☆ 4.7 Article

Metacarpophalangeal Joints in Rheumatoid Arthritis: Delayed Gadolinium-enhanced MR Imaging of Cartilage-A Feasibility Study

RADIOLOGY (2010)

Journal

RADIOLOGY

Volume 257, Issue 2, Pages 441-447

Publisher

RADIOLOGICAL SOC NORTH AMERICA

DOI: 10.1148/radiol.10100459

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Funding

Heinrich-Heine-University Dusseldorf research commission

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Abstract

Purpose: To evaluate the feasibility of delayed gadolinium-enhanced magnetic resonance (MR) imaging of the cartilage of metacarpophalangeal (MCP) joints in patients with rheumatoid arthritis (RA) compared with that in control subjects. Materials and Methods: Institutional review board approval and informed consent were obtained. Thirty-one MCP joints in 10 patients with RA (mean age, 59 years; range, 35-77 years) and six healthy volunteers (mean age, 51 years; range, 30-71 years) were examined with delayed gadolinium-enhanced MR imaging of cartilage. Sagittal images of the second and third MCP joints (hereafter, MCP II and MCP III) were acquired with a three-dimensional dual-flip-angle gradient-echo sequence at 3.0 T. B(1) field inhomogeneity-corrected T1 maps were calculated, and delayed gadolinium-enhanced MR imaging of cartilage values for phalangeal and metacarpal cartilage were determined. In addition, cartilage thickness was measured. A nonparametric Mann-Whitney U test was used to assess differences between groups. Results: Phalangeal and metacarpal delayed gadolinium-enhanced MR imaging of cartilage values in patients with RA (MCP II: 388 msec +/- 105 [standard deviation] and 342 msec +/- 79, respectively; MCP III: 409 msec +/- 96 and 371 msec +/- 89, respectively) were significantly lower than in control subjects (MCP II: 598 msec +/- 62 and 560 msec +/- 51, respectively; MCP III: 586 msec +/- 57 and 561 msec +/- 80, respectively). Cartilage thickness of both joints was comparable in patients with RA (MCP II: 1.28 mm +/- 0.50, MCP III: 1.17 mm +/- 0.24) and control subjects (MCP II: 1.42 mm +/- 0.33, MCP III: 1.18 mm +/- 0.26). Conclusion: Delayed gadolinium-enhanced MR imaging of cartilage of the MCP joints is feasible at 3.0 T. Delayed gadolinium-enhanced MR imaging of cartilage may help to assess cartilage degeneration in morphologically normal-appearing MCP II and III cartilage in patients with RA. (C) RSNA, 2010

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Ultrasound findings of calcium pyrophosphate deposition disease at metacarpophalangeal joints

Edoardo Cipolletta, Andrea Di Matteo, Gianluca Smerilli, Marco Di Carlo, Jacopo Di Battista, Abhishek Abhishek, Walter Grassi, Emilio Filippucci

Summary: This study provides pictorial evidence of the broad spectrum of ultrasound findings indicating CPP deposits at metacarpophalangeal joints in CPPD. Furthermore, different ultrasound patterns were observed in different CPPD phenotypes.

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