Article
Radiology, Nuclear Medicine & Medical Imaging
Jing Li, Thanh D. Nguyen, Qihao Zhang, Lingfei Guo, Yi Wang
Summary: This study compared the susceptibility values in subcortical gray matter structures of CSVD patients without CMBs, with CMBs, and healthy controls. It found that higher iron deposition burden of CMB lesions in the brain may be a quantitative marker for cognitive decline in patients with CSVD-C.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Chong-xi Xu, Hui Xu, Tong Yi, Xing-yang Yi, Jun-peng Ma
Summary: The study found that age and hypertension are highly correlated with cerebral microbleeds, and in acute ischemic stroke patients, the number of cerebral microbleeds increases the incidence of intracranial hemorrhage. Cerebral microbleeds >= 10 are independent predictors of ICH.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Breni Sharma, Andrew E. Beaudin, Emily Cox, Feryal Saad, Krista Nelles, Myrlene Gee, Richard Frayne, David G. Gobbi, Richard Camicioli, Eric E. Smith, Cheryl R. McCreary
Summary: This study used MRI and quantitative susceptibility mapping (QSM) to detect brain iron content in patients with CAA and found no significant difference compared to the normal control group. However, the study did not provide evidence of an association between brain iron content and cognitive abilities.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Valentina Perosa, Johanna Rotta, Renat Yakupov, Hugo J. J. Kuijf, Frank Schreiber, Jan T. T. Oltmer, Hendrik Mattern, Hans-Jochen Heinze, Emrah Duezel, Stefanie Schreiber
Summary: This study explored the implications of using quantitative susceptibility mapping (QSM) at submillimeter resolution for detecting cerebral microbleeds (MBs) in patients with cerebral small vessel disease (CSVD). The results showed that QSM can improve the detection of MBs and revealed a higher prevalence of MBs in healthy elderly individuals than previously known.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Ke Lv, Yanzhen Liu, Yongsheng Chen, Sagar Buch, Ying Wang, Zhuo Yu, Huiying Wang, Chenxi Zhao, Dingwei Fu, Huapeng Wang, Beini Wang, Shengtong Zhang, Yu Luo, E. Mark Haacke, Wen Shen, Chao Chai, Shuang Xia
Summary: The purpose of this study was to investigate the total iron burden of cerebral microbleeds (CMBs) and its effect on brain atrophy through the mediating effect of white matter hyperintensities (WMH). The results showed that periventricular WMH might be a risk factor for the presence of CMBs and could mediate the effect of CMBs on brain atrophy.
Article
Environmental Sciences
Yue Wang, Haijia Wen, Deliang Sun, Yuechen Li
Summary: This study aimed to evaluate landslide risk and distribution in Fengjie County, using various data sources and models to develop a landslide risk map and provide recommendations for prevention and control measures.
Article
Neurosciences
YangYingQiu Liu, JunYi Dong, QingWei Song, Nan Zhang, WeiWei Wang, BingBing Gao, ShiYun Tian, ChunBo Dong, ZhanHua Liang, LiZhi Xie, YanWei Miao
Summary: This study quantitatively assessed the cerebral vein oxygen levels in AD patients using QSM, finding a significant negative correlation between cerebral venous MSV and cognitive scores. The results suggest that decreasing cerebral venous oxygen levels may impact cognitive status in AD patients and be associated with disease progression.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Jong-Ho Park, Sun U. Kwon, Hyuk Sung Kwon, Sung Hyuk Heo
Summary: Prior ICH is associated with WMH severity, increasing the risk of both ischemic and hemorrhagic stroke. In patients with ICH, advanced WMH is linked to higher risk of ischemic stroke, while mild WMH is associated with increased risk of hemorrhagic stroke.
SCIENTIFIC REPORTS
(2021)
Article
Biophysics
Karthik Chary, Mikko J. Nissi, Olli Nykanen, Eppu Manninen, Ramon Rey, Karin Shmueli, Alejandra Sierra, Olli Grohn
Summary: This study investigated variations in susceptibility distribution related to secondary tissue changes after traumatic brain injury (TBI) in a rat model. Results showed that variations in susceptibility in white and grey matter areas were attributed to reduction in myelin, accumulation of iron and calcium, and gliosis. Combining quantitative susceptibility mapping (QSM) with R-2* measurement provided a more detailed assessment of tissue changes and could potentially improve diagnosis of TBI and other complex neurodegenerative diseases.
NMR IN BIOMEDICINE
(2021)
Article
Clinical Neurology
Angela Napolitano, Alberto Arrigoni, Anna Caroli, Mariangela Cava, Andrea Remuzzi, Luca Giovanni Longhi, Antonino Barletta, Rosalia Zangari, Ferdinando Luca Lorini, Maria Sessa, Simonetta Gerevini
Summary: There is increasing evidence that COVID-19 can cause neurological symptoms and cerebral microbleeds (CMBs) have been observed in patients with this condition. This study aimed to characterize CMBs patterns using susceptibility-weighted imaging (SWI) in hospitalized COVID-19 patients with neurological manifestations. The study found that CMBs are a frequent imaging finding in these patients and are associated with a pro-inflammatory state.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biophysics
Yicheng Chen, Ozan Genc, Clare B. Poynton, Suchandrima Banerjee, Christopher P. Hess, Janine M. Lupo
Summary: Quantitative susceptibility mapping (QSM) has the potential to be a biomarker for various diseases, but faces challenges. This study evaluated the effects of background field removal and dipole inversion algorithms on cerebral microbleed (CMB) quantification and provides guidance for selecting the most appropriate QSM processing pipeline.
NMR IN BIOMEDICINE
(2022)
Article
Neurosciences
Wenting Lan, Xin Wu, Yuefei Wu, Hui Zhang
Summary: This study showed that the combination of EGb and Aspirin can improve blood oxygen saturation in patients with cerebrovascular diseases. Quantitative susceptibility mapping can be used as a quantitative follow-up tool to monitor oxygen saturation and magnetic sensitivity of microbleeds in these patients.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Neuroimaging
Man Xu, Yihao Guo, Junying Cheng, Kangkang Xue, Meng Yang, Xueqin Song, Yanqiu Feng, Jingliang Cheng
Summary: This study revealed decreased iron concentration in the grey matter nuclei of patients with first-episode schizophrenia. QSM showed superior sensitivity over R2* in evaluating schizophrenia-related brain iron changes, with the QSM value of the left substantia nigra demonstrating the highest diagnostic performance for first-episode schizophrenia.
NEUROIMAGE-CLINICAL
(2021)
Article
Computer Science, Artificial Intelligence
Gyutaek Oh, Hyokyoung Bae, Hyun-Seo Ahn, Sung-Hong Park, Won-Jin Moon, Jong Chul Ye
Summary: Quantitative susceptibility mapping (QSM) is a useful MRI technique for spatially mapping the magnetic susceptibility values of tissues. Deep learning approaches have shown comparable performance to classic methods in QSM reconstruction, with the advantage of faster reconstruction time. However, existing deep learning methods are mostly based on supervised learning and require matched pairs of input phase images and ground-truth maps.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haejoon Lee, Jun-Ho Kim, Seul Lee, Kyu-Jin Jung, Woo-Ram Kim, Young Noh, Eung Yeop Kim, Koung Mi Kang, Chul-Ho Sohn, Dong Young Lee, Mohammed A. Al-masni, Dong-Hyun Kim
Summary: This study proposes a new end-to-end CMBs detection network that integrates CNNs on multiple planes, improving precision and sensitivity. This approach is clinically feasible and is expected to provide better results in detecting lesions in clinical practice.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thanh D Nguyen, Yan Wen, Jingwen Du, Zhe Liu, Kelly Gillen, Pascal Spincemaille, Ajay Gupta, Qi Yang, Yi Wang
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Multidisciplinary Sciences
Priya S. Balasubramanian, Pascal Spincemaille, Lingfei Guo, Weiyuan Huang, Ilhami Kovanlikaya, Yi Wang
Article
Radiology, Nuclear Medicine & Medical Imaging
Allen A. Champagne, Yan Wen, Magdy Selim, Aristotelis Filippidis, Ajit Thomas, Pascal Spincemaille, Yi Wang, Salil Soman
Summary: This retrospective cohort study found that the novel postprocessing QSM method from multiecho complex total field inversion (mcTFI) could better differentiate between acute and subacute ICH compared to the traditional MEDI method. The study also showed that CTindex values were more strongly correlated with mcTFI QSM measurements, suggesting that mcTFI may provide an improved method for assessing the acuity of intracranial blood products in clinical settings.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Alexey Dimov, Thanh D. Nguyen, Pascal Spincemaille, Elizabeth M. Sweeney, Nicole Zinger, Ilhami Kovanlikaya, Brian H. Kopell, Susan A. Gauthier, Yi Wang
Summary: The study demonstrated a global CSF method for consistent and automated zero referencing of brain QSM, showing improvements in repeatability and image quality compared to the ventricular CSF method. Results from healthy subjects and PD/MS patients indicated that the global CSF regularization method provided more consistent CSF volume and higher QSM repeatability, leading to better image quality in brain QSM.
JOURNAL OF NEUROIMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Wen, Pascal Spincemaille, Thanh Nguyen, Junghun Cho, Ilhami Kovanlikaya, Julie Anderson, Gaohong Wu, Baolian Yang, Maggie Fung, Ke Li, Douglas Kelley, Nissim Benhamo, Yi Wang
Summary: The proposed multiecho complex total field inversion (mcTFI) method improved QSM reconstruction accuracy over traditional field-to-source inversion through better signal modeling. It demonstrated more accurate QSM reconstruction in numerical brain simulations with lesions, as well as better image quality with fewer artifacts in brains with intracerebral hemorrhage scanned at 3T and healthy brains scanned at 7T.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Junghun Cho, Thanh D. Nguyen, Weiyuan Huang, Elizabeth M. Sweeney, Xianfu Luo, Ilhami Kovanlikaya, Shun Zhang, Kelly M. Gillen, Pascal Spincemaille, Ajay Gupta, Susan A. Gauthier, Yi Wang
Summary: Our study demonstrates the feasibility of whole brain oxygen extraction fraction mapping for measuring lesion-specific and regional abnormalities in multiple sclerosis patients. Comparing OEF and neural tissue susceptibility between MS patients and healthy controls revealed distinct differences in lesion areas and overall brain oxygen utilization, suggesting OEF as a potential quantitative marker for tissue oxygenation in MS.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Jiahao Li, Weiyuan Huang, Xianfu Luo, Yan Wen, Junghun Cho, Ilhami Kovanlikaya, Susan A. Gauthier, Thanh D. Nguyen, Pascal Spincemaille, Yi Wang
Summary: The study demonstrates that the SRO method improves the visualization of CVS compared to SWI, with higher detection rates and better image quality scores, as well as increased central vein-to-lesion contrast.
JOURNAL OF NEUROIMAGING
(2022)
Article
Clinical Neurology
Alexey Dimov, Thanh D. Nguyen, Kelly M. Gillen, Melanie Marcille, Pascal Spincemaille, David Pitt, Susan A. Gauthier, Yi Wang
Summary: This study aims to demonstrate the feasibility of separating magnetic sources in quantitative susceptibility mapping (QSM) using magnitude decay rates R2* in gradient echo (GRE) MRI. The results show that using R2* can accurately estimate the magnetic susceptibility of sources, and there is a significant correlation between susceptibility changes and longitudinal myelin water fraction (MWF) changes. The changes in magnetic susceptibility may serve as a biomarker for myelin recovery or damage in acute multiple sclerosis (MS) lesions.
JOURNAL OF NEUROIMAGING
(2022)
Article
Clinical Neurology
Kyuwon Lee, Brian Ellison, Magdy Selim, Ngo H. Long, Aristotelis Filippidis, Ajith J. Thomas, Pascal Spincemaille, Yi Wang, Salil Soman
Summary: QSM demonstrates more consistent and interpretable lesion intensity compared to SWIP for distinguishing CMBs from calcification.
JOURNAL OF NEUROIMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Alexey V. Dimov, Jiahao Li, Thanh D. Nguyen, Alexandra G. Roberts, Pascal Spincemaille, Sina Straub, Zungho Zun, Martin R. Prince, Yi Wang
Summary: Quantitative susceptibility mapping (QSM) is used to study magnetic materials in tissue, and has been predominantly applied in the brain but is now being used outside the brain as well. QSM relies on the effect of tissue magnetic susceptibility sources on the MR signal phase obtained with gradient echo sequence. However, in the body, the chemical shift of fat also affects the MR signal phase, so correcting for the chemical shift effect is crucial for body QSM. By compensating for motion artifacts, body QSM has been used to study various conditions such as liver iron and fibrosis, heart chamber blood and placenta oxygenation, myocardial hemorrhage, atherosclerotic plaque, cartilage, bone, prostate, breast calcification, and kidney stone.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Jinwei Zhang, Pascal Spincemaille, Hang Zhang, Thanh D. Nguyen, Chao Li, Jiahao Li, Ilhami Kovanlikaya, Mert R. Sabuncu, Yi Wang
Summary: In this paper, a new framework called Learned Acquisition and Reconstruction Optimization (LARO) is proposed to accelerate the multi-echo gradient echo (mGRE) pulse sequence for quantitative susceptibility mapping (QSM). The framework optimizes a Cartesian multi-echo k-space sampling pattern and implements it in an mGRE sequence using a deep reconstruction network. A recurrent temporal feature fusion module is also introduced to capture signal redundancies along echo time. Experimental results show that the optimized sampling pattern and proposed reconstruction strategy improve the quality of multi-echo image reconstructions, and the LARO framework demonstrates robustness on test data with new pathologies and different sequence parameters.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Pascal Spincemaille, Martin R. Prince
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Wen, Pascal Spincemaille, Thanh Nguyen, Junghun Cho, Ilhami Kovanlikaya, Julie Anderson, Gaohong Wu, Baolian Yang, Maggie Fung, Ke Li, Douglas Kelley, Nissim Benhamo, Yi Wang
Summary: A novel mcTFI method was developed for direct computation of susceptibility maps from multiecho gradient echo images, showing improved QSM reconstruction accuracy and image quality compared to conventional nTFI method in both numerical simulations and real brain data.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neuroimaging
Kyle D. Murray, Md Nasir Uddin, Madalina E. Tivarus, Bogachan Sahin, Henry Z. Wang, Meera Singh, Xing Qiu, Lu Wang, Pascal Spincemaille, Yi Wang, Sanjay B. Maggirwar, Jianhui Zhong, Giovanni Schifitto
Summary: This study aimed to assess the association between cardiovascular risk factors, white matter hyperintensities (WMHs), and brain tissue susceptibility in the context of cerebral small vessel disease (CSVD) using quantitative susceptibility mapping (QSM). Results showed that individuals with HIV infection had significantly higher CSVD signs compared to controls, with WMH volumes correlating significantly with age and cardiovascular risk scores. Regional QSM was found to be associated with cardiovascular risk factors, age, sex, and WMH volumes, but not with HIV status. These findings suggest that QSM may serve as an early imaging marker for alterations in brain microcirculation.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Po-Jui Lu, Youngjin Yoo, Reza Rahmanzadeh, Riccardo Galbusera, Matthias Weigel, Pascal Ceccaldi, Thanh D. Nguyen, Pascal Spincemaille, Yi Wang, Alessandro Daducci, Francesco La Rosa, Meritxell Bach Cuadra, Robin Sandkuehler, Kambiz Nael, Amish Doshi, Zahi A. Fayad, Jens Kuhle, Ludwig Kappos, Benjamin Odry, Philippe Cattin, Eli Gibson, Cristina Granziera
Summary: A method called GAMER MRI was developed to assess the relative importance of MRI measures in neurological diseases with focal pathology, potentially aiding in choosing the best combination of MR contrasts for specific classification problems.
NEUROIMAGE-CLINICAL
(2021)