☆ 4.7 Editorial Material

In Vivo Morphologic Imaging Taken to a Higher Level

RADIOLOGY (2010)

Journal

RADIOLOGY

Volume 254, Issue 3, Pages 647-650

Publisher

RADIOLOGICAL SOC NORTH AMERICA

DOI: 10.1148/radiol.09092336

Keywords

-

Categories

Radiology, Nuclear Medicine & Medical Imaging

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Radiology, Nuclear Medicine & Medical Imaging

Derive Morphologic Measures from the Human Cerebellum in Vivo

Nikos Priovoulos, Mads Andersen, Serge O. Dumoulin, Vincent O. Boer, Wietske van der Zwaag

Summary: In vivo imaging of the cerebellar cortical layers and surface, as well as deriving quantitative measures, was successfully achieved using motion-corrected 7.0-T MRI in a clinically acceptable acquisition time. This technique has significant implications for the study of various disorders.

RADIOLOGY (2023)

Add to Collection

Article Immunology

Molecular Imaging to Study Antimicrobial Pharmacokinetics In Vivo

Oren Gordon, Jogarao V. S. Gobburu, Allison Dunn

Summary: This article introduces the issues in antibiotic use and the recent progress in optimizing antibiotic use using positron-emission tomography-based imaging.

JOURNAL OF INFECTIOUS DISEASES (2023)

Add to Collection

Review Biotechnology & Applied Microbiology

THz medical imaging: from in vitro to in vivo

Zhiyao Yan, Li-Guo Zhu, Kun Meng, Wanxia Huang, Qiwu Shi

Summary: In this review, the authors discuss the research progress of Terahertz (THz) medical imaging for in vivo applications. They focus on the development of imaging contrast agents and novel imaging methods suitable for living organisms, and propose a roadmap for taking THz medical imaging from in vitro to in vivo.

TRENDS IN BIOTECHNOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

In Vivo Cellular-Level 3D Imaging of Peripheral Nerves Using a Dual-Focusing Technique for Intra-Neural Interface Implantation

Min Woo Lee, Namseon Jang, Nara Choi, Sungwook Yang, Jinwoo Jeong, Hyeong Soo Nam, Sang-Rok Oh, Keehoon Kim, Donghyun Hwang

Summary: The study introduces an optical coherence tomography-based imaging platform for visualizing the microstructural changes of peripheral nerves in vivo, which could potentially address chronic implantation failure and improve outcomes for amputated patients.

ADVANCED SCIENCE (2022)

Add to Collection

Article Optics

High-resolution, non-contact, cellular level imaging of the cornea of the eye in vivo

C. S. Suchand Sandeep, Nyein Chan Lwin, Yu-Chi Liu, Veluchamy Amutha Barathi, Tin Aung, Mani Baskaran, Vadakke Matham Murukeshan

Summary: Corneal diseases are a leading cause of blindness worldwide, and early diagnosis and prevention are crucial. A non-contact imaging system has been developed as an alternative to the current contact-based method, providing high-resolution evaluation of corneal structures in a simple and real-time manner.

OPTICS AND LASER TECHNOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Biomedical Micro-/Nanomotors: From Overcoming Biological Barriers to In Vivo Imaging

Changyong Gao, Yong Wang, Zihan Ye, Zhihua Lin, Xing Ma, Qiang He

Summary: Self-propelled micro- and nanomotors have great potential in biomedical applications, but challenges such as overcoming biological barriers and in vivo navigation still need to be addressed. With continued attention and innovation, it is believed that they will improve targeted drug delivery efficiency in the future.

ADVANCED MATERIALS (2021)

Add to Collection

Review Biochemical Research Methods

The power of imaging to understand extracellular vesicle biology in vivo

Frederik J. Verweij, Leonora Balaj, Chantal M. Boulanger, David R. F. Carter, Ewoud B. Compeer, Gisela D'Angelo, Samir El Andaloussi, Jacky G. Goetz, Julia Christina Gross, Vincent Hyenne, Eva-Maria Kramer-Albers, Charles P. Lai, Xavier Loyer, Alex Marki, Stefan Momma, Esther N. M. Nolte-'t Hoen, D. Michiel Pegtel, Hector Peinado, Graca Raposo, Kirsi Rilla, Hidetoshi Tahara, Clotilde Thery, Martin E. van Royen, Roosmarijn E. Vandenbroucke, Ann M. Wehman, Kenneth Witwer, Zhiwei Wu, Richard Wubbolts, Guillaume van Niel

Summary: Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every cell type, with diverse biological activities. Recent advances in live and high-resolution microscopy techniques, combined with innovative EV labeling strategies, provide new tools to study EVs in vivo at the single-vesicle level.

NATURE METHODS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

How to Select Firefly Luciferin Analogues for In Vivo Imaging

Ryohei Saito-Moriya, Jun Nakayama, Genta Kamiya, Nobuo Kitada, Rika Obata, Shojiro A. Maki, Hiroshi Aoyama

Summary: Bioluminescence reactions are commonly used in optical in vivo imaging for quantifying tumor cells and gene expression. Researchers have developed various bioluminescence systems, including multicolor BLI based on artificial luciferin analogues and/or luciferase mutants.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Intraperitoneal Glucose Transport to Micrometastasis: A Multimodal In Vivo Imaging Investigation in a Mouse Lymphoma Model

Zsombor Ritter, Katalin Zambo, Xinkai Jia, David Szollosi, Daniel Dezso, Hussain Alizadeh, Ildiko Horvath, Nikolett Hegedus, David Tuch, Kunal Vyas, Peter Balogh, Domokos Mathe, Erzsebet Schmidt

Summary: The study utilized a mouse model of B-cell lymphoma to investigate the performance of FDG-PET in early and advanced stages of spread, revealing significant tracer accumulation associated with the mesentery and highlighting the diagnostic importance of local FDG administration for early peritoneal manifestations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Pharmacology & Pharmacy

Current Use and Complementary Value of Combining in Vivo Imaging Modalities to Understand the Renoprotective Effects of Sodium-Glucose Cotransporter-2 Inhibitors at a Tissue Level

Sjoukje van der Hoek, Jasper Stevens

Summary: SGLT2 inhibitors have been shown to improve renal and cardiovascular outcomes in patients with and without diabetes, and imaging modalities provide unique insights into the renoprotective effects of SGLT2i and their response variability, aiding in improved treatment of individual patients.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Review Multidisciplinary Sciences

Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications

Changhuo Xu, Hanchen Shen, Tzu-Ming Liu, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang

Summary: In the late 19th century, scientists discovered the phenomena of aggregation-caused quenching and aggregation-induced emission (AIE) while studying the photophysical differences between chromophores in solution and aggregate states. The concept of AIE has led to the innovation of luminogenic materials with high emission in the aggregate state based on the restriction of intramolecular motion. This review explores recent advances in molecular engineering techniques for highly emissive AIE dots, such as nanoscale crystallization and matrix-assisted rigidification, with the goal of improving their brightness and inspiring the rational design of functional aggregates.

ISCIENCE (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

A near-infrared genetically encoded calcium indicator for in vivo imaging

Anton A. Shemetov, Mikhail V. Monakhov, Qinrong Zhang, Jose Ernesto Canton-Josh, Manish Kumar, Maomao Chen, Mikhail E. Matlashov, Xuan Li, Wei Yang, Liming Nie, Daria M. Shcherbakova, Yevgenia Kozorovitskiy, Junjie Yao, Na Ji, Vladislav V. Verkhusha

Summary: The newly designed near-infrared genetically encoded calcium indicator performs well in neuroscience, allowing simultaneous detection of neuronal and hemodynamic activities with high brightness, photostability, and increased fluorescence response rate. It enables deep-tissue imaging, is suitable for dissociated neurons and in vivo mouse experiments, and allows for detection of spontaneous and evoked neuronal activity in the mouse visual cortex with up to 25% fluorescence changes.

NATURE BIOTECHNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Optical clearing of living brains with MAGICAL to extend in vivo imaging

Kouichirou Iijima, Takuto Oshima, Ryosuke Kawakami, Tomomi Nemoto

Summary: MAGICAL is an optical brain clearing method that enhances the performance of in vivo fluorescence microscopy, allowing for vivid imaging of deeper regions in living brains. It improves transmittance of shorter wavelength light, reducing optical scattering and making living brains more transparent.

ISCIENCE (2021)

Add to Collection

Article Chemistry, Analytical

Deep Learning of Morphologic Correlations To Accurately Classify CD4+and CD8+T Cells by Diffraction Imaging Flow Cytometry

Lin Zhao, Liwen Tang, Marion S. Greene, Yu Sa, Wenjin Wang, Jiahong Jin, Heng Hong, Jun Q. Lu, Xin-Hua Hu

Summary: This study investigates the structure-function relationship of CD4+ and CD8+ T cell subtypes by analyzing their morphologic features and surface CD markers. The results show a strong correlation between the structure and function of these two major T cell subtypes. Diffraction imaging flow cytometry proves to be a potential method for accurate and label-free classification of T cell subtypes.

ANALYTICAL CHEMISTRY (2022)

Add to Collection

Article Chemistry, Organic

A BODIPY-based probe for amyloid-β imaging in vivo

Mingguang Zhu, Guoyang Zhang, Ziwei Hu, Chaofeng Zhu, Yixiang Chen, Tony D. James, Lijun Ma, Zhuo Wang

Summary: Alzheimer's disease (AD) is a neurodegenerative disease, and detecting amyloid-beta (Aβ) plaques can improve diagnosis and therapy. A new Aβ recognition unit, BocBDP, was developed using the [4-(Boc-amino) benzene] unit. BocBDP can recognize and image Aβ plaques both in vitro and in vivo through hydrogen bonding with amino acid residues Lys16 (K16), Val18 (V18), and Glu22 (E22). BocBDP has a strong binding affinity to Aβ and can cross the blood-brain barrier for at least 2 hours.

ORGANIC CHEMISTRY FRONTIERS (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Benjamin F. J. Verhaaren, Stephanie Debette, Joshua C. Bis, Jennifer A. Smith, M. Kamran Ikram, Hieab H. Adams, Ashley H. Beecham, Kumar B. Rajan, Lorna M. Lopez, Sandra Barral, Mark A. van Buchem, Jeroen van der Grond, Albert V. Smith, Katrin Hegenscheid, Neelum T. Aggarwal, Mariza de Andrade, Elizabeth J. Atkinson, Marian Beekman, Alexa S. Beiser, Susan H. Blanton, Eric Boerwinkle, Adam M. Brickman, R. Nick Bryan, Ganesh Chauhan, Christopher P. L. H. Chen, Vincent Chouraki, Anton J. M. de Craen, Fabrice Crivello, Ian J. Deary, Joris Deelen, Philip L. De Jager, Carole Dufouil, Mitchell S. V. Elkind, Denis A. Evans, Paul Freudenberger, Rebecca F. Gottesman, Vilmundur Gudnason, Mohamad Habes, Susan R. Heckbert, Gerardo Heiss, Saima Hilal, Edith Hofer, Albert Hofman, Carla A. Ibrahim-Verbaas, David S. Knopman, Cora E. Lewis, Jiemin Liao, David C. M. Liewald, Michelle Luciano, Aad van der Lugt, Oliver O. Martinez, Richard Mayeux, Bernard Mazoyer, Mike Nalls, Matthias Nauck, Wiro J. Niessen, Ben A. Oostra, Bruce M. Psaty, Kenneth M. Rice, Jerome I. Rotter, Bettina von Sarnowski, Helena Schmidt, Pamela J. Schreiner, Maaike Schuur, Stephen S. Sidney, Sigurdur Sigurdsson, P. Eline Slagboom, David J. M. Stott, John C. van Swieten, Alexander Teumer, Anna Maria Toeglhofer, Matthew Traylor, Stella Trompet, Stephen T. Turner, Christophe Tzourio, Hae-Won Uh, Andre G. Uitterlinden, Meike W. Vernooij, Jing J. Wang, Tien Y. Wong, Joanna M. Wardlaw, B. Gwen Windham, Katharina Wittfeld, Christiane Wolf, Clinton B. Wright, Qiong Yang, Wei Zhao, Alex Zijdenbos, J. Wouter Jukema, Ralph L. Sacco, Sharon L. R. Kardia, Philippe Amouyel, Thomas H. Mosley, W. T. Longstreth, Charles C. DeCarli, Cornelia M. van Duijn, Reinhold Schmidt, Lenore J. Launer, Hans J. Grabe, Sudha S. Seshadri, M. Arfan Ikram, Myriam Fornage

CIRCULATION-CARDIOVASCULAR GENETICS (2015)

Add to Collection

Article Neurosciences

Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network

Thaddeus J. Haight, R. Nick Bryan, Guray Erus, Christos Davatzikos, David R. Jacobs, Mark D'Esposito, Cora E. Lewis, Lenore J. Launer

NEUROIMAGE (2015)

Add to Collection

Article Clinical Neurology

Cardiorespiratory fitness and brain volume and white matter integrity The CARDIA Study

Na Zhu, David R. Jacobs, Pamela J. Schreiner, Lenore J. Launer, Rachel A. Whitmer, Stephen Sidney, Ellen Demerath, William Thomas, Claude Bouchard, Ka He, Guray Erus, Harsha Battapady, R. Nick Bryan

NEUROLOGY (2015)

Add to Collection

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Science to Practice: Myeloperoxidase Immunoradiology Improves Detection of Acute and Chronic Experimental Multiple Sclerosis

R. Nick Bryan

RADIOLOGY (2015)

Add to Collection

Article Cardiac & Cardiovascular Systems

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Benjamin F. J. Verhaaren, Stephanie Debette, Joshua C. Bis, Jennifer A. Smith, M. Kamran Ikram, Hieab H. Adams, Ashley H. Beecham, Kumar B. Rajan, Lorna M. Lopez, Sandra Barral, Mark A. van Buchem, Jeroen van der Grond, Albert V. Smith, Katrin Hegenscheid, Neelum T. Aggarwal, Mariza de Andrade, Elizabeth J. Atkinson, Marian Beekman, Alexa S. Beiser, Susan H. Blanton, Eric Boerwinkle, Adam M. Brickman, R. Nick Bryan, Ganesh Chauhan, Christopher P. L. H. Chen, Vincent Chouraki, Anton J. M. de Craen, Fabrice Crivello, Ian J. Deary, Joris Deelen, Philip L. De Jager, Carole Dufouil, Mitchell S. V. Elkind, Denis A. Evans, Paul Freudenberger, Rebecca F. Gottesman, Vilmundur Gudnason, Mohamad Habes, Susan R. Heckbert, Gerardo Heiss, Saima Hilal, Edith Hofer, Albert Hofman, Carla A. Ibrahim-Verbaas, David S. Knopman, Cora E. Lewis, Jiemin Liao, David C. M. Liewald, Michelle Luciano, Aad van der Lugt, Oliver O. Martinez, Richard Mayeux, Bernard Mazoyer, Mike Nalls, Matthias Nauck, Wiro J. Niessen, Ben A. Oostra, Bruce M. Psaty, Kenneth M. Rice, Jerome I. Rotter, Bettina von Sarnowski, Helena Schmidt, Pamela J. Schreiner, Maaike Schuur, Stephen S. Sidney, Sigurdur Sigurdsson, P. Eline Slagboom, David J. M. Stott, John C. van Swieten, Alexander Teumer, Anna Maria Toeglhofer, Matthew Traylor, Stella Trompet, Stephen T. Turner, Christophe Tzourio, Hae-Won Uh, Andre G. Uitterlinden, Meike W. Vernooij, Jing J. Wang, Tien Y. Wong, Joanna M. Wardlaw, B. Gwen Windham, Katharina Wittfeld, Christiane Wolf, Clinton B. Wright, Qiong Yang, Wei Zhao, Alex Zijdenbos, J. Wouter Jukema, Ralph L. Sacco, Sharon L. R. Kardia, Philippe Amouyel, Thomas H. Mosley, W. T. Longstreth, Charles C. DeCarli, Cornelia M. van Duijn, Reinhold Schmidt, Lenore J. Launer, Hans J. Grabe, Sudha S. Seshadri, M. Arfan Ikram, Myriam Fornage

CIRCULATION-CARDIOVASCULAR GENETICS (2015)

Add to Collection

Article Endocrinology & Metabolism

The Cross-sectional and Longitudinal Associations of Diabetic Retinopathy With Cognitive Function and Brain MRI Findings: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial

Christina E. Hugenschmidt, James F. Lovato, Walter T. Ambrosius, R. Nick Bryan, Hertzel C. Gerstein, Karen R. Horowitz, Lenore J. Launer, Ronald M. Lazar, Anne M. Murray, Emily Y. Chew, Ronald P. Danis, Jeff D. Williamson, Michael E. Miller, Jingzhong Ding

DIABETES CARE (2014)

Add to Collection

Article Endocrinology & Metabolism

Spatial Patterns of Structural Brain Changes in Type 2 Diabetic Patients and Their Longitudinal Progression With Intensive Control of Blood Glucose

Guray Erus, Harsha Battapady, Tianhao Zhang, James Lovato, Michael E. Miller, Jeff D. Williamson, Lenore J. Launer, R. Nick Bryan, Christos Davatzikos

DIABETES CARE (2015)

Add to Collection

Article Clinical Neurology

Change in brain and lesion volumes after CEE therapies The WHIMS-MRI studies

Laura H. Coker, Mark A. Espeland, Patricia E. Hogan, Susan M. Resnick, R. Nick Bryan, Jennifer G. Robinson, Joseph S. Goveas, Christos Davatzikos, Lewis H. Kuller, Jeff D. Williamson, Cheryl D. Bushnell, Sally A. Shumaker

NEUROLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study

Lenore J. Launer, Cora E. Lewis, Pamela J. Schreiner, Steve Sidney, Harsha Battapady, David R. Jacobs, Kelvin O. Lim, Mark D'Esposito, Qian Zhang, Jared Reis, Christos Davatzikos, R. Nick Bryan

PLOS ONE (2015)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Effect of Diabetes on Brain Structure: The Action to Control Cardiovascular Risk in Diabetes MR Imaging Baseline Data

R. Nick Bryan, Michel Bilello, Christos Davatzikos, Ronald M. Lazar, Anne Murray, Karen Horowitz, James Lovato, Michael E. Miller, Jeff Williamson, Lenore J. Launer

RADIOLOGY (2014)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

Emerging Applications of Artificial Intelligence in Neuro-Oncology

Jeffrey D. Rudie, Andreas M. Rauschecker, R. Nick Bryan, Christos Davatzikos, Suyash Mohan

RADIOLOGY (2019)

Add to Collection

Article Medicine, General & Internal

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia A Randomized Clinical Trial

Jeff D. Williamson, Nicholas M. Pajewski, Alexander P. Auchus, R. Nick Bryan, Gordon Chelune, Alfred K. Cheung, Maryjo L. Cleveland, Laura H. Coker, Michael G. Crowe, William C. Cushman, Jeffrey A. Cutler, Christos Davatzikos, Lisa Desiderio, Guray Erus, Larry J. Fine, Sarah A. Gaussoin, Darrin Harris, Meng-Kang Hsieh, Karen C. Johnson, Paul L. Kimmel, Manjula Kurella Tamura, Lenore J. Launer, Alan J. Lerner, Cora E. Lewis, Jennifer Martindale-Adams, Claudia S. Moy, Ilya M. Nasrallah, Linda O. Nichols, Suzanne Oparil, Paula K. Ogrocki, Mahboob Rahman, Stephen R. Rapp, David M. Reboussin, Michael V. Rocco, Bonnie C. Sachs, Kaycee M. Sink, Carolyn H. Still, Mark A. Supiano, Joni K. Snyder, Virginia G. Wadley, Jennifer Walker, Daniel E. Weiner, Paul K. Whelton, Valerie M. Wilson, Nancy Woolard, Jackson T. Wright, Clinton B. Wright

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Add to Collection

Article Medicine, General & Internal

Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions

Ilya M. Nasrallah, Nicholas M. Pajewski, Alexander P. Auchus, Gordon Chelune, Alfred K. Cheung, Maryjo L. Cleveland, Laura H. Coker, Michael G. Crowe, William C. Cushman, Jeffrey A. Cutler, Christos Davatzikos, Lisa Desiderio, Jimit Doshi, Guray Erus, Larry J. Fine, Sarah A. Gaussoin, Darrin Harris, Karen C. Johnson, Paul L. Kimmel, Manjula Kurella Tamura, Lenore J. Launer, Alan J. Lerner, Cora E. Lewis, Jennifer Martindale-Adams, Claudia S. Moy, Linda O. Nichols, Suzanne Oparil, Paula K. Ogrocki, Mahboob Rahman, Stephen R. Rapp, David M. Reboussin, Michael V. Rocco, Bonnie C. Sachs, Kaycee M. Sink, Carolyn H. Still, Mark A. Supiano, Joni K. Snyder, Virginia G. Wadley, Jennifer Walker, Daniel E. Weiner, Paul K. Whelton, Valerie M. Wilson, Nancy Woolard, Jackson T. Wright, Clinton B. Wright, Jeff D. Williamson, R. Nick Bryan

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Artificial Intelligence System Approaching Neuroradiologist-level Differential Diagnosis Accuracy at Brain MRI

Andreas M. Rauschecker, Jeffrey D. Rudie, Long Xie, Jiancong Wang, Michael Tran Duong, Emmanuel J. Botzolakis, Asha M. Kovalovich, John Egan, Tessa C. Cook, R. Nick Bryan, Ilya M. Nasrallah, Suyash Mohan, James C. Gee

RADIOLOGY (2020)

Add to Collection

Article Clinical Neurology

The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans

Mohamad Habes, Raymond Pomponio, Haochang Shou, Jimit Doshi, Elizabeth Mamourian, Guray Erus, Ilya Nasrallah, Lenore J. Launer, Tanweer Rashid, Murat Bilgel, Yong Fan, Jon B. Toledo, Kristine Yaffe, Aristeidis Sotiras, Dhivya Srinivasan, Mark Espeland, Colin Masters, Paul Maruff, Jurgen Fripp, Henry Volzk, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, Michael Miller, R. Nick Bryan, Hans J. Grabe, Susan M. Resnick, David A. Wolk, Christos Davatzikos

Summary: The relationship between white matter hyperintensities and various factors such as brain aging, AD neuropathology, cognitive decline, and Aβ positivity after age 65 have been observed in a large MRI database. The Brain Chart established can quantify brain-aging trajectories and provide systematic evaluation of brain-aging patterns relative to a large consortium. Brain aging, AD-like atrophy, and WMHs were shown to be better predictors of cognition than chronological age in MCI/AD subjects.

ALZHEIMERS & DEMENTIA (2021)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.