Article
Oncology
Yong Li, Junlan Wu, Fenghua Liu, Xianjun Shao, Xiaohua Liang, Feifei Zhang, Yan Meng, Meihua Shen, Mianshun Pan
Summary: This study compared the efficacy of stereotactic radiotherapy (SRT) and stereotactic radiosurgery (SRS) for the treatment of brain metastases from colorectal cancer (CRC) and found that both methods are effective. The simultaneous use of bevacizumab may be one of the most important factors that affects the survival of these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Jinxiu Yu, Jiamin Zeng, Guanye Hu, Jing Wang, Guohao Chen, Minyi Huang, Shunyao Liang, Yong He, Yinhui Deng, Ye Gong, Junyi Fu
Summary: This study investigated the outcomes of Gamma Knife radiosurgery (GKRS) for World Health Organization (WHO) grade I intracranial meningiomas after surgical resection. The results showed that GKRS is a safe and effective treatment, with large tumor volume and specific tumor location associated with tumor progression. Malignant transformation was identified as one of the main causes of tumor progression.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Michelle Shizu Miller, Won Kim, Maya Harary, Ricky R. Savjani, Justin Lee, Donatello Telesca, Stephen Tenn, John Hegde, Tania Kaprealian
Summary: The study aimed to investigate the use of antiepileptic drugs (AEDs) in patients with brain metastases (BMs) following radiosurgical treatment. The results showed that the volume of the planning target area (PTV) was significantly associated with post-SRS seizures, while the number of supratentorial BMs was not predictive.
JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
Paolo Sogono, Mathias Bressel, Steven David, Mark Shaw, Sarat Chander, Julie Chu, Nikki Plumridge, Keelan Byrne, Nicholas Hardcastle, Tomas Kron, Greg Wheeler, Gerard G. Hanna, Michael MacManus, David Ball, Shankar Siva
Summary: The study showed that single-fraction stereotactic body radiation therapy is safe and effective for patients with oligometastatic disease, reducing the number of attendances and improving efficiency. Patients had high overall survival rates and a significant proportion remained treatment-free for several years after therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biotechnology & Applied Microbiology
Namit Kumar, Ryan Golhar, Kriti Sen Sharma, James L. Holloway, Srikant Sarangi, Isaac Neuhaus, Alice M. Walsh, Zachary W. Pitluk
Summary: Single-cell sequencing allows unbiased profiling of individual cells, but the scale and complexity of the data pose a significant challenge, especially with larger datasets generated by consortium efforts. Large single-cell datasets offer valuable resources for evaluating key biological hypotheses related to human diseases, providing insights into gene expression profiles and potential therapeutic targets.
Article
Oncology
Valeria Faccenda, Denis Panizza, Valerio Pisoni, Sara Trivellato, Martina Camilla Daniotti, Sofia Paola Bianchi, Elena De Ponti, Stefano Arcangeli
Summary: This study investigated the efficacy of linac-based SRS/fSRS treatments using the single-isocenter coplanar FFF-VMAT technique for single and multiple BM. Analysis of patient cases showed that for single BM patients, GTV D95% was rarely reduced by more than 5%, while reductions of PTV D95% greater than 1% only occurred in 11 cases (29%). For multiple BM patients, dose deficits of >5% and >1% were observed in 2 GTV (2%) and 34 PTV (37%), respectively.
Review
Medicine, General & Internal
Thomas Jakubeit, Sibylle Sturtz, Dorothea Sow, Wolfram Gross, Christoph Mosch, Mattea Patt, Vera Weingaertner, Jan Bostrom, Roland Goldbrunner, Martina Markes
Summary: A systematic review comparing the benefits and harms of single-fraction stereotactic radiosurgery (sfSRS) with microsurgical resection (MR) in patients with vestibular schwannoma suggests that sfSRS has greater benefits than MR, including improvements in facial palsy, hearing function, and length of hospital stay. However, long-term studies are needed to confirm these findings and determine if the effects of sfSRS are similar in patients with bilateral vestibular schwannomas.
SYSTEMATIC REVIEWS
(2022)
Article
Oncology
Maxwell Y. Lee, Zi Ouyang, Danielle LaHurd, Ping Xia, Samuel T. Chao, John H. Suh, Lilyana Angelov, Anthony Magnelli, Salim Balik, Ehsan H. Balagamwala
Summary: The study analyzed the development of vertebral compression fractures (VCF) after single fraction SBRT treatment and associated factors. The results showed that treatment plans allowing higher volumes of vertebral body to receive elevated doses were significantly associated with an increased risk of VCF.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Michael T. Milano, Jimm Grimm, Scott G. Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A. Tome, Arjun Sahgal, Jinyu Xue, Lijun Ma, Timothy D. Solberg, John P. Kirkpatrick, Louis S. Constine, John C. Flickinger, Lawrence B. Marks, Issam El Naqa
Summary: This study analyzed dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy after single-fraction stereotactic radiosurgery or hypofractionated radiosurgery. The results showed that the maximum point dose to the optic apparatus was related to RION risk, providing insight into NTCP risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Valentina Pinzi, Marcello Marchetti, Anna Viola, Irene Tramacere, Irene Cane, Cecilia Iezzoni, Laura Fariselli
Summary: Radiosurgery is a safe and effective technique for treating intracranial meningiomas. However, when targeting large-volume or critically located lesions, single-fraction radiosurgery can lead to high toxicity rates. This study found that a fractionated RS schedule of 25 Gy in 5 fractions (hypo-RS) is a well-tolerated option for the treatment of large and/or critically located benign meningiomas, with favorable local control.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Takaya Yamamoto, Yu Katagiri, Yoko Tsukita, Haruo Matsushita, Rei Umezawa, Yoshiyuki Katsuta, Noriyuki Kadoya, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Keita Kishida, So Omata, Eisaku Miyauchi, Ryota Saito, Keiichi Jingu
Summary: This study evaluated the efficacy of a risk-adapted strategy of SRS for lung cancer, and the results showed a low rate of 3-year local recurrence and tolerable toxicity.
Article
Oncology
Neal Andruska, William R. Kennedy, Liberty Bonestroo, Rebecca Anderson, Yi Huang, Clifford G. Robinson, Christopher Abraham, Christina Tsien, Nels Knutson, Keith M. Rich, Christopher Spencer, Jiayi Huang
Summary: This study identifies BrainV25 and BrainV30 as significant dosimetric predictors of symptomatic radiation necrosis (sRN) in brain metastases treated with 5-fraction stereotactic radiosurgery (5fSRS). Maintaining BrainV25Gy < 16 cm(3) and BrainV30Gy < 10 cm(3) may minimize the risk of sRN, especially in lesions without prior SRS treatment.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Yavuz Samanci, Fatih Karakose, Sukran Senyurek, Selcuk Peker
Summary: This study compared the clinical outcomes of sfSRS versus hfSRS GKRS in patients with unresected small METs, and found that hfGKRS had advantages in terms of local control and toxicity.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Article
Oncology
Junyi Fu, Jiamin Zeng, Minyi Huang, Shunyao Liang, Yong He, Longchang Xie, Yinhui Deng, Jinxiu Yu
Summary: This study compared the long-term outcomes of primary versus postoperative Gamma Knife radiosurgery (GKRS) for benign meningiomas. The results showed that primary GKRS provided similar radiological and clinical outcomes, as well as similar complication rates compared with postoperative GKRS. For selected patients with benign meningiomas, GKRS could be considered as an alternative primary treatment.
Article
Clinical Neurology
Sheng-Han Huang, Chi-Cheng Chuang, Chun-Chieh Wang, Kuo-Chen Wei, Hsien-Chih Chen, Peng-Wei Hsu
Summary: This study evaluated the risk and predictive factors of peritumoral edema (PTE) following stereotactic radiosurgery (SRS) for intracranial benign meningiomas. The results showed that total marginal dose, preexisting PTE, tumor location, and vascular invasion were significant risk factors for post-SRS PTE.
NEUROSURGICAL FOCUS
(2022)