Article
Cardiac & Cardiovascular Systems
Graham Wilson, Mukul Sharma, Debra Eagles, Marie-Joe Nemnom, Marco L. A. Sivilotti, Marcel Emond, Ian G. Stiell, Grant Stotts, Jacques Lee, Andrew Worster, Judy Morris, Ka Wai Cheung, Albert Y. Jin, Wieslaw J. Oczkowski, Demetrios J. Sahlas, Heather E. Murray, Ariane Mackey, Steve Verreault, Marie Christine Camden, Samuel Yip, Philip Teal, David J. Gladstone, Mark I. Boulos, Nicolas Chagnon, Elizabeth Shouldice, Clare Atzema, Tarik Slaoui, Jeanne Teitlebaum, George A. Wells, Avik Nath, Jeffrey J. Perry
Summary: It is unclear whether initiating oral anticoagulation immediately in the emergency department (ED) for patients with atrial fibrillation after a transient ischemic attack (TIA) or minor stroke is more effective than deferring the decision to outpatient follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Francisco Purroy, Mikel Vicente-Pascual, Gloria Arque, Robert Begue, Joan Farre, Yhovany Gallego, Maria Pilar Gil-Villar, Gerard Mauri, Nuria Montala, Cristina Pereira, Coral Torres-Querol, Daniel Vazquez-Justes
Summary: The risk of NDAF after TIA is clinically significant, with factors such as female sex, age, previous ischemic heart disease, and cortical DWI pattern being associated with NDAF. NT-proBNP levels are related to the risk of NDAF within the first 5 years of follow-up. Patients with NDAF after admission and within 5 years have the highest risk of SIS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hooman Kamel, Mary Farrant, J. Donald Easton, Luciano A. Sposato, Jordan J. Elm, Ellen Underwood, S. Claiborne Johnston
Summary: Among patients with cerebral ischemia, the distinction between TIA and minor stroke did not stratify the risk of subsequent AF diagnosis, implying that patients with TIA should undergo similar heart-rhythm monitoring strategies as patients with ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Clinical Neurology
Amit K. Kishore, Mohammad J. Hossain, Alan Cameron, Jesse Dawson, Andy Vail, Craig J. Smith
Summary: The performance of risk scores for predicting NDAF after ischemic stroke/transient ischemic attack varies widely, with uncertainty about their utility in clinical practice. Further studies using larger cohorts and randomized control trials are needed to evaluate the usefulness of these scores for clinical decision making and preventative intervention.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Cardiac & Cardiovascular Systems
Keisuke Tokunaga, Masahiro Yasaka, Kazunori Toyoda, Etsuro Mori, Teruyuki Hirano, Toshimitsu Hamasaki, Hiroshi Yamagami, Takehiko Nagao, Shinichi Yoshimura, Shinichiro Uchiyama, Kazuo Minematsu
Summary: The present observational study found that in patients with NVAF, bridging therapy with low-dose heparin before starting rivaroxaban was associated with a higher occurrence of ischemic events and major bleeding compared to starting treatment directly with rivaroxaban.
CIRCULATION JOURNAL
(2022)
Article
Medicine, General & Internal
Phan Dinh Phong, Bui Nguyen Tung, Pham Manh Hung, Nguyen Ngoc Quang, Nguyen Thi Thu Hoai, Nguyen Viet Dung, Thanh N. Nguyen, Dao Viet Phuong, Mai Duy Ton
Summary: This study found a high prevalence of atrial fibrillation (AF) in patients with transient ischemic attack (TIA) or ischemic stroke in Northern Vietnam, exceeding rates in other Southeast Asian countries. Age, renal dysfunction, valvular heart disease, and low ejection fraction were significantly associated with AF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Anjali Bhatla, Yuliya Borovskiy, Ronit Katz, Matthew C. Hyman, Parin J. Patel, Jeffrey Arkles, David J. Callans, Neel Chokshi, Sanjay Dixit, Andrew E. Epstein, David S. Frankel, Fermin C. Garcia, Ramanan Kumareswaran, Jackson J. Liang, David Lin, Steven R. Messe, Saman Nazarian, Michael P. Riley, Pasquale Santangeli, Robert D. Schaller, Gregory E. Supple, Scott E. Kasner, Francis Marchlinski, Rajat Deo
Summary: This study assessed the prognosis of patients with ischemic stroke based on the timing of AF diagnosis. The findings indicated that patients diagnosed with AF after stroke within <= 6 months had the highest risk of death.
Article
Hematology
Po-Yin Chang, Wei-Ting Wang, Wei-Lun Wu, Hui-Chin Chang, Chen-Huan Chen, Yi-Wen Tsai, Shih-Hwa Chiou, Gregory Y. H. Lip, Hao-Min Cheng, Chern-En Chiang
Summary: This study investigated the timing of oral anticoagulant (OAC) initiation in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). The study found that early OAC use is effective for patients with mild-to-moderate AIS, while delayed use should be considered for patients with severe AIS to prevent serious bleeding events.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Clinical Neurology
Liqi Shu, Wei Jiang, Han Xiao, Nils Henninger, Thanh N. Nguyen, James E. Siegler, Adam de Havenon, Eric D. Goldstein, Daniel Mandel, Maheen Rana, Fawaz Al-Mufti, Jennifer Frontera, Karen Furie, Shadi Yaghi
Summary: This study aimed to determine the risk factors of acute ischemic stroke (AIS) during the periprocedural period in patients with atrial fibrillation (AF). The results showed that higher CHA(2)DS(2)VASc scores, cardiovascular surgery, neurological surgery, and active cancer were associated with an increased risk of periprocedural AIS.
ANNALS OF NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
James Freeman, Angela Y. Higgins, Yongfei Wang, Chengan Du, Daniel J. Friedman, Usama A. Daimee, Karl E. Minges, Lucy Pereira, Andrew M. Goldsweig, Matthew J. Price, Vivek Y. Reddy, Douglas Gibson, Shephal K. Doshi, Paul D. Varosy, Frederick A. Masoudi, Jeptha P. Curtis
Summary: This study evaluated the postprocedure care patterns and compared the risk of adverse events for different discharge antithrombotic strategies after left atrial appendage occlusion (LAAO) with the Watchman device. The study found that practitioners rarely followed the recommended postprocedure treatment protocols and that discharge on warfarin or direct oral anticoagulants (DOACs) without aspirin was associated with a lower risk of adverse outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander P. Benz, Stefan H. Hohnloser, John W. Eikelboom, Anthony P. Carnicelli, Robert P. Giugliano, Christopher B. Granger, Josephine Harrington, Ziad Hijazi, David A. Morrow, Manesh R. Patel, David J. Seiffge, Ashkan Shoamanesh, Lars Wallentin, Qilong Yi, Stuart J. Connolly
Summary: This study aimed to investigate the prognosis of patients with atrial fibrillation (AF) and ischemic stroke while on oral anticoagulation. The results showed that among the 1163 patients who had a post-randomization ischemic stroke while on study medication, 7.0% had a recurrent ischemic stroke within 1 year, and the all-cause mortality rate within 3 months was 12.4%.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Houwei Du, Duncan Wilson, Gareth Ambler, Gargi Banerjee, Clare Shakeshaft, Hannah Cohen, Tarek Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Henry Houlden, Martin M. Brown, Keith W. Muir, Hans Rolf Jager, David J. Werring
Summary: In patients anticoagulated for atrial fibrillation after recent ischemic stroke or transient ischemic attack, magnetic resonance imaging markers of cerebral small vessel disease are significantly associated with an increased risk of ischemic stroke.
Article
Medicine, General & Internal
Paula Tiili, Ioannis Leventis, Janne Kinnunen, Ida Svedjeback, Mika Lehto, Efstathia Karagkiozi, Dimitrios Sagris, George Ntaios, Jukka Putaala
Summary: Adherence to oral anticoagulation therapy was poor in half of the atrial fibrillation patients who survived an ischaemic stroke. Independent patient-related factors were associated with poor adherence quality, highlighting the importance of recognizing adherence support as a crucial part of patient care.
ANNALS OF MEDICINE
(2021)
Article
Medicine, General & Internal
Jian Chen, Ying Zhao, Changsheng Ma, Xin Du, Yihua He, Hong Li
Summary: Left atrial (LA) remodeling is closely associated with cerebral stroke. However, the relationship between early-stage impaired deformability of the left atrium and stroke/transient ischemic attack (TIA) remains unclear. This study used speckle tracking echocardiography to evaluate changes in LA deformability and found that LA strain rate during left ventricular early diastole (SRE) was lower in the stroke/TIA group compared to the non-stroke/TIA group. Multiple regression analysis showed that SRE had a linear dependence on E/A ratio, LA volume index (VI), and body mass index, and SRE and sex ratio were independent risk factors for stroke/TIA.
Article
Clinical Neurology
Flurina Lyrer, Annaelle J. Zietz, David J. Seiffge, Masatoshi Koga, Bastian Volbers, Duncan Wilson, Bruno Bonetti, Sabine Schaedelin, Henrik Gensicke, Sohei Yoshimura, Kosmas Macha, Gareth Ambler, Sebastian Thilemann, Tolga Dittrich, Manabu Inoue, Kaori Miwa, Ruihao Wang, Gabriela Siedler, Luise M. Biburger, Martin M. H. Brown, Rolf H. Jager, Keith Muir, Christopher Traenka, Kanta Tanaka, Masayuki H. Shiozawa, Leo H. Bonati, Nils Peters, Gregory Y. H. A. Lip, Philippe A. Lyrer, Manuel Cappellari, Kazunori Toyoda, Bernd Kallmunzer, Stefan J. Schwab, David J. T. Werring, Stefan T. Engelter, Gian Marco A. De Marchis, Alexandros A. Polymeris
Summary: This study aimed to compare the risk of stroke recurrence between known atrial fibrillation before stroke (KAF) and atrial fibrillation detected after stroke (AFDAS) in patients with anticoagulation, and to investigate the impact of pre-existing anticoagulation on this risk difference. The study found that only pre-existing anticoagulation, not KAF, was independently associated with a higher risk of stroke recurrence. Therefore, future research should focus on the causes of stroke despite anticoagulation to develop improved preventive treatments.
ANNALS OF NEUROLOGY
(2023)
Article
Rheumatology
Christina Charles-Schoeman, Maya H. Buch, Maxime Dougados, Deepak L. Bhatt, Jon T. Giles, Steven R. Ytterberg, Gary G. Koch, Ivana Vranic, Joseph Wu, Cunshan Wang, Kenneth Kwok, Sujatha Menon, Jose L. Rivas, Arne Yndestad, Carol A. Connell, Zoltan Szekanecz
Summary: This post hoc analysis observed a higher risk of MACE associated with tofacitinib compared to TNFi in RA patients with a history of ASCVD. Among patients without a history of ASCVD but with prevalent CV risk factors, there does not appear to be a difference in MACE risk between tofacitinib 5 mg twice daily and TNFi, although any absolute risk excess is likely low.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaowen Wang, Muthiah Vaduganathan, Brian L. Claggett, Sheila M. Hegde, Maria Pabon, Ian J. Kulac, Orly Vardeny, Eileen O'Meara, Shelley Zieroth, Tzvetana Katova, Martina M. McGrath, Anne-Catherine Pouleur, Pardeep S. Jhund, Akshay S. Desai, Silvio E. Inzucchi, Mikhail N. Kosiborod, Rudolf A. de Boer, Lars Kober, Marc S. Sabatine, Felipe A. Martinez, Piotr Ponikowski, Sanjiv J. Shah, Adrian F. Hernandez, Anna Maria Langkilde, John J. McMurray, Scott D. Solomon, Carolyn S. P. Lam
Summary: This study analyzed the efficacy and safety of sodium-glucose cotransporter-2 inhibitors in the treatment of heart failure, and assessed the impact of sex on their effectiveness and safety. The study found that, after adjusting for baseline differences, women had fewer cardiovascular and all-cause deaths, as well as lower rates of HF hospitalizations and total events, compared to men. There were no sex-related differences in adverse events or drug discontinuation. Therefore, sex does not modify the treatment effect of sodium-glucose cotransporter-2 inhibitors.
Article
Endocrinology & Metabolism
Rena Pollack, Itamar Raz, Stephen D. Wiviott, Erica L. Goodrich, Sabina A. Murphy, Ilan Yanuv, Aliza Rozenberg, Ofri Mosenzon, Anna Maria Langkilde, Ingrid A. M. Gause-Nilsson, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P. H. Wilding, Marc S. Sabatine, Avivit Cahn
Summary: This study explored the cardiorenal benefits of adding SGLT2 inhibitor therapy for patients on insulin. The results showed that dapagliflozin reduced cardiovascular and renal risks and had no significant impact on insulin dose and regimen.
Meeting Abstract
Clinical Neurology
Jay Lusk, Molly N. Hoffman, Amy G. Clark, Brian C. Mac Grory, Matthew W. Luedke, Ying Xian, Jonathan Bae, Bradley G. Hammill
Review
Geriatrics & Gerontology
Breni Sharma, Meng Wang, Cheryl R. McCreary, Richard Camicioli, Eric E. Smith
Summary: This study reviewed and analyzed the literature on the associations of cerebral small vessel disease (CSVD) with gait impairment and falls. The findings suggest that the severity of CSVD is associated with gait impairment, history of falls, and future falls risk. Therefore, preventing CSVD should be included in a comprehensive public health strategy to improve mobility and reduce the risk of falls in older adults.
Article
Medicine, Research & Experimental
Samuel C. R. Sherratt, Peter Libby, Hazem Dawoud, Deepak L. Bhatt, Tadeusz Malinski, R. Preston Mason
Summary: This study investigated the pro-inflammatory effects of air pollution PMs on pulmonary endothelial cell NO bioavailability and protein expression, and whether EPA can restore endothelial cell function. The results showed that EPA can alter protein expression related to inflammatory pathways and reduce the levels of the inflammatory molecule sICAM-1, improving the NO/ONOO- release ratio. These cellular changes may contribute to the anti-inflammatory, cytoprotective, and lipid changes associated with EPA treatment during air pollution exposure.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Javed Butler, Khawaja M. Talha, Gregg C. Fonarow
Editorial Material
Cardiac & Cardiovascular Systems
Hyeok-Hee Lee, Hokyou Lee, Deepak L. Bhatt, Ga Bin Lee, Jiyen Han, Dong Wook Shin, Danbee Kang, Jong-Chan Youn, Eliseo Guallar, Juhee Cho, Hyeon Chang Kim
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Shariq Usman, Tariq Jamal Siddiqi, Stefan D. Anker, George L. Bakris, Deepak L. Bhatt, Gerasimos Filippatos, Gregg C. Fonarow, Stephen J. Greene, James L. Januzzi, Muhammad Shahzeb Khan, Mikhail N. Kosiborod, Darren K. McGuire, Ileana L. Pina, Julio Rosenstock, Muthiah Vaduganathan, Subodh Verma, Shelley Zieroth, Javed Butler
Summary: SGLT2 inhibitors can reduce the risk of heart failure events and cardiovascular death in patients with type 2 diabetes, heart failure, and chronic kidney disease, and the effects are consistent in patients with different combinations of these diseases.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Darryl Wan, Mahshid Dehghan, Russell J. de Souza, Chinthanie Ramasundarahettige, John W. Eikelboom, Jackie Bosch, Aldo P. Maggioni, Deepak L. Bhatt, Salim Yusuf, Sonia S. Anand
Summary: This study examined the association between dietary patterns and the risk of recurrent major adverse cardiovascular and limb events in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). The findings suggest that poor diet quality is independently associated with a higher risk of such events.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Alexandra J. Mayhew, David Hogan, Parminder Raina, Christina Wolfson, Andrew P. Costa, Aaron Jones, Susan Kirkland, Megan O'Connell, Vanessa Taler, Eric E. Smith, Teresa Liu-Ambrose, Jinhui Ma, Mary Thompson, Changbao Wu, Howard Chertkow, Lauren E. Griffith, CLSA Memory Study Working Grp
Summary: This study aims to validate an NCD ascertainment algorithm to identify CLSA participants with NCDs through self-reported physician diagnosis, medication consumption, and daily function data.
Article
Cardiac & Cardiovascular Systems
Bertram Pitt, Deepak L. Bhatt, Michael Szarek, Christopher P. Cannon, Lawrence A. Leiter, Darren K. Mcguire, Julia B. Lewis, Matthew C. Riddle, Adriaan A. Voors, Marco Metra, Lars H. Lund, Michel Komajda, Jeffrey M. Testani, Christopher S. Wilcox, Piotr Ponikowski, Renato D. Lopes, Justin A. Ezekowitz, Franklin Sun, Michael J. Davies, Subodh Verma, Mikhail N. Kosiborod, SOLOIST WHF Investigators
Summary: The study finds that starting sotagliflozin before discharge in type 2 diabetes patients hospitalized for WHF can significantly decrease cardiovascular deaths and HF events through 30 and 90 days after discharge. However, sotagliflozin may have slightly higher rates of diarrhea and volume-related events compared to placebo.
JACC-HEART FAILURE
(2023)
Article
Clinical Neurology
Morgan J. Schaeffer, Noaah Reaume, Meng Wang, Arooj Aftab, Alexander Pan, Sana Tariq, Meaghan Reid, Eric E. Smith, Chris D'Esterre, Philip A. Barber
Summary: Transient ischaemic attack (TIA) is associated with increased risk of cognitive decline and dementia as early as one-year post-event. Regional brain atrophy measurements may predict future cognitive decline. This study aimed to determine whether Medial Temporal Atrophy (MTA) scores and interseptal distance (ISD) measurements are greater in TIA patients compared to controls, and whether MTA and ISD predicts cognitive change one year after TIA.
CEREBRAL CIRCULATION - COGNITION AND BEHAVIOR
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mikhail Kosiborod, Deepak L. Bhatt, Michael Szarek, Philippe Gabriel Steg, Bertram Pitt
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Samuel C. R. R. Sherratt, Peter Libby, Deepak L. Bhatt, R. Preston Mason
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)