Review
Endocrinology & Metabolism
Jill M. Siegfried
Summary: Lung cancer and COPD show sex and gender differences in their presentations and outcomes, with incidence increasing in women over the past 50 years. Estrogen may play a role in promoting the development of both diseases, affecting the immune system response and activating estrogen receptors in the lung cells.
Review
Oncology
Lauren May, Kathryn Shows, Patrick Nana-Sinkam, Howard Li, Joseph W. Landry
Summary: Lung cancer is more prevalent in males, who also have higher mortality rates. This difference is likely a combination of environmental factors, biological differences, and sex hormones. Understanding these biological differences could lead to improved personalized treatment decisions in the clinic.
Article
Oncology
Xue Qin Yu, Mei Ling Yap, Elvin S. Cheng, Preston J. Ngo, Pavla Vaneckova, Deme Karikios, Karen Canfell, Marianne F. Weber
Summary: This study in a large prospective cohort in Australia found that women with lung cancer tend to have longer survival than men. Known prognostic factors account for the sex-related survival disparity.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Nickolas Stabellini, Apoorva Krishna Chandar, Amitabh Chak, Amie J. Barda, Mantas Dmukauskas, Kristin Waite, Jill S. Barnholtz-Sloan
Summary: Esophageal cancer is the seventh most common type of cancer worldwide and the sixth leading cause of cancer-related death. The incidence of esophageal cancer is higher in males, but there is limited data on prognosis and survival. This study aimed to analyze the differences between sexes and other factors in patients with primary esophageal cancer. The analysis of data from 2005 to 2020 showed differences between males and females in age at diagnosis, histology, smoking status, and prescriptions of NSAIDs. However, there was no significant difference in survival between males and females.
SCIENTIFIC REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Lillian L. Tsai, Ngoc-Quynh Chu, William A. Blessing, Philicia Moonsamy, Yolonda L. Colson
Summary: Lung cancer is the leading cause of cancer-related death for women in the United States. Clinical characteristics, histology, epidemiology, and treatment responses are unique for women with lung cancer.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Malin Ljunggren, Caroline E. Weibull, Gabriella Palmer, Emerik Osterlund, Bengt Glimelius, Anna Martling, Caroline Nordenvall
Summary: This population-based study found that women with synchronous metastatic colorectal cancer (mCRC) were less likely to receive metastatic surgery and had slightly higher all-cause mortality compared to men.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
N. S. IJzerman, E. van Werkhoven, M. Mohammadi, D. den Hollander, R. F. Bleckman, A. K. L. Reyners, I. M. E. Desar, H. Gelderblom, D. J. Gruenhagen, R. H. J. Mathijssen, N. Steeghs, W. T. A. van der Graaf
Summary: Sex differences may exist in gastrointestinal stromal tumor (GIST) patients and have an impact on disease-specific survival (DSS). Male patients are more likely to have aggressive GISTs with larger tumors, higher mitotic rates, more frequent tumor ruptures, and metastases, which may explain the sex differences observed in DSS.
Article
Respiratory System
Meera Ragavan, Manali Patel
Summary: In contrast to a few decades ago, the incidence rates of lung cancer in women are now comparable to or higher than those in men and are rising rapidly in many parts of the world. Women face unique risk factors for lung cancer, including both exogenous and endogenous exposures. The current screening guidelines may not accurately assess the lung cancer risk in women. Women diagnosed with lung cancer have a clear mortality benefit compared to men, but there may be sex-based differences in treatment outcomes and side effects.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Oncology
Marianne C. Kalff, Willemieke P. M. Dijksterhuis, Anna D. Wagner, Sabine Oertelt-Prigione, Rob H. A. Verhoeven, Valery E. P. P. Lemmens, Hanneke W. M. van Laarhoven, Suzanne S. Gisbertz, Mark I. van Berge Henegouwen
Summary: Although the curative treatment options are the same for male and female gastroesophageal cancer patients, there may be differences in access to care and survival. This study aimed to compare treatment allocation and survival between male and female patients with potentially curable gastroesophageal cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Mandy Laube, Ulrich H. Thome
Summary: This article discusses sex-specific differences in alveolar epithelial functions, with a focus on preterm infants and respiratory disorders associated with premature birth. It provides an overview of fetal lung development and the challenges faced during the transition to air breathing. The article also explores potential sex-specific causes of pulmonary complications and highlights the importance of understanding steroidogenic enzymes' expression during fetal lung development. Additionally, it reviews the knowledge about sex-specific aspects of lung growth and maturation, with a special emphasis on alveolar epithelial Na+ transport and the observed sex differences in this process.
Article
Cardiac & Cardiovascular Systems
Joshua R. Smith, Randal J. Thomas, Amanda R. Bonikowske, Shane M. Hammer, Thomas P. Olson
Summary: This article reviews the sex differences in outpatient phase II cardiac rehabilitation (CR) programming, including CR participation rates, core components, and barriers to participation. Strategies to mitigate these disparities are discussed, along with areas for future research.
CIRCULATION RESEARCH
(2022)
Article
Nutrition & Dietetics
Jinyu Shi, Hailun Xie, Guotian Ruan, Yizhong Ge, Shiqi Lin, Heyang Zhang, Xin Zheng, Chen'an Liu, Mengmeng Song, Tong Liu, Xiaowei Zhang, Ming Yang, Xiaoyue Liu, Qi Zhang, Li Deng, Xin Wang, Hanping Shi
Summary: Lung cancer is a common lethal malignant tumor associated with a high incidence of malnutrition. Phase angle, a simple and non-invasive indicator of body composition, is found to be associated with mortality in male lung cancer patients but has limited association with female lung cancer patients.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Laura Guarga, Alberto Ameijide, Rafael Marcos-Gragera, Maria Carulla, Joaquim Delgadillo, Josep Maria Borras, Jaume Galceran
Summary: In Catalonia, there has been a decrease in new cases of lung cancer in men under 70 years old and an increase in women over 60 years old. Adenocarcinoma is the most common type, while squamous cell carcinoma and small cell carcinoma are decreasing significantly in men. The incidence of lung cancer has increased by 16% for patients over 70 years old in both sexes.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Nancy W. Lin, Cuining Liu, Ivana Yang, Lisa A. Maier, Dawn L. DeMeo, Cheyret Wood, Shuyu Ye, Margaret H. Cruse, Vong L. Smith, Carrie A. Vyhlidal, Katerina Kechris, Sunita Sharma
Summary: This study identified sex-specific differences in miRNA expression during human fetal lung development, which may impact susceptibility to pulmonary diseases later in life.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Jae-Hoon Lee, Soyoung Kim, Hye Sun Lee, Eun Jung Park, Seung Hyuk Baik, Tae Joo Jeon, Kang Young Lee, Young Hoon Ryu, Jeonghyun Kang
Summary: The study found that men had significantly higher relative VAT and VAT-SUV than women, and high rVAT and high VAT-SUV showed worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients.
SCIENTIFIC REPORTS
(2021)