Combined early dynamic 18F-FDG PET/CT and conventional whole-body 18F-FDG PET/CT provide one-stop imaging for detecting hepatocellular carcinoma

Background and objective: It is widely accepted that conventional F-18-FDG PET/CT (whole-body static F-18-FDG PET/CT, WB F-18-FDG PET/CT) has a low detection rate for hepatocellular carcinoma (HCC). We prospectively assessed the role of early dynamic F-18-FDG PET/CT (ED F-18-FDG PET/CT) and WB F-18-FDG PET/CT in detecting HCC, and we quantified the added value of ED F-18-FDG PET/CT to WB F-18-FDG PET/CT. Methods: Twenty-two patients with 37 HCC tumors (HCCs) who underwent both a liver ED F-18-FDG PET/CT (performed simultaneously with a 5.5 MBq/kg F-18-FDG bolus injection and continued for 240 s) and a WB F-18-FDG PET/CT were enrolled in the study. Results: The WB F-18-FDG PET/CT and ED F-18-FDG PET/CT scans were positive in 56.7% (21/37) and 78.4% (29/37) HCCs, respectively (P < 0.05). ED F-18-FDG PET/CT in conjunction with WB F-18-FDG PET/CT (one-stop F-18-FDG PET/CT) improved the positive detection rates of WB and ED F-18-FDG PET/CT alone from 56.7% and 78.4% to 91.9% (34/37) (P < 0.001 and P > 0.05, respectively). Conclusion: One-stop F-18-FDG PET/CT appears to be useful to improve WB F-18-FDG PET/CT for HCC detection. (C) 2014 Elsevier Masson SAS. All rights reserved.