Article
Oncology
Zsuzsa S. Kocsis, Gyoengyi Farkas, Andras Bajcsay, Marta Kun-Gazda, Jozsef Loevey, Gyula Ostoros, Tamas Pocza, Andras Herein, Katalin Ladanyi, Gabor Szekely, Zsolt Markoczy, Zoltan Takacsi-Nagy, Csaba Polgar, Zsolt Juranyi
Summary: This study found that chromosome aberrations resulting from in vitro irradiation can serve as a predictive marker for lung function decrease after lung irradiation, helping to personalize treatment. The tendency of respiratory function measurements to decrease can be predicted by chromosomal aberration data.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Igor K. K. Khvostunov, Elena Nasonova, Valeriy Krylov, Andrei Rodichev, Tatiana Kochetova, Natalia Shepel, Olga Korovchuk, Polina Kutsalo, Petr Shegai, Andrei Kaprin
Summary: This study evaluates the cytogenetic damage induced by radioiodine therapy (RIT) in two rare differentiated thyroid cancer (DTC) cases, including the first follow-up study of a pediatric DTC patient. The results show that the risk of cytogenetic damage from RIT is low and a one-time administration of RIT is safe as long as the whole-body dose does not exceed 2 Gy. However, individual planning based on cytogenetic biodosimetry is strongly recommended for rare cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Anna Embring, Eva Onjukka, Claes Mercke, Ingmar Lax, Anders Berglund, Signe Friesland
Summary: This study analyzed treatment outcomes and toxicities in 215 patients with oropharyngeal cancer who received dose-escalated radiotherapy compared to a matched cohort of patients who received standard dose radiotherapy. The results showed similar overall survival rates between the two groups, but the dose-escalated group had a higher incidence of severe toxicities, such as osteoradionecrosis and late dysphagia.
Article
Oncology
Bhavana Chapman, Diane Liu, Yu Shen, Oluwafikayo O. Olamigoke, David S. Lakomy, Angelica M. Gutierrez Barrera, Shane R. Stecklein, Gabriel O. Sawakuchi, Scott J. Bright, Isabelle Bedrosian, Jennifer K. Litton, Benjamin D. Smith, Wendy A. Woodward, George H. Perkins, Karen E. Hoffman, Michael C. Stauder, Eric A. Strom, Banu K. Arun, Simona F. Shaitelman
Summary: This study investigated the outcomes of breast cancer patients with and without BRCA1/2 pathogenic variant mutations who underwent radiation therapy. The results showed no significant differences in locoregional recurrence and disease-specific death rates between the two groups during treatment and follow-up.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Stephen Joseph McMahon, Kevin M. Prise
Summary: Variations in intrinsic radiosensitivity of different cells to ionizing radiation play a significant role in response to radiotherapy. The Medras model provides a mechanistic framework to model different radiation responses and predict individual responses, by simulating repair of radiation-induced DNA damage and predicting a range of biological endpoints. Validation of the model against various exposure types, including different radiation qualities and dose-rates, supports its potential in informing mechanistic predictions of radiation sensitivity and supporting developments in treatment personalization.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Raoul C. Reulen, David L. Winter, Ibrahim Diallo, Cristina Veres, Damien Llanas, Rodrigue S. Allodji, Francesca Bagnasco, Edit Bardi, Elizabeth A. M. Feijen, Daniela Alessi, Miranda M. Fidler-Benaoudia, Stine Hogsholt, Jop C. Teepen, Helena Linge, Nadia Haddy, Julianne Byrne, Ghazi Debiche, Desiree Grabow, Thorgerdur Gudmundsdottir, Romain Fauchery, Wael Zrafi, Gisela Michel, Hilde ofstaas, Peter Kaatsch, Giao Vu-Bezin, Helen Jenkinson, Melanie Kaiser, Roderick Skinner, Trevor Cole, Nicolas Waespe, Grit Sommer, Susanne Nordenfelt, Momcilo Jankovic, Tuomas Lahteenmaki Taalas, Milena M. Maule, Helena J. H. van der Pal, Cecile M. Ronckers, Flora E. van Leeuwen, Judith L. Kok, Monica Terenziani, Maria Winther Gunnes, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Riccardo Haupt, Paivi M. Lahteenmaki, Lorna Zadravec Zaletel, Claudia E. Kuehni, Jeanette Falck Winther, Leontien C. M. Kremer, Lars Hjorth, Florent de Vathaire, Michael M. Hawkins
Summary: Radiation and exposure to alkylating agents increase the risk of bone cancer among survivors of childhood cancer. This study demonstrates, for the first time, that the risk of bone cancer is increased 5-10 fold after exposure of bone tissue to cumulative radiation doses of 1-9 Gy. Alkylating agents exceeding 10,000 mg/m(2), particularly procarbazine, ifosfamide, and cyclophosphamide, increase the risk 7-8 fold. These findings should be used to develop/update clinical follow-up guidelines and survivorship care plans.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Surgery
Harry Frederick Dean, Emily Britton, Emily Farrow, Sameerah Abdel-Khaleq, Natasha Lakin, Molly Bradbury, Tim Cook
Summary: This observational study assessed the prevalence of colorectal cancer (CRC) in patients with acute diverticulitis (AD) and the impact of follow-up on endoscopy services. The results showed a low incidence of CRC in AD patients, and conservative follow-up strategies were deemed safe. However, age-based recommendations may limit their effectiveness in reducing the burden on endoscopy services.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Christian Hoffmann, Toke Ringbaek, Anja Eckstein, Wolfgang Deya, Alina Santiago, Martin Heintz, Wolfgang Luebcke, Frank Indenkaempen, Wolfgang Sauerwein, Andrea Fluehs, Claudia Le Guin, Andreas Huettmann, Julia von Tresckow, Sophia Goericke, Cornelius Deuschl, Sourour Moliavi, Christoph Poettgen, Thomas Gauler, Nika Guberina, Patricia Johansson, Nikolaos Bechrakis, Martin Stuschke, Maja Guberina, David Wong
Summary: This study examines the effects of lens-sparing electron irradiation on the treatment of low-grade conjunctival lymphomas and the prevention of cataract formation. The results show that the lens-shielding technique significantly reduces the incidence of cataracts while ensuring high disease control rates.
Review
Health Care Sciences & Services
Anne Dietz, Maria Gomolka, Simone Moertl, Prabal Subedi
Summary: This study aims to investigate the relationship between ionizing radiation effects on human normal tissue proteome and radiosensitivity, providing insights for radiation therapy decisions. The research will follow the guidelines established by NTP/OHAT, and will be registered in PROSPERO to ensure transparency and traceability.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Respiratory System
Ioannis T. Farmakis, Luca Valerio, Stefano Barco, Eva Alsheimer, Ralf Ewert, George Giannakoulas, Lukas Hobohm, Karsten Keller, Anna C. Mavromanoli, Stephan Rosenkranz, Timothy A. Morris, Stavros V. Konstantinides, Matthias Held, Daniel Dumitrescu
Summary: This study investigated the association between exercise limitation assessed by cardiopulmonary exercise testing (CPET) and clinical, echocardiographic, laboratory abnormalities, and quality of life (QoL) after pulmonary embolism (PE). The results showed that abnormal exercise capacity of cardiopulmonary origin is common after PE and is associated with clinical and haemodynamic impairment, as well as long-term QoL reduction. CPET can be considered for selected patients with persisting symptoms after PE to identify candidates for closer follow-up and possible therapeutic interventions.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Health Care Sciences & Services
Prabal Subedi, Maria Gomolka, Simone Moertl, Anne Dietz
Summary: This review aimed to examine the association between changes in protein expression induced by radiation in normal tissues and radiosensitivity, incorporating 28 studies. Most studies demonstrated increased DNA damage in radiosensitive individuals, with several proteins identified to be connected to radiosensitivity, providing a direction for further investigation into the mechanisms of radiosensitivity.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Letter
Medicine, General & Internal
Daniel J. Shapiro, Florence T. Bourgeois, Andrew M. Fine, Adam L. Hersh, Eric R. Coon, Mark I. Neuman, Ann Chen Wu
Summary: This cohort study examines the frequency of postdischarge follow-up visits among US emergency department encounters for bronchiolitis and assesses whether follow-up was associated with decreased hospital reutilization or increased treatment with nonrecommended medications.
Article
Biology
Juras Kisonas, Jonas Venius, Olga Sevriukova, Mindaugas Grybauskas, Daiva Dabkeviciene, Arvydas Burneckis, Ricardas Rotomskis
Summary: The purpose of this study was to evaluate the clinical manifestation of acute radiation dermatitis (ARD) in different skincare groups during whole breast radiotherapy. The results showed that additional skincare did not improve skin condition, and breast volume was the most significant risk factor for the manifestation of ARD.
Article
Oncology
Mohammad U. Zahid, Nuverah Mohsin, Abdallah S. R. Mohamed, Jimmy J. Caudell, Louis B. Harrison, Clifton D. Fuller, Eduardo G. Moros, Heiko Enderling
Summary: The study successfully modeled and predicted individual patient responses to radiation therapy by combining mathematical modeling with weekly tumor volume data, achieving high accuracy in outcome predictions.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Sylvia Verbanck, Hilde Van Parijs, Daniel Schuermans, Vincent Vinh-Hung, Guy Storme, Christel Fontaine, Mark De Ridder, Dirk Verellen, Eef Vanderhelst, Shane Hanon
Summary: Patients with breast cancer undergoing radiation therapy may experience reduced lung capacity, but the long-term effects of different radiation techniques are similar. Most patients with normal lung function at baseline maintain normal lung function status 10 years after treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)