
Review
Cardiac & Cardiovascular Systems
Xuan Wang, Brian Lee Claggett, Lu Tian, Marcus Vinicius Bolivar Malachias, Marc A. Pfeffer, Lee-Jen Wei
Summary: For personalized or stratified medicine, it is crucial to establish a reliable and efficient prediction model for a clinical outcome of interest. However, commonly used metrics like C statistics do not accurately assess the model's prediction accuracy. This article highlights the importance of finding a clinically interpretable measure that quantifies prediction accuracy for improved model selection and evaluation.
Article
Mathematics
Feng Hong, Lu Tian, Viswanath Devanarayan
Summary: High-dimensional data applications require the use of statistical and machine-learning algorithms to identify optimal biomarker signatures based on patient characteristics for predicting clinical outcomes in biomedical research. Regularization, particularly L-1-based regularization, is commonly used to improve prediction performance and feature selection. However, choosing the penalty parameter for regularization can be unstable and may lead to inflated predictive performance estimates. This paper proposes a Monte Carlo approach for robust regularization parameter selection and an additional cross-validation wrapper for objectively evaluating the final model's predictive performance.
Letter
Medicine, General & Internal
Ananya Das, Timothy A. Lin, Christine Lin, Tomer Meirson, Zachary R. McCaw, Lu Tian, Ethan B. Ludmir
Article
Clinical Neurology
Menglan Pang, Audrey Gabelle, Paramita Saha-Chaudhuri, Willem Huijbers, Arie Gafson, Paul M. Matthews, Lu Tian, Ivana Rubino, Richard Hughes, Carl de Moor, Shibeshih Belachew, Changyu Shen
Summary: This study provides a proof of concept for precision medicine in future research and drug development for Alzheimer's disease through individual treatment response analysis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Linfeng Chen, Qiming Tang, Keying Zhang, Qianyang Huang, Yun Ding, Bo Jin, Szumam Liu, Kuoyuan Hwa, C. James Chou, Yani Zhang, Sheeno Thyparambil, Weili Liao, Zhi Han, Richard Mortensen, James Schilling, Zhen Li, Robert Heaton, Lu Tian, Harvey J. Cohen, Karl G. Sylvester, Rebecca C. Arent, Xinyang Zhao, Doff B. Mcelhinney, Yumei Wu, Wenpei Bai, Xuefeng B. Ling
Summary: This study explores the potential use of metabolic changes as biomarkers for assessing ovarian cancer. The research identifies key gene expression pathways and proposes symmetric dimethylarginine (SDMA) and arginine as potential liquid biopsy biomarkers for ovarian cancer assessment.
Editorial Material
Urology & Nephrology
Vivek Charu, Lu Tian, Manjula Kurella Tamura, Maria E. Montez-Rath
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
Ruben P. A. van Eijk, Leonard H. H. van den Berg, Kit C. B. Roes, Lu Tian, Tze L. L. Lai, Lorene M. M. Nelson, Chenyu Li, Anna Scowcroft, Jesus Garcia-Segovia, Ying Lu
Summary: Hybrid designs with both randomized arms and an external control cohort are proposed to enhance clinical trials by using concurrent registries. The methodology was evaluated in a randomized, placebo-controlled clinical trial for amyotrophic lateral sclerosis. Matching eligible external controls from a different calendar period led to bias in the treatment effect estimate. Hybrid trial designs utilizing a concurrent registry with rigorous matching can minimize bias and accelerate the development of new treatments.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Developmental Biology
Agnieszka Kalinowski, Lu Tian, Reenal Pattni, Hanna Ollila, Maroof Khan, Cindy Manko, Melissa Silverman, Meiqian Ma, Laurie Columbo, Bahare Farhadian, Susan Swedo, Tanya Murphy, Mats Johnson, Elisabeth Fernell, Christopher Gillberg, Margo Thienemann, Elizabeth D. Mellins, Douglas F. Levinson, Alexander E. Urban, Jennifer Frankovich
Summary: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a sudden-onset neuropsychiatric disorder with an increased prevalence of co-morbid autoimmune illness, particularly arthritis. PANS patients with low C4B copy number are at higher risk for subsequent Juvenile Idiopathic Arthritis (JIA) diagnosis. There is a possible association between low C4B and PANS age of onset, suggesting a potential role of C4B in different types of arthritis.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Layla Parast, Lu Tian, Tianxi Cai, Latha P. Palaniappan
Summary: This study compared the effectiveness of five surrogate markers - HbA1c, fasting glucose, 2-hour postchallenge glucose, TyG index, and HOMA-IR - in predicting the reduction of type 2 diabetes mellitus risk. The results showed that glucose and HOMA-IR were the superior surrogate markers compared to the other markers.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Medicine, General & Internal
Neela D. Thangada, Dongxue Zhang, Lu Tian, Lihui Zhao, W. Jack Rejeski, Karen J. Ho, Luigi Ferrucci, Bonnie Spring, Melina R. Kibbe, Tamar S. Polonsky, Michael H. Criqui, Mary M. Mcdermott
Summary: In this meta-analysis of individual participant data, home-based walking exercise was found to improve 6-minute walk more than supervised treadmill exercise in people with PAD. These findings support home-based walking exercise as a first-line therapy for walking limitations in PAD.