Journal
RADIATION RESEARCH
Volume 181, Issue 4, Pages 376-386Publisher
RADIATION RESEARCH SOC
DOI: 10.1667/RR13545.1
Keywords
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Funding
- Nuclear R&D Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2011-0018940, NRF-2012M2B2B1055642]
- National Research Foundation of Korea [2012M2B2B1055642] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Although the diverse effects of ionizing radiation on biological and pathological processes at various levels ranging from molecular to whole body are well studied, the effects on adult stem cells by ionizing radiation remain largely unknown. In this study, we characterized the functional modifications of adult Drosophila midgut intestinal stem cells after ionizing radiation treatment. A dose of 10 Gy of radiation decreased the proliferative capacity of intestinal stem cells. Interestingly, after irradiation at 2 Gy, the intestinal stem cells exhibited increased proliferative activity, misdifferentiation and cH2AvD and 8-oxo-dG levels. In addition, the guts irradiated with 2 Gy showed increased JNK and AKT activities. Furthermore, we showed that 2 Gy of ionizing radiation induced centrosome amplification in intestinal stem cells of adult midguts. Our data gives molecular insights into the effects of ionizing radiation on functional modifications of stem cells. The adult Drosophila midgut intestinal stem cells offer a potentially rich new system for the exploration of the biological effects of ionizing radiation. (C) 2014 by Radiation Research Society
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