Journal
QUIMICA NOVA
Volume 32, Issue 5, Pages 1324-1328Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0100-40422009000500040
Keywords
celecoxib; lumiracoxib; extraction
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EXTRACTION AND PURIFICATION OF SELECTIVES CICLOOXIGENASE-2 NONSTEROIDAL ANTIINFLAMMATORY DRUGS. Celecoxib (CB) and lumiracoxib (LM) are potent COX-2 inhibitors widely marketed for the treatment of rheumatoid arthritis and osteoarthritis. Nevertheless, it is difficult to obtain because it are protected under patents. The aim of this work was to develop an extraction method of drugs, CB and LM, in order to obtain the drug with a purity degree appropriated for use in research projects. The developed method showed to be effective of both drugs, becoming interesting due to its low cost, easy and speed of execution, application to different dosage forms (capsules and tablets) and drugs with different physicochemical properties.
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