News Item
Multidisciplinary Sciences
Heidi Ledford
Summary: Base editing is being tested in CAR-T-cell treatments for leukaemia, allowing specific modifications to a cell's genome.
Article
Business
Mohamed Yousfi, Younes Ben Zaied, Nidhaleddine Ben Cheikh, Bechir Ben Lahouel, Houssem Bouzgarrou
Summary: This study provides the first comparative assessment of the impacts of the first and second waves of the ongoing COVID-19 pandemic on the US stock market and its uncertainty. The findings show significant effects on the dynamic conditional correlation and asymmetric impacts of shocks between the US and Chinese stock markets, as well as persistent links between US returns, uncertainty, and the COVID-19 pandemic during the outbreak. The results demonstrate harmful consequences of the pandemic on financial markets in general and the US economy in particular.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2021)
News Item
Multidisciplinary Sciences
Philip Ball
Summary: In order to make quantum computers useful, IBM's latest quantum chip and its competitors have a long journey ahead.
Review
Engineering, Multidisciplinary
Daniel de C. L. e Penalva Santos, Carlos Correa, Yana Amaral Alves, Cristina Gomes Souza, Ronney A. Mancebo Boloy
Summary: Due to the environmental impacts of fossil fuels, agro-industrial residues are being explored as a viable alternative for eco-friendly fuel production. This research investigates Brazil's involvement in the development of biomass-based second-generation ethanol. Findings reveal an increasing number of patents applied between 2006 and 2015, but the sector still lacks the technological maturity to address the challenges faced by industrial plants. Public investments play a significant role in fostering inventions related to second-generation ethanol, with notable contributions from Chinese public organizations and North American companies, along with a lesser extent from Brazilian universities. Despite being the second-largest ethanol producer globally, Brazil has a low level of national technological development. However, the sector is expected to have a promising future in biofuel production based on new technological advancements.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Review
Neurosciences
Janusz K. Rybakowski
Summary: The narrative review focuses on mood stabilizers. It provides the author's definition of mood-stabilizing drugs and describes the two generations of drugs that meet this definition. The article presents the clinical experiences with first and second-generation mood stabilizers and discusses their use in preventing recurrences of bipolar mood disorder.
Article
Biochemistry & Molecular Biology
Yuma Shisaka, Erika Sakakibara, Kazuto Suzuki, Joshua Kyle Stanfield, Hiroki Onoda, Garyo Ueda, Miu Hatano, Hiroshi Sugimoto, Osami Shoji
Summary: A stable complex between HasA and TPP was reported, which can inhibit the growth of Pseudomonas aeruginosa and mutant variants of HasA binding FeTPP show a different coordination mode that allows the cyclopropanation of styrene.
Article
Agricultural Economics & Policy
Curtis McKnight, Feng Qiu, Marty Luckert, Grant Hauer
Summary: The production of biofuels in Canada is limited, but the availability of wheat straw as a feedstock holds promise for future development. Research shows positive relationships between wheat and corn, ethanol, highlighting potential price risks for second-generation ethanol production in Canada.
CANADIAN JOURNAL OF AGRICULTURAL ECONOMICS-REVUE CANADIENNE D AGROECONOMIE
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Zaluska-Ogryzek, Pawel Marzeda, Paula Wroblewska-Luczka, Magdalena Florek-Luszczki, Zbigniew Plewa, Hubert Bojar, Dorota Zolkowska, Jarogniew J. Luszczki
Summary: Combination therapy with multiple antiseizure medications can be an effective treatment method for epilepsy patients. A study on albino Swiss mice found that the combination of LCM + TPM + PGB showed the most beneficial results in suppressing tonic-clonic seizures. Isobolographic analysis and polygonogram method can be recommended for classifying interactions among antiseizure medications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Bert Vankeerberghen, Jeff Op de Beeck, Gert Desmet
Summary: Due to their dimensions, micropillar array columns are ideal for high-efficiency liquid chromatography separations in proteomics. The micropillar array concept has room to progress in terms of size reduction, which can lead to even higher-efficiency separations and applications. A comparison between first-generation (Gen 1) and second-generation (Gen 2) micropillar array columns on a chip showed that reducing the pillar and interpillar size did not affect the theoretical separation potential, resulting in significant reductions in analysis time.
ANALYTICAL CHEMISTRY
(2023)
Article
Optics
Patrick Mutter, Kjell Martin Molster, Andrius Zukauskas, Valdas Pasiskevicius, Carlota Canalias
Summary: We demonstrate first-order quasi-phase-matched backward second-harmonic generation with an efficiency of 18.7%, which represents a significant improvement compared to earlier experiments. The efficient backward second-harmonic generation is achieved in bulk periodically poled Rb:KTiOPO4 with a poling period of 317 nm. By investigating the properties of backward second-harmonic generation, such as spectral bandwidth, temperature tuning, and temperature bandwidth, we compare them with co-propagating second harmonic generation and explore the potential applications.
Article
Optics
Ming-Che Chan, Qi-Xin Liu, Ankur Gogoi, Wei-Hsun Wang, Chin-Yu Lin, Guan-Yu Zhuo
Summary: In this work, a novel strategy based on the SHG signals of first-order modulation (1M) is presented to enhance the image contrast/SNR in SHG-LSM. By using 1M signal for image acquisition, the image contrast is increased by more than a factor of two and the image acquisition time is shortened by a factor of 2.5.
OPTICS AND LASERS IN ENGINEERING
(2023)
Review
Biotechnology & Applied Microbiology
Chao Ye, Xinyu Wei, Tianqiong Shi, Xiaoman Sun, Nan Xu, Cong Gao, Wei Zou
Summary: This article reviews the development of genome-scale metabolic network models and discusses their importance in industrial biotechnology and human health applications. The challenges and future trends of GSMMs are also addressed.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mei Yang, Wen-Dong Yao, Wenlong Liu, Sheng-Ping Guo
Summary: In this study, a new rare-earth oxythiogermanate Eu3GeOS4 with a polar orthorhombic Pca2(1) structure is investigated. It exhibits obvious second-harmonic generation (SHG) response and high laser-induced damage threshold, making it a potential nonlinear optical material. Additionally, Eu3GeOS4 shows Curie-Weiss ferromagnetic behavior in the high-temperature region. The SHG effect is attributed to the synergistic effect of [EuOS6] and [GeOS3] units based on theoretical calculations.
CHEMICAL COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Manasi Agrawal, Giulia Corn, Sarita Shrestha, Nete Munk Nielsen, Morten Frisch, Jean-Frederic Colombel, Tine Jess
Summary: The study estimated the relative risk of IBD among first-generation and second-generation immigrants in Denmark, finding that the risk of IBD was lower for first-generation immigrants and increased with longer duration of stay in Denmark. The relative risk of IBD was lower only among women for second-generation immigrants.
Review
Pharmacology & Pharmacy
Silvia Pasquini, Chiara Contri, Martina Cappello, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi
Summary: Adenosine receptors (ARs) have great therapeutic potential for a wide range of pathological conditions. Targeting allosteric sites with allosteric modulators can overcome the limitations of orthosteric ligands. Promising results have been achieved with various allosteric modulators, but more research is needed for certain AR subtypes.
FRONTIERS IN PHARMACOLOGY
(2022)
