Review
Biochemistry & Molecular Biology
Peter Cuthbertson, Nicholas J. Geraghty, Sam R. Adhikary, Katrina M. Bird, Stephen J. Fuller, Debbie Watson, Ronald Sluyter
Summary: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective therapy for blood cancers and other haematological disorders, but may lead to graft-versus-host disease (GVHD). Current treatments for GVHD are limited, highlighting the need for exploring inflammatory factors to identify new treatment targets. Purinergic signalling, including purinergic receptors and ectoenzymes, has been implicated in influencing GVHD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Waldemar Schaefer, Tobias Staehler, Carolina Pinto Espinoza, Welbeck Danquah, Jan Hendrik Knop, Bjoern Rissiek, Friedrich Haag, Friedrich Koch-Nolte
Summary: P2X7, an ion channel gated by extracellular ATP, plays important roles in inflammation and apoptosis. Polymorphisms in the P2X7 gene are common, and their frequencies vary among different human populations. Considering P2X7 variants of participants is important in designing clinical trials targeting P2X7.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Masayoshi Tanaka, Eiji Shigetomi, Bijay Parajuli, Hiroaki Nagatomo, Youichi Shinozaki, Yuri Hirayama, Kozo Saito, Yuto Kubota, Yosuke Danjo, Ji Hwan Lee, Sun Kwang Kim, Junichi Nabekura, Schuichi Koizumi
Summary: mGluR5 in astrocytes is regulated by ATP/adenosine signals, which helps control synapse remodeling and potentially contributes to disease pathogenesis.
Article
Neurosciences
Solen Rimbert, Joao B. Moreira, Sara Xapelli, Sabine Levi
Summary: This article reviews the expression and activity of the purinergic system during embryonic and postnatal development of the nervous system, highlighting its crucial role in various steps of brain development. The involvement of purinergic signaling in neural stem cell proliferation, neuronal differentiation and migration, as well as astrogliogenesis and oligodendrogenesis, is discussed. Additionally, the importance of purinergic signaling in the formation of peripheral neuromuscular junctions and central GABAergic and glutamatergic synapses is examined, along with the potential therapeutic implications of targeting the purinergic system in diseases.
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Bernhard Wernly, David Erlinge, John Pernow, Zhichao Zhou
Summary: Cardiometabolic diseases can lead to vascular complications globally, with altered purinergic signaling being a key mechanism. Ticagrelor, a successful drug, targets purinergic signaling by affecting platelet aggregation and RBCs to potentially provide cardiovascular benefits in patients with acute coronary syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chenhao Li, Yang Li, Wenwen Zhang, Zhenjie Ma, Shaobo Xiao, Wei Xie, Shuai Miao, Bozhi Li, Guangshuang Lu, Yingyuan Liu, Wenhao Bai, Shengyuan Yu
Summary: Clinical imaging studies have shown that the hypothalamus is activated in migraine patients before and during headache, and has increased functional connectivity with the spinal trigeminal nucleus. The dopaminergic system in the hypothalamus, particularly the A11 nucleus, may play a crucial role in the pathogenesis of migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Magdalena A. Zabielska-Kaczorowska, Alicja Braczko, Iwona Pelikant-Malecka, Ewa M. Slominska, Ryszard T. Smolenski
Summary: Myocardial ischemia leads to a decrease in adenosine production, which affects its protective functions. This study tested the relationship between cardiac adenine nucleotide pool (TAN) and adenosine production. Results showed that after 1 min ischemia at 85 min, adenosine production decreased to less than 15% of that at 40 min, accompanied by a decrease in ATP and TAN. However, when adenosine was infused after 10 min ischemia, adenosine production was partially restored. These findings suggest that only a fraction of the cardiac adenine nucleotide pool is available for adenosine production.
Article
Biochemistry & Molecular Biology
Senthilkumar S. Karuppagounder, Subramaniam Uthaythas, Manoj Govindarajulu, Sindhu Ramesh, Koodeswaran Parameshwaran, Muralikrishnan Dhanasekaran
Summary: Parkinson's disease is a progressive neurodegenerative disorder affecting over 10 million people worldwide, with oxidative stress and mitochondrial dysfunction playing key roles in its progression. Studies suggest that caffeine may improve neurological function in PD patients and potentially prevent disease progression.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Plant Sciences
Yunjeong Song, Sowoon Seo, Santosh Lamichhane, Jungwon Seo, Jin Tae Hong, Hye Jin Cha, Jaesuk Yun
Summary: Limonene exhibits anxiolytic effects by regulating dopamine and GABA neurotransmission to inhibit anxiety-related behavior. Moreover, the action of limonene is mediated by adenosine A2A receptor.
Article
Multidisciplinary Sciences
Sarah J. Brown, Ibrahim Boussaad, Javier Jarazo, Julia C. Fitzgerald, Paul Antony, Marcus Keatinge, Janna Blechman, Jens C. Schwamborn, Rejko Krueger, Marysia Placzek, Oliver Bandmann
Summary: Recent evidence suggests that neurogenesis continues throughout life but the impact on neurodegenerative disorders like Parkinson's disease is still unclear. Studies in zebrafish and human organoids show that PINK1 deficiency impairs adult dopaminergic neurogenesis, potentially affecting future therapeutic approaches for PD patients with biallelic PINK1 mutations.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Alfredo Oliveros, Ki Hyun Yoo, Mohammad Abdur Rashid, Ana Corujo-Ramirez, Benjamin Hur, Jaeyun Sung, Yuanhang Liu, John R. Hawse, Doo-Sup Choi, Detlev Boison, Mi-Hyeon Jang
Summary: Chemotherapy-induced cognitive impairment (CICI) can be prevented by blocking the adenosine A(2A) receptor signaling pathway. In this study, the A(2A) receptor antagonist KW-6002 was used to prevent neural damage caused by the chemotherapy drug cisplatin, and improve memory and anxiety-like behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Nicholas Dale
Summary: This review emphasizes the importance of real-time measurements of extracellular ATP and adenosine concentrations, provides additional mechanistic insights, and outlines current techniques available for spatially localized measurements. The examples of CO2 and nutrient sensing highlight the impact of direct real-time measurements, demonstrating the role of purinergic signaling in breathing control, weight regulation, and sleep-wake state. Additionally, the complex mechanisms of activity-dependent adenosine release in different brain regions are discussed, underscoring the potential of whole blood purine measurements in clinical practice.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Min Liu, Cui Liu, Xue Xiao, Shuai-Shuai Han, Ming-Xia Bi, Qian Jiao, Xi Chen, Chun-Ling Yan, Xi-Xun Du, Hong Jiang
Summary: The upregulation of the SUR1 subunit in ATP-sensitive potassium channels is found to play an important role in the selective degeneration of dopaminergic neurons in Parkinson's disease. Delaying the progression of dopaminergic neuron degeneration is possible through interference with SUR1 expression. The elevated expression of transcription factors FOXA1 and FOXA2 has been identified as a mechanism causing the upregulation of the SUR1 subunit.
Review
Neurosciences
Melissa Talita Wiprich, Carla Denise Bonan
Summary: Huntington's disease is a devastating neurodegenerative disorder characterized by motor dysfunction, psychiatric disturbance, and cognitive decline. Purinergic signaling, particularly involving adenosine A(2A) receptors, plays a significant role in the pathophysiology of HD, offering potential pharmacological targets and biomarkers for this disorder.
FRONTIERS IN NEUROSCIENCE
(2021)