Article
Medicine, General & Internal
Michaela Kreuzer, Veronika Deffner, Maria Schnelzer, Nora Fenske
Summary: Underground miners employed by Wismut AG exhibited significantly higher mortality rates due to silicosis/other pneumoconiosis and lung cancer. Different levels of exposure to radon and respirable crystalline silica led to increased mortality rates for different diseases, with this impact still evident more than 20 years after Wismut AG ceased its activities.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Biology
M. Kreuzer, V. Deffner, M. Sommer, N. Fenske
Summary: UNSCEAR recently recommended focusing future research on the lung cancer risk from low radon exposures or exposure rates on contemporary uranium miners. To meet this recommendation, risk models in the German Wismut cohort were updated using an extended follow-up period. The results showed that lung cancer risk decreased with older age, longer time since exposure, and higher exposure rates among uranium miners, emphasizing the importance of radiation protection against radon.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Public, Environmental & Occupational Health
D. B. Richardson, E. Rage, P. A. Demers, M. T. Do, N. DeBono, N. Fenske, V Deffner, M. Kreuzer, J. Samet, C. Wiggins, M. K. Schubauer-Berigan, K. Kelly-Reif, L. Tomasek, L. B. Zablotska, D. Laurier
Summary: The Pooled Uranium Miners Analysis (PUMA) study found increased mortality rates among uranium miners due to various causes of death, including lung cancer and silicosis. It highlights the importance of long-term follow-up of these workers to monitor health outcomes over time.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Fabian Jost-Brinkmann, Muenevver Demir, Alexander Wree, Tom Luedde, Sven H. Loosen, Tobias Mueller, Frank Tacke, Christoph Roderburg, Raphael Mohr
Summary: The combination of atezolizumab and bevacizumab has been established as the standard treatment for unresectable hepatocellular carcinoma. However, concerns about its efficacy in non-viral HCC and its safety in patients with advanced cirrhosis remain. This study found that atezolizumab plus bevacizumab showed good efficacy and safety in patients with unresectable HCC, including those with advanced cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Engineering, Chemical
Di Zhang, Lin Fang, Lijie Liu, Bing Zhao, Baowei Hu, Shujun Yu, Xiangke Wang
Summary: There are abundant uranium resources in the ocean and seawater uranium extraction is a way to regenerate uranium resources with high potential value. The adsorption method has become one of the most commonly used techniques for uranium extraction from seawater due to its low cost, simple operation, practicality, and environmental friendliness. This review introduces commonly used adsorbents, lists the main influencing factors of seawater uranium extraction by adsorption, presents experimental examples of advanced techniques, and discusses the opportunities and challenges in seawater uranium extraction.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Virology
Erwan Sallard, Frank Schult, Carolin Baehren, Eleni Buedding, Olivier Mboma, Parviz Ahmad-Nejad, Beniam Ghebremedhin, Anja Ehrhardt, Stefan Wirth, Malik Aydin
Summary: Respiratory viruses play a significant role in exacerbating asthma, and human rhinovirus (HRV) infection is a strong biomarker for exacerbation.
Review
Environmental Sciences
Sourav Prusty, Prathap Somu, Jitendra Kumar Sahoo, Debasish Panda, Sunil Kumar Sahoo, Shraban Kumar Sahoo, Yong Rok Lee, T. Jarin, L. Syam Sundar, Koppula Srinivas Rao
Summary: Groundwater contamination, particularly the pollution caused by nuclear power plants and their by-products, is a significant concern. Adsorption has emerged as a simple, effective, and cost-efficient method for addressing this issue.
Article
Hematology
Franz Ewendt, Marvin Schmitt, Alexander Kluttig, Julia Kuehn, Frank Hirche, Frank B. Kraus, Beatrice Ludwig-Kraus, Rafael Mikolajczyk, Wim Waetjen, Paul-Christian Buerkner, Michael Foeller, Gabriele I. Stangl
Summary: Vitamin D can regulate apoptosis, including a special form called eryptosis, which is associated with diseases such as sepsis, malaria, and iron deficiency. This study is the first to link vitamin D with eryptosis in humans. It found a weak but clear correlation between low vitamin D status and increased eryptosis, raising questions about the importance of vitamin D for anemia or cardiovascular events.
ANNALS OF HEMATOLOGY
(2023)
Article
Clinical Neurology
Thomas Sauvigny, Henrik Giese, Julius Hoehne, Karl Michael Schebesch, Christian Henker, Andreas Strauss, Kerim Beseoglu, Niklas von Spreckelsen, Jurgen A. Hampl, Jan Walter, Christian Ewald, Aleksandrs Krigers, Ondra Petr, Vicki M. Butenschoen, Sandro M. Krieg, Christina Wolfert, Khaled Gaber, Klaus Christian Mende, Thomas Bruckner, Oliver Sakowitz, Dirk Lindner, Jan Regelsberger, Dorothee Mielke
Summary: The authors analyzed 502 patients in a prospective multicenter database to evaluate early surgery-related complications after cranioplasty. They found that 46% of patients used autologous bone flaps for CP, with titanium, polyetheretherketone, and polymethylmethacrylate being the most common engineered materials.
JOURNAL OF NEUROSURGERY
(2022)
Article
Engineering, Biomedical
Tobias Hepp, Dominik Blum, Karim Armanious, Bernhard Schoelkopf, Darko Stern, Bin Yang, Sergios Gatidis
Summary: This study utilizes Deep Learning to predict brain aging with high accuracy, but insufficiently addresses uncertainty and physiological variability. By implementing a neural network model and providing visual explanations, the study aims to explore physiological patterns in brain aging.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2021)
Article
Environmental Sciences
Catalina Ciocan, Enrico Pira, Maurizio Coggiola, Nicolo Franco, Alessandro Godono, Carlo La Vecchia, Eva Negri, Paolo Boffetta
Summary: The long-term follow-up study on talc miners and millers in Northern Italy showed no association between talc exposure without detectable asbestos levels and lung cancer or mesothelioma. However, there was a significant increase in mortality from pneumoconiosis, particularly among miners, which was linked to past exposure to silica. The risk of pneumoconiosis increased with longer duration of employment in the cohort, with miners having a higher risk compared to millers.
ENVIRONMENTAL RESEARCH
(2022)
Article
Health Care Sciences & Services
Nico Riedel, Susanne Wieschowski, Till Bruckner, Martin R. Holst, Hannes Kahrass, Edris Nury, Joerg J. Meerpohl, Maia Salholz-Hillel, Daniel Strech
Summary: This study aims to evaluate the performance of German university medical centers in timely dissemination of clinical trial results in recent years. The study found that despite minor improvements compared to previous samples, the proportion of timely reported trials led by German UMCs remains low.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Oncology
Annika Stock, Caroline-Viktoria Hancken, Daniela Kandels, Rolf-Dieter Kortmann, Stefan Dietzsch, Beate Timmermann, Torsten Pietsch, Brigitte Bison, Rene Schmidt, Mirko Pham, Astrid Katharina Gnekow, Monika Warmuth-Metz
Summary: This study evaluated the occurrence of pseudoprogression (PsPD) in pediatric low-grade glioma (LGG) after radiation therapy and investigated the frequency and duration of PsPD in different radiation therapy modalities. The study found that PsPD is common in pediatric LGG and independent of the radiation therapy modality.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Environmental Studies
Xaquin S. Perez-Sindin, Kristof Van Assche
Summary: This article addresses the survival of social identities associated with resource extraction, emphasizing the importance of state planning and a central actor in shaping social, political, and economic life. It highlights the concept of symbolic violence and the internalization of identities and categories promoted by actors benefiting from the current social order.
Article
Public, Environmental & Occupational Health
Xiaoke Zeng, Nathan L. DeBono, Anne M. Harris, Victoria H. Arrandale, Paul A. Demers
Summary: The study examined the association between employment in mining occupations and industries and the incidence of neurological diseases. Results suggested that workers in mining occupations and industries may have elevated rates of neurodegenerative diseases, highlighting the need for further research in this area.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Lydia B. Zablotska, Nora Fenske, Maria Schnelzer, Sergey Zhivin, Dominique Laurier, Michaela Kreuzer
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2018)
Review
Biology
M. Kreuzer, A. Auvinen, E. Cardis, M. Durante, M. Harms-Ringdahl, J. R. Jourdain, B. G. Madas, A. Ottolenghi, S. Pazzaglia, K. M. Prise, R. Quintens, L. Sabatier, S. Bouffler
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2018)
Article
Biology
M. Kreuzer, C. Sobotzki, M. Schnelzer, N. Fenske
RADIATION RESEARCH
(2018)
Review
Biology
K. N. Apsalikov, A. Lipikhina, B. Grosche, T. Belikhina, E. Ostroumova, S. Shinkarev, V. Stepanenko, T. Muldagaliev, S. Yoshinaga, T. Zhunussova, M. Hoshi, H. Katayama, D. T. Lackland, S. L. Simon, A. Kesminiene
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2019)
Article
Biology
Takamitsu Morioka, Benjamin J. Blyth, Tatsuhiko Imaoka, Mayumi Nishimura, Hiroshi Takeshita, Takeo Shimomura, Jun Ohtake, Atsuro Ishida, Paul Schofield, Bernd Grosche, Ulrike Kulka, Yoshiya Shimada, Yutaka Yamada, Shizuko Kakinuma
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Estelle Rage, David B. Richardson, Paul A. Demers, Minh Do, Nora Fenske, Michaela Kreuzer, Jonathan Samet, Charles Wiggins, Mary K. Schubauer-Berigan, Kaitlin Kelly-Reif, Ladislav Tomasek, Lydia B. Zablotska, Dominique Laurier
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2020)
Article
Medicine, General & Internal
Michaela Kreuzer, Veronika Deffner, Maria Schnelzer, Nora Fenske
Summary: Underground miners employed by Wismut AG exhibited significantly higher mortality rates due to silicosis/other pneumoconiosis and lung cancer. Different levels of exposure to radon and respirable crystalline silica led to increased mortality rates for different diseases, with this impact still evident more than 20 years after Wismut AG ceased its activities.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Environmental Sciences
Enora Clero, Evgenia Ostroumova, Claire Demoury, Bernd Grosche, Ausrele Kesminiene, Liudmila Liutsko, Yvon Motreff, Deborah Oughton, Philippe Pirard, Agnes Rogel, An Van Nieuwenhuyse, Dominique Laurier, Elisabeth Cardis
Summary: Exposure of the thyroid gland to ionizing radiation at a young age is the main recognized risk factor for differentiated thyroid cancer. Cancer screening aims to reduce morbidity and mortality, but can also have negative effects, thus requiring a proper evaluation of the benefits and risks of screening.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
D. B. Richardson, E. Rage, P. A. Demers, M. T. Do, N. DeBono, N. Fenske, V Deffner, M. Kreuzer, J. Samet, C. Wiggins, M. K. Schubauer-Berigan, K. Kelly-Reif, L. Tomasek, L. B. Zablotska, D. Laurier
Summary: The Pooled Uranium Miners Analysis (PUMA) study found increased mortality rates among uranium miners due to various causes of death, including lung cancer and silicosis. It highlights the importance of long-term follow-up of these workers to monitor health outcomes over time.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Omid Azimzadeh, Maria Gomolka, Mandy Birschwilks, Shin Saigusa, Bernd Grosche, Simone Moertl
Summary: Studies have shown that archived FFPE tissue samples provide reliable materials for retrospective molecular fingerprinting and biomarker investigation of diseases and susceptibility. However, challenges remain in omics profiling of FFPE samples due to tissue fixation and extraction methods. Application of advanced omics technologies on archived materials offers new opportunities to enhance research and evaluation of radiation exposure biological effects.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
David B. Richardson, Estelle Rage, Paul A. Demers, Minh T. Do, Nora Fenske, Veronika Deffner, Michaela Kreuzer, Jonathan Samet, Stephen J. Bertke, Kaitlin Kelly-Reif, Mary K. Schubauer-Berigan, Ladislav Tomasek, Lydia B. Zablotska, Charles Wiggins, Dominique Laurier
Summary: A study of 57,873 male uranium miners in different countries showed a linear relationship between radon progeny exposure and lung cancer mortality. The association is also influenced by factors such as attained age, age at exposure, and annual exposure rate.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Biology
Lydia B. Zablotska, David B. Richardson, Ashley Golden, Elisa Pasqual, Brian Smith, Estelle Rage, Paul A. Demers, Minh Do, Nora Fenske, Veronika Deffner, Michaela Kreuzer, Jonathan Samet, Stephen Bertke, Kaitlin Kelly-Reif, Mary K. Schubauer-Berigan, Ladislav Tomasek, Charles Wiggins, Dominque Laurier, Iulian Apostoaei, Brian A. Thomas, Steven L. Simon, F. Owen Hoffman, John D. Boice, Lawrence T. Dauer, Sara C. Howard, Sarah S. Cohen, Michael T. Mumma, Elizabeth D. Ellis, Keith F. Eckerman, Rich W. Leggett, David J. Pawel
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kaitlin Kelly-Reif, Stephen J. Bertke, Estelle Rage, Paul A. Demers, Nora Fenske, Veronika Deffner, Michaela Kreuzer, Jonathan Samet, Mary K. Schubauer-Berigan, Ladislav Tomasek, Lydia B. Zablotska, Charles Wiggins, Dominique Laurier, David B. Richardson
Summary: This study is the largest and most up-to-date pooled study of uranium miners, involving 7 cohorts of male uranium miners with 7754 lung cancer deaths and 4.3 million person-years of follow-up. The study found a linear exposure-response relationship between cumulative radon exposure and lung cancer mortality, which is modified by temporal and exposure factors.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Review
Medicine, General & Internal
Mark P. Little, Tamara Azizova, David B. Richardson, Soile Tapio, Marie-Odile Bernier, Michaela Kreuzer, Francis A. Cucinotta, Dimitry Bazyka, Vadim Chumak, Victor K. Ivanov, Lene H. S. Veiga, Alicia Livinski, Kossi Abalo, Lydia B. Zablotska, Andrew J. Einstein, Nobuyuki Hamada
Summary: This study conducted a systematic review and meta-analysis on the radiation associated risks of cardiovascular disease. The results showed a causal association between radiation exposure and cardiovascular disease, especially at high dose. However, the heterogeneity among studies complicates the interpretation of the findings and further research is needed to explore the modifications of radiation effect by lifestyle and medical risk factors.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Biology
M. Kreuzer, V. Deffner, M. Sommer, N. Fenske
Summary: UNSCEAR recently recommended focusing future research on the lung cancer risk from low radon exposures or exposure rates on contemporary uranium miners. To meet this recommendation, risk models in the German Wismut cohort were updated using an extended follow-up period. The results showed that lung cancer risk decreased with older age, longer time since exposure, and higher exposure rates among uranium miners, emphasizing the importance of radiation protection against radon.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
