Article
Chemistry, Applied
Amira Noui, Tarek Boudiar, Houssem Boulebd, Lynda Gali, Maria del Mar Contreras, Antonio Segura-Carretero, Gema Nieto, Salah Akkal
Summary: Ephedra, a plant used in medicine for various purposes, was found to contain compounds with antioxidant, anti-inflammatory, and hepatoprotective activities. The study identified 27 compounds, including alkaloids and phenolic compounds, in Ephedra alata, showing high antioxidant potential and inhibitory effects against acetylcholinesterase, suggesting therapeutic benefits against Alzheimer's disease.
NATURAL PRODUCT RESEARCH
(2022)
Article
Food Science & Technology
Jing Wan, Peng He, Yuanshan Chen, Qiujin Zhu
Summary: A practical, efficient, and rapid method for quantifying 19 pyrethroids in tea and orange samples was developed. Out of 262 tea samples, 11 pyrethroids were detected positive with concentrations below maximum residue limits. No pyrethroid was found in 209 peeled orange samples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Zihong Yang, Linghong Shi, Yunyang Qi, Cundong Xie, Wanrong Zhao, Colin J. Barrow, Frank R. Dunshea, Hafiz A. R. Suleria
Summary: This study investigated the changes in polyphenol content during pumpkin processing and comprehensively characterized and quantified the phenolic compounds using LC-ESI-QTOF-MS/MS and HPLC-PDA. The results showed that pumpkin seeds and skins had the highest total phenolic content and total antioxidant capacity, while separated pumpkin puree had a higher total condensed tannins content. Epicatechin and catechin were found to be the most abundant phenolic compounds in pumpkin seeds and skins. This study highlights the potential of pumpkins as a source of antioxidant polyphenols.
Article
Plant Sciences
Adriana Trifan, Monika E. Czerwinska, Constantin Mardari, Gokhan Zengin, Kouadio Ibrahime Sinan, Izabela Korona-Glowniak, Krystyna Skalicka-Wozniak, Simon Vlad Luca
Summary: Our study provided a comprehensive metabolite and bioactivity profile of Artemisia campestris subsp. lednicensis, showing its antioxidant, enzyme inhibitory, anti-inflammatory, and antimicrobial activities, indicating its potential applications in food, pharmaceutical, and cosmetic industries.
Article
Biochemistry & Molecular Biology
Milena Masullo, Antonietta Cerulli, Cosimo Pizza, Sonia Piacente
Summary: This study analyzed the specialized metabolites of Pouteria lucuma fruit pulp and skin, identifying phenolic, flavonoid, and polar lipid compounds. The study also evaluated the phenolic content and antioxidant activity of the extracts and isolated compounds from the fruit.
Article
Plant Sciences
Erika Anayetzi Chavez-Bustos, Angel Morales-Gonzalez, Liliana Anguiano-Robledo, Eduardo Osiris Madrigal-Santillan, Carmen Valadez-Vega, Olivia Lugo-Magana, Jorge Alberto Mendoza-Perez, Tomas Alejandro Fregoso-Aguilar
Summary: Bauhinia forficata is a tree used in alternative medicine as an anti-diabetic agent. This study investigated its hypoglycemic, antioxidant, and genoprotective activities, and found that it has the potential to be used as an adjuvant therapy for diabetes.
Article
Food Science & Technology
Akhtar Ali, Jeremy J. Cottrell, Frank R. Dunshea
Summary: This study aimed to investigate the biologically active phenolic metabolites in Australian native commercial fruits and their potential health benefits. The results showed that Kakadu plum had higher concentrations of polyphenols and biological activities compared to other fruits.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Engineering, Environmental
Lotfi Sellaoui, Mohamed Bouzidi, Dison S. P. Franco, Abdullah S. Alshammari, Mohamed Gandouzi, Jordana Georgin, Naim Bel Haj Mohamed, Alessandro Erto, Michael Badawi
Summary: This paper examines the adsorption of methylene blue (MB) and crystal violet (CV) dyes onto Bauhinia forficata residual fruit powder (BFRFP) as a potential adsorbent. The results show that BFRFP has a higher affinity for CV dye, and it can be a competitive material for removing MB and CV dyes from polluted water. A physical model is used to interpret the adsorption mechanisms, indicating the presence of physical interactions during the adsorption process.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemical Research Methods
William Craig Byrdwell, Hari K. Kotapati, Robert Goldschmidt, Pavel Jakubec, Lucie Novakova
Summary: The study demonstrates the use of split-flow two-dimensional liquid chromatography (SF-2D-LC) and quadruple parallel mass spectrometry (LC3MS4) for analyzing NIST SRM 1849a adult/infant formula, achieving successful three-dimensional chromatographic separation with optimized separation space and mass spectrometry methods.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemistry & Molecular Biology
B. S. Manoj, Moni Gupta, M. Iqbal Jeelani, Sachin Gupta
Summary: Climate change has caused long-term changes in temperature and weather patterns, leading to unprecedented drought conditions. This study found that by imposing drought stress and applying chitosan treatment, the antioxidant content of red kidney bean seeds can be improved.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Juana Rozalen, M. Mercedes Garcia, Amaya Zalacain, Horacio Lopez-Corcoles, Jorge Hurtado de Mendoza, Katrina Cornish, Manuel Carmona
Summary: Guayule, as a promising renewable source of natural rubber/latex, has resins with various activities potentially related to sesquiterpenes. By exploring different analytical methods, it was found that there may be new members of the guayulins family and the relationship in seasonal changes was identified.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Arghya Chattopadhyay, Anand Prakash Singh, Deepak Kasote, Indrajit Sen, Ahmed Regina
Summary: The study found that 30 mg kg(-1) of P was the optimal application amount to significantly reduce arsenic accumulation in rice grains, decrease arsenic toxicity on agronomic parameters and chlorophyll biosynthesis, and increase polyphenol levels in rice grains.
Article
Biochemistry & Molecular Biology
Douaa Bekkai, Yassine Oulad El Majdoub, Hamid Bekkai, Francesco Cacciola, Natalizia Miceli, Maria Fernanda Taviano, Emilia Cavo, Tomader Errabii, Roberto Lagana Vinci, Luigi Mondello, Mohammed L'Bachir El Kbiach
Summary: This study investigated the phenolic profile and biological activities of three Ericaceae species from northern Morocco, revealing that the aerial extract of Erica scoparia is the richest in polyphenols and shows the highest antioxidant activity. All extracts were found to be non-toxic against Artemia salina, indicating their potential safety.
Article
Chemistry, Analytical
Ernesto de Jesus Zapata Flores, Nguyen Kim Ngan Bui, Sigrid Selberg, Koit Herodes, Ivo Leito
Summary: This study proposes derivatization reagents based on azobenzene, AzoB and AzoC, for LC-ESI-MS analysis of free amino acids in fermented beverages and juices. The results show that AzoB can be used for targeted and non-targeted analysis, while AzoC has advantages such as fast reaction and good reactivity with secondary amines but is affected by side products for quantitation.
Article
Biochemistry & Molecular Biology
Jesus Alfredo Araujo-Leon, Rolffy Ortiz-Andrade, Efren Hernandez-Baltazar, Emanuel Hernandez-Nunez, Julio Cesar Rivera-Leyva, Victor Yanez-Perez, Priscila Vazquez-Garcia, Carla Georgina Cicero-Sarmiento, Juan Carlos Sanchez-Salgado, Maira Rubi Segura-Campos
Summary: This study evaluated and compared the pharmacokinetic parameters of two dosage forms of hesperidin and naringenin: mixture and tablet. The results showed that tablet form did not significantly alter the pharmacokinetic parameters and could be a suitable candidate for drug product development.
Article
Biochemical Research Methods
Rafaela Sponchiado, Julia Medeiros Sorrentino, Natalia Olegario, Sendy Sales Oliveira, Leticia Malgarim Cordenonsi, Gustavo Pozza Silveira, Alexandre M. Fuentefria, Andreas S. L. Mendez, Martin Steppe, Cassia V. Garcia
BIOMEDICAL CHROMATOGRAPHY
(2019)
Article
Biochemical Research Methods
Fabio de Souza Barbosa, Leonardo Capra Pezzi, Marisa Tsao, Tiago Franco de Oliveira, Sandra Manoela Dias Macedo, Elfrides E. S. Schapoval, Andreas S. L. Mendez
BIOMEDICAL CHROMATOGRAPHY
(2019)
Article
Chemistry, Analytical
Fabio de Souza Barbosa, Leonardo Capra Pezzi, Marisa Tsao, Sandra Manoela Dias Macedo, Tiago Franco de Oliveira, Elfrides E. S. Schapoval, Andreas S. L. Mendez
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Plant Sciences
Mari C. Santos, Natally S. B. Toson, Maria C. B. Pimentel, Sergio A. L. Bordignon, Andreas S. L. Mendez, Amelia T. Henriques
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Analytical
Mari C. Santos, Mariana Koetz, Andreas S. L. Mendez, Amelia T. Henriques
Article
Chemistry, Applied
Mari C. Santos, Krissie D. Soares, Betina M. Beltrame, Sergio A. L. Bordignon, Miriam A. Apel, Andreas S. L. Mendez, Amelia T. Henriques
Summary: The study demonstrated significant antichemotactic activity of Cuphea species extracts, miquelianin, and myricitrin, indicating their potential as anti-inflammatory drugs in the future.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Analytical
Cassia Garcia, Andressa S. Bitencourt, Sendy S. Oliveira, Caren Gobetti, Andreas S. L. Mendez
Summary: This study validated an alternative microbiological assay for quantitation of posaconazole in bulk and investigated its stress stability, showing susceptibility to degradation factors. Three major degradation products of posaconazole were identified, with first-order kinetics observed for photolytic decomposition. The microbiological method was proven to be equivalent to physico-chemical ones, and impurities found in posaconazole were described for the first time in raw material studies.
JOURNAL OF AOAC INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Mari C. Santos, Krissie D. Soares, Betina M. Beltrame, Natally S. B. Toson, Maria do Carmo B. Pimentel, Sergio A. L. Bordignon, Miriam A. Apel, Andreas S. L. Mendez, Amelia T. Henriques
Summary: This study explored the chemical composition, anti-inflammatory, and antihypertensive activities of extracts from Cuphea lindmaniana and Cuphea urbaniana leaves. The extracts contain a rich diversity of flavonoids and exhibit in vitro anti-inflammatory and antihypertensive potential, as well as anti-chemotactic effects.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Analytical
Fabio de Souza Barbosa, Leonardo Capra Pezzi, Favero Reisdorfer Paula, Sarah Eller, Elfrides E. S. Schapoval, Tiago Franco de Oliveira, Andreas S. L. Mendez
Summary: The stability of the antibiotic doripenem was evaluated by LC-ESI-Q-TOF method, revealing six degradation products under stress conditions and the formation of a major degradation product through cleavage of the beta-lactam ring under hydrolytic conditions. Additionally, oxidation of the drug using H2O2 led to the formation of three new degradation products. The study provides insight into the degradation behavior of doripenem and its important antibiotic class.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Sabrina Laiz Buttenbender, Anderson Ramos Carvalho, Fabio de Souza Barbosa, Rafael Scorsatto Ortiz, Renata Pereira Limberger, Andreas S. L. Mendez
JOURNAL OF AOAC INTERNATIONAL
(2022)
Letter
Toxicology
Sabrina Buttenbender, Graciela Carlos, Martin Steppe, Rafael Scorsatto Ortiz, Renata Pereira Limberger, Andreas Sebastian Loureiro Mendez
FORENSIC TOXICOLOGY
(2022)
Article
Plant Sciences
Hemerson Silva da Rosa, Mari Castro Santos, Marcio Tavares Costa, Andreia Salgueiro, Morgana Duarte da Silva, Daniele Rubert Nogueira-Librelotto, Cristiano Jesse, Michel Mansur Machado, Luis Flavio Souza de Oliveira, Vanderlei Folmer, Andreas S. L. Mendez
Summary: The study evaluated the cytotoxic and anti-inflammatory properties of Sida tuberculata extracts in vitro and in vivo. The results showed that the extracts had stronger cytotoxic effects on tumor cell lines, and the leaf extract significantly reduced acute inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Caren Gobetti, Andressa da Silva Bitencourt, Marcio Vinicius Ayres, Ana Lucia Peixoto de Freitas, Andreas Sebastian Loureiro Mendez, Cassia Virginia Garcia
Summary: Tizanidine hydrochloride is a centrally acting skeletal muscle relaxant used for spasticity management, currently available only in tablet form. Liquid formulations prepared in a hospital environment from the tablets showed good chemical stability for 56 days, but were prone to microbial contamination, reducing their stability to only 7 days.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Meeting Abstract
Immunology
E. Jaime Sanchez, E. E. Lara Ramirez, J. E. Lopez Ramos, A. L. Cisneros Mendez, Y. Bastian Hernandez, J. E. Castaneda Delgado, R. Zenteno Cuevas, J. A. Enciso Moreno
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Integrative & Complementary Medicine
Guilherme Pires Amaral, Caren Rigon Mizdal, Silvio Terra Stefanello, Andreas Sebastian Loureiro Mendez, Robson Luiz Puntel, Marli Matiko Anraku de Campos, Felix Alexandre Antunes Soares, Roselei Fachinetto
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2019)
