Review
Radiology, Nuclear Medicine & Medical Imaging
Lais Uyeda Aivazoglou, Julio Brandao Guimaraes, Thomas M. Link, Maria Alice Freitas Costa, Fabiano Nassar Cardoso, Bruno de Mattos Lombardi Badia, Igor Braga Farias, Wladimir Bocca Vieira de Rezende Pinto, Paulo Victor Sgobbi de Souza, Acary Souza Bulle Oliveira, Alzira Alves de Siqueira Carvalho, Andre Yui Aihara, Artur da Rocha Correa Fernandes
Summary: This review discusses the imaging modalities for assessing muscle changes in myopathies, outlines patterns of muscle involvement in inherited myopathies in magnetic resonance imaging (MR), and presents imaging-based diagnostic algorithms for diagnostic workup. Familiarity with these patterns is crucial for radiologists and neurologists in the diagnosis and follow-up of patients.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Han Sol Kang, Jin You Kim, Jin Joo Kim, Suk Kim, Nam Kyung Lee, Ji Won Lee, Hie Bum Suh, Lee Hwangbo, Yohan Son, Robert Grimm
Summary: Quantitative diffusion parameters derived from DKI and DWI are associated with prognostic factors for breast cancer. Moreover, DKI-derived kurtosis can help distinguish between the molecular subtypes of breast cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Uma Sharma, Naranamangalam R. Jagannathan
Summary: This article reviews the application of NMR, MRS, and MRI methods in understanding breast cancer biology, as well as in the diagnosis and therapeutic monitoring of breast cancer.
Review
Radiology, Nuclear Medicine & Medical Imaging
Pietro Valerio Foti, Mario Travali, Renato Farina, Stefano Palmucci, Corrado Spatola, Rocco Luca Emanuele Liardo, Roberto Milazzotto, Luigi Raffaele, Vincenzo Salamone, Rosario Caltabiano, Giuseppe Broggi, Lidia Puzzo, Andrea Russo, Michele Reibaldi, Antonio Longo, Paolo Vigneri, Teresio Avitabile, Giovani Carlo Ettorre, Antonio Basile
Summary: The therapy for uveal melanoma aims to preserve eye function and prevent metastasis, and requires personalized treatment strategies combining various techniques. Plaque brachytherapy is commonly used for smaller melanomas, while proton beam therapy is for larger tumors with complex shapes. Enucleation is reserved for advanced cases. Radiation therapy complications are common and varied, dependent on tumor characteristics. The review summarizes diagnostic methods, therapeutic options, and potential ocular complications for radiologists to consider.
INSIGHTS INTO IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Angela Bernabeu-Sanz, Maria Fuentes-Baile, Cristina Alenda
Summary: The study found that IDH1-wt tumors are more necrotic than IDH1-mut tumors, and that the infiltrative pattern in HGG is associated with loss of p53 expression, Ki-67 index, and Glx levels. Additionally, tumor choline levels could be used as a predictive factor in survival, in addition to IDH1 status, to provide a more accurate prediction of survival in HGG patients.
EUROPEAN RADIOLOGY
(2021)
Review
Pharmacology & Pharmacy
A. SEYFETTIN, I. DEDE, S. HAKVERDI, B. D. U. Z. E. L. ASIG, M. TEMIZ, S. KARAZINCIR
Summary: This study investigated the MR imaging features of breast cancer molecular subtypes according to the BIRADS Atlas. Different molecular subtypes showed significant differences in mass/non-mass enhancement, shape, contour, and axillary lymphadenopathy rates in MRI imaging.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pietro Valerio Foti, Mario Travali, Renato Farina, Stefano Palmucci, Corrado Spatola, Luigi Raffaele, Vincenzo Salamone, Rosario Caltabiano, Giuseppe Broggi, Lidia Puzzo, Andrea Russo, Michele Reibaldi, Antonio Longo, Paolo Vigneri, Teresio Avitabile, Giovani Carlo Ettorre, Antonio Basile
Summary: Uveal melanoma is a malignant tumor originating from pigmented melanocytes, with prognosis related to histopathologic and genetic features, tumor size and location. MRI plays a key role in diagnosis and treatment planning, mainly depending on melanin content for tumor visualization. Radiologists and MRI are significant in the clinical management of uveal melanoma.
INSIGHTS INTO IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Avan Kader, Julia Brangsch, Jan O. Kaufmann, Jing Zhao, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Ingolf Sack, Matthias Taupitz, Bernd Hamm, Marcus R. Makowski
Summary: This review summarizes recent developments in molecular imaging markers for magnetic resonance imaging of prostate cancer, aiming to improve the molecular characterization of the tumor and enable targeted therapies to suppress tumor growth or reduce tumor size in a non-invasive manner.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samuel I. Adams-Tew, Sara Johnson, Henrik Od, Dennis L. Parker, Allison Payne
Summary: Real-time temperature monitoring is crucial for successful thermally ablative therapies, and this study validates a 3D thermometry sequence with k-space field drift correction for magnetic resonance-guided focused ultrasound treatments on breast cancer. The results show that the magnetic resonance temperature measurements closely match those of fiberoptic probes, with a confidence interval of -2.0 to 1.4 degrees C. The field drift correction method significantly improves precision and accuracy, making it a reliable tool for clinical investigations on focused ultrasound treatments for breast cancer.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Biotechnology & Applied Microbiology
Yan Xu, Wanlin Tan, Mingyu Chen, Sijie Chen, Kui Tang, Haiqin Liao, Chengcheng Niu
Summary: Sonodynamic therapy is a promising tumor treatment method that inhibits tumor growth by activating sonosensitizers with ultrasound to produce reactive oxygen species. A core-shell structured nanoparticle loaded with sonosensitizer and oxygen was developed as a nanocarrier to transport these agents to the tumor tissue. This nanoparticle can alleviate tumor tissue hypoxia and enhance magnetic resonance imaging signal intensity for tumor diagnosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Jin Zhang, Shenghao Ding, Bing Zhao, Beibei Sun, Qinhua Guo, Yaohua Pan, Xiao Li, Lingling Wang, Jianjian Zhang, Jiaqi Tian, Yan Zhou, Jianrong Xu, Chun Yuan, Jieqing Wan, Xihai Zhao, Huilin Zhao
Summary: Using MR vessel wall imaging (MR-VWI), the morphological and compositional features of chronic internal carotid artery occlusion (CICAO) were found to predict the success of endovascular recanalization.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexis Ollitrault, Frederique Charbonneau, Marie-Laure Herdan, Olivier Berges, Kevin Zuber, Lama Giovansili, Pauline Launay, Julien Savatovsky, Augustin Lecler
Summary: This study concluded that compared to a conventional MRI protocol, a single Dixon-T2WI sequence showed higher sensitivity and specificity, fewer artifacts, and increased confidence when assessing thyroid eye disease.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Torgeir Mo, Siri Helene Bertelsen Brandal, Alvaro Kohn-Luque, Olav Engebraaten, Vessela N. Kristensen, Thomas Fleischer, Tord Hompland, Therese Seierstad
Summary: Hypoxia is common in solid tumors and is associated with treatment resistance. Identifying hypoxia in solid tumors is important for treatment planning. This study validates the concept of hypoxia in breast cancer and develops a new approach for hypoxia imaging.
Article
Engineering, Multidisciplinary
Jun Zhao, Tiejun Gan, Jianhong Zhao, Junjie Mao, Wenjuan Zhang, Xiaoying Guan, Junlin Zhou
Summary: Medical image processing and quantitative analysis are crucial in clinical scenarios for diagnosis and treatment. Studying differentially expressed genes can improve accuracy in tumor grading and guide treatment decisions.
ALEXANDRIA ENGINEERING JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Angele Bonnin, Carole Durot, Manel Djelouah, Anthony Dohan, Lionel Arrive, Pascal Rousset, Christine Hoeffel
Summary: The perihepatic space is commonly involved in various diseases, including intrahepatic lesions extending to the liver capsule and disease conditions from adjacent organs. The dissemination of peritoneal processes can also affect this space. MRI is valuable in assessing and diagnosing infectious, tumor-related, and other conditions in the perihepatic area compared to CT.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Veronica Magni, Andrea Cozzi, Simone Schiaffino, Anna Colarieti, Francesco Sardanelli
Summary: The ultimate goals of applying artificial intelligence (AI) to digital breast tomosynthesis (DBT) are to reduce reading times, improve diagnostic performance, and decrease interval cancer rates. While AI has shown promising results in improving DBT screening by enhancing diagnostic performance and reducing recall rates and reading times, its ability to reduce interval cancer rates still needs further investigation. Prospective validation studies are needed to assess the cost-effectiveness and real-world impact of AI models assisting DBT interpretation.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Rossano Girometti, Michele Bertolotto
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Sardanelli, Isabella Castiglioni, Anna Colarieti, Simone Schiaffino, Giovanni Di Leo
Summary: Artificial intelligence (AI) has been around for a while, with different approaches such as machine learning and deep learning. This article discusses the frequency of AI declaration in article titles. The percentage of titles declaring AI followed a U-shaped curve, starting at around 30% in the early 1990s, dropping to less than 13% in 2005-2014, and rising to 30% again in 2020-2021. This trend was also observed in AI in medical imaging. The initial decline may be attributed to the establishment of AI methods, while the recent increase may be due to AI's superior performance and unresolved concerns about AI.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2023)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Genetics & Heredity
Luciana Mastrodomenico, Claudia Piombino, Beatrice Ricco, Elena Barbieri, Marta Venturelli, Federico Piacentini, Massimo Dominici, Laura Cortesi, Angela Toss
Summary: Hereditary cancer syndromes are inherited disorders caused by germline pathogenic variants that increase the risk of developing certain types of cancer. The personalized treatment of hereditary tumors that target germline pathogenic variants has shown promising results in clinical trials.
Article
Oncology
Antonio Franco, Alba Di Leone, Alessandra Fabi, Paolo Belli, Luisa Carbognin, Elisabetta Gambaro, Fabio Marazzi, Elena Jane Mason, Antonino Mule, Armando Orlandi, Antonella Palazzo, Ida Paris, Alessandro Rossi, Lorenzo Scardina, Daniela Andreina Terribile, Giordana Tiberi, Diana Giannarelli, Giovanni Scambia, Riccardo Masetti, Gianluca Franceschini
Summary: Screening programs have led to a decrease in the diagnosis of locally advanced breast cancer, but the optimal surgical treatment strategy is still under debate. This study compared conservative breast surgery (CBS) with radical breast surgery (RBS) in cT4 breast cancer patients who underwent neoadjuvant chemotherapy (NA) and surgery. The results suggest that CBS may be a safe alternative to RBS in patients with major or complete response to NA, while RBS remains the best choice for patients with poor response to NA.
Article
Medicine, General & Internal
Daniel Alvarez Sanchez-Bayuela, Navid Ghavami, Cristina Romero Castellano, Alessandra Bigotti, Mario Badia, Lorenzo Papini, Giovanni Raspa, Gianmarco Palomba, Mohammad Ghavami, Riccardo Loretoni, Massimo Calabrese, Alberto Tagliafico, Gianluigi Tiberi
Summary: In this study, the effectiveness of the MammoWave microwave imaging device for breast cancer detection is investigated through a multicentric European clinical trial. The device uses a Huygens-principle-based radar algorithm for image reconstruction and dedicated image analysis software. Conductivity weighted microwave images are created for each breast, and various image parameters are used to quantify their non-homogenous behavior. Welch's t-test is used to verify the statistical significance between the selected image features and the gold standard radiological study review.
Article
Radiology, Nuclear Medicine & Medical Imaging
Caterina Beatrice Monti, Moreno Zanardo, Davide Capra, Giulia Lastella, Gianluca Guarnieri, Emilia Giambersio, Giulia Pasqualin, Francesco Sardanelli, Francesco Secchi
Summary: The study aimed to evaluate the correlations between right ventricular late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) and post-pulmonary valve replacement (PVR) functional data in patients with tetralogy of Fallot (ToF). The results showed a moderate positive correlation between RV LGE score and the normalized variation of RV stroke volume, as well as a borderline moderate positive correlation between RV LGE score and the normalized variation of RV end-diastolic indexed volume.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rossano Girometti, Gianluca Giannarini, Maria De Martino, Elena Caregnato, Lorenzo Cereser, Matteo Soligo, Davide Rozze, Stefano Pizzolitto, Miriam Isola, Chiara Zuiani
Summary: The purpose of the study was to identify clinical and mpMRI factors predicting false positive target biopsy (FP-TB) of PI-RADSv2.1 = 3 findings. A multivariable model was built and internally validated to identify features predicting FP-TB of index lesions. Adjusting PI-RADSv2.1 categories for a multivariable risk of FP-TB is potentially more effective in triggering target biopsy of index lesions.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Editorial Material
Oncology
Paolo Belli, Simone Palma, Melania Costantini
Article
Health Care Sciences & Services
Antonio Franco, Alba Di Leone, Marco Conti, Alessandra Fabi, Luisa Carbognin, Andreina Daniela Terribile, Paolo Belli, Armando Orlandi, Martin Alejandro Sanchez, Francesca Moschella, Elena Jane Mason, Giovanni Cimino, Alessandra De Filippis, Fabio Marazzi, Ida Paris, Giuseppe Visconti, Liliana Barone Adesi, Lorenzo Scardina, Sabatino D'Archi, Marzia Salgarello, Diana Giannarelli, Riccardo Masetti, Gianluca Franceschini, Kenneth P. H. Pritzker
Summary: This study developed a post-Neoadjuvant Score System (pNESSy) to choose the appropriate surgery and improve oncological and aesthetic outcomes. The system uses clinical and radiological features to predict the optimal surgery method post-neoadjuvant chemotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicole Brunetti, Irene Valente, Francesca Pitto, Massimo Calabrese
Summary: We present the case of a 35-year-old woman with a palpable lump on her left breast. Ultrasound-guided core needle biopsy revealed high-grade ductal carcinoma in situ on fibroadenoma. The patient was diagnosed with triple-negative breast cancer arising on fibroadenoma and a BRCA1 gene mutation was detected.
JOURNAL OF MEDICAL ULTRASOUND
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Cozzi, Giovanni Di Leo, Nehmat Houssami, Fiona J. Gilbert, Thomas H. Helbich, Marina Alvarez Benito, Corinne Balleyguier, Massimo Bazzocchi, Peter Bult, Massimo Calabrese, Julia Camps Herrero, Francesco Cartia, Enrico Cassano, Paola Clauser, Marcos de Lima F. Docema, Catherine Depretto, Valeria Dominelli, Gabor Forrai, Rossano Girometti, Steven E. Harms, Sarah Hilborne, Raffaele Ienzi, Marc B. I. Lobbes, Claudio Losio, Ritse M. Mann, Stefania Montemezzi, Inge-Marie Obdeijn, Umit A. Ozcan, Federica Pediconi, Katja Pinker, Heike Preibsch, Jose L. Raya Povedano, Carolina Rossi Saccarelli, Daniela Sacchetto, Gianfranco P. Scaperrotta, Margrethe Schlooz, Botond K. Szabo, Donna B. Taylor, Ozden S. Ulus, Mireille Van Goethem, Jeroen Veltman, Stefanie Weigel, Evelyn Wenkel, Chiara Zuiani, Francesco Sardanelli
Summary: This study aimed to investigate the mastectomy and reoperation rates in breast cancer patients who underwent MRI for screening or diagnostic purposes. The results showed that patients who had MRI for screening had higher mastectomy rates and lower reoperation rates compared to those who had MRI for diagnostic purposes.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Federica Rossi, Matteo Lambertini, Nicole Brunetti, Sara De Giorgis, Maria Grazia Razeti, Massimo Calabrese, Alberto Stefano Tagliafico
Summary: The purpose of this study was to evaluate pectoralis muscle area (PMA) depletion in breast cancer patients aged 45 years or younger undergoing neoadjuvant chemotherapy (NAC) and its correlation with clinical and histopathological data. The results showed a decrease in PMA before and after NAC. However, there were no significant associations between PMA changes and other clinical and histopathological data. Therefore, assessing PMA variation on breast MRI during NAC could be a potential tool for monitoring body composition and improving outcomes in young breast cancer patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chiara Zuiani, Iris Mansutti, Guido Caronia, Anna Linda, Viviana Londero, Rossano Girometti
Summary: The study found that using the diffusion levels (DLs) proposed by EUSOBI can improve the diagnostic accuracy of breast MRI, especially in terms of diagnosing malignant lesions.
EUROPEAN RADIOLOGY
(2023)