Review
Materials Science, Multidisciplinary
Muzamil Hussain, Syed Hasan Askari Rizvi, Naseem Abbas, Uzair Sajjad, Muhammad Rizwan Shad, Mohsin Ali Badshah, Asif Iqbal Malik
Summary: Titanium, stainless steel, and CoCrMo alloys are the most widely used biomaterials for orthopedic applications, but various factors can lead to implant failure. Coating is considered an effective method to improve implant material performance, and its impact on metallic implants has been extensively studied.
Article
Engineering, Biomedical
Diana C. Martinez, Anna Dobkowska, Romy Marek, Hanna Cwieka, Jakub Jaroszewicz, Tomasz P. Plocinski, Crtomir Donik, Heike Helmholz, Berengere Luthringer-Feyerabend, Berit Zeller-Plumhoff, Regine Willumeit-Roemer, Wojciech Swieszkowski
Summary: This study investigated the degradation of an Mg-0.45Zn-0.45Ca (ZX00) screw in vitro and in vivo. The results showed that the ZX00 alloy promoted bone healing and the formation of new bone. Despite the correlation with the production procedure, the ZX00 alloy was still suitable for temporary bone implants.
BIOACTIVE MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Deepak Rajendra Unune, Georgina R. Brown, Gwendolen C. Reilly
Summary: This review article discusses the importance of metallic biomaterials in clinical applications and their corrosion and wear resistance on implants. The article presents the properties of metallic biomaterials, the reasons for implant failure, and various surface modification techniques to enhance their corrosion and wear resistance.
Review
Engineering, Biomedical
Niyou Wang, Jerry Ying Hsi Fuh, S. Thameem Dheen, A. Senthil Kumar
Summary: Bone defects and diseases can have severe consequences, but orthopedic implants and scaffolds help in the treatment by promoting bone growth. Metallic and metallic oxide nanoparticles offer unique properties that can enhance orthopedic implants and scaffolds, but their potential toxicity to cells and tissues needs to be carefully considered.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Review
Chemistry, Physical
Sung-ryul Choi, Ji-won Kwon, Kyung-soo Suk, Hak-sun Kim, Seong-hwan Moon, Si-young Park, Byung Ho Lee
Summary: As surgical treatments in orthopedics expand, the development of biomaterials used for these treatments has advanced. Biomaterials have osteobiologic properties and can be classified as natural polymers, synthetic polymers, ceramics, allograft-based substitutes, and metallic implants. This review discusses the fundamental characteristics of metals and biomaterials used in the field, as well as advancements in nanotechnology and 3D-printing technology. A complementary relationship between doctors and biomaterial scientists is likely to be necessary in the future.
Review
Engineering, Biomedical
M. Prestat, D. Thierry
Summary: This review article discusses the in vitro corrosion of titanium and alloys under inflammation conditions, emphasizing the role of reactive oxygen species in degrading the passive layer protecting titanium implants. Inflammation contributes to the deterioration of biomedical devices, leading to health issues and implant failure. The review highlights the importance of electrochemical and microstructural aspects in understanding this process.
ACTA BIOMATERIALIA
(2021)
Review
Biotechnology & Applied Microbiology
Ming-qi Chen
Summary: Bioimplant engineering aims to provide biological replacements for injured tissues and organs. Nanoparticles play a vital role in orthopaedic implant applications by mimicking tissue features, offering antibacterial properties, and supporting cell development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Emilie Frisch, Lisa Clavier, Abdessamad Belhamdi, Nihal Engin Vrana, Philippe Lavalle, Benoit Frisch, Beatrice Heurtault, Varvara Gribova
Summary: Currently, implants and prostheses are widely used in medical practice, but their use carries the risk of complications. To address this issue, new antimicrobial and anti-inflammatory materials are being developed and require thorough preclinical testing. However, there is a lack of advanced in vitro models for evaluating these materials. This article provides an overview of current methods and models for preclinical evaluation of biomaterials and discusses future directions for innovative assays.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Metallurgy & Metallurgical Engineering
Violeta Tsakiris, Christu Tardei, Florentina Marilena Clicinschi
Summary: In the past decade, there has been significant growth in the market for alloys used for implants, especially in orthopedic implants. Research on biodegradable magnesium-based alloys has made great strides in the medical industry due to the desire to improve quality of life and reduce costs.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Review
Pharmacology & Pharmacy
Sadeq Alshimaysawee, Rasha Fadhel Obaid, Moaed E. Al-Gazally, Andres Alexis Ramirez-Coronel, Masoud Soroush Bathaei
Summary: In the past decade, metallic drug-eluting implants have gained significance for controlled drug release in orthopedic and dental applications, particularly in preventing infection. Recent studies have shown that these implants, loaded with drugs, can achieve sustained and controlled drug release, leading to desirable therapeutic effects. Various types of drug-eluting implants, containing drugs such as anti-inflammatory agents, antibiotics, growth factors, and anti-resorptive drugs, have been developed to meet specific needs.
Article
Chemistry, Physical
Naeimeh Sadat Peighambardoust, Armin Asghari Alamdari, Ugur Unal, Amir Motallebzadeh
Summary: In this study, a non-equimolar Ti1.5ZrTa0.5Nb0.5Hf0.5 RHEA film was successfully deposited on various substrates, showing improved mechanical properties and corrosion resistance, especially on the Ti6Al4V substrate. The results indicate the potential application prospects of RHEA films in surface coating technology.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Review
Biochemistry & Molecular Biology
Joana Barros, Fernando Jorge Monteiro, Maria Pia Ferraz
Summary: One of the most serious complications following orthopedic biomaterial implantation is infection, which not only causes clinical problems and patient suffering, but also burdens healthcare systems. Microorganisms can form biofilms on implant surfaces, leading to tissue destruction, infection development, and implant failure. Biofilms provide protection to bacteria and increase the pathogenesis of infection. The emergence of antibiotic-resistant strains has prompted the development of new approaches to prevent and control implant-related infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
B. Subramanian, P. Sasikumar, S. Thanka Rajan, K. Gopal Shankar, Murugan Veerapandian
Summary: This study developed a novel ternary amorphous alloy (Zr54Ti35Si11) coating using DC magnetron sputtering technique, which exhibited excellent corrosion resistance and bioactivity for biomedical implant application.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Review
Electrochemistry
Umanath Puthillam, Renold Elsen Selvam
Summary: Tribocorrosion is gaining popularity in biomaterials research as the synergistic effects of wear and corrosion deviate from the anticipated results of individual corrosion or wear studies. The corrosive nature of the host body, consisting of the immune system and dissolved proteins, presents unique challenges in material selection for implant materials. Research on tribocorrosion offers insights into this phenomenon and proposes strategies to prevent premature implant failure.
Article
Materials Science, Multidisciplinary
G. Jagadeesh, Srinivasu Gangi Setti
Summary: The tribological characteristics of magnesium Ze41A alloy were significantly improved by the ball burnishing process, leading to a decrease in wear rate and coefficient of friction. The enhancement is mainly attributed to the improvement in surface roughness and microhardness during the ball burnishing process.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2022)