Article
Engineering, Biomedical
Alessio Parisi, Keith M. Furutani, Chris J. Beltran
Summary: This study systematically analyzed various biological weighting functions and microdosimetric models, revealing a common issue of overestimation of RBE values at high linear energy transfer. The importance of improving model accuracy was emphasized.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Alessio Parisi, Chris J. Beltran, Keith M. Furutani
Summary: The study developed a new model to accurately describe cell survival under different linear energy transfer conditions, which is of great importance for cancer radiotherapy treatment planning.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alessio Parisi, Chris J. Beltran, Keith M. Furutani
Summary: This article presents the design and application of the Mayo Clinic Florida MKM (MCF MKM) and compares it with the local effect model (LEM). Through extensive benchmarking and predictions with in vitro data, it is found that the MCF MKM can be reliably used for RBE calculations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Tatsuhiko Sato, Shintaro Hashimoto, Taku Inaniwa, Kenta Takada, Hiroaki Kumada
Summary: The study developed two simplified SMK models using TE or FFT, achieving good results in calculating photon isoeffective doses.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Cebastien Joel Guembou Shouop, Serge Mbida Mbembe, Cedric Tayou Kamkumo, Jean Felix Beyala Ateba, Maurice Ndontchueng Moyo, Eric Jilbert Nguelem Mekongtso, Augustin Simo, David Strivay
Summary: The optimum encapsulation of Am-241/Be disused sealed radioactive sources (DSRS) for long-term storage in Cameroon was evaluated using PHITS Monte Carlo simulations. The country's capacity for managing disused neutron sources was also assessed. The computed effective dose rates in the DSRS container were found to be lower than the acceptable limit, indicating compliance with safety regulations. Additionally, the dose profile, neutron flux, and gamma radiation generated from neutron absorption for Am-241/Be source were validated.
SCIENTIFIC REPORTS
(2022)
Article
Astronomy & Astrophysics
Xuemei Chen, Songying Xu, Xiaojian Song, Ran Huo, Xi Luo
Summary: We propose a new method to calculate the astronaut dose rate from galactic cosmic rays in free space at 1 AU. The calculation is based on unshielded isotropic fluence-to-dose conversion coefficients provided by the International Commission on Radiological Protection. A new 3D and time-dependent solar modulation model is used to calculate the galactic cosmic ray spectra at 1 AU. The model is validated against PAMELA and AMS-02 observations, and the calculated dose agrees well with AMS-02 spectra.
SPACE WEATHER-THE INTERNATIONAL JOURNAL OF RESEARCH AND APPLICATIONS
(2023)
Article
Engineering, Biomedical
Taku Inaniwa, Nobuyuki Kanematsu, Makoto Shinoto, Masashi Koto, Shigeru Yamada
Summary: The study developed the OSMK model to incorporate oxygen-pressure dependent cell responses for estimating the biological effectiveness of radiation beams with different LET ranges on radioresistant tumors with oxygen-deficient regions.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Alessio Parisi, Lara Struelens, Filip Vanhavere
Summary: The study utilized simulated microdosimetric lineal energy spectra and a biological weighting function to evaluate experimental uncertainty and investigate biological effectiveness, revealing good agreement between simulated predictions and in vitro data.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alessio Parisi, Chris J. Beltran, Keith M. Furutani
Summary: In order to compute the RBE of ion radiation therapy with the MCF MKM, it is necessary to process entire microdosimetric distributions. However, storing all this data for each clinical voxel is not practical. The purpose of this study is to develop a methodology that allows for a limited amount of physical information storage without losing accuracy in RBE calculations nor the possibility of recalculations.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Bertolet, M. A. Cortes-Giraldo, A. Carabe-Fernandez
Summary: This study implemented RBE calculations in treatment planning systems based on MKM, using LQ curves to determine cell-specific domain radii. Results showed that MKM provided better predictability for experimentally obtained RBE compared to other models.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tatsuhiko Sato, Takuya Furuta, Yuwei Liu, Sadahiro Naka, Shushi Nagamori, Yoshikatsu Kanai, Tadashi Watabe
Summary: An individual dosimetry system was developed for nuclear medicine based on PHITS coupled with the microdosimetric kinetic model, enabling prediction of therapeutic and side effects of TAT. The system showed reliable performance in calculating organ doses from PET-CT images, with a significant decrease of EQDX(alpha/beta) for higher-activity injections in TAT. The system can utilize clinical data from external radiotherapy to enhance precision in nuclear medicine dosimetry.
Article
Engineering, Biomedical
Andrea Attili, Emanuele Scifoni, Francesco Tommasino
Summary: This study investigates the concerns of late toxicities, particularly secondary cancer risk, associated with particle therapy treatments. Through statistical and modeling analysis, the study reveals a strong correlation between the relative biological effectiveness (RBE) for mutation induction and the RBE for survival. The study also introduces the successful application of the microdosimetric kinetic model (MKM) in describing mutation induction, providing a new approach for treatment planning system evaluations.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
B. Kopp, S. Mein, T. Tessonnier, J. Besuglow, S. Harrabi, E. Heim, A. Abdollahi, T. Haberer, J. Debus, A. Mairani
Summary: This study developed and verified the effective dose calculation in helium ion beam therapy based on the modified microdosimetric kinetic model, and evaluated the bio-sensitivity of the plans to clinical parameters. The research utilized fast analytical engine to optimize SOBPs in water and investigate the impact on dose and bio-sensitivity for patient cases. The results suggest that the MRFS-D-RBE calculation approach can be effectively implemented and bio-sensitivity analysis plays a significant role in helium ion therapy planning.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Biology
Mehrdad Shahmohammadi Beni, Kwan Ngok Yu, M. Rafiqul Islam, Hiroshi Watabe
Summary: The Monte Carlo method is a powerful tool for modeling nuclear radiation interaction with matter. In this study, a custom-made GUI bundled with a 3D OpenGL visualizer has been developed for the PHITS MC package. The program focuses on modeling proton induced positron emitting radioisotopes, which can be used for verifying proton ranges in proton therapy. The GUI program is user-friendly and distributed under an open-source license.
JOURNAL OF RADIATION RESEARCH
(2022)
Article
Environmental Sciences
Alessio Parisi, Chris J. Beltran, Keith M. Furutani
Summary: The Mayo Clinic Florida microdosimetric kinetic model (MCF MKM) is a recently developed clonogenic survival model that relies on the parameter values of the linear-quadratic model (LQM) to calculate cell survival rates. This article investigates the influence of fitting the reference photon survival curve on the MCF MKM calculations for two cell lines and ions.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Environmental Sciences
Tatsuhiko Sato, Shin-ichiro Masunaga, Hiroaki Kumada, Nobuyuki Hamada
RADIATION PROTECTION DOSIMETRY
(2019)
Article
Biology
J. Schuemann, A. L. McNamara, J. W. Warmenhoven, N. T. Henthorn, K. J. Kirkby, M. J. Merchant, S. Ingram, H. Paganetti, K. D. Held, J. Ramos-Mendez, B. Faddegon, J. Perl, D. T. Goodhead, I Plante, H. Rabus, H. Nettelbeck, W. Friedland, P. Kundrat, A. Ottolenghi, G. Baiocco, S. Barbieri, M. Dingfelder, S. Incerti, C. Villagrasa, M. Bueno, M. A. Bernal, S. Guatelli, D. Sakata, J. M. C. Brown, Z. Francis, I Kyriakou, N. Lampe, F. Ballarini, M. P. Carante, M. Davidkova, V Stepan, X. Jia, F. A. Cucinotta, R. Schulte, R. D. Stewart, D. J. Carlson, S. Galer, Z. Kuncic, S. Lacombe, J. Milligan, S. H. Cho, G. Sawakuchi, T. Inaniwa, T. Sato, W. Li, A. Solov'yov, E. Surdutovich, M. Durante, K. M. Prise, S. J. McMahon
RADIATION RESEARCH
(2019)
Article
Geosciences, Multidisciplinary
Ryuho Kataoka, Takanori Nishiyama, Yoshimasa Tanaka, Akira Kadokura, Herbert Akihito Uchida, Yusuke Ebihara, Mitsumu K. Ejiri, Yoshihiro Tomikawa, Masaki Tsutsumi, Kaoru Sato, Yoshizumi Miyoshi, Kazuo Shiokawa, Satoshi Kurita, Yoshiya Kasahara, Mitsunori Ozaki, Keisuke Hosokawa, Shoya Matsuda, Iku Shinohara, Takeshi Takashima, Tatsuhiko Sato, Takefumi Mitani, Tomoaki Hori, Nana Higashio
EARTH PLANETS AND SPACE
(2019)
Article
Engineering, Electrical & Electronic
Shinichiro Abe, Wang Liao, Seiya Manabe, Tatsuhiko Sato, Masanori Hashimoto, Yukinobu Watanabe
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lukas M. Carter, Troy M. Crawford, Tatsuhiko Sato, Takuya Furuta, Chansoo Choi, Chan Hyeong Kim, Justin L. Brown, Wesley E. Bolch, Pat B. Zanzonico, Jason S. Lewis
JOURNAL OF NUCLEAR MEDICINE
(2019)
Article
Multidisciplinary Sciences
Yusuke Matsuya, Stephen J. McMahon, Mihaela Ghita, Yuji Yoshii, Tatsuhiko Sato, Hiroyuki Dates, Kevin M. Prise
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Yusuke Matsuya, Toshiaki Nakano, Takeshi Kai, Naoya Shikazono, Ken Akamatsu, Yuji Yoshii, Tatsuhiko Sato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Engineering, Biomedical
Yusuke Matsuya, Tatsuhiko Sato, Rui Nakamura, Shingo Naijo, Hiroyuki Date
PHYSICS IN MEDICINE AND BIOLOGY
(2020)
Article
Nuclear Science & Technology
Hiroshi Yasuda, Kazuaki Yajima, Tatsuhiko Sato
RADIATION MEASUREMENTS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryuichi Yada, Kazusuke Maenaka, Shuji Miyamoto, Go Okada, Aki Sasakura, Motoi Ashida, Masashi Adachi, Tatsuhiko Sato, Tianyuan Wang, Hiroaki Akasaka, Naritoshi Mukumoto, Yasuyuki Shimizu, Ryohei Sasaki
Article
Radiology, Nuclear Medicine & Medical Imaging
Tatsuhiko Sato, Takuya Furuta, Yuwei Liu, Sadahiro Naka, Shushi Nagamori, Yoshikatsu Kanai, Tadashi Watabe
Summary: An individual dosimetry system was developed for nuclear medicine based on PHITS coupled with the microdosimetric kinetic model, enabling prediction of therapeutic and side effects of TAT. The system showed reliable performance in calculating organ doses from PET-CT images, with a significant decrease of EQDX(alpha/beta) for higher-activity injections in TAT. The system can utilize clinical data from external radiotherapy to enhance precision in nuclear medicine dosimetry.
Article
Biology
Tatsuhiko Sato, Shintaro Hashimoto, Taku Inaniwa, Kenta Takada, Hiroaki Kumada
Summary: The study developed two simplified SMK models using TE or FFT, achieving good results in calculating photon isoeffective doses.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takuya Furuta, Tatsuhiko Sato
Summary: PHITS is a general-purpose Monte Carlo simulation code that has been applied in various areas of medical physics, including different types of radiotherapy, shielding calculations, radiation biology applications, and research and development of medical tools. This article explains the useful features of PHITS by referring to actual examples of various medical applications.
RADIOLOGICAL PHYSICS AND TECHNOLOGY
(2021)
Article
Nuclear Science & Technology
Yosuke Iwamoto, Shintaro Hashimoto, Tatsuhiko Sato, Norihiro Matsuda, Satoshi Kunieda, Yurdunaz Celik, Naoya Furutachi, Koji Niita
Summary: The benchmark study of PHITS version 3.24 using neutron-shielding experiments from SINBAD demonstrated satisfactory overall agreements when simulating neutron- and proton-induced reactions up to 200 MeV with JENDL-4.0/HE, but discrepancies were found in neutron production and scatterings at energies below 100 MeV using default settings in the code system. It was concluded that using JENDL-4.0/HE in PHITS calculations is preferable.
JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY
(2022)
Article
Nuclear Science & Technology
Tatsuhiko Sato, Yosuke Iwamoto, Shintaro Hashimoto, Tatsuhiko Ogawa, Takuya Furuta, Shin-Ichiro Abe, Takeshi Kai, Yusuke Matsuya, Norihiro Matsuda, Yuho Hirata, Takuya Sekikawa, Lan Yao, Pi-En Tsai, Hunter N. Ratliff, Hiroshi Iwase, Yasuhito Sakaki, Kenta Sugihara, Nobuhiro Shigyo, Lembit Sihver, Koji Niita
Summary: PHITS is a general-purpose Monte Carlo radiation transport code. The latest version, PHITS3.33, improves the compatibility with nuclear data libraries and the algorithm of the track-structure modes, and adds new utility functions and software. It can be applied in various fields of research.
JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY
(2023)