Article
Oncology
Ryota Hamada, Yohei Oshima, Susumu Sato, Yuji Yoshioka, Tatsuya Sato, Manabu Nankaku, Tadakazu Kondo, Toyofumi F. Chen-Yoshikawa, Ryosuke Ikeguchi, Daisuke Nakajima, Hiroshi Date, Shuichi Matsuda
Summary: This study investigated the long-term changes in physical functions of patients who underwent lung transplantation for LONIPCs after allo-HSCT. Results showed that while dyspnea scores and performance status improved after 2 years, physical functions such as knee extensor strength and exercise tolerance gradually recovered over the course of 2 years, with exercise tolerance being influenced by recovery in %VC and KES.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Hematology
Johnathan Fraebel, Brian G. Engelhardt, Tae Kon Kim
Summary: Pulmonary complications after hematopoietic stem cell transplantation (HSCT) are important sources of morbidity and mortality, with noninfectious complications becoming increasingly significant due to improvements in infection-related complications. These complications can be categorized as early or late complications, with idiopathic pneumonia syndrome and bronchiolitis obliterans syndrome being the most prevalent. The effectiveness of historical treatment with corticosteroids is often poor, highlighting the need for a deeper understanding of the underlying disease biology and the adoption of novel therapies in the modern era.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Aryan Shiari, Mo'ath Nassar, Ayman O. Soubani
Summary: Hematopoietic stem cell transplantation (HSCT) is used for treating both malignant and nonmalignant disorders, but patients remain at risk for post-transplant complications. Pulmonary complications, including infectious and non-infectious, highlight the importance of early identification and treatment of infections, as well as the toxicities related to chemoradiation and immunosuppressive drugs. This report serves as a guide for pulmonologists caring for these patients.
RESPIRATORY MEDICINE
(2021)
Review
Oncology
Lama Elbahlawan, Jenny McArthur, Cara E. Morin, Hafeez Abdelhafeez, M. Beth McCarville, Robert E. Ruiz, Saumini Srinivasan, Amr Qudeimat
Summary: Pulmonary complications are common in children following hematopoietic cell transplantation, early diagnosis is crucial for management and prevention of progression, bronchoscopy and lung biopsy can assist in diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hyewon Shin, Mi-Sun Yum, Min-Jee Kim, Jin Kyung Suh, Ho Joon Im, Hyery Kim, Kyung-Nam Koh, Tae-Sung Ko
Summary: Most children with neurologic complications and neuroimaging abnormalities during HSCT had recovered. However, children with neurologic complications associated with infectious causes, malignant disease or severe brain MRI abnormalities should be more carefully monitored during HSCT.
Review
Immunology
Xiaofeng Zhou, Bethany B. Moore
Summary: Pulmonary infections are a major concern for hematopoietic cell transplantation recipients, with mouse models playing a key role in understanding the impacts of these infections. Studies have shown that post-transplant infectious complications adversely affect innate immunity, and previous infections may contribute to noninfectious pulmonary issues post-HCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Shahzaib Maqbool, Muhammad Nadeem, Ahmad Shahroz, Kiran Naimat, Imran Khan, Hassaan Tahir, Abdur Rehman, Faiz Anwer, Raheel Iftikhar, Ka Yiu Lee
Summary: Engraftment syndrome (ES) is a common non-infectious complication in hematopoietic stem cell transplants, characterized by fever, diarrhea, and skin rash. ES has a high incidence and is often treated with intravenous methylprednisolone.
Article
Hematology
Sagar S. Patel, Kwang Woo Ahn, Manoj Khanal, Caitrin Bupp, Mariam Allbee-Johnson, Navneet S. Majhail, Betty K. Hamilton, Seth J. Rotz, Hasan Hashem, Amer Beitinjaneh, Hillard M. Lazarus, Maxwell M. Krem, Tim Prestidge, Neel S. Bhatt, Akshay Sharma, Shahinaz M. Gadalla, Hemant S. Murthy, Larisa Broglie, Taiga Nishihori, Cesar O. Freytes, Gerhard C. Hildebrandt, Usama Gergis, Sachiko Seo, Baldeep Wirk, Marcelo C. Pasquini, Bipin N. Savani, Mohamed L. Sorror, Edward A. Stadtmauer, Saurabh Chhabra
Summary: Noninfectious pulmonary toxicity (NPT) is a significant complication of allogeneic hematopoietic cell transplantation (alloHCT), including idiopathic pneumonia syndrome (IPS), diffuse alveolar hemorrhage (DAH), and cryptogenic organizing pneumonia (COP). This study found that severe pulmonary comorbidity, acute graft-versus-host disease, mismatched unrelated donor and cord blood transplantation, and HCT Comorbidity Index (HCT-CI) score >= 1 were risk factors for developing NPT, while alloHCT performed in 2014 or later, non-total body irradiation-based conditioning, and platelet recovery were associated with a decreased risk of NPT.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Respiratory System
Ole Henrik Myrdal, Trond Mogens Aalokken, Phoi Phoi Diep, Ellen Ruud, Lorentz Brinch, Kristian Fossa, Henrik Mangseth, Johny Kongerud, Liv Ingunn Sikkeland, May B. Lund
Summary: Long-term allo-HSCT survivors had significantly lower pulmonary function than age- and gender-matched healthy controls, and nearly half had pathological findings on HRCT. Airways disease, interstitial lung disease, and apical subpleural interstitial thickening were common HRCT findings.
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Hanne Beeckmans, Gene P. L. Ambrocio, Saskia Bos, Astrid Vermaut, Vincent Geudens, Arno Vanstapel, Bart M. Vanaudenaerde, Frans De Baets, Thomas L. A. Malfait, Marie-Paule Emonds, Dirk E. Van Raemdonck, Helene M. Schoemans, Robin Vos, Leuven Lung Transplant Grp
Summary: Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by surfactant accumulation, and lung transplantation followed by hematopoietic stem cell transplantation may be an effective treatment for end-stage hereditary PAP-induced pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sikemi Ibikunle, Dolores Grosso, Usama Gergis
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for multiple hematological conditions. The two-step approach to HSCT, described here, aims to achieve an optimal balance in immune recovery, graft-versus-host disease control, and disease control. This review highlights key results from studies over the past two decades and discusses current strategies to optimize graft-versus-tumor effect and limit transplant-related toxicities.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Katarzyna Duda, Agata Wieczorkiewicz-Kabut, Anna Koclega, Patrycja Zielinska, Krzysztof Wozniczka, Helena Krzemien, Anna Armatys, Grzegorz Helbig
Summary: The incidence of acute myeloid leukemia (AML) increases with age, but recent developments in reduced intensity conditioning and supportive care have made allo-HSCT feasible for elderly patients. This study aimed to assess the safety and efficacy of allo-HSCT in elderly AML patients.
ANNALS OF HEMATOLOGY
(2023)
Article
Immunology
Lilli Leimi, Jessica R. Koski, Outi Kilpivaara, Kim Vettenranta, A. Inkeri Lokki, Seppo Meri
Summary: This study investigated genetic complement system variants in patients with documented endotheliopathy and found that variants in complement genes may be related to endotheliopathy and poor prognosis in these patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Peter Riddell, Ram Vasudevan-Nampoothiri, Jin Ma, Lianne G. Singer, Jeff H. Lipton, Stephen C. Juvet
Summary: This study found an increased risk of post-LTx mortality in recipients with previous allo-HSCT, especially related to infections. The 1-year survival rate post-LTx was similar to re-LTx recipients, but the conditional 1-year survival rate was lower. Therefore, optimization of post-LTx immunosuppressive and antimicrobial strategies should be considered in this patient population.
RESPIRATORY RESEARCH
(2021)
Article
Pathology
Saleh Fadel, Patrick J. Villeneuve, Ashish Gupta, Sarah Strickland, Marcio Gomes
Summary: Primary biphasic tumors of the lung are rare, often misdiagnosed as other types of tumors. Diagnosis of lung tumors requires a comprehensive approach incorporating radiographic characteristics, histologic appearance, and immunohistochemical studies.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Cell & Tissue Engineering
Harinad B. Maganti, Aidan M. Kirkham, Adrian J. M. Bailey, Risa Shorr, Natasha Kekre, Nicolas Pineault, David S. Allan
Summary: This systematic review evaluated the efficacy and safety of CRISPR/Cas9 gene editing in combination with CAR-T therapy in animal models of acute leukemia, glioma, melanoma, and other cancers. The edited CAR-T cells were found to reduce tumor volume and improve survival without adverse side effects.
Article
Pathology
Kianoosh Keyhanian, William J. Phillips, Benjamin S. Yeung, Marcio Gomes, Bryan Lo, Harmanjatinder S. Sekhon
Summary: This study provides evidence of significant NE differentiation in B-SqCC through IHC and molecular analysis, showing their aggressive clinical behavior and biological distinction from SqCC. The study suggests that B-SqCC share characteristics with SCLC and differentially express genes related to NOTCH signaling, SCLC, and pulmonary neuroendocrine differentiation.
DIAGNOSTIC PATHOLOGY
(2022)
Article
Hematology
David S. Allan, Meagan Green, Gail Morris, Jason Weiss, Nicholas Dibdin, Dena Mercer, Matthew Seftel
Summary: This study investigates the demand and usage of unrelated allogeneic haematopoietic cell transplantation (HCT) donors and cord blood units (CBUs) at Canadian Blood Services (CBS) during the COVID-19 pandemic. The results show that the demand for adult HCT donors remains stable despite the evolving pandemic, with a transient and recurring increased interest and usage of domestic adult donors. The use of CBUs for pediatric patients has increased and remains elevated.
Review
Cell & Tissue Engineering
Aidan M. Kirkham, Adrian J. M. Bailey, Madeline Monaghan, Risa Shorr, Manoj M. Lalu, Dean A. Fergusson, David S. Allan
Summary: This study confirms that mesenchymal stromal cells (MSCs) may reduce mortality in patients with severe or critical COVID-19 through a living systematic review and meta-analysis. It also suggests the need for a Faster Approval framework to accelerate the accumulation of high-quality evidence and improve standardization in product characterization and outcome reporting.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Cell & Tissue Engineering
Aidan M. Kirkham, Adrian J. M. Bailey, Risa Shorr, Manoj M. Lalu, Dean A. Fergusson, David S. Allan
Summary: MSCs may reduce the risk of death in severe or critical COVID-19 patients and improve secondary clinical outcomes. Variable outcome reporting, inconsistent product characterization, and variable control group treatments remain barriers to higher-quality evidence and may constrain clinical usage.
Article
Cell & Tissue Engineering
An Duong, Gaganvir Parmar, Aidan M. Kirkham, Dylan Burger, David S. Allan
Summary: This scoping review identifies the increasing interest in cell-based therapy using extracellular vesicles (EVs) and highlights the need for standardized product characterization, quantifiable product quality attributes, and consistent outcome reporting in clinical trials to facilitate the clinical translation of EV-based treatment.
Article
Hematology
John T. T. Blake, Gaganvir Parmar, Kathy Ganz, Matthew D. D. Seftel, David S. S. Allan
Summary: Simulated recruitment modeling can help find new donor options for patients who cannot find HLA-matched unrelated donors, especially for certain ethnic groups. The study used historical data and HLA data from the Canadian Blood Services Stem Cell Registry to simulate recruitment cohorts. The results showed that larger recruitment cohorts increased the proportion of novel HLA matches.
Article
Hematology
Adrian J. M. Bailey, John Blake, Kathy Ganz, Matthew D. Seftel, David S. Allan
Summary: Understanding the redundancy and rareness of HLA phenotypes can optimize unrelated donor registries for allogeneic hematopoietic cell transplantation. This study found that there is variation in the redundancy and rareness of HLA phenotypes across ethnic groups. Redundancy was greater in the donor registry compared to the cord blood bank and was most common in the Caucasian ethnicity. Recruiting non-Caucasian donors and continuing cord blood banking can help reduce redundancy and support new donor-supported cellular therapies that do not require HLA matching.
Article
Hematology
Muhammad Bilal Abid, Noel Estrada-Merly, Mei-Jie Zhang, Karen Chen, Christopher Bredeson, David Allan, Mitchell Sabloff, David I. Marks, Mark Litzow, Christopher Hourigan, Partow Kebriaei, Wael Saber
Summary: This retrospective study found that selecting younger unrelated donors can significantly reduce the risk of disease relapse in older ALL patients. However, younger unrelated donors also increase the risk of chronic GVHD and nonrelapse mortality.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Muhammad Bilal Abid, Noel Estrada-Merly, Mei-Jie Zhang, Karen Chen, David Allan, Christopher Bredeson, Mitchell Sabloff, Guru Subramanian Guru Murthy, Talha Badar, Shahrukh Hashmi, Mahmoud Aljurf, Mark R. Litzow, Partow Kebriaei, Christopher S. Hourigan, Wael Saber
Summary: For older patients with AML undergoing alloHCT, the use of younger MUDs is associated with decreased relapse risk and improved DFS compared with the use of older MSDs.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Review
Hematology
Jasmine Candeliere, Aidan M. Kirkham, Risa Shorr, Gail Morris, Philip Berardi, Matthew D. Seftel, David S. Allan
Summary: This study aimed to identify the breadth of donor-derived abnormalities identified by testing HCT recipients and to determine the extent of disclosure and donor follow-up. The findings from 38 studies indicate that diseases in donor-derived cells may impact the post-transplantation risk of illness in the recipient.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Oncology
Glenwood D. Goss, Johanna N. Spaans, David Huntsman, Timothy Asmis, Natalie M. Andrews Wright, Marc Duciaume, Pardeep Kaurah, Ruth R. Miller, Shantanu Banerji, Harmanjatinder S. Sekhon, Marcio M. Gomes
Summary: Inuit, the Indigenous Arctic peoples and residents of Nunavut, have the highest global rate of lung cancer. This study characterizes the histologic and genomic profiles of lung cancer in the Inuit population, showing a high incidence of squamous cell carcinoma (SCC) and an elevated rate of STK11 mutations, distinguishing this group from the North American population.
Review
Cell & Tissue Engineering
Adrian J. M. Bailey, Heidi Li, Aidan M. Kirkham, Alvin Tieu, Harinad B. Maganti, Risa Shorr, Dean A. Fergusson, Manoj M. Lalu, Heidi Elomazzen, David S. Allan
Summary: Extracellular vesicles from mesenchymal stromal cells (MSC-EVs) show promise in accelerating wound healing particularly in diabetic wounds. Studies have shown that MSC-EVs, especially when enriched in specific RNAs, can significantly improve wound closure, blood vessel density, scar width, and re-epithelialisation in preclinical models of diabetic wounds.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Cell & Tissue Engineering
Adrian J. M. Bailey, Alvin Tieu, Manika Gupta, Mitchell Slobodian, Risa Shorr, Tim Ramsay, Rosendo A. Rodriguez, Dean A. Fergusson, Manoj M. Lalu, David S. Allan
Summary: MSC-EVs have mixed effects on tumor growth, with some studies showing inhibition and others showing progression. EVs containing anti-tumor RNAs lead to a significant reduction in tumor growth.
STEM CELL REVIEWS AND REPORTS
(2022)
