Review
Oncology
Stanley Gutiontov, Sean P. Pitroda, Phuoc T. Tran, Ralph R. Weichselbaum
Summary: The understanding of oligometastatic state has evolved, emphasizing that cancer metastasis represents a spectrum of disease. Recent clinical trials have shown improvements in cancer-specific outcomes with the use of metastasis-directed local therapies. Biological aspects of oligometastases, including genetic, epigenetic, and immune determinants, were discussed along with considerations for future clinical trial design for patients with oligometastatic disease.
Article
Oncology
Ping-Chung Tsai, Hung-Che Chien, Po-Kuei Hsu, Jung-Jyh Hung, Chien-Sheng Huang, Wen-Hu Hsu, Han-Shui Hsu
Summary: This study aimed to evaluate the role of surgical resection in patients with resectable recurrences after curative esophagectomy and to identify their prognostic factors. The study found that mediastinum lymph node recurrence and pathologic T3 stage were associated with worse overall survival (OS) and post-recurrence survival (PRS). No definite survival benefit was noted in patients undergoing surgery for resectable recurrence, except in those without comorbidities.
Article
Oncology
J. Janssen, F. H. E. Staal, C. L. Brouwer, J. A. Langendijk, I. J. de Jong, R. J. A. van Moorselaar, E. Schuit, J. F. Verzijlbergen, R. J. Smeenk, S. Aluwini
Summary: This phase III randomized controlled trial aims to assess the potential benefits of adding 6 months of ADT to MDRT in oligo-recurrent PCa patients, in order to improve metastases progression-free survival, toxicity, quality of life, and overall survival.
Article
Oncology
So Jeong Yoon, Seung Soo Hong, Min Jae Gwon, Sang Hyun Shin, Jin Seok Heo, Chang Moo Kang, Kyung Sik Kim, Ho Kyoung Hwang, In Woong Han
Summary: This study aimed to assess the impact of local control (surgical resection or radiofrequency ablation) on survival outcomes in patients with oligo-recurrent distal extrahepatic bile duct (EHBD) cancer. The results showed that patients with local recurrence had better recurrence-free and overall survival compared to those with non-local recurrence. Factors such as lymph node ratio, perineural invasion, timing of recurrence, and platelet-to-lymphocyte ratio at recurrence were found to be independent risk factors for post-recurrence survival in the oligo-recurrent group. Local treatment was associated with improved 3- and 5-year post-recurrence survival in patients with oligo-recurrence, particularly for those with recurrence more than 2 years after initial resection.
Review
Medicine, General & Internal
Alice Bellini, Sara Mazzarra, Sara Sterrantino, Desideria Argnani, Franco Stella
Summary: Malignant pleural mesothelioma is an aggressive asbestos-related tumor with poor prognosis. Multimodality treatment is currently the standard therapy, and the goal of surgery is to achieve complete resection. The treatment for recurrent MPM has not been established, and the role of surgery in this context is still controversial.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Dai Sonoda, Yosuke Matsuura, Yasuto Kondo, Junji Ichinose, Masayuki Nakao, Hironori Ninomiya, Makoto Nishio, Sakae Okumura, Yukitoshi Satoh, Mingyon Mun
Summary: The optimal definition of oligo-recurrence in non-small-cell lung cancer (NSCLC) remains unclear. A retrospective study found that patients with 1 or 2 recurrences who underwent local therapy had longer postrecurrence survival (PRS), suggesting a potential for cure. Therefore, defining oligo-recurrence in NSCLC as the presence of 1 or 2 recurrences treated with local therapy may be reasonable.
CLINICAL LUNG CANCER
(2022)
Review
Oncology
Michael Mayinger, Rupesh Kotecha, Arjun Sahgal, Mi-Sook Kim, Simon S. Lo, Alexander V. Louie, Marta Scorsetti, Ben Slotman, Matthias Guckenberger
Summary: This study aims to develop the practice guideline of the International Stereotactic Radiosurgery Society (ISRS) based on a systematic review of treatment characteristics, outcomes, and treatment-related toxicities of stereotactic body radiation therapy (SBRT) for pulmonary oligometastases. The study included 1884 articles reporting on the treatment of over 3600 patients and 4650 metastases. The results demonstrated that SBRT has high local control rates and low risk of radiation-induced toxicities.
Article
Oncology
Tae Hyung Kim, Taek-Keun Nam, Sang Min Yoon, Tae Hyun Kim, Young Min Choi, Jinsil Seong
Summary: This multi-institutional retrospective study investigated the clinical efficacy of SABR in patients with oligometastatic hepatocellular carcinoma. The results showed that SABR appeared to be an effective and safe treatment for all metastatic lesions. Patients with good performance status and liver function could achieve long-term survival.
Article
Endocrinology & Metabolism
Marilyne Daher, Jeena Varghese, Stephen K. Gruschkus, Camilo Jimenez, Steven G. Waguespack, Sara Bedrose, Lina Altameemi, Hadil Bazerbashi, Aung Naing, Vivek Subaiah, Matthew T. Campbell, Amishi Y. Shah, Miao Zhang, Rahul A. Sheth, Jose A. Karam, Christopher G. Wood, Nancy D. Perrier, Paul H. Graham, Jeffery E. Lee, Mouhammed Amir Habra
Summary: This study reports that the disease burden and clinical outcomes of adrenocortical carcinoma (ACC) have improved over the past two decades. More patients underwent complete surgical resection and received multiple lines of systemic therapy, indicating the importance of these advancements for guiding management strategies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Meritxell Molla, Julen Fernandez-Plana, Santiago Albiol, Constantino Fondevila, Ivan Vollmer, Carla Cases, Angeles Garcia-Criado, Jaume Capdevila, Carles Conill, Yliam Fundora, Carlos Fernandez-Martos, Estela Pineda
Summary: The prognosis for oligometastatic colorectal cancer has improved due to recent advances in new techniques and approaches such as new surgical procedures, better systemic treatments, percutaneous ablation, and stereotactic body radiation therapy. Factors to consider when deciding on the best approach include tumor factors, patient factors, and physician factors. These advances have presented challenges and opportunities for oncologic multidisciplinary teams to treat patients with limited liver and lung metastases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Ali Sabbagh, Osama Mohamad, Katie E. Lichter, Thomas A. Hope
Summary: PSMA PET is increasingly used in the management of prostate cancer patients, improving accuracy in disease detection and changing clinical management. However, it is unclear whether this leads to improved patient survival or quality of life.
Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Soraya Puglisi, Anna Calabrese, Francesco Ferrau, Maria Antonia Violi, Marta Lagana, Salvatore Grisanti, Filippo Ceccato, Carla Scaroni, Guido Di Dalmazi, Antonio Stigliano, Barbara Altieri, Letizia Canu, Paola Loli, Rosario Pivonello, Emanuela Arvat, Valentina Morelli, Paola Perotti, Vittoria Basile, Paola Berchialla, Sara Urru, Cristian Fiori, Francesco Porpiglia, Alfredo Berruti, Anna Pia, Giuseppe Reimondo, Salvatore Cannavo, Massimo Terzolo
Summary: This study retrospectively analyzed 512 patients with ACC diagnosed in 12 referral centers in Italy from January 1990 to June 2018. The results showed that ACC is predominantly diagnosed as incidentalomas, with female patients being younger and having smaller tumors that more frequently secrete hormones. Surgery is mainly performed through open approach, and adjuvant mitotane therapy is commonly used. Recurrence and death rates are high, and recurrence-free survival predicts overall survival. ACCs presenting as adrenal incidentalomas have a better prognosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sae-Jin Park, Jung Hoon Kim, Ijin Joo, Kyoung Bun Lee, Joon Koo Han
Summary: The study found that EPNI and TRG may be important factors affecting RFS and OS in patients with pancreatic ductal adenocarcinoma who underwent surgery after neoadjuvant FOLFIRINOX. EPNI and TRG were identified as significant predictors of early recurrence and overall survival, indicating their prognostic value in this context.
EUROPEAN RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Anna Calabrese, Soraya Puglisi, Chiara Borin, Vittoria Basile, Paola Perotti, Anna Pia, Paola Berchialla, Marco Volante, Cristian Fiori, Francesco Porpiglia, Andrea Veltri, Giuseppe Reimondo, Massimo Terzolo
Summary: The management of adrenocortical carcinoma (ACC) recurrences remains controversial. In this retrospective analysis, ACC recurrences were found to occur as a single lesion, multiple lesions in a single organ, or affecting multiple organs. Patients with a single lesion recurrence had a better prognosis, suggesting the use of locoregional treatments for ACC recurrence.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Laigang Hu, Wenhao Wu, Li Gong, Hongxia Zhu, Ling Jiang, Min Hu, Daohui Lin, Kun Yang
Summary: In this study, a novel metal-organic framework (MOF) called ZJU-620(Al) was synthesized using low toxic aluminum (Al) as the metal. ZJU-620(Al) has a uniform micropore size of 8.37 +/- 0.73 angstrom and a specific surface area of 1347 m(2) g(-1). It shows excellent chemical-thermal stability and adsorption for trace BTEX.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Meteorology & Atmospheric Sciences
Xu Yuan, Kun Yang, Hui Lu, Yan Wang, Xiaogang Ma
Summary: This study clarifies the impacts of moisture transport between the lower layer and the upper layer through and over the Yarlung Tsangpo Grand Canyon (YTGC). The results show that moisture transport in the lower layer through the YTGC is critical to precipitation in the YTGC, while moisture transport in the upper layer over the YTGC is more important to precipitation in the eastern Tibetan Plateau (TP).
ATMOSPHERIC RESEARCH
(2023)
Article
Meteorology & Atmospheric Sciences
Jing Sun, Kun Yang, Hui Lu, Xu Zhou, Xin Li, Yingying Chen, Weidong Guo, Jonathon S. Wright
Summary: This study comprehensively explores the effects of soil organic matter (SOM) on the hydrothermal state of the land-atmosphere system on the eastern Tibetan Plateau. The results show that SOM can improve the simulations by reducing cold and wet biases, increasing air temperature, decreasing humidity, and reducing precipitation. Including SOM in climate models not only improves the representation of atmospheric energy and water cycles, but also enhances the simulation of frozen soil evolution with increased confidence and reliability.
JOURNAL OF HYDROMETEOROLOGY
(2023)
Article
Environmental Sciences
Jun Qin, Min He, Wei Yang, Ning Lu, Ling Yao, Hou Jiang, Jin Wu, Kun Yang, Chenghu Zhou
Summary: The Tibetan Plateau is experiencing rapid warming, leading to increased glacial melting and natural hazards. However, due to a lack of high-quality, long-term observations, there is no complete understanding of its temperature status in the past few decades. This study uses satellite and weather station data to derive long-term surface air temperatures, revealing widespread warming across the plateau, particularly in the western region. The derived warming rate is higher than other datasets, implying a severe threat to the cryosphere.
REMOTE SENSING OF ENVIRONMENT
(2023)
Article
Environmental Sciences
Xiaoming Tao, Jiang Xu, Kun Yang, Daohui Lin
Summary: The new paradigm in wastewater treatment focuses on resource recovery, especially for non-renewable phosphorus (P). Nanomaterial-based adsorption technology, such as oxymagnesite/green rust (OMGR) nanohybrids, offers high efficiency and selectivity for P recovery from wastewater. OMGR demonstrated excellent selectivity for phosphate removal, wide pH adaptability, and a high removal capacity of 141 mg P.g-1. Phosphate-loaded OMGR also acted as a slow-release P-fertilizer, providing a green and eco-friendly approach to P resource recovery and reuse.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Computer Science, Artificial Intelligence
Fan Meng, Kunlin Yang, Yichen Yao, Zhibin Wang, Tao Song
Summary: Tropical cyclones are extreme disasters with significant impact on human beings, and forecasting their intensity has been a challenging task. Deep learning-based intensity forecasting has shown potential to outperform traditional methods, but inherent uncertainty in weather forecasting needs to be quantified for decision-making and risk assessment. This study proposes an intelligent system, PTCIF, based on deep learning to quantify uncertainty using multimodal meteorological data, the first study to assess uncertainty of tropical cyclones using a deep learning approach. Probabilistic forecasts are made for the intensity of 6-24 hours, showing comparable performance to weather forecast centers in terms of deterministic forecasts. Reliable prediction intervals and probabilistic forecasts are obtained, which are crucial for disaster warning and expected to complement operational models.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2023)
Article
Engineering, Environmental
Hongyuan Zheng, Zhiyi Chen, Kunde Yang, Kaiyan Xiao, Jincai Zhu, Zhiwei Gao, Zheyi Han, Yanguang Liu, Minghong Cai
Summary: Current-use Organoamine Pesticides (CUOAPs) are emerging pesticide pollutants found in Chinese Marginal Seas (CMSs), with the highest levels detected in the East China Sea. The Yangtze and Yellow rivers play a crucial role as significant terrestrial sources, leading to variations in the source, distribution, and seasonal patterns of CUOAPs. Spatial redistribution occurs through ocean current transport, resulting in significant regional disparities. CMSs may become a secondary source region for the surrounding seas.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Limin Duan, Huihao Jiang, Wenhao Wu, Daohui Lin, Kun Yang
Summary: Introducing crystal defects into iron-based metal-organic frameworks (Fe-MOFs) is a promising strategy to enhance Fenton-like performance. However, developing a facile and effective strategy to construct defective Fe-MOFs as highly efficient Fenton-like catalysts is still challenging. In this study, MIL-100(Fe) (Def-MIL-100 (Fe)) with missing ligand defects was synthesized by a simple heterogeneous reaction, and it exhibited significantly higher Fenton-like activity compared to the perfect MIL-100(Fe). The missing ligand defects played a key role in promoting fast H2O2 adsorption, accelerating electron transfer, and improving OH generation and utilization efficiency.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Civil
Yanbin Lei, Tandong Yao, Yongwei Sheng, Kun Yang, Wei Yang, Shenghai Li, Jing Zhou, Yaozhi Jiang, Yifan Yu
Summary: Extreme events on the Tibetan Plateau, such as unprecedented lake expansion, have become more frequent and severe due to climate warming and moistening. This expansion, attributed to abnormally high precipitation, poses a substantial threat to regional ecosystems, infrastructure, and habitats. Therefore, it is necessary to identify threatened areas using satellite images and conduct real-time observations of lake level changes.
JOURNAL OF HYDROLOGY
(2023)
Article
Multidisciplinary Sciences
Vagner Ferreira, Bin Yong, Henry Montecino, Christopher E. E. Ndehedehe, Kurt Seitz, Hansjoerg Kutterer, Kun Yang
Summary: The availability and use of terrestrial water storage anomaly (TWSA) data from Gravity Recovery and Climate Experiment (GRACE) supports various hydrological applications. There are currently five operational TWSA products, three based on mass concentration (mascon) solutions and two based on spherical harmonic coefficients (SHCs) synthesis. This study presents a new TWSA data set based on novel processing protocols, with a spatial re-sampling of 0.25 arc-degrees from 2002 to 2022, which reliably agrees with mascon solutions. The proposed data set would be valuable for regional hydrological applications, particularly for improved assessment of regional water budgets.
Article
Medicine, General & Internal
Bing Wang, Wenzhi Gao, Kunlin Yang, Honglei Liu, Yangjun Han, Mingxin Diao, Chao Zuo, Minghua Zhang, Yingzhi Diao, Zhihua Li, Xinfei Li, Gang Wang, Peng Zhang, Chunji Wang, Chunjuan Xiao, Chen Huang, Yaming Gu, Xuesong Li
Summary: This study aimed to investigate the efficacy of balloon dilation in ureteral stricture and analyze the risk factors for its failure. A retrospective analysis of 196 patients who underwent balloon dilation was conducted, with 127 patients having complete data. The success rates of balloon dilation and balloon dilation combined with endoureterotomy for lower ureteral stricture were higher compared to other cases. Balloon circumference and multiple ureteral strictures were identified as risk factors for balloon dilation failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Fang Li, Yishui Shui, Jiayao Liang, Kun Yang, Junyi Yu
Summary: By modeling the measured data of marine wireless channels and creating sea surface morphology models under multiple wind speeds, this paper calculates the radio propagation characteristics of the Pearl River estuary and estimates the path loss in the same area under different conditions using the Monte Carlo method. The simulation results show that the electric wave propagation gradually changes from the round earth loss (REL) model to the free space model with increasing wind speed. The distribution of the shadow fading varies with distance. The findings provide references for the network planning of marine communication.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Oncology
Fangyuan Zhou, You Qin, Xixi Liu, Jing Huang, Bian Wu, Zhanjie Zhang, Zhongyuan Yin, Jinsong Yang, Sheng Zhang, Ke Jiang, Kunyu Yang
Summary: This study evaluates the efficacy and safety of thoracic radiotherapy in patients with stage IV non-small-cell lung cancer (NSCLC) treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). The findings show that the combination of EGFR inhibitors and thoracic radiotherapy significantly improves overall survival but not progression-free survival. Therefore, preemptive thoracic radiotherapy during EGFR-TKI treatment could be considered as a competitive first-line therapeutic option with superior progression-free survival and a lower incidence of side effects.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Geosciences, Multidisciplinary
Yaozhi Jiang, Kun Yang, Youcun Qi, Xu Zhou, Jie He, Hui Lu, Xin Li, Yingying Chen, Xiaodong Li, Bingrong Zhou, Ali Mamtimin, Changkun Shao, Xiaogang Ma, Jiaxin Tian, Jianhong Zhou
Summary: This study produced a high-resolution long-term precipitation dataset (TPHiPr) for the Third Pole region by merging atmospheric simulation-based ERA5_CNN and gauge observations. The dataset showed higher accuracy and better detection of precipitation extremes compared to widely used datasets. It has broad applications in meteorological, hydrological, and ecological studies.
EARTH SYSTEM SCIENCE DATA
(2023)
Article
Urology & Nephrology
Zhihua Li, Xiang Wang, Yicen Ying, Xinfei Li, Weijie Zhu, Chang Meng, Guanpeng Han, Jing Liu, Jie Wang, Yanbo Huang, Kunlin Yang, Peng Zhang, Hongjian Zhu, Hua Guan, Xuesong Li, Liqun Zhou
Summary: This study evaluated the health-related quality of life, anxiety, and depression levels in patients with ureteral stricture (US) and identified independent factors affecting these outcomes. The results showed that patients with US had poor quality of life and emotional well-being. Factors such as increased age, female gender, and higher education level were associated with worse health-related quality of life. Additionally, iatrogenic US, nephrostomy tube placement, urinary symptoms, and high levels of anxiety and depression independently predicted poorer quality of life.
WORLD JOURNAL OF UROLOGY
(2023)
