Article
Oncology
Yun Huang, Zeyu Zhang, Weijun Liao, Kuan Hu, Zhiming Wang
Summary: The study showed that combination therapy with sorafenib, camrelizumab, TACE, and SBRT is an effective downstaging strategy for advanced HCC with PVTT, resulting in good treatment responses and survival outcomes with few adverse events.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Chonlakiet Khorprasert, Kanokphorn Thonglert, Petch Alisanant, Napapat Amornwichet
Summary: For individuals with HCC and PVTT in Thailand, limited treatment options are available due to disease extent, poor liver function, and lack of coverage for immuno/targeted therapy. Radiotherapy has become increasingly important in these patients and is considered a safe and effective therapeutic option, with overall survival being closely related to factors such as patient age, tumor size, radiation dose, and tumor/PVTT response. Further research is necessary to validate these findings through prospective randomized trials.
Article
Biology
Gun Ha Kim, Sang Lim Choi, Jin Hyoung Kim, Ju Hyun Shim, Meshari Alali, Nayoung Kim
Summary: This study aimed to compare the efficacy and safety of TACE plus sorafenib with TACE alone in patients with locally advanced HCC. The results showed that TACE plus sorafenib had better outcomes in terms of PFS and OS, indicating a potential benefit of combination therapy in this patient population.
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Review
Gastroenterology & Hepatology
Anxin Chen, Shijie Li, Zhiyuan Yao, Jiahao Hu, Jiasheng Cao, Win Topatana, Sarun Juengpanich, Hong Yu, Jiliang Shen, Mingyu Chen
Summary: The meta-analysis showed that TACE plus sorafenib combination therapy is superior to sorafenib monotherapy in unresectable HCC patients, significantly improving overall survival, time to progression, and objective response rate. Combination therapy was particularly effective for patients with macrovascular invasion.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Gang Yuan, Zhiyin Liu, Weiming Wang, Mengnan Liu, Yanneng Xu, Wei Hu, Yao Fan, Xun Zhang, Yong Liu, Guangyan Si
Summary: Hepatocellular carcinoma (HCC) is a major global health concern with high incidence and mortality rates. Transarterial chemoembolization (TACE) is commonly used for the treatment of unresectable HCC, but its therapeutic effect is often limited. Recent research has focused on using nanomaterials as a drug delivery platform to improve the distribution and bioavailability of drugs in tumor tissues. Functionalized nanomaterials have been developed for targeted embolization, controlled drug release, and real-time imaging, aiming to enhance the therapeutic effect of TACE against HCC.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Immunology
Ke Su, Fei Wang, Xueting Li, Hao Chi, Jianwen Zhang, Kun He, Zhaoyang Wang, Lianbin Wen, Yanqiong Song, Jiali Chen, Zhenying Wu, Yi Jiang, Han Li, Tao Gu, Chenjie Wang, Yaqi Li, Mengxiang Liu, Qulian Guo, Ke Xu, Lu Guo, Yunwei Han
Summary: This study compared the effectiveness of external beam radiation therapy (EBRT) and transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) with a tumor diameter of 5 cm or larger. The results showed that EBRT was more effective than TACE in terms of overall survival, especially for patients with a tumor diameter of 5-10 cm.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Munire Abulimiti, Zhenyu Li, Haifeng Wang, Palida Apiziaji, Yisikandaer Abulimiti, Yao Tan
Summary: The study compared the outcomes of hepatocellular carcinoma (HCC) patients with portal vein thrombosis (PVTT) receiving intensity-modulated radiotherapy (IMRT) concurrent with sorafenib versus IMRT alone. Results showed that the combination therapy group had significantly better overall survival (OS), progression-free survival (PFS), and median distant metastasis-free survival (DMFS) compared to the IMRT alone group.
JOURNAL OF ONCOLOGY
(2021)
Review
Multidisciplinary Sciences
Simon Lemieux, Alex Buies, Alexis F. Turgeon, Julie Hallet, Gaetan Daigle, Francois Cote, Steeve Provencher
Summary: Yttrium-90 transarterial radioembolization did not show significant effects on survival, progression-free survival, time to progression, disease control rate, and incidence of gastro-intestinal ulcers in non-surgical HCC patients, but was associated with significantly lower rates of grade >= 3 adverse events. Further randomized controlled trials are needed to determine optimal treatment.
Article
Multidisciplinary Sciences
Jongmoo Park, Jaehyeon Park, Sean Oh, Ji Woon Yea, Jeong Eun Lee, Jae Won Park
Summary: The study compared the efficacy of VMAT plans with and without multi-criteria optimization (MCO), finding that the MCO plan improved gross treatment volume coverage, reduced maximal dose, and improved dose distribution quality. In terms of OAR sparing, the MCO plan performed better by sacrificing tolerable dose to bilateral femoral heads for better protection of the rectum and bladder.
Article
Gastroenterology & Hepatology
Won Ick Chang, Byoung Hyuck Kim, Yoon Jun Kim, Jung-Hwan Yoon, Yong Jin Jung, Eui Kyu Chie
Summary: This study aimed to investigate the clinical benefits of locoregional radiation therapy (RT) before, after, and concurrent with sorafenib therapy for Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) patients. The results showed that locoregional RT was associated with significantly longer survival in BCLC stage C HCC patients who were treated with sorafenib, especially in patients treated with sorafenib for 12 weeks or more. Incorporating locoregional RT could improve the dismal prognosis for these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jens Ricke, Regina Schinner, Max Seidensticker, Antonio Gasbarrini, Otto M. van Delden, Holger Amthauer, Bora Peynircioglu, Irene Bargellini, Roberto Iezzi, Enrico N. De Toni, Peter Malfertheiner, Maciej Pech, Bruno Sangro
Summary: The study revealed that selective internal radiation therapy (SIRT) has a negative impact on liver function in patients with hepatocellular carcinoma, which may affect patient outcomes. Patients should be carefully selected before undergoing SIRT and treatment techniques should be optimized to maximize protection of non-target liver parenchyma.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Kishan J. Pithadia, Pragati G. Advani, Deborah E. Citrin, Justin E. Bekelman, Diana R. Withrow, Amy Berrington de Gonzalez, Lindsay M. Morton, Sara J. Schonfeld
Summary: A retrospective cohort study found that intensity-modulated radiotherapy (IMRT) for prostate cancer is not associated with an increased risk of second primary cancers. Any inverse associations may be correlated with the calendar year of treatment.
Review
Medicine, General & Internal
Yong Xie, Huan Tian, Bin Xiang, Yongjin Zhang, Jian Liu, Zhuoyan Cai, Hua Xiang
Summary: This study compared the clinical outcomes of transarterial chemoembolization (TACE) plus sorafenib with sorafenib monotherapy for intermediate-advanced hepatocellular carcinoma (HCC), finding that the TACE + sorafenib group had significantly better overall survival, time to progression, disease control rate, and objective response rate compared to sorafenib alone. Adverse events were similar between the two groups except for elevated alanine aminotransferase (ALT), warranting further research to clarify the benefits of different TACE and sorafenib combinations for certain subgroups.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisabeth Dhondt, Bieke Lambert, Laurens Hermie, Lynn Huyck, Peter Vanlangenhove, Anja Geerts, Xavier Verhelst, Maridi Aerts, Aude Vanlander, Frederik Berrevoet, Roberto Ivan Troisi, Hans Van Vlierberghe, Luc Defreyne
Summary: This study compared the efficacy and safety of Y-90 glass TARE and DEB-TACE for unresectable HCC. The results showed that TARE conferred superior tumor control and overall survival compared to DEB-TACE. Both treatments had similar safety profiles.
Article
Gastroenterology & Hepatology
Shulin Yu, Yuchen Li, Zhuan Liao, Zheng Wang, Zhen Wang, Yan Li, Ling Qian, Jingjing Zhao, Huajie Zong, Bin Kang, Wen-Bin Zou, Kun Chen, Xianghuo He, Zhiqiang Meng, Zhen Chen, Shenglin Huang, Peng Wang
Article
Oncology
Chien-Shan Cheng, Jing-Xian Chen, Jian Tang, Ya-Wen Geng, Lan Zheng, Ling-Ling Lv, Lian-Yu Chen, Zhen Chen
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Oncology
Ling Qian, Kun Chen, Changhong Wang, Zhen Chen, Zhiqiang Meng, Peng Wang
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Ke Zhang, Shu Dong, Yan-Hua Jing, Hui-Feng Gao, Lian-Yu Chen, Yong-Qiang Hua, Hao Chen, Zhen Chen
Article
Oncology
Fengjiao Wang, Lai Wang, Chao Qu, Lianyu Chen, Yawen Geng, Chienshan Cheng, Shulin Yu, Dan Wang, Lina Yang, Zhiqiang Meng, Zhen Chen
Summary: Kaempferol effectively suppresses pancreatic cancer by upregulating ROS levels and inducing apoptosis via TGM2-mediated Akt/mTOR signaling pathway. High TGM2 expression is correlated with poor prognosis in pancreatic cancer patients, and TGM2 may serve as a promising prognostic biomarker for pancreatic cancer.
Article
Mathematical & Computational Biology
Soutik Ghosal, Zhen Chen
Summary: The study used longitudinal ultrasound examination data to estimate diagnostic accuracy parameters for predicting large fetuses at birth. The integration of placement value and Bayesian regression model proved to be more effective in simulations and application to real data. The diagnostic accuracy of estimated fetal weight was found to improve by about 65% from week 17 to 37 of gestation according to the Scandinavian Study data.
STATISTICS IN BIOSCIENCES
(2022)
Review
Integrative & Complementary Medicine
Jiao Ju-ying, Cheng Chien-snan, Cao Zhang-qi, Chen Lian-Yu, Chen Zhen
Summary: Cancer, a deadly disease, has limited therapeutic options. Complementary and alternative medicine, particularly Chinese medicine, has been widely used in cancer management. However, there is a lack of understanding about the molecular characteristics of dampness-heat syndrome and a standardized animal model for studying this core syndrome in vivo.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Cardiac & Cardiovascular Systems
Lai Wang, Fengjiao Wang, Lianyu Chen, Yawen Geng, Shulin Yu, Zhen Chen
Summary: The study found that long-term adolescent and young adult cancer survivors have a higher risk of cardiovascular disease mortality compared to the general population and childhood cancer survivors, especially those with Hodgkin's lymphoma and central nervous system tumors who require continued close monitoring for cardiovascular conditions.
EUROPEAN HEART JOURNAL
(2021)
Article
Mathematical & Computational Biology
Yu-Bo Wang, Cuilin Zhang, Zhen Chen
Summary: Research indicates a positive association between childhood obesity and chronic diseases later in life, possibly linked to maternal metabolic disorders during pregnancy. Mediation analysis identifies how multiple maternal risk factors can directly or indirectly impact a child's body mass index. The use of shrinkage priors in parameter estimation shows good performance in selecting relevant prevention pathways.
STATISTICS IN BIOSCIENCES
(2021)
Article
Oncology
Yawen Geng, Jie Fan, Lianyu Chen, Chenyue Zhang, Chao Qu, Ling Qian, Kun Chen, Zhiqiang Meng, Zhen Chen, Peng Wang
Summary: This study uncovered a Notch-dependent feedback circuit between pancreatic cancer cells and macrophages, which promotes PDAC metastasis through miR-124, IL6, and STAT3 signaling pathways. Disrupting this circuit could potentially be a therapeutic approach for treating PDAC metastasis.
Article
Gastroenterology & Hepatology
L. Feng, Q. Qi, P. Wang, H. Chen, Z. Chen, Z. Meng, L. Liu
ACTA GASTRO-ENTEROLOGICA BELGICA
(2020)