Article
Multidisciplinary Sciences
Yaxin Shi, Zhibin Guo, Qiang Fu, Xinyuan Shen, Zhongming Zhang, Wenjia Sun, Jinqiang Wang, Junliang Sun, Zizhu Zhang, Tong Liu, Zhen Gu, Zhibo Liu
Summary: Boron neutron capture therapy (BNCT) is a clinically approved radiotherapy that selectively deposits deadly particles within cancer cells, but its abscopal anti-tumour effect has been limited. In this study, a boron capsule was engineered to synergize BNCT with controlled immune adjuvants release, promoting a potent anti-tumour immune response. The study revealed that the nuclear reaction in the boron capsule enhances drug release and uncovered the mechanism of BNCT-induced heat on anti-tumour immunity. In preclinical cancer models, BNCT and controlled drug release led to significant regression of both primary and distant tumour grafts.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Dawid Kozien, Paulina Zeliszewska, Bozena Szermer-Olearnik, Zbigniew Adamczyk, Anna Wroblewska, Agnieszka Szczygiel, Katarzyna Wegierek-Ciura, Jagoda Mierzejewska, Elzbieta Pajtasz-Piasecka, Tomasz Tokarski, Grzegorz Cios, Stanislaw Cudzilo, Zbigniew Pedzich
Summary: This research presents the synthesis of B4C nanoparticles via vapor deposition and investigates their characteristics. The study evaluates the cytotoxicity effect of the synthesized nanoparticles on various cell lines, providing insights into their potential application in boron neutron capture therapy.
Review
Oncology
Timothy D. Malouff, Danushka S. Seneviratne, Daniel K. Ebner, William C. Stross, Mark R. Waddle, Daniel M. Trifiletti, Sunil Krishnan
Summary: Boron neutron capture therapy (BNCT) is an emerging treatment modality that utilizes boron-10 to target tumors and has shown promising results in various cancer types in clinical studies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Song Wang, Zhengchao Zhang, Lele Miao, Jiaxing Zhang, Futian Tang, Muzhou Teng, Yumin Li
Summary: Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy that uses neutron capture reaction to kill tumor cells. It has been included in the clinical backup program for the treatment of glioma, melanoma, and other diseases. However, the key challenge of BNCT lies in developing more efficient boron delivery agents to improve targeting and selectivity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Chemical
Mizuki Kitamatsu, Ken Inoue, Naoki Yamagata, Hiroyuki Michiue
Summary: This study assessed the reactivity between chloroacetyl-modified tripeptides with different amino acid residues and mercaptoundecahydrododecaborate. The results showed that the reactivity varied with the type and number of amino acid residues as well as the length of the alkyl linker. The electrostatic attraction between positively charged amino acid residues and negatively charged mercaptoundecahydrododecaborate was found to play a key role in the accelerated reaction.
Review
Pharmacology & Pharmacy
Anne-Marie Caminade, Max Milewski, Evamarie Hey-Hawkins
Summary: The use of boron clusters in nanoparticles for cancer treatment, particularly in dendrimers, is highlighted in this review. The synthesis methods and biological properties of boronated dendritic structures are discussed, along with their efficiency in animal models and potential for boron neutron capture therapy (BNCT) experiments.
Article
Biology
Andrea Monti Hughes, Jessica A. Goldfinger, Monica A. Palmieri, Paula Ramos, Iara S. Santa Cruz, Luciana De Leo, Marcela A. Garabalino, Silvia Thorp, Paula Curotto, Emiliano C. C. Pozzi, Kazuki Kawai, Shinichi Sato, Maria E. Itoiz, Veronica A. Trivillin, Juan S. Guidobono, Hiroyuki Nakamura, Amanda E. Schwint
Summary: This study evaluated the distribution and therapeutic effect of MID:BSA in a hamster cheek pouch oral cancer model, demonstrating that the 15 mg B/kg dose reached therapeutically useful boron concentration values in the tumor and was well-tolerated, while the 30 mg B/kg dose induced high toxicity.
Article
Biochemistry & Molecular Biology
Tien-Li Lan, Chun-Fu Lin, Yi-Yen Lee, Ko-Han Lin, Feng-Chi Chang, Shih-Chieh Lin, Jia-Cheng Lee, Fong-In Chou, Jinn-Jer Peir, Hong-Ming Liu, Pei-Fan Mu, Yi-Wei Chen
Summary: Meningiomas are the most common primary intracranial tumors in adults. Surgical resection is the preferred treatment, but for those not suitable for surgery, radiotherapy can be considered. Recurrent meningiomas present a challenge due to their location in previously irradiated areas. This article introduces four patients from Taiwan who were treated with Boron Neutron Capture Therapy (BNCT) for recurrent meningiomas. The study shows promising results, with two stable diseases, one partial response, and one complete response. BNCT is proven effective and safe as an alternative salvage treatment for recurrent meningiomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Makoto Shirakawa, Alexander Zaboronok, Kei Nakai, Yuhki Sato, Sho Kayaki, Tomonori Sakai, Takao Tsurubuchi, Fumiyo Yoshida, Takashi Nishiyama, Minoru Suzuki, Hisao Tomida, Akira Matsumura
Summary: The study focuses on improving the accumulation and retention of boron in tumor tissues by designing novel PBL liposomes, providing promising candidates for BNCT treatment.
Review
Oncology
Song Wang, Zhengchao Zhang, Lele Miao, Yumin Li
Summary: Boron neutron capture therapy (BNCT) is an emerging therapy that selectively kills tumor cells by using boron delivery agents to release alpha and lithium particles through neutron-triggered fission. It has been developed for the treatment of various cancers and requires further research on efficient delivery agents and accurate dose measurement systems.
FRONTIERS IN ONCOLOGY
(2022)
Article
Materials Science, Characterization & Testing
Feng Zhao, Kaibo Hu, Chen Shao, Guofan Jin
Summary: This paper designed and synthesized two boron-polymers as fluorescent targeting markers for rapid, accurate, real-time, and inexpensive detection of boron-containing drugs. Both polymers showed high levels of biological activity in terms of cytotoxicity and cell imaging.
Article
Chemistry, Multidisciplinary
Masahiro Nishikawa, Jie Yu, Heon Gyu Kang, Minoru Suzuki, Naoki Komatsu
Summary: Boron neutron capture therapy is an advanced cancer treatment that utilizes nuclear fission of B-10 atom in cancer cells. In this study, anticancer nanoformulations were designed by conjugating a boron cluster moiety and an active targeting moiety to enhance selectivity and retention in tumors. The results showed that the boron cluster moiety facilitated cellular uptake and the nanodrugs exhibited good anticancer efficacy under thermal neutron irradiation.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Chun-Yi Wu, Hsin-Hua Hsieh, Ting-Yu Chang, Jia-Jia Lin, Chin-Ching Wu, Ming-Hua Hsu, Ming-Chia Lin, Shin-Lei Peng
Summary: This study aimed to develop novel AuNPs containing boron and gadolinium for BNCT. The in vitro MR images showed a positive correlation between signal intensity and Gd concentration, allowing clear visualization of tumors. The developed AuNPs show potential for theranostic applications in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Andrea Monti Hughes, Naonori Hu
Summary: Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy that combines boron accumulation in tumors and neutron irradiation. Utilizing hospital-based accelerators as neutron sources, instead of nuclear reactors, in BNCT clinical trials opens up possibilities for more trials and randomized studies. The implementation of new boron compounds and strategies, along with communication among healthcare professionals, will optimize BNCT for cancer patients.
Article
Biology
Yu Sanada, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Tsubasa Watanabe, Minoru Suzuki, Shin-ichiro Masunaga
Summary: The study revealed that hypoxia may reduce the effectiveness of boron neutron capture therapy (BNCT) with BPA in murine squamous cell carcinoma cells, while disruption of Hif-1 alpha increased sensitivity to BNCT.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. O. Farias, M. A. Garabalino, S. Ferraris, J. Santa Maria, O. Rovati, F. Lange, V. A. Trivillin, A. Monti Hughes, E. C. C. Pozzi, S. I. Thorp, P. Curotto, M. E. Miller, G. A. Santa Cruz, S. Bortolussi, S. Altieri, A. M. Portu, G. Saint Martin, A. E. Schwint, S. J. Gonzalez
Article
Nuclear Science & Technology
J. L. Tripp, J. D. Law, T. E. Smith, V. J. Rutledge, W. F. Bauer, R. D. Ball, P. A. Hahn
NUCLEAR TECHNOLOGY
(2015)
Article
Biology
Veronica A. Trivillin, Leandro J. Bruno, David A. Gatti, Mariela Stur, Marcela A. Garabalino, Andrea Monti Hughes, Jorge Castillo, Emiliano C. C. Pozzi, Luis Wentzeis, Hugo Scolari, Amanda E. Schwint, Sara Feldman
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2016)
Article
Biology
Veronica A. Trivillin, Emiliano C. C. Pozzi, Lucas L. Colombo, Silvia I. Thorp, Marcela A. Garabalino, Andrea Monti Hughes, Sara J. Gonzalez, Ruben O. Farias, Paula Curotto, Gustavo A. Santa Cruz, Daniel G. Carando, Amanda E. Schwint
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2017)
Article
Biology
Andrea Monti Hughes, Juan Longhino, Esteban Boggio, Vanina A. Medina, Diego J. Martinel Lamas, Marcela A. Garabalino, Elisa M. Heber, Emiliano C. C. Pozzi, Maria E. Itoiz, Romina F. Aromando, David W. Nigg, Veronica A. Trivillin, Amanda E. Schwint
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2017)
Article
Biology
Veronica Andrea Trivillin, Ayelen Serrano, Marcela A. Garabalino, Lucas Luis Colombo, Emiliano Cesar Pozzi, Andrea Monti Hughes, Paula M. Curotto, Silvia Ines Thorp, Ruben O. Farias, Sara J. Gonzalez, Silva Bortolussi, Saverio Altieri, Maria E. Itoiz, Romina F. Aromando, David W. Nigg, Amanda E. Schwint
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Biology
Marcela A. Garabalino, Nahuel Olaiz, Agustina Portu, Gisela Saint Martin, Silvia Thorp, Emiliano C. C. Pozzi, Paula Curotto, Maria E. Itoiz, Andrea Monti Hughes, Lucas L. Colombo, David W. Nigg, Veronica A. Trivillin, Guillermo Marshall, Amanda E. Schwint
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2019)
Article
Dentistry, Oral Surgery & Medicine
Iara S. Santa Cruz, Marcela A. Garabalino, Veronica A. Trivillin, Maria E. Itoiz, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Juan S. Guidobono, Elisa M. Heber, David W. Nigg, Amanda E. Schwint, Andrea Monti Hughes
Article
Biology
Amanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Gustavo A. Santa Cruz, Sara J. Gonzalez, Juan Longhino, Lucas Provenzano, Paulina Ona, Monica Rao, Maria de los Angeles Cantarelli, Andrea Leiras, Maria Silvina Olivera, Veronica A. Trivillin, Paula Alessandrini, Fabricio Brollo, Esteban Boggio, Hernan Costa, Romina Ventimiglia, Sergio Binia, Emiliano C. C. Pozzi, Susana I. Nievas, Iara S. Santa Cruz
Article
Radiology, Nuclear Medicine & Medical Imaging
Veronica A. Trivillin, Yanina Langle, Monica A. Palmieri, Emiliano C. C. Pozzi, Silvia Thorp, Debora N. Benitez Frydryk, Marcela A. Garabalino, Andrea Monti Hughes, Paula M. Curotto, Lucas L. Colombo, Iara S. Santa Cruz, Paula S. Ramos, Maria E. Itoiz, Claudia Arguelles, Ana M. Eijan, Amanda E. Schwint
Summary: This study evaluated the local, regional, and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with Bacillus Calmette-Guerin (BCG) in a colon cancer model. The results showed that the combination therapy induced significant anti-tumor responses locally and reduced metastatic spread to lymph nodes, suggesting a potential comprehensive approach for cancer treatment.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Biology
Andrea Monti Hughes, Jessica A. Goldfinger, Monica A. Palmieri, Paula Ramos, Iara S. Santa Cruz, Luciana De Leo, Marcela A. Garabalino, Silvia Thorp, Paula Curotto, Emiliano C. C. Pozzi, Kazuki Kawai, Shinichi Sato, Maria E. Itoiz, Veronica A. Trivillin, Juan S. Guidobono, Hiroyuki Nakamura, Amanda E. Schwint
Summary: This study evaluated the distribution and therapeutic effect of MID:BSA in a hamster cheek pouch oral cancer model, demonstrating that the 15 mg B/kg dose reached therapeutically useful boron concentration values in the tumor and was well-tolerated, while the 30 mg B/kg dose induced high toxicity.
Article
Cell Biology
Nahuel Olaiz, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Veronica A. Trivillin, Paula S. Ramos, Monica A. Palmieri, Guillermo Marshall, Amanda E. Schwint, Marcela A. Garabalino
Summary: Electroporation improves the therapeutic efficacy of GB-10/BNCT in vivo in the hamster cheek pouch oral cancer model without increasing the radiotoxicity.
Article
Pharmacology & Pharmacy
Andrea Monti Hughes, Jessica A. Goldfinger, Lara S. Santa Cruz, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Marcela A. Garabalino, Maria E. Itoiz, Monica A. Palmieri, Paula Ramos, Elisa M. Heber, Romina F. Aromando, David W. Nigg, Hanna Koivunoro, Veronica A. Trivillin, Amanda E. Schwint
THERAPEUTIC DELIVERY
(2019)
Article
Engineering, Biomedical
S. J. Gonzalez, E. C. C. Pozzi, A. Monti Hughes, L. Provenzano, H. Koivunoro, D. G. Carando, S. I. Thorp, M. R. Casal, S. Bortolussi, V. A. Trivillin, M. A. Garabalino, P. Curotto, E. M. Heber, G. A. Santa Cruz, L. Kankaanranta, H. Joensuu, A. E. Schwint
PHYSICS IN MEDICINE AND BIOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Christopher A. Zarzana, Dean R. Peterman, Gary S. Groenewold, Lonnie G. Olson, Rocklan G. McDowell, William F. Bauer, Sabrina J. Morgan
SEPARATION SCIENCE AND TECHNOLOGY
(2015)