Prevalence, characteristics and prognostic significance of anemia in daily practice

Background: The prevalence of anemia has been studied in well-defined populations, but no large study is available for less restricted populations with various disorders. Design: Two-phase nationwide study: (i) a cross-sectional study including 1351 patients aimed to define the prevalence and characteristics of anemic patients seen in France, and (ii) a prospective longitudinal study of 398 anemic patients aimed to define factors associated with survival. Results: Anemia was present in 874 (65%) patients according to WHO criteria, and 573 (42%) patients had hemoglobin levels < 110 g/l. Characteristics independently associated with anemia were the presence of cancer, hematological disorder, renal failure and inflammatory syndrome. Baseline factors negatively associated with the 3-month survival were cancer, older age and a lower target hemoglobin level defined at baseline. Negative predictive factors at Month 3 of the 6-month survival were older age and the absence of correction of anemia according to the target hemoglobin level defined at baseline. Conclusion: Anemia is frequent and is associated with cancer, hematological disorders, renal failure and inflammatory syndrome. At baseline, prognostic factors of 3-month survival include cancer, older age and lower target hemoglobin level, whereas reaching the target hemoglobin level at Month 3 has a favorable prognostic impact on 6-month survival.