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Clinical Neurology
Theodore E. Liston, Aldric Hama, Johannes Boltze, Russell B. Poe, Takahiro Natsume, Ikuo Hayashi, Hiroyuki Takamatsu, William S. Korinek, James D. Lechleiter
Summary: This study demonstrates the therapeutic effect of AST-004 agonist in the treatment of acute ischemic stroke in a nonhuman primate model. AST-004 reduces lesion volume and increases penumbra volume. The changes are correlated with unbound AST-004 concentrations in the plasma and cerebrospinal fluid as well as estimated brain A1R and A3R occupancy.
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Biochemistry & Molecular Biology
Silvia Sgambellone, Silvia Marri, Stefano Catarinicchia, Alessandro Pini, Dilip K. Tosh, Kenneth A. Jacobson, Emanuela Masini, Daniela Salvemini, Laura Lucarini
Summary: This study demonstrates the therapeutic potential of the A(3)AR agonist, MRS5980, in lung fibrosis by reducing inflammation, TGF-β expression, and fibrotic remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hisataka Shoji, Steven M. Opal
Summary: Endotoxin removal therapy using PMX has been used clinically since 1994 for sepsis and septic shock patients, with effectiveness demonstrated for over a quarter of a century. However, a clear survival benefit has not been shown in a large, multicenter, randomized controlled trial. Ongoing research is exploring the potential long-term survival benefits of PMX therapy for septic patients, along with studies on the endotoxin adsorption capacity of PMX columns and immunomodulatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria E. Hammarlund, Vladimer Darsalia, Filip Mjornstedt, Bagmi Pattanaik, Carina Mallard, Eridan Rocha-Ferreira, Cesare Patrone, Maria E. Johansson
Summary: The study investigated the expression of alpha 7nAChR in different brain regions and evaluated the potential effect of the alpha 7nAChR agonist AR-R17779 on ischemia-reperfusion brain injury in mice. It was found that alpha 7nAChR expression varies in different brain regions, and despite a decrease in white blood cells in sham mice receiving AR-R17779, this compound does not affect stroke-induced brain injury.
BIOSCIENCE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Hamid Merdji, Mohamad Kassem, Louise Chomel, Raphael Clere-Jehl, Julie Helms, Kei Kurihara, Ahmed Bey Chaker, Cyril Auger, Valerie Schini-Kerth, Florence Toti, Ferhat Meziani
Summary: Our study found that sepsis can induce vascular aging, inflammation, and oxidative stress, leading to long-term cardiovascular events. Endothelial and vascular senescence are associated with sepsis-induced long-term vascular dysfunction.
VASCULAR PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Grace E. Falk, Jerad Rogers, Liuqiang Lu, Elizabeth Ablah, Hayrettin Okut, Mohinder R. Vindhyal
Summary: The study found that sepsis patients with subsequent septic shock have an increased frequency of in-hospital cardiovascular events and procedures. Compared to those without septic shock, these patients are more likely to experience acute kidney injury, acute systolic heart failure, NSTEMI, and ischemic stroke.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Ophthalmology
David L. Wirta, Michelle Senchyna, Amber E. Lewis, David G. Evans, Eugene B. McLaurin, George W. Ousler, David A. Hollander
Summary: The study found that AR-15512 demonstrated statistically significant improvements in the signs, symptoms, and disease-related quality of life (QoL) for dry eye disease (DED) patients.
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Respiratory System
Jan Krzysztof Nowak, Andrzej Wykretowicz, Edyta Madry, Tomasz Krauze, Slawomira Drzymala-Czyz, Patrycja Krzyzanowska-Jankowska, Paulina Sobkowiak, Agata Schneider, Joanna Gozdzik-Spychalska, Szymon Kurek, Victoria Kononets, Nataliya Kashirskaya, Aleksandra Lisowska, Jaroslaw Walkowiak
Summary: Patients with cystic fibrosis (CF) have increased arterial stiffness and greater intima-media thickness (IMT), especially in those with pancreatic insufficient (PI) CF. The arterial stiffness index (SIDVp) is higher in PI CF patients compared to pancreatic sufficient (PS) CF patients and healthy controls. PS CF patients have higher IMT than PI CF patients and SIDVp is independently associated with age, PI, lack of liver cirrhosis, and Pseudomonas aeruginosa colonization.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Endocrinology & Metabolism
Momoka Mizoguchi, Hiroshi Takemori, Saho Furukawa, Masafumi Ito, Mutsumi Asai, Hirofumi Morino, Takanori Miura, Daisuke Yabe, Takashi Shibata
Summary: Metformin, a medication used to treat type 2 diabetes mellitus, can cause severe diarrhea in some patients. This study aimed to investigate the molecular mechanisms of metformin-induced diarrhea. The results showed that metformin increased bile flow and the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which plays a key role in diarrhea.
Review
Chemistry, Medicinal
Delia Preti, Pier Giovanni Baraldi, Allan R. Moorman, Pier Andrea Borea, Katia Varani
MEDICINAL RESEARCH REVIEWS
(2015)
Review
Chemistry, Medicinal
Chiara Ruzza, Girolamo Calo, Salvatore Di Maro, Salvatore Pacifico, Claudio Trapella, Severo Salvadori, Delia Preti, Remo Guerrini
EXPERT OPINION ON THERAPEUTIC PATENTS
(2017)
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Biochemistry & Molecular Biology
Mauro Marastoni, Claudio Trapella, Alessandra Scotti, Anna Fantinati, Valeria Ferretti, Erika Marzola, Gallerani Eleonora, Riccardo Gavioli, Delia Preti
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2017)
Meeting Abstract
Pharmacology & Pharmacy
G. Aquila, G. Morciano, D. De Marco, D. Preti, G. Pedriali, C. Trapella, G. Campo, P. Rizzo, P. Pinton
VASCULAR PHARMACOLOGY
(2018)
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Biochemistry & Molecular Biology
Delia Preti, Romeo Romagnoli, Riccardo Rondanin, Barbara Cacciari, Ernest Hamel, Jan Balzarini, Sandra Liekens, Dominique Schols, Francisco Estevez-Sarmiento, Jose Quintana, Francisco Estevez
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Giampaolo Morciano, Delia Preti, Gaia Pedriali, Giorgio Aquila, Sonia Missiroli, Anna Fantinati, Natascia Caroccia, Salvatore Pacifico, Massimo Bonora, Anna Talarico, Claudia Morganti, Paola Rizzo, Roberto Ferrari, Mariusz R. Wieckowski, Gianluca Campo, Carlotta Giorgi, Claudio Trapella, Paolo Pinton
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
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Multidisciplinary Sciences
Salvatore Pacifico, Alfonso Carotenuto, Diego Brancaccio, Ettore Novellino, Erika Marzola, Federica Ferrari, Maria Camilla Cerlesi, Claudio Trapella, Delia Preti, Severo Salvadori, Girolamo Calo, Remo Guerrini
SCIENTIFIC REPORTS
(2017)
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Pharmacology & Pharmacy
Francesco De Logu, Simone Li Puma, Lorenzo Landini, Tiziano Tuccinardi, Giulio Poli, Delia Preti, Gaetano De Siena, Riccardo Patacchini, Merab G. Tsagareli, Pierangelo Geppetti, Romina Nassini
PHARMACOLOGICAL RESEARCH
(2019)
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Chemistry, Medicinal
Salvatore Pacifico, Valeria Ferretti, Valentina Albanese, Anna Fantinati, Eleonora Gallerani, Francesco Nicoli, Riccardo Gavioli, Francesco Zamberlan, Delia Preti, Mauro Marastoni
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
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Biochemical Research Methods
Salvatore Pacifico, Valentina Albanese, Davide Illuminati, Anna Fantinati, Erika Marzola, Federica Ferrari, Joaquim Azevedo Neto, Chiara Sturaro, Chiara Ruzza, Girolamo Cato, Delia Preti, Remo Guerrini
BIOCONJUGATE CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Maira Macedo Noroes, Larissa Gonzaga Santos, Elaine Cristina Gavioli, Vanessa de Paula Soares Rachetti, Michel Fleith Otuki, Daniela de Almeida Cabrini, Arthur da Silveira Prudente, Janiana Raiza Jentsch Matias Oliveira, Muryel de Carvalho Goncalves, Juliano Ferreira, Delia Preti, Francesco De Logu, Romina Nassini, Eunice Andre
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Giulia Breveglieri, Salvatore Pacifico, Cristina Zuccato, Lucia Carmela Cosenza, Shaiq Sultan, Elisabetta D'Aversa, Roberto Gambari, Delia Preti, Claudio Trapella, Remo Guerrini, Monica Borgatti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Salvatore Pacifico, Federica Ferrari, Valentina Albanese, Erika Marzola, Joaquim Azevedo Neto, Chiara Ruzza, Girolamo Calo, Delia Preti, Remo Guerrini
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
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Pharmacology & Pharmacy
Chiara Ruzza, Federica Ferrari, Remo Guerrini, Erika Marzola, Delia Preti, Rainer K. Reinscheid, Girolamo Calo
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2018)
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Pharmacology & Pharmacy
Emlyn Clay, Riccardo Patacchini, Marcello Trevisani, Delia Preti, Maria Pia Brana, Domenico Spina, Clive Page
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2016)