Journal
RADIATION AND ENVIRONMENTAL BIOPHYSICS
Volume 52, Issue 4, Pages 493-503Publisher
SPRINGER
DOI: 10.1007/s00411-013-0480-y
Keywords
BNCT; alpha-Spectrometry; Boron concentration; Thermal neutrons
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Measurement of boron concentration in biological tissues is a fundamental aspect of boron neutron capture therapy, because the outcome of the therapy depends on the distribution of boron at a cellular level, besides on its overall concentration. This work describes a measurement technique based on the spectroscopy of the charged particles emitted in the reaction B-10(n,alpha)Li-7 induced by thermal neutrons, allowing for a quantitative determination of the boron concentration in the different components that may be simultaneously present in a tissue sample, such as healthy cells, tumor cells and necrotic cells. Thin sections of tissue containing B-10 are cut at low temperatures and irradiated under vacuum in a thermal neutron field. The charged particles arising from the sample during the irradiation are collected by a thin silicon detector, and their spectrum is used to determine boron concentration through relatively easy calculations. The advantages and disadvantages of this technique are here described, and validation of the method using tissue standards with known boron concentrations is presented.
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